the role of iron in retinal diseases

... total proteins) In all examined subregions of brains of DS subjects, the level of Role of DYRK1A in neurodegenerative diseases DYRK1A is higher than in control brains, but with an increase that ... speckles, the site of storage of inactivated serine ⁄ arginine-rich proteins, including ASF This mechanism prevents ASF from facilitating tau exon 10 inclusion and upregulates the expression of 3R-tau ... NFTs in the brains of people with DS ⁄ AD [17]; phosphorylation of ASF, leading to alternative splicing of exon 10; and the several-fold greater number of 3R-tau-positive NFTs in the brains of...

Ngày tải lên: 22/03/2014, 16:21

... The role of the intestinal microflora for the development of the immune system in early childhood Eur J Nutr 2002, 41(Suppi 1):I32-7 Penders J, et al.: Molecular finger printing of the intestinal ... allergy factors influencing development of the microbiota Ann Med 1999, 31(4):288-92 Kalliomaki M, Isolauri E: Role of intestinal flora in the development of allergy Curr Opin Allergy Clin Immunol ... Clin Immunol 2007, 120(2):343-50 (WHO), FaAOFotUNaWHO: Guidelines for the Evaluation of Probiotics in Food Report of a Joint FAO/WHO Working Group on Drafting Guidelines for the Evaluation of...

Ngày tải lên: 08/08/2014, 21:20

... instructive in elucidating the role of stress in symptom expression From a vast array of experimental studies it is reasonable to conclude that a variety of stressors may cause pain, that pain ... or serotonin–norepinephrine reuptake inhibitors) are equally effective analgesics in chronic pain conditions in patients with and without depression [8] The lack of direct overlap in the central ... between these systems Observable changes in the ANS or HPA axis tone in some individuals may represent a baseline diathesis or risk factor for the subsequent development of chronic pain, or the changes...

Ngày tải lên: 12/08/2014, 14:21

... profitability is declining The internalization of information within the same institution may thus enhance intra-circuit and inter-circuit stability by reducing the incentive to overfinancing The ... Creating a stronger investor base amounts to strengthening the circuit by completing the financial market structure of the economy, thus eliminating discontinuities in the transmission of information ... placing money with investment financial institutions in the capital market, and hold the remaining share in noninterest bearing, short-term bank deposits (eq 7) The share of savings going to the...

Ngày tải lên: 24/10/2012, 09:33

... English at the expense of the other languages that exist in the country, the adult language program in Botswana maintains the hegemony and the gap between the poor and the rich, the major and minority ... for the betterment of their conditions It could mobilize the so called minorities to oppose their status and challenge the hegemony of the majority communities in Botswana 31 In most parts of the ... is for the most part the preserve of the few (elites) The choice of which language or dialect to use to teach (medium of instruction) reflects the interests of those elite In countries in which...

Ngày tải lên: 05/11/2012, 16:27

... categories of business-to-business advertising are industrial and professional advertising b.1 Industrial advertising Advertising targeted at individuals who buy or influence the purchase of industrial ... development of the industry also fosters the other industries in society, which contributes to the development of the economy as a whole In Vietnam, spending for advertising is rather lower than that in ... advertising industry Since the opening policy and law of foreign investment, advertising industry has seen remarkable changes The growth rate of advertising service is the highest in economy, in which...

Ngày tải lên: 16/04/2013, 11:05

... establishment of the Faculty of Arts and the Faculty of Medicine in 1935, the Faculty of Economics and Law in 1936, the Faculty of Theology in 1942 and, finally, the Faculty of Science in 1954 The main ... the Folketing, on the role of the University as the principal shareholder in Cheminova The listing of Cheminova on the Stock Exchange in 1986 and the establishment of the first science park in ... behind the economic upswing and increase in employment in Denmark since the start of the economic boom at the beginning of 1994 The Greater Copenhagen area together with the Municipalities of...

Ngày tải lên: 16/01/2014, 16:33

... critical in ensuring the effective use of ICTs in the health sector Programme designs should consider the role of the intermediary at the same time as, if not before, the role of the technology The ... reminding them about their medication The messages can be sent in one of three languages and in a range of styles to ensure they not become boring Of the 138 patients involved in the pilot, there ... that ‘there has been virtually no progress in making the internet available in the least developed countries, especially in the rural areas’ By including the rural population in the group of beneficiaries...

Ngày tải lên: 14/02/2014, 09:20

... president of the National Academy of Engineering The Institute of Medicine was established in 1970 by the National Academy of Sciences to secure the services of eminent members of appropriate professions ... Engineering in providing services to the government, the public, and the scientific and engineering communities The Council is administered jointly by both Academies and the Institute of Medicine ... by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of...

Ngày tải lên: 15/02/2014, 16:20

... to the natural protectorate law and the decision of the Prime Minister regulating to activities inside the protectorates in addition to the inefficiency of the biological treatment project of ... microbiological properties of groundwater in Saint Katherine, South Sinai, Egypt and exploring the diversity, occurrence and distribution of fungal taxa in groundwater in South Sainai, samples of groundwater ... Azeem was one of a few Media reported the progress in increasing interest.[19],[20].to investigate the amount and seriousness of pollution caused by factories dumping their waste in the Egyptian...

