... selective inhibitor of Glc6P hydrolysis [31], for evaluating theroleof Glc6P, we determined the effect of different inhibitor concentrations on the Glc6P content and the rate of glycogen synthesis in ... that the increase of Glc6P inthe presence of S4048 was caused by the inhibition of Glc6P hydrolysis inthe absence of detectable changes in glucose phosphorylation S4048 causes inactivation of ... Harndahl et al ¨ levels through the interaction of glucokinase with binding proteins [5,6] The glucokinase regulatory protein (GKRP) is a specific inhibitor of glucokinase [5] and also a nuclear...
... 216 lauric acid, suggesting a roleinthelipid oxidative metabolism Interestingly, the percentage ofthe x-hydroxylated product increases from 2.5 to 12% when increasing the temperature from 24 ... strong indications for the involvement of a bacterial P450 inthe hydroxylation of octane in Rhodococcus rhodochrous, theroleof bacterial P450s in alkane degradation in addition to the well-established ... fatty acids is Theroleof P450 in microbial fatty acid metabolism an essential step inthe alkane assimilation process On the other hand, P450s are also involved inthe synthesis of special fatty...
... phosphorylation of insulin receptor substrate (IRS-1) [37-40] Ceramide, a sphingolipid derivative of palmitate, on the other hand, inhibits Akt/protein kinase B [41] Both of these lipid derivatives turn off ... enhanced inthe liver and markedly increased inthe skeletal muscle of fasted PDK4 KO mice (Table 3) In spite ofthe absence of any effect of knocking out PDK2, the combined deficiency of PDK2 ... favors the acetylations ofthe reduced lipoyl moieties of E2 The reduced and acetylated lipoyl moieties of E2 subunit attract the binding ofthe PDKs and ensure maximum kinase activity, resulting in...
... Regional Learning Alliance – workforce development and training/collaborations with business and industry; meeting the training and education needs of businesses within 60 mile radius in Northern Allegheny ... $28,000 in average annual salary) Preserving Value Continuing education is important to preserving the market value of specialized education – particularly in professional fields Continuing education ... Shippensburg University Small Business Initiative inthe Frehn Center for Management; offering information and assistance to individuals and groups planning to start a new business Best Practice Highlights...
... Ala219 ofthe catalytic site and His135 ofthe Mg2+ binding site The most striking result was the loss ofthe psychrophilic character of mutant W260K/A219N (as reflected by a threefold increase ofthe ... value in this temperature range is considerably lowered On the basis ofthe model, the behavior ofthe G261A variant can be interpreted in terms of constraints introduced by the Ala side chain The ... our incomplete understanding ofthe relation between enzyme properties and conformational flexibility limits the exploitation ofthe full potential of protein engineering inthe redesign of psychrophilic...
... evaluate the OS-fitness ofthe clone, the ratio ofthe specific absorbance inthe presence of 10 lgÆmL)1 HEL to that inthe absence of HEL was taken as an index To analyze the effect ofthe type of each ... antigen binding, this ‘increasing the affinity by increasing the VH ⁄ VL interaction’ might represent a mechanism of increasing Fv affinity This is also supported by the kinetic study of purified ... to retain the specificity and affinity to antigen in itself [7,20] At least for these antibodies, theroleofthe VL domain might be to increase the affinity by supporting the VH domain The phenomenon...
... Cardie, Vincent Ng, David Pierce, Chris Buckley Examining theroleof statistical and linguistic knowledge sources in a general-knowledge que stion answering system In Proceedings ofthe 6th Applied ... hypernyms inthe answer semantic form Step 3: The assessment ofthe similarities of dependencies Inthe third step, two classes of similar dependencies are considered, generating unications ofthe ... example, inthe case of question Q209: Who invented the paper clip ?, the expected answer type is P ERSON and so is the subject ofthe verb invented , lexicalized as the nominalization inventor...
... change their brand attitude, may suggest an interesting implication for the new brand advertising strategy Instead of focusing on the content ofthe message which only emphasizes the benefits ofthe ... birthday This finding is just reverse ofthe finding of Belk (1973) Ruth, Brunel, Otnes (1999) classified categories of gift-giving into public occasion (i.e., Christmas, Chinese New Year), individual ... situational conditions of gift-giving may differ according to characteristics ofthe gift-giving occasion, whether the presentation ofthe gift is public, private, or anonymous, and whether the gift is...
... important for explaining wilt Inthe case of income, youth living in low-income households experience higher levels of wilt (45%) than youth living in either modest-income (35%) or high-income (23%) ... financing school Conley (2001) finds that a doubling of net worth results in an 8.3% increase inthe probability of attending college Further, when net worth is included inthe model, Black youth are ... youth Youth savings Youth were asked in 2002 whether they had a savings or bank account in their name If they had an account, they were also asked whether they were saving some of this money for...
... the short ones) have all zeroes in them In other words, none ofthe bigrams from the training set appears in these reviews This suggests that the main problem with the bigram model is likely to ... Following Pang et al (2002), we use frequency as presence In other words, the ith element ofthe document vector is if the corresponding unigram is present inthe document and otherwise The resulting ... relation is capturing two different situations, one in which the author himself likes the movie, and inthe other, the author’s cousin likes the movie The overgeneralization resulting from these “stemmed”...
