the role of chromosomal mosaicism in humans

... treatment of the former, almost lethal, severe SOS to date To increase response to treatment, ongoing investigations focus on the combination of defibritode with other drugs as the inhibitor of glutathione ... prostacyclin, prostaglandin E2 and thrombomodulin, as well as downregulation of the release of plasminogen activator-inhibitor It also seems to decrease endothelin activity [8] The reason for the gastrointestinal ... cysteine In general, management of SOS should be based on prophylaxis: identification of patients at risk, avoidance of SOSinducing therapies, preventative medical therapy [9] and, finally, therapy...

Ngày tải lên: 11/08/2014, 17:21

... studies of lung injury in humans, showing reduction in intrapulmonary VEGF levels in the early stages of ARDS Whereas there were no intergroup differences in VEGF plasma levels, protein concentration, ... at the discretion of the attending physician Neither the baseline cortisol value nor ∆max1 and ∆max249 values were able to predict the norepinephrine removal in the general population or in the ... increase of interstitial cellularity, interstitial edema, and vascular congestion together with enhanced severity of lung injury were observed in the intestinal I/R group These findings are consistent...

Ngày tải lên: 13/08/2014, 03:21

... life-threatening bleeding from these therapies, then one can consider anti-fibrinolytic therapies, including aminocaproic acid, tranexamine, and aprotinin Recently, Ono and colleagues [24] reported that the ... [25] Interpreting the literature on therapy for TAMOF The medical literature on therapy for patients with TAMOF is growing Activated protein C studies in adults and children show it has the best ... recrudescence of thrombocytopenia The endpoint of therapy is resolution of thrombocytopenia (attainment of a platelet count greater than 150,000) and no further deterioration of neurological status Vincristine...

Ngày tải lên: 13/08/2014, 03:20

... reducing the pathophysiology of MOF A histological resolution of organ damage to administration of GW0742 was highlighted in pancreas, lung and gut by haematoxylin-eosin staining too Indeed, the ... differential staining At 18 h after treatment, the mice were anesthetized with intramuscular injection of ketamine/xylazine The mice were injected with mL of ice-cold RPMI-1640 medium (Gibco Inc., Grand ... was minimized by incubating the section in Page of 28 2% (v/v) normal goat serum in PBS for 20 Endogenous biotin or avidin binding sites were blocked by sequential incubation for 15 with avidin...

Ngày tải lên: 11/08/2014, 08:22

... was made following lymph node biopsy The decision to biopsy an inguinal lymph mode, rather than a cervical node was based on the clinical findings of a large and easily palpable inguinal lymph node ... acknowledge the expert and dedicated contribution of doctors, nurses, physiotherapists and all other health care professionals involved in the care of this patient Author details Department of Intensive ... remission Interruption of chemotherapy usually results in clinical recurrence and most patients remain chemotherapy-dependent for life In addition its use can be associated with cytopaenias The use of...

Ngày tải lên: 11/08/2014, 14:21

... is the cumulative dosage of major catecholamines (noradrenaline [norepinephrine] or adrenaline [epinephrine]), with dobutamine being given at µg/kg per minute *Statistically significant finding ... until renal recovery During the first session of CVVHDF a strictly neutral fluid balance was maintained, using the digital balance included in the Prisma pump During the following sessions, a negative ... renal injury was defined as diuresis below 30 ml/hour during the observational period of 6–12 hours In 12 surgical patients, initially managed during the period of observation in the surgical intensive...

Ngày tải lên: 12/08/2014, 23:20

... determining outcome in these patients Mortality in patients undergoing DL remains high and deserves further investigation Several factors may explain the fact that half of the patients in the included ... analysis of the outcome parameters in this review The effects of the timing of DL and the speed of diagnosis of ACS on patient outcome remain to be elucidated The timing of surgical intervention ... yielded 85 papers, 19 of which could be included in the analysis based on the analysis of the type of article and review of the abstract From the references in these articles, another papers were...

Ngày tải lên: 12/08/2014, 23:23

... but also renal acidosis However, in our opinion, this is better for evaluating the severity of illness in such patients because it takes into account two of the main parameters that have been reported ... be futile in the intensive care unit patient with multiple organ failure Crit Care Med 2000, 28:947-949 Martin C, Viviand X, Leone M, Thirion X: Effect of norepinephrine on the outcome of septic ... to be of questionable usefulness in assessing metabolic acidosis However, as they point out above, it appears not to perform so poorly because the change in base excess after 12 hours of CVVHDF...

Ngày tải lên: 12/08/2014, 23:23

... representation of the performance of LOD, SOFA and MODS: cardiovascular system Shown are data of another patient, illustrating differences between organ failure scores in assessing the cardiovascular ... analyze these relations quantitatively Competing interests YAK is the author and director of the Muavenet Intensive Care Information System, which is an open access, online academic information ... to describe organ dysfunction/failure On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine Intensive Care Med 1996, 22:707-710 Le Gall JR,...

