the problem of chronic pain
Báo cáo khoa học: " Science review: Mechanisms of impaired adrenal function in sepsis and molecular actions of glucocorticoids" pdf
Ngày tải lên :
12/08/2014, 20:20
... continuous with the sinuses of the medulla, which drain into the central vein of the medulla The right adrenal vein drains into the inferior vena cava and the left into the renal vein Hence, the rich ... normal rates of secretion for more than a few minutes in the absence of continuing biosynthesis Thus, the rate of secretion is directly proportional to the rate of biosynthesis In other words, ... member of the serine protease inhibitor (serpin) superfamily It has retained the stressed native structure typical of the inhibitor members of the family, and the transition from the stressed to the...
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MECHANISMS OF HEXOSAMINE-INDUCED CHOLESTEROL ACCUMULATION AND THERAPEUTIC ACTIONS OF CHROMIUM
Ngày tải lên :
24/08/2014, 10:54
... recommended by the Food and Nutrition Board of the Institute of Medicine of the National Academy of Sciences, 34 the adequate intake of chromium is set to 30 µg/d (243) Given the known absorption of chromium ... regulation of protein synthesis to the modulation of the activity of numerous enzymes Importantly, insulin is a primary hormone responsible for the regulation of glucose homeostasis in the post-prandial ... ingestion of a meal, glucose enters the bloodstream and is sensed by the endocrine pancreas, specifically β cells in the islets of Langerhans Glucose then stimulates the secretion of insulin from the...
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Mixture toxicity of POPs dioxins, PCBs, PBDEs considerations from mechanisms of actions and for risk assessment
Ngày tải lên :
16/04/2015, 08:52
... Canton (2010) A Global Foodborne Burden of Disease? WHO-‐FERG In prep Es*ma*on of number of W-‐Europe children exceeding the TDI significantly (< 10x) in period 2005-‐2010 ... largely on uptake studies) Applica'on these ‘intake or inges'on’ TEFs has limited toxicological relevance and use for risk assessment of environmental matrices Aspects reduced ... not in present REP/TEF studies evaluated Mixtures of PCDDs, PCDFs and DL-‐PCBs s*ll a health risk? One order of magnitude decline in background human exposure since...
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Báo cáo y học: "Proteomic analysis of mechanisms of hypoxia-induced apoptosis in trophoblastic cells"
Ngày tải lên :
31/10/2012, 15:12
... 43 the balance of the expression of such positive and negative regulators of apoptosis would determine apoptotic propensity In this study, we focused on the role of Bag-1 in the regulation of ... represented the general trend of protein changes, either increasing or decreasing, for the experimental sample relative to the control Changes were classified in the order of confidence, level having the ... transfection of Bag-1 Morpho/AS to JAR cells did not alter the expression of PTEN after the exposure to hypoxia, which would mean that the expression of PTEN, and also that of Bcl-X, was independent of...
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Study on the Photolytic Mechanisms of Red 141 Dye Wastewaters with an 185nm Vacuum-UV lamp
Ngày tải lên :
05/09/2013, 09:08
... considerable disadvantage of the majority of the degradation processes introduced above is the need to add external agents into the aqueous medium In such situation, the effectiveness of the processes relies ... Each run of the experiments in this work was replicated twice The standard deviations of the concentration of Red 141 was analyzed to be ±0.1 mg/l, respectively The concentration of H2O2 in the aqueous ... the excitement of O2 OH· indirect oxidation generated from the excitement of H2O OH· indirect oxidation generated from the excitement of H2O2 Figure The driving forces for the decomposition of...
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ISOTOPE HYDROGRAPH SEPARATION FOR MODELING OF RUNOFF MECHANISMS OF ATMOSPHERICALLY DERIVED CHEMICAL AND RADIOACTIVE POLLUTANTS
Ngày tải lên :
05/09/2013, 09:08
... 22-23 of 2003 The amount of precipitation was 30 mm in total Figure shows the precipitation record of the studied event (Fig 2a) and the record of the river flow rate (solid line, Fig 2b) of the ... to the amount-weighed mean δD of the precipitation samples (-28.1 ‰), and C2 was set to the δD of the river water just before the precipitation event (-47.9 ‰) For the main part of the runoff ... previously As a result of the calculation, and by setting C1 and C2 as mentioned above, the fraction of new water evaluated for the main part of the runoff (0000 of Oct 22 to 1600 of Oct 23, 40 h in...
