the role of rad51 protein and its genetic variants

... the following activities; Profilin and ADF cofilin bind G- and F-actin and they are mostly concentrated at the leading edge of the cell They promote the disassembly of actin filament Gelsolin ... activate other Ras family proteins and the presence of separate Rho-specific GEF catalytic domains in Sos and RasGRF proteins provide the links between Ras activation and the function of Ras and Rho ... is dependent on the relative rates of reactions, the exchange of GDP for GTP and the hydrolysis of bound GTP These reactions occur spontaneously at a slow rate But the rates of these reactions...

Ngày tải lên: 14/09/2015, 14:14

... biologically plausible because this is the site of protein C activation, the endothelium contains the receptor for APC (EPCR), and the endothelium contains the PARs, which may also mediate APC ... antibody to PAR1, the endothelial protective effects of APC and the endothelial disruptive effects of thrombin could both be blocked, which suggests that the opposing effects of the two proteases ... Feistritzer and Riewald [26] concluded that the Available online http://ccforum.com/content/10/6/239 Figure The role of the protein C pathway in the endothelial cell APC modulates endothelial phenotype...

Ngày tải lên: 13/08/2014, 03:20

... SP-D in the prevention of bacterial colonisation of the alveolar epithelium Elimination of these SP-D functions could explain the colonisation of the trachea and nasopharynx, the decreased pneumococcal ... surfactant protein D plays an important role in delaying the appearance of pneumococci in the blood and in limiting their numbers in the bloodstream SP-D binds and agglutinates S pneumoniae in the presence ... mice cleared bacteria from their blood by 48 hrs post infection and that the numbers of pneumococci in the blood of both strains of mice reflected their levels in the lung These results strongly...

Ngày tải lên: 12/08/2014, 18:20

... ELUCIDATING THE ROLE OF REDOX EFFECTS AND THE KU80 CTERMINAL REGION IN THE REGULATION OF THE HUMAN DNA REPAIR PROTEIN KU DNA double strand breaks (DSB) are among the most lethal forms of DNA damage and ... has the potential to influence the DNA binding activity of Ku (51) To further understand the role of the C-terminus of Ku80, we created two mutants The first mutant contains a truncated form of ... between the Ku70 and 80 subunits, despite the fact that they share minimal sequence homology (15) The three-dimensional structure of Ku enables the protein to slide or translocate along the length of...

Ngày tải lên: 24/08/2014, 11:02

... position 13 of the other subunit [25,26], yielding a covalently bridged dimer The 4170 oxidized and reduced forms of the Y74C mutant had very different thermal stabilities While the stability of the ... and in the presence of denaturants [27] Extending these studies, we examine here the effect of increasing the bulk of the residue at position 74 Surprisingly, the Y74W mutant exhibited loss of ... solvent exposure of the buried Trp74 residue Figure summarizes the dependence of the emission maxima (kmax) on protein concentration for Y74W* and the PfTIM WT protein The wild-type protein shows...

Ngày tải lên: 18/02/2014, 11:20

Ngày tải lên: 18/02/2014, 11:20

... Thus, given the values of the four target fluxes v9, v16, v21 and v26, the values of all other stationary fluxes are fully determined by the value of the glucose uptake flux Calculation of the stationary ... this report briefly outlines the mathematical basis of the method The second part presents two applications of the method to the metabolism of erythrocytes and of the microorganism, Metylobacterium ... provided that other reactions in the system are capable of accomplishing the required change in the concentration of the reactants For example, the standard free energy change of the glyco- 2908...

Ngày tải lên: 07/03/2014, 15:20

... patterns of B2wt and of B1 ⁄ B2 chimeras reflect their agonist-inducible internalization The segment between the NPXXY motif and the conserved cysteine represents one of the regions with the highest ... because the presence of detergent or membrane lipids influences the formation of a helical structure These authors proposed that activation of the receptor, and subsequently of the G protein, ... 2004 FEBS A Faussner et al Role of helix and C-termini in bradykinin receptors Fig Schematic representation of the C-terminal B1wt and B2wt sequences and chimera thereof The C-terminal sequences...

Ngày tải lên: 07/03/2014, 16:20

... in the tiger prawn Penaeus monodon As there is a high degree of sequence similarity and structural conservation of these genes and gene products, confirmation of the true identity and function of ... nmol or 0.66 nmol of rMIH-B at the arthropodial membrane of the periopod and returned to the culture tanks At 24, 48 and 72 h after injection, the hepatopancreas and ovary of the shrimp were dissected ... rMIH-A, and rMIH-B Right: western blot analysis (upper) of the hemolymph level of vitellogenin for shrimp injected with rMIH-B The 148 kDa protein is one of the vitellogenin subunits recognized by the...