Ngày tải lên: 13/08/2014, 03:21

... Karnofsky Index above 60, which corresponds to being able to live independently without assistance from others Of the 144 patients without MOF, 94% had a Karnofsky Index above 60, and in the MOF ... anatomical description of injury, has not been part of the routine ICU database, and was therefore calculated in retrospect using the 1990 version (update 1998) of the Abbreviated Injury Scale (AIS) ... to the original definitions Severe organ failure was defined as a SOFA score ≥3 in any organ system MOF was defined as the occurrence of severe organ failure in two or more organ systems during...

Ngày tải lên: 13/08/2014, 08:20

... standardisation of scoring MOF in trauma? This question remains unanswered and needs further investigation The Ulvik paper adds a further step to the knowledge of long-term outcome in trauma patients MOF ... better comprehension of the causes of long term disability and death is crucial for a further improvement of care Competing interests The authors declare that they have no competing interests References ... but the point is crucial Is it the efficacy of the resuscitation, or the treatment of sepsis that affects long-term survival? If sepsis is the key, late outcome in trauma might be an effect of...

Ngày tải lên: 13/08/2014, 08:20

Ngày tải lên: 13/08/2014, 10:20

... glutamine, limiting its use in patients already identified as having sepsis Nevertheless, the mechanism of heat shock protein induction is intriguing and could lead to further investigation in humans ... protein 70 was increased in the heart, the endothelium, the lung and the liver of animals treated with glutamine compared with control animals While this is an interesting finding, the study used ... for therapeutic intervention [16-18] Lipopolysaccharide-binding protein is a component of the innate immune system that acutely increases with infection and plays a role in clearance of endotoxin...

Ngày tải lên: 13/08/2014, 11:22

... using the databases of the general intensive care unit (ICU) and renal unit of the participating hospitals (Hammersmith, Charing Cross and St Mary's Hospitals, London) Patients included in the ... to stop the follow up after two years because arguably beyond this point the major factor determining mortality is underlying or novel serious disease, rather than the tail end of the index critical ... associated with an increased mortality This report did not use the same definition of multiple-organ failure as used for enrolment in our study The cohort of ESRF patients in the study by Uchino and colleagues...

Ngày tải lên: 13/08/2014, 16:20

Ngày tải lên: 13/08/2014, 19:20

... and the "flexibility" (compliance) of the abdominal wall Investigation into the physiologic effects of IAP on renal function in humans essentially began in 1947 with the work of Bradley [35] The ... either rigid (costal arch, spine, and pelvis) or flexible (abdominal wall and diaphragm) The compliance of these walls and the volume of the organs contained within determine the pressure within ... experiences of surgeons treating infants with gastroschisis or omphalocele further contributed to our understanding of both the concept of "loss of abdominal domain" as well as the life-threatening cardiac,...

Ngày tải lên: 13/08/2014, 23:20

... skin, be readily available and inexpensive, and maintain the abdominal domain In addition, the preservation of the accessibility to the abdominal cavity and the feasibility of gradual closure of ... application of the skin graft over the bowel seems to enhance the tuning down of the inflammatory process sustained by the large raw surface, and to make the subsequent reconstruction process easier The ... caused by the direct effect of the decrease in IAP on the thoracic cavity Cardiac function improved in the majority of the patients There was an improvement in PaO2/FIO2 ratio and decrease in peak...

Ngày tải lên: 13/08/2014, 23:20

... the clamp level (80 mg/dl) This problem was considered to indicate the necessity of the improvement for measuring the M value in patients with severe GT (eg increasing the amount of insulin infu- ... * mMOF score = MOF score – points of coagulopathy of the MOF score AT, Antithrombin; DIC, disseminated intravascular coagulation; PAI-1, plasminogen activator inhibitor-1; PIC, α2 plasmin inhibitor–plasmin ... Prothrombin time/control Supplemental data 1 3 2 reports (1) Detection of soluble fibrin monomer (2) Increase of D-dimer (3) Increase of thrombin–antithrombin complex (4) Increase of plasmin-a2–plasmin...

Ngày tải lên: 12/08/2014, 18:20

... combined infusion of AVP and norepinephrine did not increase oscillation frequency of the Doppler signal when compared with norepinephrine infusion alone At least in these patients, this finding ... finding may indicate that AVP/ norepinephrine does not result in further deterioration in microcirculatory oxygen supply in skin These findings are in striking contrast to the results of a physiologic ... administered Norepinephrine infusion was adjusted to maintain MAP above 65 mmHg In patients in the norepinephrine group, a MAP above 65 mmHg was achieved by adjusting the norepinephrine dosage Age,...

Ngày tải lên: 12/08/2014, 23:22