the role of hypoxia and hyperthermia in chemotherapy

... diagnosis and management of head and neck cancer 2.2.3 combined effects of smoking and alcohol consumption The combination of smoking and alcohol consumption increases the risk of developing cancer ... new cancers of the head and neck are registered in Scotland each year The incidence of disease has tended to increase with age and in the UK 85% of cases are in people aged over 50 There is now ... diagnosis and management of head and neck cancer Platinum monochemotherapy is as effective as polychemotherapy containing platinum when given concurrently with radiotherapy Non-platinum chemotherapy...

Ngày tải lên: 14/02/2014, 22:20

... carcinogens The anterior aspect of the oral cavity is the contact point of the skin with the vermilion of the lips extending posteriorly to the junction of the hard and soft palates, and with the ... vestibule and the vermillion borders of the lips and continues to the junction of the cricoid cartilage and the cervical trachea and at the level of the cricoid where the hypopharynx meets the cervical ... is the junction of the skin and vermilion border of the lip The posterior border is formed by the junction of the hard and soft palates superiorly, the circumvallate papillae inferiorly, and the...

Ngày tải lên: 15/03/2014, 00:20

... ALL HEAD AND NECK CANCERS REDUCING RISK The risk of having head and neck cancer can be reduced by: B B not smoking or chewing tobacco C increasing the intake of fruit and vegetables (specifically ... and fish oils C reducing the intake of red meat, fried food and fat limiting alcohol consumption, in line with government guidelines PRESENTATION AND SCREENING All healthcare practitioners, including ... radiotherapy with concurrent cisplatin chemotherapy A In patients medically unsuitable for chemotherapy, consider concurrent administration of cetuximab with radiotherapy Single modality radiotherapy...

Ngày tải lên: 15/03/2014, 01:20

... includes the under surface of the soft palate, the base of the tongue and the tonsils, the hypopharynx (bottom part of the throat) and the nasopharynx (behind the nose) The most common site of cancer ... on the lip or in the mouth, but there may also be pain and/ or a lump in the neck Other symptoms are a white or red patch on the gums, tongue or lining of the mouth, and unusual bleeding, pain ... heard of it are more likely to be aware of the role of smoking than of other risk behaviours.25 Cancer of the larynx Cancer of the larynx (voice box) is the second most common form of head and...

Ngày tải lên: 22/03/2014, 16:21

... cause inter- and intrastrand cross-linking These DNA cross-links are recognized and removed by the nucleotide excision repair pathway which arms to guard the integrity of the genome [15,16] The ... insurance, cisplatin is the backbone of the chemotherapy regimen as a component of IC and CCRT in the treatment of locally advanced HNSCC Its main cytotoxic activity is based on the formation of DNA adducts, ... multiplied by the staining intensity to obtain a final semi-quantitative H score The median value of the H score was chosen as the cutoff point for separating low and high levels of ERCC1 expression...

Ngày tải lên: 18/06/2014, 19:20

... cause inter- and intrastrand cross-linking These DNA cross-links are recognized and removed by the nucleotide excision repair pathway which arms to guard the integrity of the genome [15,16] The ... insurance, cisplatin is the backbone of the chemotherapy regimen as a component of IC and CCRT in the treatment of locally advanced HNSCC Its main cytotoxic activity is based on the formation of DNA adducts, ... multiplied by the staining intensity to obtain a final semi-quantitative H score The median value of the H score was chosen as the cutoff point for separating low and high levels of ERCC1 expression...

Ngày tải lên: 20/06/2014, 03:20

... local anesthesia in the CT room After determining the target volume, 18gauge interstitial needles were inserted into the tumor through the skin surface with PTV under CT supervision Most of the 18-gauge ... LDR irradiation, which, in turn, minimizes injury to the overlying skin and surrounding neurovascular structures In this study, we investigated the efficacy and feasibility of percutaneous CT-guided ... reported Catheters are inserted during intraoperative HDR or PDR brachytherapy on the basis of preoperative images and intraoperative presentation Planning of intraoperative HDR or PDR brachytherapy...

Ngày tải lên: 09/08/2014, 09:20

... reirradiation alone or with chemotherapy The likelihood of cure is impacted by the interval between the initial course of radiotherapy and reirradiation depending on, whether the carcinoma is a recurrence ... tumor involving the Rosenmueller fossa that invades deeply into the foramen lacerum, which is the location where the cervical portion of the internal carotid artery curves upward and enters the ... http://www.ro-journal.com/content/6/1/98 99-11; the chemotherapy- alone arm allowed selection of one of the cisplatin-based chemotherapy regimens (cisplatin + paclitaxel, docetaxel, or 5-FU) The primary end point of this trial...

Ngày tải lên: 09/08/2014, 09:21

... according to the guidelines of the International Commission on Radiation Units and Measurements Report 62 [11] They were not blinded to each other and outlined together the contours achieving a final ... is the study coordinator, participated in the development of the study and drafted the manuscript GL worked on analysis of data, DB, GG, EI and MB participated in the design of the study and ... are involved in continuing optimization MK is the study chairman, developed the design of the study, is involved in continuing optimization and helped to draft the manuscript All authors read and...

