the role of endosomes during mitotic cell division

... Phong Page 41 of 291 Chapter 1: Introduction 1.6.5 Transition through Mitosis The final stage of the cell- cycle is the act of cell division In terms of total time, the act of cell- division is a ... regulators of the cell cycle, including Cdc2/cyclinB complex, now known CDK1 (100) The main goal of cells in the G1 phase of the cell cycle is to prepare for DNA synthesis in the ensuing S phase The ... play a major role in the transmission of external stimuli to the inside of the cell A large number of signal transduction receptors are found on the surface of the cell and are termed cell surface...

Ngày tải lên: 11/09/2015, 09:02

... incorporated during the first meiotic prophase, then concentrated in a limited number of chromatin regions and further disappears with the other core histones during the elongation of spermatids ... could have a role in organizing the centromeres during the final stages of spermiogenesis and/or the paternal genome during early embryogenesis [81] A role for specific histone chaperones Cellular ... 2C) The observation of a pair of neighbouring amino acids both targets of post-translational modifications has recently led to the proposal of the Ôbinary switchesÕ hypothesis modulating the readout...

Ngày tải lên: 07/03/2014, 16:20

... wtSOD1 cells These results highlighted the role of the level of mutant protein in the response of the GSH pathway In agreement with this, in transgenic G93ASOD1 mice, expressing very high levels of ... G93A-NSC cell lines were maintained in the presence of 0.5 mgÆmL)1 G418 The cell Samples of the conditional cell lines were thawed (time 0) and cultured with dox (Fig 1A) At the end of the second ... modulation of the activity and ⁄ or expression of GCL Knowledge of the strategies by which cells expressing wtSOD1 limit their damage may help improve our ability to counteract the toxicity of the mutant...

Ngày tải lên: 29/03/2014, 23:20

... we determined the effect of the individual N-glycans on the maturation cleavage by analysing the presence of the cleaved subunit GP-2 Disruption of the N-glycosylation sites within the GP-1 mutants ... participated in the analysis of the results and drafted the manuscript OL helped to draft the manuscript and revised it critically WG designed the study, participated in the analysis of the results ... is also transported to the cell surface of SKI-1/S1P deficient cells (data not shown) The finding that only an endo H-sensitive form of Lassa virus GP-C was found at the cell surface suggests...

Ngày tải lên: 20/06/2014, 01:20

... have documented the relative efficiency of bone growth factors FGF-2, TGFb, and PGE2 markedly enhanced the synthesis of the total protein content of the dishes (Table 1) Rate of proliferation ... explain the ability of the FGF-2 to enable the cultured cells to fill the defect void efficiently The fact that FGF-2 induces its own expression suggests that after injury, the FGF-2 released from the ... mineralization [2,26-29] These two stages are the result of a specific sequential regulation of gene expression from the early phase of osteoblast proliferation to the final steps of mineralization...

Ngày tải lên: 20/06/2014, 04:20

... have documented the relative efficiency of bone growth factors FGF-2, TGFb, and PGE2 markedly enhanced the synthesis of the total protein content of the dishes (Table 1) Rate of proliferation ... explain the ability of the FGF-2 to enable the cultured cells to fill the defect void efficiently The fact that FGF-2 induces its own expression suggests that after injury, the FGF-2 released from the ... mineralization [2,26-29] These two stages are the result of a specific sequential regulation of gene expression from the early phase of osteoblast proliferation to the final steps of mineralization...

Ngày tải lên: 20/06/2014, 07:20

... condition Similarly, the contribution of angiogenesis to the development of psoriatic plaques may preclude the use of PHDIs The use of PHDIs in IBD does, however, show some promise The profound protection ... http://arthritis-research.com/content/11/1/215 suggested that the regulation of intestinal epithelial cell apoptosis is crucial in the development of inflammation in the gut [67,68] Further support for the above data is provided ... with FG-4497 [69], coupled with the pre-eminent role of the intestinal epithelial cell in preventing inflammation, makes the use of PHDIs an attractive potential therapeutic strategy in IBD 10...

Ngày tải lên: 09/08/2014, 01:22

... IL-17R [18] (Table 1) The expression pattern of these new receptors seems to be more cell/ tissuespecific than that of the IL-17R, and the ligand specificities of many of these receptors have not ... between the innate and adaptive parts of the immune system that might be an interesting target for the immunotherapy of inflammatory autoimmune diseases [26,27] Role of IL-17 in the pathogenesis of ... stimuli induced the expression of IL-17 together with TNF-α in both murine and human T cells [19] Cell cell contact of human T cells with fibroblasts resulted in increased mRNA expression of IL-17 and...

Ngày tải lên: 09/08/2014, 06:22

... [1] further analyzed the role of HIF-1 in chondrocytic energy generation, matrix synthesis and cell survival During hypoxic and normoxic conditions, functional inactivation of HIF-1α in the presence ... underwent massive cell death [15] Thus, the work by Yudoh and colleagues adds further experimental evidence for the suggested role of HIF-1 in protecting chondrocytes from cell death induced ... Loss of HIF-1α in all cartilaginous elements using the Cre/loxP-technology of conditional tissue knock-out led to distinctive defects in the center of most long bone growth-plates reaching from the...

Ngày tải lên: 09/08/2014, 07:20

... 2005 at 1200 UTC At the early stage, a hot low occurs immediately to the southeast of the Tibetan Plateau, and the Mei-yu front is found to originate from the eastern flank of the plateau and extends ... interesting that the weakening of the upper-level jet leads to an increase of rainfall in the central Indochina peninsular where the lower-level jet crosses over The reason may be the increase of moisture ... intensification of the upper-level jet that blows along the northern flank of the Tibetan Plateau toward Japan The simulated precipitation shows that the Mei-yu rainfall is well organized in form of a band...

