... era in the treatment of cardiac diseases.” Others clearly felt that the time was already right to undertake cardiac transplantation in man, and a planned approach was made toward this goal at the ... University of Birmingham, and Associate Medical Director, Organ Donation and Transplantation, NHS Blood and Transplant, Bristol, UK Abbreviations 6-MP A2 ALL ABOi ABVC ACAID ACD ACE ACOT ACR ACT ADCC ADH ... ADCC ADH AHR aHUS aICB AIDS AIH ALF ALG AMR AP-1 APC APOLT ARB ARDS ATC ATG ATN ATP AV AZA BASM BCC 6-mercaptopurine Adult-to-Adult Living Donor Liver Transplantation Cohort Study ABO incompatible...
... congenital, valvar, or pericardial disease As primary diseases of heart muscle, cardiomyopathies are less common causes of heart failure, but awareness of their existence is necessary to make a diagnosis ... fall in cardiac output The fall in cardiac output leads to activation of several neurohormonal compensatory mechanisms aimed at improving the mechanical environment ofthe heart Activation of ... output and raises atrial pressure—for example, atrial fibrillation x Dissociation of atrial and ventricular activity impairs diastolic ventricular filling, particularly in the presence ofa tachycardia—for...
... disease (aortic stenosis, mitral regurgitation) Permanent pacemakers and implantable cardiodefibrillators Bradycardias; resistant ventricular arrhythmias Cardiac transplantation End stage heart ... patients (aged < 60 years) who are without severe concomitant disease (for example, renal failure or malignancy) Bradycardias are managed with conventional permanent cardiac pacing, although a ... intensive medical treatment It is associated with a one year survival of about 90% and a 10 year survival of 50-60%, although it is limited by the availability of donor organs Transplantation should...
... SA Current status of cardiac transplantation JAMA 1998;280:1692-8 x Remme WJ The treatment of heart failure The Task Force ofthe Working Group on Heart Failure ofthe European Society of Cardiology ... in a high dependency unit Urinary catheterisation facilitates accurate assessment of fluid balance, while arterial blood gases provide valuable information about oxygenation and acid-base balance ... transluminal coronary angioplasty and coronary artery bypass graft) x Valve replacement (or repair) x Pacemaker or implantable cardiodefibrillator x Ventricular assist devices x Heart transplantation...
... Center, Winnipeg, Canada Joe Helou University of Ottawa, Ottawa Heart Institute, Ottawa, Canada VIII Paul J Hendry University of Ottawa, Ottawa Heart Institute, Ottawa, Canada Jeiirey D Hosenpud ... Montreal General Hospital, Montreal, Canada Umer Darr Yale University, Cardiothoracic Surgery, New Haven, Connecticut, U.S .A Naranjan S Dhalla University of Manitoba, Institute of Cardiovascular ... of Ottawa, Ottawa Heart Institute, Ottawa, Canada Robert Kormos University of Pittsburgh, Pittsburgh, Pennsylvania U.S .A Roy G Masters University of Ottawa, Ottawa Heart Institute, Ottawa, Canada...
... Correlation of changes in cardiac calcium channels with hemodynamics in Syrian hamster cardiomyopathy and heart failure Life Sci 1987;41:153-9 Kobayashi A Yamashita T Kaneko M, Nishiyama T, Haya.shi ... ofthe extracellular matrix and the subcellular organelles such as myot'ibrils sarcolemma (SL) and sarcoplasmic reticulum (SR) in the failing heart Neurohumoral activiation The activation ofthe ... by cardiomyoc\tes is altered both in failing human hearts as well as in animal models of heart failure Abnormal intracellular Ca"^^ handling is one ofthe major causes of both systolic and dia.stolic...
... that mcorporatcs patch exclusion of any aneuiysmal septum.^'' To address the latter they advocate the placmg of sutures farther apart on the tissue than on the Teflon to plicate the length ofthe ... consi.stmg of only the fibrous pericardium Approximately 85% of left ventricular aneurysms are located anterolaterally near the apex At the Ottawa leart Institute of 95 patients having resection ofa ... a reasonablefiinctionalstatus and longevity Age, other concomitant disease, and the wishes ofthe patient and family must be taken into account in these high-risk cases Usually, in these advanced...
... thev may hasten death Selection and Management of Potential Candidate for Cardiac Transpkmtaiion 71 Indications for Cardiac Transplantation The goal of cai'diac transplantation is to maximize the ... Selection and management ofa potential candidate for cardiac transplantation In: Cooper DKC, Miller LW and Patterson GA (Eds) The transplantation and replacement of thoracic organs, 1996, Kluwer Academic ... Selection and management ofa potential candidate for cardiac transplantation In: Cooper DKC Miller LW and Patterson GA (Eds) The transplantation and replacement of thoracic organs, 1996 Kluwer Academic...
... despite all attempts at catheter ablation and chemical control Unusual trauma or isolated intracardiac tumours are rare indications for fransplantation Contraindications to Cardiac Transplantation ... transplantations reported from a total of 150 lung transplantation programs For purposes of analysis, the data set was closed as of March 1, 1998 Survival was calculated actuarially (Harris and ... Selection and management ofa potential candidate for cardiac transplantation In: Cooper DKC, Miller LW and Patterson GA (Eds) The transplantation and replacement of thoracic organs, 1996, Kluwer Academic...
... demonstrates survival rates after pediatnc heart transplantation overall and IS broken down by age groups The older age pediatric group has sur\ival rates nearly identical to the adult population, ... tlie pnmar}' cause, and late atter transplantation, infection and bronchiolitis obliterans are the pnncipal causes of death CAV does account for a small mmorit}' of deaths (3%) late after heart-lung ... factors for I-year mortality after adult lung transplantation Variable Ventilator Retransplant Diagnoses Congenital heart PPH AlA Emphysema Female recip Recip age (linear) Recip age 20 Recip age...