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Mechanisms of Unstable Nitrite Inhibition of Aerobic Phosphate Uptake
Ngày tải lên :
05/09/2013, 09:38
... rate in the presence of nitrite was 13 mgP.gVSS-1.h-1 and the % activity of phosphate uptake was 39% On the other hands, in the case of AA with 1.9 mgN/gVSS of initial nitrite concentration, the ... concentration, the size of inhibition was the smallest among them The phosphate uptake rate in the presence of nitrite was 20 mgP.gVSS-1.h-1 and the % activity of phosphate uptake was 60 % These results ... 1980), in other words, ‘aerobic nitrite denitrification’ If some of PAOs can that, the inhibitory effect of nitrite will be reduced Hence, the purpose of this study is to examine the effect of anoxic...
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Transmission mechanisms of monetary policy the evidence
Ngày tải lên :
05/01/2014, 17:01
... Examines whether one variable affects another by using data to build a model that explains the channels through which the variable affects the other • Transmission mechanism – The change in the money ... not • Neither model has turned out be more accurate than the other Historical Evidence • If the decline in the growth rate of the money supply is soon followed by a decline in output in these episodes, ... component of aggregate spending (output) Reduced-Form • Examines whether one variable has an effect on another by looking directly at the relationship between the two • Analyzes the effect of changes...
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Tài liệu Women''''s attitudes towards mechanisms of action of family planning methods: survey in primary health centres in Pamplona, Spain doc
Ngày tải lên :
13/02/2014, 06:20
... assessment of understanding and attitudes for postfertilization effects The purpose of our study was to assess the attitudes about the mechanisms of action of FP in terms of whether these may ... hypothetical method of FP In further sections women were asked about their knowledge of the mechanism of action of specific FP methods and if doctors or providers should explain the details of ... Demographic information was asked at the conclusion of the questionnaire The Spanish and the English version of the questionnaire are available from the authors upon request The questionnaire was distributed...
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Tài liệu Báo cáo khoa học: Mechanisms of amyloid fibril formation – focus on domain-swapping doc
Ngày tải lên :
14/02/2014, 18:20
... of amyloid fibrils differing in the number of filaments and the helicity of their intertwining [22–24] The structure of the mature fibrils has been determined in a limited number of cases by either ... those of Sanders et al [155] On the basis of thermodynamic and kinetic data, they concluded that oligomerization of the chicken cystatin occurred in the pre-exponential phase of the fibril growth They ... domain-swapping For some of the case proteins relevant to the focus of this review on domain-swapping, descriptions of the mechanisms are provided, whereas, for most of the other cases, the original publications...
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Tài liệu Báo cáo khoa học: Survival mechanisms of pathogenic Mycobacterium tuberculosis H37Rv ppt
Ngày tải lên :
16/02/2014, 15:20
... the novel features of macrophage defenses and host immune responses The success of M tuberculosis during the parasitization of macrophages involves a modulation of the normal progression of the ... within the host macrophages [47] The intracellular survival of bacteria was impaired with the spontaneous loss of DNA from the transformants Four copies of the mce gene have been identified in the ... help in the establishment of the disease The uptake of M tuberculosis by macrophages is associated with a number of early signaling events, such as the recruitment and activation of members of FEBS...
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Tài liệu Báo cáo khoa học: Mechanisms of obesity and related pathologies: Androgen deficiency and endothelial dysfunction may be the link between obesity and erectile dysfunction pptx
Ngày tải lên :
18/02/2014, 06:20
... integrity of the vascular bed of the penis; (b) the endothelium lining the cavernosal arteries and the helicine arterioles, as well as the endothelium lining the lacunar spaces of the corpus ... flow to the corpus cavernosum The increased blood flow stimulates the endothelium lining the lacunar spaces of the corpus cavernosum to release endothelial NO from the endothelium NO synthase These ... linked to the development of IR and T2DM, and the latter contributes profoundly to endothelium dysfunction and ED [130,131], the concept of androgen deficiency reinforces the important role of androgens...
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Tài liệu Báo cáo khoa học: Reaction mechanisms of thiamin diphosphate enzymes: redox reactions pdf
Ngày tải lên :
18/02/2014, 08:20
... [18] Second, the hyperfine splitting of the radical EPR signal was shown to be dependent on the chemical nature of the substrate methyl substituent (i.e the number of nuclear spins at C3 of pyruvate) ... proximity to the ThDP cofactor), followed by sequential reduction of the other two clusters leading towards the surface of the protein, where FEBS Journal 276 (2009) 2454–2468 ª 2009 The Author ... Fontecilla-Camps et al then reported the high-resolution X-ray structure of the free AcThDP radical trapped at the active center of PFOR from D africanus [26] The electron density maps suggested the thiazolium...
