the role of biobanks for the understanding of gene environment interactions
Báo cáo y học: "Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking" potx
Ngày tải lên :
09/08/2014, 10:23
... and gene- gene interactions We conducted assessments for gene- environment interactions by testing for both additive and multiplicative interactions For additive interactions, we calculated the ... of ACR criteria for the classification of RA was (± 1) [43] Table shows the characteristics of the RA cases and matched controls at the time of RA diagnosis (or index date for the controls) A ... either in each cohort or in the combined dataset Overall, genotyping call rates were 97.5% for PTPN22, 96.4% for CTLA-4, 97.9% for PADI-4, and 98.7% for HLA-SE The frequency of the T allele of...
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Báo cáo y học: " A model of gene-gene and gene-environment interactions and its implications for targeting environmental " doc
Ngày tải lên :
13/08/2014, 16:21
... importance of genetic differences in determining the risk of some conditions (for example, lung cancer); (ii) the complexity of gene- gene and gene- environment interactions and/or lack of knowledge of environmental ... from the under-determined system of simultaneous Equations (29), (30) and (31) However, in the absence of prior knowledge about the form of the genetic model, the presence or absence of gene- environment ... (i) there are no gene- gene interactions (epistasis); (ii) there are no gene- environment interactions; (iii) the effects of environmental factors shared by twins are independent of zygosity (the...
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Tài liệu The Role of BCG Vaccine in the Prevention and Control of Tuberculosis in the United States: A Joint Statement by the Advisory Council for the Elimination of Tuberculosis and the Advisory Committee on Immunization Practices docx
Ngày tải lên :
15/02/2014, 13:20
... explore the sources of the heterogeneity in the efficacy of the BCG vaccine reported in the individual studies Using a model that included the geographic latitude of the study site and the data ... Anthony Robbins, M.D Office of the Assistant Secretary for Health Washington, DC U.S Department of Defense Michael Peterson, D.V.M., Dr.P H Office of the Surgeon General Department of the Army Falls ... RR-4 MMWR The Role of BCG Vaccine in the Prevention and Control of Tuberculosis in the United States A Joint Statement by the Advisory Council for the Elimination of Tuberculosis and the Advisory...
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Tài liệu The Role of Nutrition in Maintaining Health in the Nation’s Elderly: Evaluating Coverage of Nutrition Services for the Medicare Population ppt
Ngày tải lên :
15/02/2014, 16:20
... research, dedicated to the furtherance of science and technology and to their use for the general welfare Upon the authority of the charter granted to it by the Congress in 1863, the Academy has a ... secure the services of eminent members of appropriate professions in the examination of policy matters pertaining to the health of the public The Institute acts under the responsibility given to the ... with the exception of the role of enteral and parenteral nutrition therapy, a preliminary review of the literature revealed insufficient data at this time regarding the role of nutrition therapy,...
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Tài liệu Báo cáo Y học: Role of sulfoquinovosyl diacylglycerol for the maintenance of photosystem II in Chlamydomonas reinhardtii ppt
Ngày tải lên :
22/02/2014, 04:20
... pocket, which is the exit of the electron flow in the PSII complex According to the increase in the sensitivity to diuron in hf-2, the limitation of the electron transfer at the exit of the PSII complex ... conformational change of the PSII complex may cause the decrease of PSII activity in hf-2 by the lack of specific binding of SQDG to the PSII complex Alternatively, the change of the lipophilic surrounding ... condition The supplementation of SQDG in the medium enabled the mutant to grow even in the presence of diuron (Fig 3) The exogenously applied SQDG is incorporated into the mutant cells in the form of...
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Role of The Controller - Mike Allred Associate Vice Chancellor for Finance & Controller UC-Davis doc
Ngày tải lên :
06/03/2014, 15:20
... for implementation of the initiative across the campus – Responsible for the quality of controls in areas directly reporting to them, and will assist other campus management in their responsibilities ... Communications to the Regents’ Committee on Audit • Letter of Comments & Recommendations to the Regents • Letter of Comments & Recommendations to the Chancellor – Reports to the Board of Regents from ... confidence in the financial markets in the wake of Enron, Tyco, Global Crossing, WorldCom, HealthSouth… – Created a new accounting oversight board to police the practices of the accounting profession...
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Báo cáo khoa học: Critical role of the plasma membrane for expression of mammalian mitochondrial side chain cleavage activity in yeast pptx
Ngày tải lên :
08/03/2014, 08:20
... concentrations of the steroid (Fig 5) Therefore, these results reveal two levels of complexity of the CYP11A1 reaction in yeast On one hand, the content of free ergosta-5-eneol poorly correlates with the ... and the rate of progesterone biosynthesis is only marginally reduced compared to the rate observed for pregnenolone alone Therefore, an efficient coupling of the two first steps of steroidogenesis ... and the efficient coupling of the SCC and the 3b-HSD activities in yeast require the use of strains lacking this acetylating activity For this reason, the CA10 ATF2 gene was disrupted, yielding the...
