the relation of human language to human emotion

... inhibitor of the influenza A M2 proton channel and hence prevents the uncoating of the viral particle and release of its genome into the cell [18,23] Therefore, the influx of protons through the ... that the Trp41 side chain blocks the pore of the channel and that the interaction between protonated His37 and Trp41 pulls the Trp41 side chain out of the pore of the channel, thereby opening the ... turns of the helix above His119 and not on the same face of the helix Therefore, the distance and the orientation of His119 to Trp125 is too great to permit a cation–p interaction similar to that...

Ngày tải lên: 07/03/2014, 16:20

Ngày tải lên: 08/03/2014, 01:20

... band on these gels, as the ODN hybridizes to the center of the input target RNA The asterisk indicates the input target RNA; the arrow indicates the digested product bands The amount of digested ... Due to an increased fragility of the transfectants, it was not possible to analyze the effects of ODNs delivered by electroporation The data of the 15PC3 cells are compatible with the hypothesis ... response To investigate the nature of the differences in response to antisense ODNs we analyzed the RNase H levels in the cell lines, as RNase H is claimed to be a key component in the mechanism of...

Ngày tải lên: 08/03/2014, 10:20

... revealed the structures of the unliganded (super-open) and Glc-bound (fully-closed) states of hGK [12], the residue contacts that make essential contributions to the binding of Glc to the super-open ... to examine the contribution of its three tryptophan residues (Fig 1A) to the multiphasic fluorescence enhancement induced by Glc binding; (b) to identify the active site residues involved in the ... binding of Glc to the super-open state (Fig 1C) of this two domain [large (L) and small (S)] enzyme, and thus the site of initiation of the global conformational transition; and (c) to gain some...

Ngày tải lên: 30/03/2014, 04:20

... added to give a total plasmid concentration of mg per well The figures in the bottom row are means of two independent replicates and represent densitometric values normalized to the intensity of the ... As the CAGA box at position 21811 is located at the very margin of the known SeP promoter sequence, the 50 flanking bases not represent the context of the genomic promoter but the sequence of the ... directing them to the CAGA box, thereby reducing the amount of repressor molecules available for Smad and to recruit Also, overexpression of Smad along with Smad seems to attenuate the inhibitory...

Ngày tải lên: 31/03/2014, 23:20

... want to convey some of what the modern science of linguistics teaches us about the basic properties of language To put the result of that inquiry into some sort of perspective, I take other communication ... from whether or not they have the capacity to learn and use a language in the specific sense that refers to human languages By using the expression ‘ human language ’ repeatedly, I not of course ... turns out to be rather important, at least according to some theories The motor theory of speech perception claims that the way we perceive the speech of others involves a direct reference to what...

Ngày tải lên: 11/06/2014, 14:43

... resource of knowledge related to the mechanics of human movement The work at the University of California formed the basis for many of the fundamental techniques currently used for the study of human ... factors limiting the advancement of the study of human movement is the measurement of skeletal movement from markers or sensors placed on the skin The movement of the markers is typically used to ... need to capture the kinematics and kinetics of human movement without the constraints of the laboratory or the encumbrance of placing markers on the limb segments Second, we need to relate the...

Ngày tải lên: 19/06/2014, 10:20

... selection on the PB1-F2 itself match in the herd immunity of the population and in the protection of the seasonal influenza vaccine containing the A/Moscow/10/99(H3N2) strain [29] The fitness of the Fujian-like ... with strains from the avian reservoir, as was the case of the pandemics of 1957 and 1968, or by direct introduction of an avian strain into the human population as suggested for the 1918 pandemic ... the rest of the world and the H1N1 component in the trivalent vaccine recommended for the northern hemisphere has been A/New Caldonia/20/99(H1N1) since 2000– 2001 The greater variability of the...

Ngày tải lên: 20/06/2014, 01:20

... Office of the Auditor The missions of the Office of the Auditor are assigned by the Hawai‘i State Constitution (Article VII, Section 10) The primary mission is to conduct post audits of the ... of the Department of Human Resources Development A Report to the Governor and the Legislature of the State of Hawai‘i Conducted by The Auditor State of Hawai‘i and Accuity LLP Submitted by THE ... Introduction This is a report of our financial audit of the Department of Human Resources Development, State of Hawai‘i The audit was conducted by the Office of the Auditor and the independent certified...

Ngày tải lên: 20/06/2014, 02:20

... authority to engage services to establish, administer, or maintain the plan under its direction Prior Financial Audit The Office of the Auditor and the certified public accounting firm of Deloitte & Touche ... Objectives of the Audit Assess the adequacy, effectiveness and efficiency of the systems and procedures for the financial accounting, internal control, and financial reporting of the Department of Human ... employed to record and report financial transactions and results as well as to design and monitor a system of internal control over the process to ensure the reliability of the process and accuracy of...

