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Báo cáo khoa học: Interactions of HIPPI, a molecular partner of Huntingtin interacting protein HIP1, with the specific motif present at the putative promoter sequence of the caspase-1, caspase-8 and caspase-10 genes pdf

Báo cáo khoa học: Interactions of HIPPI, a molecular partner of Huntingtin interacting protein HIP1, with the specific motif present at the putative promoter sequence of the caspase-1, caspase-8 and caspase-10 genes pdf

... at the last base, G to A, abolished the interaction of HIPPI, so the last motif would not interact with HIPPI. The other two motifs might be the target of HIPPI. In the upstream sequence of the Table ... positions of the motifs are indicated by distance from the transcription start site (TSS). The position upstream of the TSS of any gene is denoted by ‘–’ followed by the distance from the TSS. In the caspase-8 ... confirmed the in vitro result that mutation of the motif abolished the binding of HIPPI to the specific sequence of the caspase-1 gene upstream sequence, and the increased expression of caspase-1...

Ngày tải lên: 07/03/2014, 10:20

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Báo cáo khoa học: Dissociation/association properties of a dodecameric cyclomaltodextrinase Effects of pH and salt concentration on the oligomeric state pot

Báo cáo khoa học: Dissociation/association properties of a dodecameric cyclomaltodextrinase Effects of pH and salt concentration on the oligomeric state pot

... in the presence of KCl. Considering also the 3D structure of CDase I-5, the analysis of the quaternary state of CDase I-5 revealed Fig. 8. Fluorescence spectra of CDase I-5. (A) - - - -, the ... the adjacent monomer, of which G538 forms a hydrogen bond to the carbonyl oxygen of M51. Two residues at the N-terminus (H49 and H89) of a subunit were located close to the C-domain of the other ... either in the secondary structure of the protein according to far-UV CD data or in the size of the protein determined by size- exclusion HPLC. They suggested that the change might occur either...

Ngày tải lên: 07/03/2014, 12:20

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Báo cáo Y học: Introducing Wilson disease mutations into the zinc-transporting P-type ATPase ofEscherichia coli The mutation P634L in theÔhingeÕ motif (GDGXNDXP) perturbs the formation of the E2P state pdf

Báo cáo Y học: Introducing Wilson disease mutations into the zinc-transporting P-type ATPase ofEscherichia coli The mutation P634L in theÔhingeÕ motif (GDGXNDXP) perturbs the formation of the E2P state pdf

... than the wild-type both in the absence a nd in the p resence of Fig. 3. Normalized zinc-dependent ATPase activity of the wild-type and mutated enzymes. TheATPaseactivity(percentageoftheactivityofthe wild-type) ... The effect of 30 l M Zn 2+ on the P i -phosphorylation of the wild-type and the P401L enzymes (gray columns). Note that the maximal phosphorylation of the P401L mutant is only 8% of the wild-type ... possible that the tolerance for the s ubstitutions at this site is related to the size and hydrophobicity of the substituting side chain. Inspection of a theoretical model of the Ca-ATPase in the E 2 state...

Ngày tải lên: 17/03/2014, 17:20

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Báo cáo khoa học: Internalization of the human CRF receptor 1 is independent of classical phosphorylation sites and of b-arrestin 1 recruitment potx

Báo cáo khoa học: Internalization of the human CRF receptor 1 is independent of classical phosphorylation sites and of b-arrestin 1 recruitment potx

... with the Substance P receptor [25]. Detachment of the cells from the surface of the culture dish could r eflect disassembly of the actin cytoskeleton in the me mbrane regions as a consequence of ... both the cAMP and the PLC pathway [22], the second messenger product of either or both of these pathways could be invo lved in agonist-stimulated internalization of this receptor. The effect of ... f 125 I-labelled sauvagine could be observed in the presence of any of these inhibitors. These findings indicate that neither the activation of PKA nor the activation of PKC is necessary for agonist-induced...

