the policy sciences at the crossroads

... growthJudgement - works best where metrics are compatible with CBA *? Policy levers – bus deregulation and privatisation, rail privatisation, concessionary fares,reform of HA, road pricing Judgement ... interviewed 18 experts, reviewed literature OUTLINE How we got to where we now are? What role has appraisal played in the decision making process? What are the present challenges? Development of ... The Report for the RAC Foundation - Front Cover Context Report commissioned by the RAC Foundation Challenges facing transport appraisal and its...

Ngày tải lên: 27/11/2015, 12:41

... each other across species, indicating that their function is possibly interchangeable and that sex determination in invertebrates might rely on conserved molecules, at least at the bottom of the ... development, including spermatogenesis Despite the attention that Dmrt1 factors have received, to date it has not been elucidated how Dmrt1s mediate their activities and putative downstream targets ... Oreochromis niloticus Oryzias latipes Expression localization n.i n.i Spermatogonia, spermatocytes Spermatogonia, spermatocytes spermatids and developing oocytes Spermatogonia, spermatocytes Germ cells...

Ngày tải lên: 14/02/2014, 19:20

Ngày tải lên: 08/03/2014, 15:20

... on the days that these two statements were released In each case, there is a clear, immediate effect on expectations of the future path of the funds rate: OIS rates fall, despite the fact that the ... rate at horizons farther in the future Under the null hypothesis of no effect of the statements on expectations, there should be no appreciable variation in either factor Under the null hypothesis ... “wellbalanced policy at the later date will take no account of the effects of expected policy at that date on decisions expected to be taken in the private-sector earlier, according to the policy projections...

Ngày tải lên: 15/03/2014, 14:20

... ESIA noted the deficiencies in the national legal framework in relation to customary rights when stating that ‘people and the state are at odds as to who owns the forests’, and that the lack of ... said the government had given them the land, so whether you agree or not we will take the land Another community member stated that: They pushed everything in the water, cleared too close to the ... let them take the land We had to pay them bribes to get them to survey the crops [so that any compensation would be reduced by the amount paid as a bribe] Another community member stated: They...

Ngày tải lên: 17/03/2014, 11:20

... Central Themes in NIH Communications: A Vision for the Future and Congressional Hearings • What is the return on the American people‘s investment in the National Institutes of Health? • What has the ... —Personalize“ Cancer Treatment Identified 16 informative genes Impact: Test tumor samples for mutations in these genes Predict which patients need chemotherapy 70,000 breast cancer patients per year ... Applications Translational Research Basic Research and Technology Development NIH Clinical Applications Translational Research Basic Research Private Sector Protecting the Future: Pathway to Independence...

Ngày tải lên: 17/03/2014, 18:20

... emulate their fathers in some areas and other men in other aspects More important, Johnson and Staples also cite studies that reveal that mothers can communicate appropriate male roles to their ... share the provider and expressive roles, the fatherdaughter and mother-son relationships are just as important for understanding child development and aspirations as are the motherdaughter and father-son ... father-son relationships.” Thus, they underscore the need for more studies of the impact of Black fathers on the development of their daughters and how Black mothers influence the development of their...

Ngày tải lên: 03/06/2014, 01:30

... resembles the face of a juvenile ape The resemblance fades as the ape’s jaw grows, relative to the rest of the skull, to produce the adult ape’s muzzle The foramen magnum, the hole in the mammalian ... accept the good fortune that has brought them to a place where huge rewards are there for the taking, ignore protests in the popular press about troughing and fat cats and try to ensure that their ... close to the grindstone, and you have a job for life); the re-emergence of the market rather than the organization as the mechanism for valuing human worth and allocating human resources; the opportunities...

Ngày tải lên: 21/06/2014, 03:20

... candidates for the CEO job are: the current position of the candidate, and the performance and stature of the candidate’s company These automatically exclude from the candidates’ pool the good ... to the CEO, rather than to the shareholders who pay their fees They cultivate relationships with individuals, rather than organizations Their objective is to enhance their CEO clients’ reputations, ... When thinning down the long list of those who satisfy these rather arbitrary tests, the most important criterion for elevation to the short list is the requirement that the candidates are superstars...

Ngày tải lên: 21/06/2014, 03:20

... Business at a Crossroads Part of the answer is that the fitness landscape of each firm is a creature of the fitness landscapes of other firms In the past, there were only a few climbers and they ... with the environment Others said that the company had stood still while the environment changed; that a natural, institutional inertia had caused the firm to cling to the status quo until the ... and the Social Construction of the Early Electricity Industry in America,4 they argued that, when the industry was born in the 1880s, three development roads were open: power generation at the...

Ngày tải lên: 21/06/2014, 03:20

... plate shifts in the world economy, such as the disintegration of the Soviet bloc, European integration, the opening up of China and globalization in general Another partnership theme has been the ... their due consideration Over the past 160 years or so large CEO-led companies have created a great deal of value for their shareholders I suspect that they, or rather the resources they commanded, ... deserve the name “strategy” and must borrow instructions from other agents, are more robust than conventional strategies, because they work with, rather than against, the self-organization that shapes...