Ngày tải lên: 20/06/2014, 02:20

... expression in the subsets of the receptor for MCSF It is therefore of interest to compare the genes that distinguish the monocyte subsets [6,7] with those involved in the maturation of total human monocytes ... one subset but not in the other are indicated Gene labels are positioned according to the location of the protein in the cell - in the plasma membrane, the cytoplasm or the nucleus Several studies ... scatter-plot of the fold expression difference in CD16+ compared with CD16- monocytes shows correlation of the values in the two studies Red and green cutoff lines extend along the values 1.5 and -1.5 The...

Ngày tải lên: 06/08/2014, 19:21

... and CDR3 of the IgG VL region and also part of the downstream expression vector containing the lambda constant region cDNA, while the kb fragment contained CDR1 and the rest of the vector The kb ... mutation of Arg27a to serine led to a reduction in binding to DNA [37] In the present study the same change has been shown to reduce binding to CL, supporting the conclusion of Cocca The presence of ... is therefore likely to be relevant in the pathogenesis of APS We found that the sequence of IS4VH was dominant in conferring the ability to bind cardiolipin (CL) while the identity R48 of the...

Ngày tải lên: 09/08/2014, 06:22

... read-through of the transcript into the flanking genomic region These sequences could then be used to identify the genomic location of the element In some cases, the terminal few bases of the L1 3' ... 40 -4

Ngày tải lên: 09/08/2014, 20:20

... detection of HCMV infection in transplanted patient to initiate the therapy, but also to continuously monitor them if needed thereafter Because of the latent life long HCMV infection many transplant ... importance of correlating the test results with clinical symptoms is given Results A total of 57 donor recipient pairs were included in the study Based on the availability of follow-up samples, they ... presence of antigenemia in 32/33 patients The HCMV infection observed among twenty six recipients of sub-group II is probably due to the reactivation of the latent virus present in them or other...

Ngày tải lên: 12/08/2014, 02:20

... to the overall replicative fitness of a virus isolate Therefore, future studies should try to elucidate the role of those genes that have a mosaic appearance for their impact on the fitness of ... has contributed to the experimental work GV has contributed to the study-design and helped to draft the manuscript CC has contributed to the experimental work WJ has contributed to the data analysis ... It is important to mention that aliquots of PBMC of the same buffy coat were used to grow the virus stocks, determine infectious titers and perform the competitions A second set of competitions...

Ngày tải lên: 13/08/2014, 09:20

... used these fingerprints as inputs into the alignment algorithm Figure illustrates the sensitivity and positional accuracy of the mapping of these synthetic clones as a function of the number of ... of the FPP alignment (left/right) is considered to be the breakpoint technologies, and the median lengths of many of the structural alterations reported are in the range of tens to hundreds of ... of alignments that passed were scored on the basis of the reconstruction fraction, defined as the total size of all alignments in the combination relative to the average fingerprint size of the...

Ngày tải lên: 14/08/2014, 08:20

... acceptance of the thesis is contingent upon the submission of the final copy of the thesis to the Council of Graduate Studies (CGS) through the Departmental Graduate Committee (DGC) of the candidate’s ... one regime to another, an effort has been made to increase the productivity of the citizens and the total income of the country 1.2 Statement of the Proble m Human capital refers to the “knowledge, ... granted by the head of the major department or the Dean of the School of Graduate Studies when in his or her judgment the proposed use of the material is in the interests of scholarship In all other...

Ngày tải lên: 12/12/2016, 20:32

Ngày tải lên: 16/12/2012, 15:24

... sulphur dioxide and other greenhouse gases • carbon dioxide traps heat in the atmosphere and causes the temperature of the earth to rise • This leads to disruption of the weather patterns eg drought, ... problems Burning the timber increases the level of carbon dioxide in the air Less trees means less carbon dioxide absorbed for photosynthesis Soil is eroded as it is exposed to the wind and rain ... grow more food as they are replacing the nutrients removed from the soil by plants • However, if too much fertiliser is added and it then rains, the fertiliser finds its way into rivers and lakes...

Ngày tải lên: 28/09/2013, 11:10

... sulphur dioxide and other greenhouse gases • carbon dioxide traps heat in the atmosphere and causes the temperature of the earth to rise • This leads to disruption of the weather patterns eg drought, ... problems Burning the timber increases the level of carbon dioxide in the air Less trees means less carbon dioxide absorbed for photosynthesis Soil is eroded as it is exposed to the wind and rain ... grow more food as they are replacing the nutrients removed from the soil by plants • However, if too much fertiliser is added and it then rains, the fertiliser finds its way into rivers and lakes...

Ngày tải lên: 26/01/2014, 10:20