the reformation in germany is linked with

... dark, when they stopped at an hostelry to refresh themselves, a strong guard being placed in the room into which the prisoners were conducted. The moon then rising, they continued their journey, ... arguments which they boldly put forth, nor indeed could the father confessor, nor the other visiting priests. Of the last one heartily agreed with them, and the others boldly acknowledged that there was ... Redeemer's arms. Trust in Him in the righteousness of His life in the atonement of His death. Do not shrink back, God is not angry with you; it is you who are angry with God. Listen to the Son of God,...

Ngày tải lên: 21/02/2014, 14:20

Ngày tải lên: 09/08/2014, 08:23

... [28]. These findings agree with the hypothesis [29] that an increase in the mitochondrial membrane potential would slow the transport of elec- trons through the respiratory chain, increasing the ... [2,3]. UCP1 is the best characterized of these proteins, mediating non-shivering thermogenesis in brown adipose tissue by catalysing proton leak acti- vated by long-chain fatty acids and inhibited ... increase the inefficiency of oxidative phosphoryla- tion. In this regard, the effect on state 4 is similar to an uncoupling effect. UCP2 acts as a mild uncoupler, controlling both ATP synthesis and the...

Ngày tải lên: 05/03/2014, 23:20

Ngày tải lên: 09/08/2014, 07:20

Ngày tải lên: 12/08/2014, 13:22

... listed along with the 20 amino acids and the three stop codons. A risk score ω is shown as ω = 0 (yellow), ω = 1 (orange), and ω = 2 (red). The list is sorted according to the mean risk of the ... =  sequence  random (3) This F defines the risk of acquiring nonsense muta- tions for each species relative to the risk with an unbiased codon usage. With the intention to compare the risk of acquiring nonsense ... could be explained by including unfavorable non-conservative missense muta- tions in the analysis. Conflict of interest disclosure The authors declare that they have no competing interests. Additional...

Ngày tải lên: 18/06/2014, 19:20

... to their role in insulin signaling, the role of FOXO proteins in protecting against cellular stress is highly conserved. The mechanism by which dFOXO confers oxidative-stress resis- tance is ... regarding the output of the insulin pathway. First, the complete epistasis of daf-16 over the insulin pathway mutants daf-2, age-1, akt-1 and akt-2 suggests that the primary function of PKB is to inactivate ... phenotype is insensitive to caspase inhibitors, and is not accompanied by increased acridine-orange-detectable apoptosis in the imaginal disc [44]. It therefore remains unclear whether high levels...

Ngày tải lên: 06/08/2014, 18:20

Ngày tải lên: 13/08/2014, 13:20

Ngày tải lên: 14/08/2014, 14:21

... Japan Heme is an invaluable molecule that is essential for life and is involved in many cellular processes that sense or use oxygen. The intracellular concentration of heme is maintained by the rate ... expression of HO-1 protein was also induced by the treatment with HO-2 siRNA in HepG2 cells. These results indicate that the down-regulation of HO-2 expression is associated with induction of HO-1 expression. Fig. ... cells with HO-2 siRNA induced the expres- sion of HO-1 mRNA and protein without affecting the concentration of GAPDH mRNA and b-actin (Fig. 4A,B). Likewise, the selective reduction of HO-2 mRNA with...

Ngày tải lên: 19/02/2014, 05:20

... likely that distinct regulatory mechanisms are operative in the two receptors, as indeed is the case, and shown in the studies described here. Until date, the role of glycosylation in either GC-A ... raised to the protein kinase-like domain of GC-C [32] or with GC-C:4D7 antibody preadsorbed with a fusion protein of the kinase- like domain of GC-C and glutathione S-transferase, in blocking ... desensitization of these receptors. GC-A is phos- phorylated on six serine and threonine residues present in the protein kinase-like domain in the basal state [2]. Mutation of any of these sites to alanine...

Ngày tải lên: 08/03/2014, 08:20

... moreover, the relative intensity of these signals was the highest compared to other pools from the same strain. Therefore, further structural investigation was performed with this preparation. The 1 H ... stereoisomerism). The lower-®eld 1 H NMR signal of 3 belonged to the N-methyl group at N 2 in the E isomer and t he higher-®eld signal t o that in t he Z isomer, in which N 1 is in trans and cis ... an (N,N-dimethylacetimidoyl)amino group is presen t (Fig. 8, structure 2). This group is linked to C5 of a legionaminic acid residue, which is substituted with a nonmethylated N-acetimidoyl group in the other legionaminic...

