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... If this is the case, then the protective effect of EGF on TRAIL-induced apoptosis should also depend on JNK activity To test this hypothesis, we treated HEK-293T cells with TRAIL and EGF in the ... activator of caspase (Smac ⁄ DIABLO) allows for the formation of the apoptosome, a complex that enables the activation of caspases within the cell [18,19] In this pathway, Bid is activated by caspase ... of the proteasome increases apoptosis by increasing tBid levels [14] Thus, we have identified the ligase responsible for limiting the extent of tBidinduced apoptosis This conclusion is strengthened...

Ngày tải lên: 16/02/2014, 09:20

... Distance d (Table 1) between stefin A and the different enzymes is the average distance between the centre of mass of CA atoms of the stefin molecule and the centre of mass of the CA atoms of the ... H110A mutant and the reactive site of the enzyme is turned off by the C29A mutant (it is assumed that the cathepsin B mutations not affect the geometry of binding of chagasin) The wild-type sequences ... and H and the center of CA atoms of stefins in the structures of ˚ both complexes The average distance is 23.4 A, which is the same for both enzymes (Table 1) The comparison shows that the final...

Ngày tải lên: 18/02/2014, 04:20

... and to measure the mobility of the components in the PGCs The medaka embryo was peeled off the chorion, and the segment containing the part of PGCs was excised for observation by microscopy and ... measurement of the PGC, the 10 Time (s) 15 20 Fig FCS and FRAP analyses of OlvasGFP in the PGC FCS was used to measure the movement of OlvasGFP into the cytosol out of the nuage region of the PGC ... protein in the HeLa cell [24], suggesting the existence of some interactive cellular partner FRAP analysis of the nuage revealed the slow recovery of OlvasGFP (Fig 3B) When the whole part of the single...

Ngày tải lên: 18/02/2014, 16:20

... one of the manganese ions This, together with the fact that the positions of other Fig Scheme of the binuclear manganese cluster and the localization of the side-chains of Asp153 and Asn153 in the ... affected by the mutation, as revealed by the conservation of the whole topology of the active site, would explain the essentially unaltered interaction of the D153N variant with the metallic cofactor ... with the same region of the arginases (Fig 4) Since the arginase loop contains residues that interacts with the a-carboxylate group of the substrate arginine [13], and this is the part of the...

Ngày tải lên: 21/02/2014, 01:21

... formation of the autophagosome The machinery controlling formation of the autophagosome involves two ubiquitin-like conjugation systems The first is the conjugation of Atg12 to Atg5 [15] The other is the ... inconsistent with the notion that Bcl-2 functions as a direct suppressor of Beclin activity These results suggested the existence of another mechanism FEBS Journal 274 (2007) 3184–3197 ª 2007 The ... rheostatic control of autophagy by Beclin 1–Bcl)2 interaction is not a universal mechanism Further experiments are needed to clarify the nature of Bcl-2 control of autophagy at the level of S ⁄ ER calcium...

Ngày tải lên: 07/03/2014, 09:20

... licensing and the reader is referred to them and to the published decisions of the courts on a variety of licensing disputes for more complete information The references at the end of this Report ... 17 years from the date of issue of the patent (more commonly understood as the date of grant) rather than from the date of application; the unique reliance on the principle of the personal ‘first ... business and exist even in the absence of trade marks There is no time limit on the life of this property right and its protection is enforced by the English common law of ‘passing off’, which forbids...

Ngày tải lên: 07/03/2014, 11:20

... state of amino-acid residues is influenced by their unique microenvironment; therefore, predicting the impact of the residues based solely on theoretical pKa of their individual side chains is speculative ... in pathogenesis of the disease process this species exhibits in mammalian host The ECM protein binding ability of the leishmanial LBP could allow the parasite to persist within the host and thus ... Adhesion of pathogen to host tissue is a prerequisite for many types of infections Diseases such as leishmaniases are is generally initiated when sand fly, the vector, regurgitates promastigote form of...

Ngày tải lên: 08/03/2014, 23:20

... voluntarily to his family, his conscience, his feelings of charity, his church, his clubs, his city, his country He may feel impelled by these responsibilities to devote part of his income to causes ... that is in the best interests of the corporation or that is required by law in order to contribute to the social objective of improving the environment Or that, at the expense of corporate profits, ... if they wished to so The executive is exercising a distinct "social responsibility," rather than serving as an agent of the stockholders or the customers or the employees, only if he spends the...

Ngày tải lên: 15/03/2014, 20:20

... resolve some of these discrepancies in order to (a) identify the subcellular localization of GLUT8 in testis, (b) elucidate the role of APs in GLUT8 sorting, and (c) understand the role of the EXXXLL ... localization of the endogenous GLUT8 in testis, the nature of its sorting, and the interaction of its Nterminal dileucine motif with the various AP subunits The [DE]XXXL[LI] signal of GLUT8 has ... family isoforms is not understood – especially in the context of their intracellular localization as described for all class III members [4,5,8,9,28] This raises the question of whether these transporters...

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