... the transaction from the vantage point of firm A, the floatingrate payer The cost of synthetic floating-rate financing is determined by the cost of servicing fixed-rate debt plus the net cost ofthe ... to the desire on the part of firms to hedge cash flows against the effects of interest rate volatility The timing ofthe appearance of interest rate swaps, coming as it did during a period of volatile ... argue, trading in interest rate swaps has helped to complete forward markets and to lower the cost to firms of managing their exposure to interest rate risk TheRole for Hedging inthe Theory of Corporate...
... unfolding of one ofthe I27 modules inthe chain Unfolding then extends the overall length ofthe protein, relaxing the pulling force to a low value As the slack inthe length is removed by further ... bridging the A’ and G b-strands ofthe I27 protein during the main unfolding barrier.[39] To further validate this view and gain insight into theroleof solvent hydrogen bonds in protein unfolding, ... repeats ofthe I27 module, in D2O, showing a prominent hump inthe rising phase ofthe initial force peaks which cannot be fitted with the worm-like chain (WLC) model (thin lines) B) The hump begins...
... explains some ofthe key concepts and outlines some ofthe basic IdM processes The range of conceptions of identity is very broad The examination ofthe following concepts is for the purposes of ... to take into account inthe assessment ofthe security risks to − and privacy impact on − the delivery of online services, and in determining appropriate levels of security Inthe case of sensitive ... accounts within the organisation The organisation is in some sense wasting resources and duplicating efforts in maintaining separate profiles with (mostly) the same information Nonetheless, there can...
... very often the first step inthe biochemical analysis oftheroleof these domains in cellular signalling After disruption of cells, lipid rafts ⁄ caveolae can be extracted by virtue of their ... extraction during lipid raft isolation Moreover, these studies have provided some insights into the significance ofthe localization ofthe P2X7 receptors inlipid rafts regarding the regulation of intracellular ... formulation ofthelipid raft’ hypothesis inthe context of membrane transport in polarized epithelial cells [27] It was postulated that domains rich in cholesterol and sphingolipids are preformed in the...
... contribute to the optimization of electrostatic charges balance of pfLamA inthe native state, independently of their interaction with calcium Theroleof electrostatic interactions in protein stability ... [2] The solid lines through the mutants unfolding data points (lled symbols) are intended to guide the eye ofthe reader and not represent the tting ofthe data Reversibility points are indicated ... binding of calcium to the mutant proteins in native conditions The single and combined mutations dramatically decrease the thermodynamic stability ofthe proteins with a signicant decrease of...
... Properties ofthe iron-binding site ofthe N-terminal lobe of human and bovine lactotransferrins Importance ofthe glycan moiety and ofthe non–covalent interactions between the N- and C-terminal lobes ... lactoferrin where the protein has to survive the harsh environment ofthe gastrointestinal tract Thus, on the basis of this study, rhLF may be preferred over bLF in oral applications of lactoferrins in ... (1994) Lactoferrin is a lipid A-binding protein Infect Immun 62, 2628–2632 Lee, W.J., Farmer, J.L., Hilty, M & Kim, Y.B (1998) The protective effects of lactoferrin feeding against endotoxin lethal...
... both ADAM10 and TACE are involved inthe shedding of APP, neither ADAM is involved inthe shedding of ACE Furthermore we show that APMA can distinguish between the shedding of ACE and APP Materials ... dose-dependent increase inthe shedding of ACE (Fig 3B,C), with a 12-fold increase inthe amount of soluble ACE inthe CHO cell medium observed with 500 lM APMA The effect of APMA on the shedding of ACE ... cells inthe absence or presence of APMA Following this second incubation, the level of sAPPa inthe medium was examined (Fig 4A,B) There was no significant difference inthe level of sAPPa in the...
... containing the same information, we conduct collinearity tests (VIF) when the regressions are run FINDINGS We now report the findings of a multivariate regression analysis to determine the community ... they not appear to contain the same information, since the clustering is generally made within a similar distance the main exception is the close connection between beauty of physical setting ... – the home, work and school environment – helps define an individual’s sense of being in a particular location Other research has focused on the attitude of “being at home” in a community; in...
... observe the factors that influence the perception and the purchasing attitude towards such products and theroleof logos on the label in influencing their choices In particular, to investigate ... factors that influence the perception and the purchasing attitude towards PDO/PGI products, to analyse theroleof labelling in influencing consumers’ choices and ascertain the existence of market ... foods were very interested inthe Italian origin ofthe product, as opposed to 63.7% ofthe buyers of typical foods (p
... facility level in Zambia served inthe capacity of district managers of health programmes The finding that the nurses in Sudan were less involved in planning of activities (15.2% in polio and in measles) ... appears, inthe case of Zambia, that an increase inthe burden of one disease, mainly HIV-related care, takes up much ofthe nursing personnel's time Nurses were not performing the tasks related to their ... to HIV infection, including HIV counselling - including prevention of mother to child transmission - referral of patients and administrative tasks Furthermore, there was more delegation of tasks...