Ngày tải lên: 16/03/2014, 05:20

... As the pKa values of the catalytic residues determine the pH optima, the ionization constants (pKa) of the catalytic glutamates (E187 and E399) in the ES complex and in the free enzyme (E) of ... contribute to the observed result In the Y331F mutant the replacement of Y331 for phenylalanine shifted the pKa of E399 by +0.7 pH units (from 4.8 to 5.5) and the pKa of E187 by +1.6 pH units (7.49.0) ... b-glucosidase affected the rate constant of the glycosylation step and also changed the enzyme pH optimum [14] Despite that, the effect of the tyrosine on the pKa values of the b-glycosidase catalytic glutamates...

Ngày tải lên: 23/03/2014, 15:21

... for explaining the determinants of economic growth The focus on labor and capital as the primary factors of production, and the general exclusion or trivialization of the role of knowledge, was ... skilled labor, and technology The neo-technology theories focused on the role of R&D and the creation of new economic knowledge in shaping the comparative advantage and flows of foreign direct ... function of the number and concentration of permanent links 199 Dispersion as a function of the number and concentration of permanent links 200 Expertise as a function of the number and concentration...

Ngày tải lên: 01/06/2014, 11:20

... (ADC) on the the microcontroller, streamed to PC software Position sensors were attached to the thumb and forefinger, the wrist and the base of the object, to enable accurate Saunders and Vijayakumar ... random unpredictable delays to the hand controller In contrast to experiments and 2, where the control of the hand was repeatable and predictable, this experiment was designed to examine the role ... briefly before the start of the first trial, with full feedback sensibility, so that they could get used to the control mechanism of the hand Subjects performed the four blocks of the experiment...

Ngày tải lên: 19/06/2014, 08:20

... mineralizing RNA profile of igf-1, alp, and bmp-2 and significantly increased expression of other genes associated with mineralization like col1a1, fn, ilgf-1, noggin and oc Fgf-2, on the other hand, significantly ... matrix and promote healing [24] In this study, we have documented the relative efficiency of bone growth factors FGF-2, TGFb, and PGE2 markedly enhanced the synthesis of the total protein content of ... proliferation and mineralization [2,26-29] These two stages are the result of a specific sequential regulation of gene expression from the early phase of osteoblast proliferation to the final steps of mineralization...

Ngày tải lên: 20/06/2014, 04:20

... mineralizing RNA profile of igf-1, alp, and bmp-2 and significantly increased expression of other genes associated with mineralization like col1a1, fn, ilgf-1, noggin and oc Fgf-2, on the other hand, significantly ... matrix and promote healing [24] In this study, we have documented the relative efficiency of bone growth factors FGF-2, TGFb, and PGE2 markedly enhanced the synthesis of the total protein content of ... proliferation and mineralization [2,26-29] These two stages are the result of a specific sequential regulation of gene expression from the early phase of osteoblast proliferation to the final steps of mineralization...

Ngày tải lên: 20/06/2014, 07:20

... interviews Some of the patient interviews were historical and the primary purpose of those interviews was not to assess the QoL of the patients, but rather to assess their perceptions of current treatments ... ICT, and by the condition (thalassemia, SCD, MDS) Figure provides an overview of the hypotheses for the impact of infusion ICT on the QoL of patients with iron overload In thalassemia, the impact ... that the impact of such therapy included pain at the injection site (3/9 [33%]), although one patient reported that the problem was not the pain from the injection site but rather awareness of the...

Ngày tải lên: 20/06/2014, 16:20

Ngày tải lên: 20/06/2014, 21:20

Ngày tải lên: 21/06/2014, 17:20

Ngày tải lên: 21/06/2014, 19:20

... electrons in the valence band (VB) can be excited to the conduction band (CB) to form the photo-generated electrons in the CB and the same amount of holes in the VB The holes in the VB are prone ... photocatalytic activity of ZnO nanowires (grown in the mixed gas stream) is higher than that of the ZnO Fig Curves of the degradation rate of MO and UV irradiation time with the photocatalyst of the ZnO nanowires ... solution and 60 mg ZnO nanowires The UV lamp (6 W) was placed in the center of the tube and surrounded by the reactor Prior to irradiation, the solution was sonicated for 30 and then stirred in the...

Ngày tải lên: 22/06/2014, 00:20

... equality, the rule of law and respect for and protection of human rights […] Recognizing the need to strengthen the important role of the United Nations in the prevention of violent conflicts, and ... emerged from the growing realization of the need to put the poor and all aspects of their lives and means of living at the centre of development and humanitarian work, while maintaining the sustainability ... led to the onset of war, the characteristics of the conflict itself, the nature of the peace settlement, and the influence of external forces (i.e global economic or political pressures) The previous...

Ngày tải lên: 28/06/2014, 19:20