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Center for Audit Quality Observations on the Evolving Role of the Auditor: A Summary of Stakeholder Discussions doc
Ngày tải lên :
15/03/2014, 20:20
... appropriate, the CAQ formed a task force on the role of the auditor and moved to convene investors and other financial reporting stakeholders to examine the role of the auditor and the value of the audit ... isolation The “what, whys, and hows” related to changing the role of the auditor has to be considered within the context of the overall financial reporting system, including the important roles of the ... evolve the role of the auditor to meet the needs of investors in the near and longer term In the near term, the CAQ and its member firms have developed model reports for the PCAOB and other stakeholders...
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Báo cáo khoa học: New evidence for the role of calcium in the glycosidase reaction of GH43 arabinanases pot
Ngày tải lên :
15/03/2014, 23:20
... that the presence of the C-terminal domain is crucial for the acquisition of the correct enzyme fold Analysis of the interactions between the two domains led us to presume that expression of the ... in the absence of chelators (90.94 ± 7.85 UÆmg)1) These results suggest that the presence of calcium is important for the optimal activity of BsArb43B Furthermore, to determine whether the role ... Together, these results confirm that the atom in the cluster is calcium To determine whether the calcium ion has a specific role in the activity of BsArb43B, assays were performed in the presence of...
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Báo cáo khoa học: Essential role of the C-terminus in Melanocarpus albomyces laccase for enzyme production, catalytic properties and structure pdf
Ngày tải lên :
16/03/2014, 00:20
... present in the mutant structure (Fig 5B) Owing to the lower steric limitations of the side chain of the Ala than of the Leu, water may occupy the space Furthermore, the side chain of His140, ... similarities between the far-UV CD spectra of the mutants and that of the wild-type ScMaL not support any major conformational changes of the deletion mutant The reduced thermostability of the Sc(L559A) ... show the critical role of the last amino acids in the C-terminus of MaL Deletion of the four last amino acids strongly reduced the expression of the protein in T reesei and S cerevisiae Furthermore,...
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Báo cáo khóa học: Assembly of the silk fibroin elementary unit in endoplasmic reticulum and a role of L-chain for protection of a1,2-mannose residues in N-linked oligosaccharide chains of fibrohexamerin/P25 ppt
Ngày tải lên :
16/03/2014, 16:20
... secretion of H-chains There seem to be two key events in the assembly of the (H-L)6fhx1-type elementary unit: (a) the formation of disulfide-linked H-L heterodimers and (b) the formation of the three-component ... A role of L-chain in the protection of a1,2-mannose residues of the N-linked oligosaccharide chains of fhx/P25 in the elementary unit The PSG cell extract of Nd-sD mutant was subjected to the ... only the 27-kDa form is present in the Ó FEBS 2003 Role of L-chain in the elementary unit of fibroin (Eur J Biochem 271) 359 Fig Fractionation of ER from the PSG cell lysate and purification of the...
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Báo cáo khoa học: Multidrug efflux pumps: The structures of prokaryotic ATP-binding cassette transporter efflux pumps and implications for our understanding of eukaryotic P-glycoproteins and homologues ppt
Ngày tải lên :
22/03/2014, 21:20
... namely the presence of a linker domain between the two halves of the transporter The mouse ABCB1a structure is missing the 56 amino acids between the end of the first NBD and the start of the second ... number of concerns arise from close inspection of the structure Of most relevance to the current discussion are the resolution, the completeness of the structure, the spatial separation of the NBDs ... in the transition from the nucleotide-free to the ADP ⁄ Vi-trapped states of MsbA With all five pairs of residues (located along the axis of the protein perpendicular to the membrane) the sign of...
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WORKING PAPER NO. 218 THE ZERO-INTEREST-RATE BOUND AND THE ROLE OF THE EXCHANGE RATE FOR MONETARY POLICY IN JAPAN potx
Ngày tải lên :
22/03/2014, 23:20
... investigate the role of the exchange rate for monetary policy by exploring the performance of the three different proposals for avoiding or escaping the liquidity trap by means of depreciation of the ... downward bias in the variability of the real rate depending on the level of the nominal equilibrium rate of interest The downward bias in the variability of the real rate accounts for the reduced ... variables), the level of the equilibrium nominal interest rate (i.e the sum of the policymaker’s inflation target and the equilibrium real interest rate) and the choice of the policy rule In the following...