... importance in the rehabilitation of these patients and plays an important role in their preparation for the cardiac transplant and the attendant risks of immunosupression The patients are also started ... failure The mean duration of implant was 34 days (range 0-186 days) and the mean age ofthegroup was 45 years (range 16-62 years) In a 1996 review, Arabia et al compared the outcomes of patients supported ... same abdominal location They differ mainly m their method of pump actuation The VE-HeartMate LVAS is electrically powered by a wearable rechargeable battery pack, whereas the IP-HeartMate LVAS...
... burst parameters and synchronization delay can be programmed as a percentage ofthe RR interval in order to allow the stimulator to automatically adapt to changing heart rates Stimulation voltage ... along its antero-lateral anatomic border The LDM is then atraumatically dissected from the chest wall with preservation of its thoracodorsal neurovascular pedicle The assistance ofa plastic surgeon ... can be estimated by axillary palpation ofthe extrathoracic portion ofthe muscle graft, or by visualization using ultrasonography orfluoroscopy As there are subtle variations in the hemodynamic...
... non-transgenic aintrol pig hearts and had a cardiac performance similar to the Xenotransplantation 169 rhesus hearts'' Furthermore, markers of myocardial damage, such as creatme phosphokinase remained ... provide a solution to the problem The main advantage of xenotransplantation would be the provision ofa readily available supply of organs to meet the demand, and perhaps being Roy Masters (editor) ... temporary use as a bridge to transplantation Total A rtificial Hearts Total Artificial Hearts (TAHs) are designed to replace the total heart (both ventricles) and require excision ofthe native heart...
... migration and 3) eliminating the need for diaphragmatic perforation and extension ofthe incision into the abdominal area However, to achieve the goal of intrathoracic implantation, significant efforts ... VemricularAssist Devices Several groups including the joint Cardiovascalar Devices Division ofthe University of 0.ttawa Heart Institate and the Ottawa-based World Heart Cori:ioration are developing ... hospital setting During the last three years device utilization has accelerated at an increasingly rapid pace as clinical acceptance ofthe technology has been gained I'o highlight this acceptance...
... implantation [3] The role of biventricular pacemakers in this population remains unclear Finally, where pharmacological therapy fails to halt the progression to cardiac failure, heart transplantation ... visualisation ofthe left ventricular intertrabecular recesses These features should be present in the absence of any other significant cardiac abnormality Cardiac magnetic resonance imaging may also be of ... trabeculations (Fig 2) Intravenous injection of ultrasound contrast agent confirmed an area of non-compacted myocardium subtending a thinner walled area of compaction and a diagnosis of IVNC was made...
... patients with cardiac resynchronization therapy Am J Card 2006;97:1622-25 Inoue T, Sakai Y, Morooka S, Hayashi T, Takayanagi K, Yamanaka T, Kakoi H, Takabatake Y Coronary flow reserve in patients ... activation and myocardial disease on left ventricular ejection and filling times Heart 2000;84:272-6 Hayashida W, Kumada T, Nohara R, Tanio H, Kambayashi M, Ishikawa N, Nakamura Y, Himura Y, Kawai ... comparison ofthe individually observed and predicted time values and for comparison of within -group changes a repeated measures analysis of variance was used If analysis of variance showed an...
... care Standards of care are determined on the basis of all clinical data available for an individual case and are subject to change as scientific knowledge and technology advance and patterns of ... revascularisation in these patients An indication ofthe presence of coronary disease as the cause of LVSD is often apparent from the history, ECG and echocardiogram but in cases of doubt coronary ... from an ACE inhibitor or an ARB 4.13 HEART FAILURE AND ANGINA Beta blockers are the drug of choice in patients with heart failure and angina (see SIGN guideline 96 on the management of stable angina).94...
... decompensated chronic heart failure Am J Cardiol 2006, 98:102-6 Kawamura A, Yoshikawa T, Takahashi T, Hayashi T, Takahashi E, Anzai T, Sato T, Ogawa S: Randomized trial of phosphodiesterase inhibitors ... notable in several ways The fact that all ofthe subjects had measurable TnI at baseline suggests that patients with very advanced HF have ongoing myocardial injury The lack of worsening ofthe ... decompensation of cachectic and noncachectic patients with advanced congestive heart failure Scand Cardiovasc J 1999, 33:344-50 Paraskevaidis IA, Parissis JT, Th Kremastinos D: Anti-inflammatory and anti-apoptotic...
... interpretation GK Collection and assembly of data AD Collection and assembly of data AK Data analysis and interpretation, collection and assembly of data CP Conception and design, data analysis and ... G, Funatsu T, Yoshitatsu M, Sekiya N, Fukui S, Hoashi T, Hori M, Yoshikawa H, Kanakura Y, Ishikawa J, Aozasa K, Kawaguchi N, Matsuura N, Myoui A, Matsuyama A, Ezoe S, Iida H, Matsuda H, Sawa Y: ... Conception and design, provision of patients, data analysis and interpretation, manuscript writing PA Conception and design, data analysis and interpretation, manuscript writing HA Data analysis and...
... Sacred Heart of Rome out of 210 patients admitted to the unit during the same period Baseline patient demographic variables, heart failure classification and echocardiographic parameters of patients ... cardiac valve disease LVEF and left ventricular internal diastolic diameter (LVIDd) were calculated from 2-D and M-mode transthoracic echocardiographic images Duration of disease was calculated as ... Discussion The aim of this study was to further our understanding ofthe inflammatory pathways associated with CHF and to assess whether disease etiology affects cytokine cascades To this end we analyzed...