Ngày tải lên: 18/02/2014, 04:20

Ngày tải lên: 18/02/2014, 11:20

... the name of ‘alpha-synucleinopathies’ The mechanism of alpha-syn aggrega- tion in PD and DLB is not yet clear The presence of ubiquitin in LBs and the association of mutations in the ubiquitin-proteasome ... developmental delay The protein defective in this disorder is also a NHEJ protein The distinct clinical features of the patients will be discussed in the context of the protein function 3.4 Diabetes, ... Mutations in the ERCC1 gene induce a distinct set of accelerated ageing features, with a rate of onset depending on the severity of the mutation The correlation between repair defect severity and clinical...

Ngày tải lên: 19/02/2014, 07:20

... income, thereby providing a more accurate measure of the impact of the disease If one looked only at the impact of HPAI on the income from poultry without accounting for its role in the whole income ... detail the role of poultry (both as a source of income and as an asset) in the entirety of the households’ income and asset portfolios Regarding the sources of data used in this study, for the West ... matching approach The results of this study generate valuable information regarding the role of poultry in the livelihoods of small-scale poultry-producing households and the livelihoods impacts of...

Ngày tải lên: 21/02/2014, 01:20

... of Computer Science TR-70, Rutgers University, New Brunswick,N.J Reinhart, T;mya [1976] The Syntactic Domain of Anaphora unpublished Ph.D dissertation, Department of Foreign Literature and LinBuistics,M.I.T ... Charles J [1974] Conceptual Memory: A Theory and Compufer Program for Processing Ihe Meaning Content of Natural Language Utterances Stanford Artificial Intelligence Lab Memo AIM-233 Sidner, Candace ... Candace L [1979] To,'ards a Computational Thmr7 of Definite Anaphora Comprehension in £nglish Discour~ unpublished Ph.D disseration, Electrical Engineering and Computer Science, M.I.T Webber, Bonnie...

Ngày tải lên: 21/02/2014, 20:20

... sharing of initiative — the expert had initiative for 60% of the turns in finance ADs and 51% of the turns in software ADs This is because in the ADs, the novice must communicate the details of ... determining the current discourse focus" (p 6), and that task initiative "tracks the lead in the development of the agents' plan" (p 6) Presumably, determining the discourse focus means setting the ... overview of the evidence in favor of Socratic tutoring as well as describing an opposing viewpoint supporting a tutoring style referred to as didactic Here, rather than drawing out the answer from the...

Ngày tải lên: 22/02/2014, 02:20

... made the role of the dentist in diagnosing and treating pain in the head and neck region increasingly obscure rather than more clear In the academic debate concerning the etiology—predominantly ... Evaluation Findings in the Teeth and Mucous Membrane The intraoral evaluation includes in particular: • careful evaluation of the mucous membranes • determination of the status of the teeth, including ... fibrocartilaginous joint surface (thin arrows) of the condyle of a 58-year-old individual In spite of the intact joint surface on the condyle, the pars posterior (1) of the disk is flattened and the functional...

Ngày tải lên: 06/03/2014, 11:20

... of lack of relevant data They used the education of the total labor force in a state for the measurement of the quality of the labor force of individual industries within the same state But the ... number of men and e1 the proportion of the workers in the lth category of labor services, one may write the index of the total labor input in the form: L = —+—+ H N — Thus, to eliminate errors of ... L4 be the quantity of input of the Ith labor service, measured in man- hours The rate of growth of the index of total labor input, say L, is: i — —— L — where v1 is the relative share of the lth...

Ngày tải lên: 06/03/2014, 21:20

... that the coordination of the Zn(II) ion bound at the C-terminal moiety of CeMT1 is contributed to by histidines, and the number of these involved in metal binding is analyzed below Thus, the overall ... some hint of partial participation in a subset of the metal complexes present in our preparations The role of histidine in metal ion coordination in MTs is a subject that has gathered increasing ... noteworthy in view of their coordinative potential, CeMT1 includes four histidines, whereas CeMT2 only has a terminal one In the absence of a comprehensive analysis of the metal-binding abilities of...

Ngày tải lên: 07/03/2014, 02:20

... divergence in chromatin remodelling One of the most distinctive characteristics of chromatin remodelling during spermatogenesis is the expression of a large number of histone variants Indeed, in addition ... bromodomain-bearing proteins, enabling them to bind acetylated chromatin (Fig 3) Bromodomains are acetyl-lysine binding modules present in ATP-dependent chromatin remodelling factors as well as in ... phophorylation of Thr/Ser in Thr/Ser-Lys or Lys-Thr/Ser pairs found in the four histones may negatively regulate the binding of chromodomains to methylated lysines Indeed, chromodomain-containing proteins...

Ngày tải lên: 07/03/2014, 16:20

... THE ROLE OF THEORY IN AESTHETICS* MORRIS WEITZ Theory has been central in aesthetics and is still the preoccupation of the philosophy of art Its main avowed concern remains the determination ... assert that what they find in that art can be generalized for what is "art" in the others as well The essence of painting, they maintain, are the plastic elements in relation Its defining property ... recommendations; rather it is the debates over the reasons for changing the criteria of the concept of art which are built into the definitions In each of the great theories of art, whether correctly...

Ngày tải lên: 07/03/2014, 17:20