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The Role of Consulting Psychiatrists for Obstetric and Gynecologic Inpatients pptx
Ngày tải lên :
28/03/2014, 14:20
... psychiatric consultation during the study period, which is a relatively low referral rate in comparison with the rates for the other major departments of the hospital such as the internal medical department ... in the future studies There were some limitations of our study First, the results of a single hospital survey might not be readily generalized Second, the study was a retrospective review of ... behalf of the consultee who initiates the process of consultation The service provided in consultation models is related to conditions that interfere with the hospital care process rather than...
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Báo cáo khoa học: Towards understanding the functional role of the glycosyltransferases involved in the biosynthesis of Moraxella catarrhalis lipooligosaccharide ppt
Ngày tải lên :
30/03/2014, 08:20
... proposed by Edwards et al [5]) The elucidation of the biosynthetic pathway of LOS structures of known serotypes will allow further examination of the role of LOS in pathogenesis In addition, it will ... assignment for this oligosaccharide was more challenging than for the other oligosaccharides, due to the poor dispersion of signals in the 3.2–4.1 p.p.m region of the spectra Although the 1H signals of ... to obtain the 13C shift of the C1 and C2 resonances of Kdo Examination of the 400 ms NOESY spectrum confirmed each of the glycosidic linkages for the 2951lgt1 ⁄ 4D oligosaccharide and the terminal...
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Báo cáo Y học: Conformationally constrained human calcitonin (hCt) analogues reveal a critical role of sequence 17–21 for the oligomerization state and bioactivity of hCt ppt
Ngày tải lên :
31/03/2014, 21:21
... small changes of these residues may dramatically affect the type and stability of the turn [34,35] To investigate the importance of the type of the postulated turn for hCt bioactivity, the i + turn-residue ... to hCt Since the peptides were monomers, this finding suggested they were b turn stabilized On the other hand, the similarity of the spectra of 2–4 to the spectrum of suggested that the introduced ... reduction of 19.90% ± 0.81 (mean ± SEM of eight mice treated with peptide vs control mice) Statistical significance of the hypocalcemic effects of the analogues vs the effects of the respective doses of...
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the role of labour mobility and informal networks for knowledge transfer
Ngày tải lên :
01/06/2014, 11:20
... primary factors of production, and the general exclusion or trivialization of the role of knowledge, was not limited only to the sphere of macroeconomics The most compelling theories of international ... only for a minor share of R&D inputs, raising the question of where such firms obtained access to R&D inputs Either the model of the knowledge production did not hold, at least at the level of the ... unit of analysis of the enterprise was not completely adequate for estimating the model of the knowledge production function, scholars began to look for externalities In refocusing the model of the...
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báo cáo hóa học: " Understanding the role of discriminative instruments in HRQoL research: can Ferguson''''s Delta help?" docx
Ngày tải lên :
18/06/2014, 19:20
... the Hankins' paper, and there is no explanation for how the use of Ferguson's Delta would enhance interpretability Although the use of Ferguson's Delta may someday improve our understanding of ... Hence, we look forward to seeing relevant demonstration of the usefulness of this novel psychometric method in HRQOL research that fully encompasses the intent of the taxonomy, integrates the relevant ... given to allow the reader to know the basis of this validity assessment Moreover, no results on the relationship of the reported measures or items in Example and are provided Likewise, the third and...
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báo cáo hóa học: " Discrimination and reliability: equal partners? Understanding the role of discriminative instruments in HRQoL research: can Ferguson''''s Delta help? A response" pptx
Ngày tải lên :
18/06/2014, 19:20
... points Delta then indexes the degree to which the instrument makes valid discriminations Wyrwich suggests that the results of another study [6], in which the dichotomous scoring method of the GHQ-12 ... measure of discrimination would be useful if the discriminations observed were meaningful Recall that the value of Delta is derived from ordinal comparisons of persons that classify them as either the ... about the extent to which people differ: indeed, this is the whole point of my argument Norman correctly states that the reliability coefficient reflects the 'proportion of the variance in the...
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Báo cáo hóa học: " The role of feed-forward and feedback processes for closed-loop prosthesis control" doc
Ngày tải lên :
19/06/2014, 08:20
... random delays to the hand motion before the onset of movement and before the onset of the force ramp Delays were drawn uniformly from the interval s to 1.5 s, the order of magnitude of a typical ... pulse-widths of 500μs to 64 ms Subjects were fitted with a socket containing the vibrating motors (shown in Figure 1) The eight motors spanned the full length of the palmar-side of the forearm The grip force ... grasp force, fi, as the average grip force (in Newtons) applied to the object for the duration of its elevation Ramp Duration The duration of the control signal is directly related to the subjects...
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