Ngày tải lên: 21/06/2014, 03:20

... number that the company will decide it can without a CEO 10 corporate reformation 191 Redeeming the corporation The dramatic events of the past two years or so in banking and in business at large, ... employees They also advocate the replacement of hierarchies by what they call “heterarchies” in which the employees “make decisions for themselves and one another horizontally.” I approve fully of the ... democratization of Semco; the opening up, the laying of cards on the table, an end to secrecy Most writers on organizational democracy make much of the need for open- 188 Business at a Crossroads...

Ngày tải lên: 21/06/2014, 03:20

... At the Crossroads The Remarkable CPA Firm That Nearly Crashed, Then Soared Gale Crosley, C.P.A and Debbie Stover At the Crossroads At the Crossroads The Remarkable CPA Firm That Nearly ... information They work to bring all the available information together, they develop strategy and then refine it as they go along, and they keep the focus constantly on competition and how to win They ... wrong I think it’s the unhappy families who are alike They all the same things They hide their toys, and they won’t share They keep secrets, and they snipe at each other when their backs are turned...

Ngày tải lên: 28/06/2014, 00:20

... emulate their fathers in some areas and other men in other aspects More important, Johnson and Staples also cite studies that reveal that mothers can communicate appropriate male roles to their ... share the provider and expressive roles, the fatherdaughter and mother-son relationships are just as important for understanding child development and aspirations as are the motherdaughter and father-son ... father-son relationships.” Thus, they underscore the need for more studies of the impact of Black fathers on the development of their daughters and how Black mothers influence the development of their...

Ngày tải lên: 28/06/2014, 10:20

... At the Crossroads The Remarkable CPA Firm That Nearly Crashed, Then Soared Gale Crosley, C.P.A and Debbie Stover At the Crossroads At the Crossroads The Remarkable CPA Firm That Nearly ... information They work to bring all the available information together, they develop strategy and then refine it as they go along, and they keep the focus constantly on competition and how to win They ... wrong I think it’s the unhappy families who are alike They all the same things They hide their toys, and they won’t share They keep secrets, and they snipe at each other when their backs are turned...

Ngày tải lên: 28/06/2014, 22:20

... Characterization of the AMP-activated protein kinase kinase from rat liver, and identification of threonine-172 as the major site at which it phosphorylates and activates AMP-activated protein ... AMPK-activating drugs could prove promising in the treatment of LKB1-deficient cancers Furthermore LKB1 now joins AMPK as an attractive target for activating drugs that would be useful in the treatment ... [1] The existence of an AMPKK was suggested by the observation that AMPK could be deactivated by protein phosphatases An AMPKK was partially purified by several laboratories, and these preparations...

Ngày tải lên: 06/08/2014, 18:20

... regulation of the Crumbs complex, as a null mutation in Crumbs did not compensate for the effects of the scribble mutations on cell polarity and proliferation [2] This study clearly highlights the ... Stardust or Crumbs [2,14] Whether these oncogenic signals modulate JNK activation levels and alter its function, or whether they control other transcriptional regulators that may divert JNK signals, ... of aPKC to dictate cell polarity in the directed migration of mammalian astrocytes and epithelial cells [10,11] The antagonism between aPKC and the Scribble complex in the regulation of cell polarity...

Ngày tải lên: 06/08/2014, 19:21

... [14], and it is often referred to as the Barker hypothesis This hypothesis of fetal origins proposes that these diseases originate through adaptations that the fetus makes when it is undernourished ... to develop asthma [28] The risk of atopy and asthma is related to failure of the neonate to generate interferon-γ and the resultant failure to transition from the Th2 to the Th1 immunophenotype ... asthma in the neonate Moreover, these postnatal environmental risk factors are themselves only part of a greater scheme that includes fetal development and genetic predisposition Together, these...

Ngày tải lên: 12/08/2014, 18:20

... facilitates the formation of a clathrin coated pit that leads to the internalization of CD4 Left (Yellow), Nef downregulates MHCI from the surface of the infected cell Nef binds to the cytoplasmic ... (cytosolic) location of Nef bound to Hck with no attachment of the myristate to a membrane indicates that the activation of Hck is the only Nef function that does not require this post-translational ... having a Nef that downregulates CD3 which prevents activation of the infected T cell and subsequent activation induced cell death The authors further propose that the downregulation of CD3 evolved...

Ngày tải lên: 13/08/2014, 05:21

... of misconduct? The answer is the road to the VSC However, it is not this theoretical construct itself that has created this situation and led us back to the crossroads, but rather the way it is ... of the VSC, that road has inevitably taken them back to the crossroads and the stark choice of science or ideology Chiropractic today So what is the state of chiropractic in Australia today? There ... month treatment plan for a 41/2 week old infant The defendant later appealed the decision in the Victorian Civil and Administrative Tribunal (VCAT) and the transcript of the proceedings is on the...

Ngày tải lên: 13/08/2014, 15:21