the prime minister of canada is elected by

... this is the case, then the protective effect of EGF on TRAIL-induced apoptosis should also depend on JNK activity. To test this hypothesis, we treated HEK-293T cells with TRAIL and EGF in the ... interaction of tBid with Itch. The molecular basis of this interaction is currently unknown, as tBid does not contain any of the usually recognized interaction motifs with Itch. However, this is not ... increases apoptosis by increasing tBid levels [14]. Thus, we have identified the ligase responsible for limiting the extent of tBid- induced apoptosis. This conclusion is strengthened by our observation...

Ngày tải lên: 16/02/2014, 09:20

... Distance d (Table 1) between stefin A and the different enzymes is the average distance between the centre of mass of CA atoms of the stefin molecule and the centre of mass of the CA atoms of the ... by the H110A mutant and the reactive site of the enzyme is turned off by the C29A mutant. (it is assumed that the cathepsin B mutations do not affect the geometry of binding of chagasin). The ... shows that the magnitude of the shift of the occlud- ing loop is related to the size of the binding region. It is smallest in the procathepsin structures and increases in the series of complexes...

Ngày tải lên: 18/02/2014, 04:20

... and to mea- sure the mobility of the components in the PGCs. The medaka embryo was peeled off the chorion, and the segment containing the part of PGCs was excised for observation by microscopy and ... in the HeLa cell [24], suggesting the existence of some interactive cellular partner. FRAP analysis of the nuage revealed the slow recovery of Olvas–GFP (Fig. 3B). When the whole part of the single ... on the same setup of the laser scanning microscope as used for FCS analysis. The detection gain was adjusted to the fluorescence of the GFP fusion proteins almost at the saturation level of the detector,...

Ngày tải lên: 18/02/2014, 16:20

... with the same region of the arginases (Fig. 4). Since the arginase loop contains residues that interacts with the a-carboxylate group of the substrate arginine [13], and this is the part of the ... one of the manganese ions. This, together with the fact that the positions of other Fig. 4. A superimposition of the structures of B. caldovelox arginase (red), rat liver arginase (yellow) and the ... structure of E. coli agmatinase (blue). Note the shorter extension, in the case of E. coli agmatinase, of the loop indicated by the letter a. Fig. 5. Scheme of the binuclear manganese cluster and the...

Ngày tải lên: 21/02/2014, 01:21

... formation of the autophago- some. The machinery controlling formation of the autophagosome involves two ubiquitin-like conjuga- tion systems. The first is the conjugation of Atg12 to Atg5 [15]. The other ... of Bcl-2- wt were inconsistent with the notion that Bcl-2 func- tions as a direct suppressor of Beclin 1 activity. These results suggested the existence of another mechanism B % Cells with Numerous GFP-LC3 ... accurate reflection of autophagic activity, and therefore the accumulation of LC3-II in the presence of lysosomal inhibitors is a more accurate indicator of autophagy [20]. For these reasons, studies which...

Ngày tải lên: 07/03/2014, 09:20

... viz., the period of protection is 17 years from the date of issue of the patent (more commonly understood as the date of grant) rather than from the date of application; the unique reliance on the ... prior permission of the publisher. This Report is sold subject to the condition that it shall not, by way of trade or otherwise, be lent, re-sold, hired out or otherwise circulated without the publisher’s prior ... only the expression of an idea not the idea itself and thus provides the crucial right of preventing unauthorised copying of a work. The illegal copying of computer software, often described by the...

Ngày tải lên: 07/03/2014, 11:20

... behind the curtain, were called to the bar of public opinion. The ministers endeavored to make a scapegoat of the general; the general, to fix the responsibility for defeat upon the ministers. His ... Built 1755-56 by the French, taken 1759 by the British, under Amherst. Three weeks before the battle of Lexington, an agent of Massachusetts was sent to ascertain the feelings of the people of Canada. His ... us of the herds of red deer seen quietly browsing on the hillsides; of the flocks of pigeons, darkening the air in their flight; and of the store of pike, bass, and maskelonge with which the...

Ngày tải lên: 08/03/2014, 12:20

... be mentioned that the ionization state of amino-acid residues is influenced by their unique microenvironment; therefore, predicting the impact of the residues based solely on theoretical pK a of their individual ... in pathogenesis of the disease process this species exhibits in mammalian host. The ECM protein binding ability of the leishmanial LBP could allow the parasite to persist within the host and ... tissue is a prerequisite for many types of infections. Diseases such as leishmaniases are is generally initiated when sand fly, the vector, regurgitates promastigote form of the parasite at the...

Ngày tải lên: 08/03/2014, 23:20

... executive, the manager is the agent of the individuals who own the corporation or establish the eleemosynary institution, and his primary responsibility is to them. the iron fist of Government bureaucrats. ... socialism. Businessmen who talk this way are unwitting puppets of the intellectual forces that have been undermining the basis of a free society these past decades. The discussions of the "social ... and on. The whole justification for permitting the corporate executive to be selected by the stockholders is that the executive is an agent serving the interests of his principal. This justification...

Ngày tải lên: 15/03/2014, 20:20

... family isoforms is not understood – especially in the context of their intracellular locali- zation as described for all class III members [4,5,8,9,28]. This raises the question of whether these transporters ... resolve some of these discrepancies in order to (a) identify the subcellu- lar localization of GLUT8 in testis, (b) elucidate the role of APs in GLUT8 sorting, and (c) understand the role of the EXXXLL ... localization of the endogenous GLUT8 in tes- tis, the nature of its sorting, and the interaction of its N- terminal dileucine motif with the various AP subunits. The [DE]XXXL[LI] signal of GLUT8...

Ngày tải lên: 16/03/2014, 02:20

... using the supermole- cular method assuming the optimized geometries. The inter- action energy is therefore determined as the difference between the energy of the complex and energies of the isolated ... complex. The NH amide atoms of the drug in particular form H-bonds with thymine O2 and adenine N3 atoms in the AATT-rich sequence of the decamer. Part of the spine of hydration is substituted by the ... [exponents of 0.25, desig- nated as 6–31G*(0.25)] to properly account for the dispersion attraction [28,29,44,45]. The contact area of the NAE has been studied by evalu- ating the effect of adenine...

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