Ngày tải lên: 08/03/2014, 10:20

... material in the volume bounded by the inner boundary membrane was signifi- cantly higher in mitochondria untreated with ADP than in those treated with the nucleotide. This is in line with the experimental ... than in the presence of the nucleotide. This is at odds with the finding that mito- chondrial Ca 2+ capacity is decreased in the presence of adenine nucleotides, and even the volume fraction of the ... transcribes a protein with a stretch of amino acids in the 198–225 region with 48–56% similarity to those from other species, includ- ing the deletion of three amino acids in positions 211, 212...

Ngày tải lên: 29/03/2014, 00:20

... the RNA-binding protein RBM3 is associated with a favourable prognosis in breast cancer. The aim of this study was to examine the prognostic value of RBM3 mRNA and protein expr ession in epithelial ... RBM3 in the cisplatin-sensitive A2780 ovarian cancer cell line comp ared to the cisplatin-resistant cell line A2780-Cp70 and the effects of cisplatin treatment on viability, cell cycle phase distribution ... and apoptosis in A2780 and A2780-Cp70 cell lines. (A) Immunocytochemical staining and (B) immunoblotting of RBM3 showing substantially lower RBM3 protein expression in the cisplatin-resistant A2780-Cp70...

Ngày tải lên: 18/06/2014, 16:20

... either a ballistic or a ramp pinch task, an increase in force and acceleration, asso- ciated with an increase in MEP amplitude, was observed in the muscle involved in the training, but not in a mus- cle ... with extensive motor training [4-6], depending on the nature of movements performed during training [7]. These studies have clinical implications since motor training is known to positively influence ... cortical inhibition are therefore appealing for augmenting motor learning in behavioral therapies [38-40]. Here we present data supporting the idea that depending on the nature of the training and role...

Ngày tải lên: 19/06/2014, 08:20

... changes in depression [13]. This hypothesis is based on the observation that the above mentioned proinflammatory cytokines induce a shift from serotonin synthesis to tryptophan metabolism via the ... cytokines, including interleukin-1 and -6 (IL-1, IL-6), tumor necrosis factor a (TNFa), or interferon g (IFNg). These enzymes are inhibited by anti-inflammatory cytokines, including IL-4. Serotonin ... activations in the pACC in humans [52]. Our finding of relatively increased QUIN immunoreactivity, which is potentially associated with serotonin depletion due to changes in the kynurenine pathway,...

Ngày tải lên: 19/06/2014, 22:20

... viral variants [9,13], the low levels of HIV detected in many of the samples only allowed the analysis of the predominant genotypes in genital secretions. Despite this, and the inherent limita- tions ... the manuscript. PK participated in the study design and con- ducted the statistical analyses. RC participated in the design and coordination of the study and facilitated the collection of clinical ... the V3 genotype of predominant variants found in vaginal secretions, and assessed ART use in a cohort of 43 women attending an HIV outpatient clinic in New Orleans. Informed consent was obtained...

Ngày tải lên: 20/06/2014, 01:20

... infection with RSV or influenza virus or IN or intradermal (ID) infection with vaccinia virus expressing an RSV CTL antigen. The impairment was observed in the lungs after IN infection with RSV, influenza ... is dependent on the virus, the route of infection, or the type of infection (respiratory, disseminated, or localized dermal), we compared the CTL responses in mice following intranasal (IN) infection ... administered IN, and a non-respiratory virus, a recombinant Western Reserve (WR) strain of vaccinia virus (VV) expressing the RSV M2- 1 protein (VV-M2), which was administered either by the IN...

Ngày tải lên: 20/06/2014, 01:20

... some ascites in CaOV3 cells is unclear at this point but Akt activa- tion has been associa ted with the inhibition of cisplatin- induced apoptosis [28]. The present study suggests the importance ... their ability to inhibit TRAIL-induced cell death in the CaOV3 cell line. These ascites originated from var- ious sub-types of ovarian cancer including serous, endo- metrioid, mucinous and others. ... glycoprotein of high molecular weight which is used in the clinic as a marker of tumor burden. There is indeed a strong correlation between rising and falling levels of serum CA125 with progression...

Ngày tải lên: 20/06/2014, 07:20

... of tumors with low AR expression are visualized in the left panels and tumors with high expression in the right panels. Bars in the middle represent the distribution of positive cases in ab- solute ... use, distribution, and reproduction in any medium, provided the original work is properly cited. Research Increased androgen receptor expression in serous carcinoma of the ovary is associated with ... have been implicated in ovarian carcinogenesis but the relationship between AR expression in ovarian cancer and clinical outcome remains unclear. Methods: In this study, the prognostic impact...

Ngày tải lên: 20/06/2014, 07:20