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Tài liệu Báo cáo khoa học: Models and mechanisms of O-O bond activation by cytochrome P450 A critical assessment of the potential role of multiple active intermediates in oxidative catalysis doc
Ngày tải lên :
19/02/2014, 16:20
... intermediate [11] The sum of these ndings points at the involvement of more than one active oxidant in the diverse types of P450-catalyzed substrate processing [1215] The goal of the present perspective ... which small alterations in the environment can cause drastic changes in the reactivity of the active species [76] Further support in favour of the idea of the involvement of a high-valent iron-oxene ... alignment of the CYP19 sequence with the known crystal structures of bacterial P450s, E302 was postulated to be essential to activation of the 19-oxo group of the substrate for attack by the peroxo-iron...
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Motivating Better Hygiene Behaviour: Importance for Public Health Mechanisms of Change doc
Ngày tải lên :
05/03/2014, 21:20
... why the people did not use the new facilities, they invariably found that from their own point of view, the people had very good reasons for their behaviours Not the users, but the approach of the ... Handwashing of mothers before the preparation of food Defecaetion of the children in the living area ofthe family Children placing garbage or waste products in their mouth Based upon these associations ... sanitationis often a great risk to the health of the children But using the toilets and keeping them clean requires more than the individual belief, willingness, time and means of the children themselves;...
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Báo cáo khoa học: Post-ischemic brain damage: the endocannabinoid system in the mechanisms of neuronal death ppt
Ngày tải lên :
07/03/2014, 03:20
... mechanism? Modulation of excitatory and inhibitory neurotransmission The almost ubiquitous presence of the endocannabinoid machinery in every cell of the CNS, together with the high level of CB1 receptor ... isoform of this enzyme are beneficial by, among other mechanisms, sustaining blood flow in the periphery of the ischemic brain On the other hand, under normal circumstances, stimulation of NMDA ... to the many other classes of anti-excitotoxic drugs tested thus far in clinical trials and certainly may provide the basis for other failures in the future [6] Therefore, a better design of protective...
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Báo cáo khoa học: Molecular mechanisms of the phospho-dependent prolyl cis ⁄ trans isomerase Pin1 docx
Ngày tải lên :
07/03/2014, 05:20
... dimer are mainly limited to the conformation of the Glu-Pro dipeptide in the hinge region between the last b-strand and the core of CKS The crystal structure of the complex of CKS with CDK2 ⁄ cyclin ... for destabilizing the double bond character of the pThr-Pro bond [26] Further evidence is available for the catalytic mechanism of Pin1 resembling more closely that of the other prolyl cis ⁄ ... whereas in the study on cyclin E degradation, Pin1 was brought in by the phospho-cyclin E and not by the CDC4a component of the final complex (Fig 2) [35] Therefore, the outcome of the molecular...
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Báo cáo khoa học: Two L-amino acid oxidase isoenzymes from Russell’s viper (Daboia russelli russelli) venom with different mechanisms of inhibition by substrate analogs pdf
Ngày tải lên :
07/03/2014, 05:20
... deprotonation of the a-NH3+ group of the substrate by His223 of the enzyme and subsequent movement of the lone pair of electrons from NH2 to the a-C atom, which activates the substrate to transfer the ... tively The spectral features of the dissociated cofactor were similar to those of FAD The shifting of absorption maxima of the enzyme-bound avin was due to its microenvironment The RP-HPLC proles of ... of apoptosis [9] The evidence to date implicates the glycan moiety of LAAO for the docking onto the host cell that enhances localization of high concentrations of hydrogen peroxide The mode of...
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Báo cáo khoa học: Mechanisms of accumulation of arachidonate in phosphatidylinositol in yellowtail A comparative study of acylation systems of phospholipids in rat and the fish species Seriola quinqueradiata pot
Ngày tải lên :
08/03/2014, 08:20
... contribute to the enrichment of arachidonate in PtdIns in mammals Further experiments are needed to clarify the involvement of the PtdIns cycle in the accumulation of arachidonic acid in PtdIns of fish ... agreement with the distribution patterns of arachidonic acid between PtdCho and PtdIns observed in the fatty acid analysis of tissues of yellowtail Furthermore, they indicate that the one-sided ... both the PtdEtn and PtdSer fractions, docosahexaenoic acid was the predominant PUFA in all the tissues The presence of dimethylacetals in PtdEtn suggested the existence of a substantial amount of...
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