Ngày tải lên: 09/08/2014, 09:22

... implants, and the remaining single plan implants The interval between the end of I-HDR and the start of the second course of EBRT ranged from to 37 days (median days) No patient had concurrent I-HDR and ... compare means The follow up time was defined as the interval between the date of being admitted to the hospital and the date of the last objective follow up information or death Statistical significance ... option, especially because of the high number of centers that possesses the HDR after loading facilities, due the high incidence of cervix cancer, and the lack of IMRT or 3D-RT In conclusion, our results...

Ngày tải lên: 09/08/2014, 10:21

... and JO were involved in the conception and design of the study AO acquired the data AO and BF participated in the analysis and interpretation of the data BF, EEU and B were involved in drafting ... types of head and neck cancer in the maxillofacial area Carcinomas and sarcomas of the maxillofacial region were commonest in the maxilla, while the highest number of lymphomas occurred in the mandible ... Lagos in which the mandibular gingiva, maxillary gingiva and hard palate were the most common intraoral sites (in descending order) Other studies from Nigeria showed the tongue, palate and mandibular...

Ngày tải lên: 11/08/2014, 20:21

... kinase (IKK)α/β/γ and casein kinase complexes modulating NFκB1, RELA and cREL, and alternative pathways involving NF-κB inducing kinase and IKKα modulating NFκB2 and RELB [1,2,11,24-26] Furthermore, ... thousands of direct and indirect physical and functional interactions from peer-reviewed publications The relationships in the network include protein-protein interactions, protein binding to ... al R53.15 Binding activityprevious page) of RELA and NFκB1 Figure (see and motif logo Binding activity and motif logo of RELA and NFκB1 (a) The basal and inducible binding activity of RELA or...

Ngày tải lên: 14/08/2014, 08:20

... against infection and invading connective tissue There are still very few studies applying the methods of tissue engineering to produce tracheal replacements and to examine these in vitro and in ... technique and bearing in mind the contraindications, more than 90% of the children can nowadays be extubated without problems In spite of the progress, in children undergoing single-step surgical therapy ... for the reconstruction of pharyngeal defects is currently at the early beginning Until now, there are only data concerning the use of implant materials in the area of the oral mucosa and the...

Ngày tải lên: 25/10/2013, 08:20

... begins in the gut of the sandfly, but the organism completes its life cycle in the host following the fly bite The sandfly inoculates the host with the organisms in the promastigote stage Once the ... mass at the angle of the jaw The masses gradually increase in size and number and form sinuses that open onto the face and neck Although infection is often seen in the jaw area, Actinomyces infections ... weapon There are major forms of infection with the organism: cutaneous, inhalation, and gastrointestinal.93 The details of these forms of anthrax will not be discussed with the exception of gastrointestinal...

Ngày tải lên: 19/02/2014, 08:20

... staining (data not shown) Her2 staining was scored based on the scoring system applied to breast cancers, with scores of 0,+1, +2, +3 for increasing intensity and “continuity” of staining of the ... difference of antibodies used for staining or method of assessment for determination of Her3 status So far, there are no standardized methods of Her3 staining and scoring, our findings suggest the importance ... tissues and 17 recurrent HNSCC tissues The clinical information of these patients was obtained from the University of Immunohistochemistry and scoring To investigate the significance of Her2 and...

Ngày tải lên: 18/06/2014, 22:20

... by one of the authors (AB) The percentage of tumor cells showing a positive membranous/cytoplasmatic staining and the intensity of staining were assessed Cases with complete lack of staining were ... guidelines of treatment at the time All patients gave written informed consent for research use of the tissues and for participating in the research project The study was conducted according to the ... (rs4986791) These polymorphisms alter the amino acid sequence of the TLR4 protein and affect the extracellular domain and ligand-recognition area of the TLR4 receptor These SNPs have been reported to...

Ngày tải lên: 18/06/2014, 22:20

... staining (data not shown) Her2 staining was scored based on the scoring system applied to breast cancers, with scores of 0,+1, +2, +3 for increasing intensity and “continuity” of staining of the ... difference of antibodies used for staining or method of assessment for determination of Her3 status So far, there are no standardized methods of Her3 staining and scoring, our findings suggest the importance ... tissues and 17 recurrent HNSCC tissues The clinical information of these patients was obtained from the University of Immunohistochemistry and scoring To investigate the significance of Her2 and...

Ngày tải lên: 20/06/2014, 04:20

... by one of the authors (AB) The percentage of tumor cells showing a positive membranous/cytoplasmatic staining and the intensity of staining were assessed Cases with complete lack of staining were ... guidelines of treatment at the time All patients gave written informed consent for research use of the tissues and for participating in the research project The study was conducted according to the ... (rs4986791) These polymorphisms alter the amino acid sequence of the TLR4 protein and affect the extracellular domain and ligand-recognition area of the TLR4 receptor These SNPs have been reported to...

Ngày tải lên: 20/06/2014, 04:20