Ngày tải lên: 09/08/2014, 18:20

... without palpation of the soft and hard tissues Others use the clients’ history of pain or obtain the cause of the pathology from a previous case of extraction [14,15] Traditional healers therefore have ... Latin America, where the soft wood of the lapa lapa tree is applied to the gums, causes swelling of the gingivae and assists to dislodge the root prior to extraction [24] The use of herbs as an adjunct ... with the fingers It is thought that formic acid (among other substances) in the stinging ants is responsible for the loosening of the tooth [14] One repeated application of swabs of the latex of...

Ngày tải lên: 10/08/2014, 09:21

... also limited by the fact that the standing rearfoot angle was the only structural measurement of the foot For instance, the range of motion (ROM) of the rearfoot might influence the degree to which ... fixed against the 1st metatarsal head of the subject to enable the measurement of a maximal voluntary contraction (MVC) during isometric foot adduction Prior to the commencement of the fatigue-inducing ... differences throughout any part of the stance phase There appeared to be no relationship between the static anatomical structure of the rearfoot with the magnitude of the change in rearfoot kinematics...

Ngày tải lên: 10/08/2014, 21:24

... (C) Cell line Lower semicell formed after the second, upper semicell after the third cell division (D) Cell line Lower semicell formed after the first, upper semicell after the second cell division ... division (E) Cell line 18 Upper semicell resulting from the first cell division, after which the cell died (F-I) Cell line 13 Loss of growth polarity and planarity upon cell division (G, H) Other focal ... proportions of cells at the major morphogenetic stages (Figure 1A,C,D) cDNA-AFLP expression profiling of these samples allowed the assignment of differentially Page of 17 expressed genes to either the...

Ngày tải lên: 11/08/2014, 11:21

... appeared in the cells within the embryo Detailed study revealed that the JIM11 epitope was abundant in the cell walls and especially in the tricellular junctions of the inner cortical cells (Figure ... [3-5] The polarity within the embryo is established through the precisely controlled cell division pattern of embryogenic cells (ECs) and elongation of supporting suspensor-like and callus cells The ... http://www.biomedcentral.com/1471-2229/11/38 Background Plant cell wall and the cytoskeleton control plant polarity and morphogenesis [1,2] They determine cell shapes and control the fate of cells during cell differentiation To better...

Ngày tải lên: 11/08/2014, 11:21

... Other studies have found that the CDK inhibitor, p27kip1, plays an important role in the inhibition of CDK activity and in the proliferation of vascular smooth muscle cells [8,21-23] On the other ... affinity for the PGI2 receptor [19] The proliferation of PASMC, which causes pulmonary vascular remodeling, requires the cells to enter the cell cycle The most important molecular process for cell cycle ... 8-Br-cAMP The cells were then harvested and resuspended in protein lysis buffer (150 mM of NaCl, 20 mM of Tris-HCl, 1% NP-40, 10 mM of EDTA, 10% glycerol, mM of PMSF, 10 µg/ml of aprotinin, µg/ml of...

Ngày tải lên: 12/08/2014, 15:21

... cells and produced IFN-γ [23] The present study focuses on the regulation of the IP-10 secretion The aim was to investigate the pathways of IP10 secretion in a in vitro system including the cell ... bronchial epithelial (NHBE) cells Materials and methods Maintenance of human epithelial cell lines Cells from a human bronchial epithelial cell line (Calu-3) and from a human alveolar epithelial cell ... total cell number and the purity of the cell preparation This method typically yields a cell suspension containing 80– 95% of lymphocytes and 5–20% monocytes The cells were resuspended in cell...

Ngày tải lên: 12/08/2014, 15:21

... mice cleared bacteria from their blood by 48 hrs post infection and that the numbers of pneumococci in the blood of both strains of mice reflected their levels in the lung These results strongly ... addition, binding of SPD to lipoteichoic acid and peptidoglycan [22] may suggest a role for SP-D in the prevention of bacterial colonisation of the alveolar epithelium Elimination of these SP-D functions ... influences the accumulation of T cells within the vicinity of inflamed bronchioles, whereby increased levels of T cell infiltration into SP-D deficient lungs was observed This is the first report...

Ngày tải lên: 12/08/2014, 18:20

... It therefore follows that if there are more active cyclin D2/cdk4 complexes available to phosphorylate Rb, the faster the cell can progress through the G1 phase of the cell cycle The role of ... cycle To observe the expression of cyclin D2 and p21/ waf1 during the various stages of the cell cycle, a time course study for the expression of these proteins was performed Cells were serum ... infected cells The abundance of p21/cyclin D2/ cdk4 complexes in infected cells has the effect of shortening the G1 phase of the cell cycle This is accomplished through increased phosphorylation of...

Ngày tải lên: 13/08/2014, 13:20

... part of the great lab team iv Abstract Krzysztof Kamocki THE ROLE OF CERAMIDES IN CIGARETTE SMOKE-INDUCED ALVEOLAR CELL DEATH The complex pathogenesis of emphysema involves disappearance of alveolar ... exposure on the activity of ceramide synthesis enzymes in the whole lung tissue of DBA2/J mice 93 Figure 10 Effect of CS on enzymes of the de novo ceramide synthesis pathway in the whole lung ... first acylated and the subsequent introduction of the 4,5-double bond by the dihydroceramide desaturase leads to the formation of ceramide [98] There are isoforms of DHC desaturase The DHC desaturase...

Ngày tải lên: 24/08/2014, 09:42

Ngày tải lên: 13/11/2014, 10:36