... at the last base, G to A, abolished
the interaction of HIPPI, so the last motif would not
interact with HIPPI. The other two motifs might be
the target of HIPPI. In the upstream sequence of the
Table ... positions ofthe motifs are indicated
by distance from the transcription start site (TSS). The
position upstream ofthe TSS of any gene is denoted
by ‘–’ followed by the distance from the TSS. In the
caspase-8 ... confirmed the in vitro result
that mutation ofthe motif abolished the binding of
HIPPI to the specific sequence ofthe caspase-1 gene
upstream sequence, and the increased expression of
caspase-1...
... in the presence of KCl.
Considering also the 3D structure of CDase I-5, the
analysis ofthe quaternary state of CDase I-5 revealed
Fig. 8. Fluorescence spectra of CDase I-5. (A) - - - -, the ... the adjacent
monomer, of which G538 forms a hydrogen bond to
the carbonyl oxygen of M51. Two residues at the
N-terminus (H49 and H89) of a subunit were located
close to the C-domain ofthe other ... either in the secondary
structure ofthe protein according to far-UV CD
data or in the size ofthe protein determined by size-
exclusion HPLC. They suggested that the change
might occur either...
... than
the wild-type both in the absence a nd in the p resence of
Fig. 3. Normalized zinc-dependent ATPase activity ofthe wild-type and
mutated enzymes. TheATPaseactivity(percentageoftheactivityofthe
wild-type) ... The effect of 30 l
M
Zn
2+
on the P
i
-phosphorylation ofthe wild-type and the P401L
enzymes (gray columns). Note that the maximal phosphorylation of
the P401L mutant is only 8% ofthe wild-type ... possible that the tolerance for the s ubstitutions at this site
is related to the size and hydrophobicity ofthe substituting
side chain. Inspection of a theoretical model of the
Ca-ATPase in the E
2
state...
... with the Substance P receptor [25]. Detachment
of the cells from the surface ofthe culture dish could r eflect
disassembly ofthe actin cytoskeleton in the me mbrane
regions as a consequence of ... both the
cAMP and the PLC pathway [22], the second messenger
product of either or both of these pathways could
be invo lved in agonist-stimulated internalization of this
receptor.
The effect of ... f
125
I-labelled sauvagine could be observed
in the presence of any of these inhibitors. These findings
indicate that neither the activation of PKA nor the
activation of PKC is necessary for agonist-induced...
... used. The distal entry ofthe tib-
ial tunnel is positioned through the distal aspect of the
incision near the tibial tubercle [28]. The femoral tunnel
was drilled through the tibial tunnel.
The ... per-
formance, the score may appear too high, and will reflect
the actual function ofthe knee as well as the satisfaction
of the patient. The Lysholm score has never been validated
for the purpose of following ... test). These
patients were considered at high risk of further knee injury
due to the degree of laxity and the desired level of activity
[27]. In order to minimise the development of arthrofi-
brosis,...
... major motivat ional theme as it demon-
strates yet another dimension ofthe QOL Appraisal
Profile and further helps e lucidate the nuances o f
the profile. The major theme of reaching an event/
milestone ... examination of patien t character-
istics and quality of life, thematic content coding of
responses to the Brief Quality of Life Appraisal Profile,
examination ofthe relationship of goal attainment ... needed. Other patients c om-
pleted the Quality of Life Appraisal Profile and other
measures during the time that they were receiving neo-
adjuvant chemotherapy. In order to see whether these
confounders...
...
boiling time and the degree of starch swelling (Crosbie 1992).
Accurate measurement ofthe color of boiled noodles necessitates
the use of a method that minimizes the effect of variation on ... but expected to be largely
independent of noodle thickness. These were considerations in the
development of methods in the present study. The aims ofthe study
were to develop new and improved ...
Tests in Experiment 1
The distance along the visual analogue scales (VAS) for each of
the six samples was measured, the results ofthe 32 panelists were
combined, and the mean scores were compared...
... bone
cementing for these grade II tumors. Ofthe 10 primary
cases, initial preoperative biopsy confirmation of GCT
was done in 3 cases, all of which had a grade III tumor
and there was a suspicion of a malignant ... maintained all the records of
the patients and followed them. All the authors read and approved the final
manuscript
Conflict of Interests
The authors declare that they have no competing interests.
Received: ... bloc
excision ofthe distal radius and fibular autograft replacement. J Bone
Joint Surg Br 1983, 65(5):618-20.
26. Vander Griend RA, Funderburk CH: The treatment of giant-cell tumors of
the distal part of...
... maintained all the records of
the patients and followed them. All the authors read and approved the final
manuscript
Conflict of Interests
The authors declare that they have no competing interests.
Received: ... bone
cementing for these grade II tumors. Ofthe 10 primary
cases, initial preoperative biopsy confirmation of GCT
was done in 3 cases, all of which had a grade III tumor
and there was a suspicion of a malignant ... graft in the treatment of aggressive bone tumours
of the distal end ofthe radius. Arch Orthop Trauma Surg 1981, 98(4):285-7.
13. Seradge H: Distal ulnar translocation in the treatment of giant-cell
tumors...