Ngày tải lên: 30/03/2014, 15:20

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báo cáo hóa học:" The occurrence of osteoarthritis at a minimum of ten years after reconstruction of the anterior cruciate ligament" pdf

báo cáo hóa học:" The occurrence of osteoarthritis at a minimum of ten years after reconstruction of the anterior cruciate ligament" pdf

... used. The distal entry of the tib- ial tunnel is positioned through the distal aspect of the incision near the tibial tubercle [28]. The femoral tunnel was drilled through the tibial tunnel. The ... per- formance, the score may appear too high, and will reflect the actual function of the knee as well as the satisfaction of the patient. The Lysholm score has never been validated for the purpose of following ... test). These patients were considered at high risk of further knee injury due to the degree of laxity and the desired level of activity [27]. In order to minimise the development of arthrofi- brosis,...

Ngày tải lên: 20/06/2014, 01:20

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báo cáo hóa học:" The psychological context of quality of life: a psychometric analysis of a novel idiographic measure of bladder cancer patients’ personal goals and concerns prior to surgery" pot

báo cáo hóa học:" The psychological context of quality of life: a psychometric analysis of a novel idiographic measure of bladder cancer patients’ personal goals and concerns prior to surgery" pot

... major motivat ional theme as it demon- strates yet another dimension of the QOL Appraisal Profile and further helps e lucidate the nuances o f the profile. The major theme of reaching an event/ milestone ... examination of patien t character- istics and quality of life, thematic content coding of responses to the Brief Quality of Life Appraisal Profile, examination of the relationship of goal attainment ... needed. Other patients c om- pleted the Quality of Life Appraisal Profile and other measures during the time that they were receiving neo- adjuvant chemotherapy. In order to see whether these confounders...

Ngày tải lên: 20/06/2014, 15:20

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Measurement of Color, Gloss, and Translucency of White Salted Noodles- Effects of Water Addition and Vacuum Mixing.pdf

Measurement of Color, Gloss, and Translucency of White Salted Noodles- Effects of Water Addition and Vacuum Mixing.pdf

... boiling time and the degree of starch swelling (Crosbie 1992). Accurate measurement of the color of boiled noodles necessitates the use of a method that minimizes the effect of variation on ... but expected to be largely independent of noodle thickness. These were considerations in the development of methods in the present study. The aims of the study were to develop new and improved ... Tests in Experiment 1 The distance along the visual analogue scales (VAS) for each of the six samples was measured, the results of the 32 panelists were combined, and the mean scores were compared...

Ngày tải lên: 16/12/2012, 15:25

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báo cáo hóa học:" En bloc excision and autogenous fibular reconstruction for aggressive giant cell tumor of distal radius: a report of 12 cases and review of literature" doc

báo cáo hóa học:" En bloc excision and autogenous fibular reconstruction for aggressive giant cell tumor of distal radius: a report of 12 cases and review of literature" doc

... bone cementing for these grade II tumors. Of the 10 primary cases, initial preoperative biopsy confirmation of GCT was done in 3 cases, all of which had a grade III tumor and there was a suspicion of a malignant ... maintained all the records of the patients and followed them. All the authors read and approved the final manuscript Conflict of Interests The authors declare that they have no competing interests. Received: ... bloc excision of the distal radius and fibular autograft replacement. J Bone Joint Surg Br 1983, 65(5):618-20. 26. Vander Griend RA, Funderburk CH: The treatment of giant-cell tumors of the distal part of...

Ngày tải lên: 20/06/2014, 04:20

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báo cáo hóa học:" En bloc excision and autogenous fibular reconstruction for aggressive giant cell tumor of distal radius: a report of 12 cases and review of literature" ppt

báo cáo hóa học:" En bloc excision and autogenous fibular reconstruction for aggressive giant cell tumor of distal radius: a report of 12 cases and review of literature" ppt

... maintained all the records of the patients and followed them. All the authors read and approved the final manuscript Conflict of Interests The authors declare that they have no competing interests. Received: ... bone cementing for these grade II tumors. Of the 10 primary cases, initial preoperative biopsy confirmation of GCT was done in 3 cases, all of which had a grade III tumor and there was a suspicion of a malignant ... graft in the treatment of aggressive bone tumours of the distal end of the radius. Arch Orthop Trauma Surg 1981, 98(4):285-7. 13. Seradge H: Distal ulnar translocation in the treatment of giant-cell tumors...

Ngày tải lên: 20/06/2014, 07:20

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