... injury Table 3-1: EC50 of VC, pHLandLeo for the eliminationof DPPH radicals Table 3-2: Thepercentageincreasein SOD, CAT, GPxandGSTactivitiesin TBI/ pHLand TBI/ LeocomparedwithTBIgroup ... In this study, only antioxidant activitiesand anti-apoptotic effects were chosen for observation Leo increased theactivities of SOD, CAT, GPxandGSTin brain tissue but only theincreasein ... higher percentage increase/ decrease of the treatment outcome compared to theTBIgroupThe difference inactivities of SOD, CATandGPx was significant between both treatment groups Furthermore, there...
... study, of the 48 Oxford unicompartmental knee replacements had been revised within the 4.5 year follow up period and our outcomes inthe surviving knees were disappointing comparedwith other studies ... be done by extending our indications and ignoring the presence of patellofemoral arthritis (if not clinically symptomatic) as suggested inthe new guidelines by the Oxford groupThe vast majority ... recorded together withthe degree of overhang of the prosthesis in millimeters andthe presence or absence of posterior osteophyte Each prosthesis was then scored radiographically by summing the degree...
... midpoint of the aggregation process measured by DSLS) were PRPP, GMP and IMP Large increasein thermal shift is an indication of protein-compound binding The high thermal shifts for GMP, and IMP indicated ... HPRT The differences in catalytic efficiency could be explained by the difference in amino acid residues involved in catalysis between PRTFDC1 and HPRT Inthe structure, residues interacting with ... whereas the side chain of Lys173 interacts with both O6 and N7 (Fig 1C) The 2¢OH of the ribose is hydrogen bonded to the main chain andthe side chain of Asp142 (Fig 1C) Both hydroxyl groups of the...
... [51] Interestingly, in all WhiB proteins except WhiB2, the amino acid immediately after the C-terminal cysteine of the CXXC motif is proline (Fig S6) In WhiB2 the absence of proline and therefore ... out by incubating the purified proteins (50 lM) with 20 mM IAA for h at 25 °C inthe dark andthe spectra were recorded (thin line) after the baseline correction The spectra for WhiB3 and WhiB4 ... conserved andthe position of the N-terminal cysteine appears to be flexible Therefore, inthe primary structure, although the cysteines lie far apart with respect to each other, in a 3D form they...
... search using the DALI server withthe C terminal domain as the query did not produce any significant hits other than the SurEs already known However, the N-terminal domain aligned with certain other ... 242–245, bringing the polypeptide chain back to the same subunit We analyzed the interactions of corresponding residues in SurEs to understand the reasons for domain swapping A few strong interactions ... domain swapping in St SurE The A and B subunits are shown in green and blue, respectively and van der Waals interactions Most of the residues that are involved inthe dimerization are found on the...
... and clinical isolate strains, as well as the characterization of the high-activity binding peptide (HABP) involved inthe binding to and invasion of monocytes (U937) and type II alveolar epithelial ... used in Plasmodium falciparum research) for the identification of the HABPs interacting with U937 and A549 cells (in this case), their binding dissociation constants, their critical binding residues ... Figure shows the Rv2560 synthetic peptide sequences andthe corresponding U937 or A549 cell binding activitiesThe black bars represent the binding activity Those peptides having a binding activity...
... structure andthe key heparin-binding residues inthe N-terminal domain held coordinately by the two subunits on the top of the hollow (Fig 1A) The model structure of the C-terminal domain illustrates ... and Trp394) exposed to the surface (Fig 1A) The cluster of basic residues inthe C-terminal domain may constitute heparin binding-site residues that coordinate with heparin-binding residues in ... the basic amino acids inthe C-terminal domain are in green, andthe cluster of hydrophobic residues Trp390, Trp393, and Trp394 is in red The catalytic site is enlarged in B and illustrates the...
... single 22 kDa protein that coeluted with sPPase activity in both cases The positions and molecular masses of protein standards are indicated on the left side of the gels (A) The upper right inset ... localized inthe active site (shown in bold) and involved in catalysis in Ec-sPPase [2,11] In all cases, the molecular mass determined by SDS ⁄ PAGE and ⁄ or MS is in good agreement with values ... Gingrich JC, Gasparich GE, Sauer K & Bryant DA (1989) Nucleotide sequence and expression of the two genes encoding D2 protein andthe single gene encoding the CP43 protein of photosystem II in...
... progesterone and androstenedione in bovine theca cells in vitro[38] The results from Experiment clearly indicate that treatment of follicles in vivo with inhibiters of the Akt and Erk pathways inthe ... coordinating and conducting all the tasks for the study in collaboration with co-authors CG and PK participated in cell culture, and immunoassays AE and PL participated inthein vivo parts of the ... Figure activin-A and follistatinin vitro with control medium, FSH cell number and theper replicate)oestradiol,combination inhibin-Atreating granulosa cells (N = replicates with wells included per...
... results Delay inthe surgery is known to result in poor results in brachial plexus surgeries In our study all the cases were operated within months of injury When dividing the patient in two groups, ... was scored M5 and grip and pinch strength inthe hand was normal in all the cases With a minimum follow up of 12 months, all of them were evaluated for range of movements at shoulder and elbow; ... 4, show clinical photograph of patient with good recovery of flexion at the elbow The details of the patients andthe final grading of their elbow and shoulder function are detailed in Table Table...
... 1% osmic acid and embedded in araldite Semithin resin transverse and longitudinal sections were stained using haematein and eosin, solochrome blue and paraphenylene diamine Ultrathin sections were ... testing with neuromuscular histology could therefore help inthe precise identification of the type and severity of neuromuscular weakness, and may lead to a better understanding of the causes and ... enrolled, clinical examination was performed daily during their stay inthe ICU, and we assessed motor deficit, muscle wasting, sensory loss and tendon reflexes In these patients undergoing cardiac...
... declines with increasing disability However, in patients who died inthe course of the disease, increased rates of consent were presumed by the families This reflects a previously unnoticed and ... HBH designed the study and wrote the manuscript ICK, JBK, LB, and CM obtained clinical data by reviewing institutional databases andthe patient’s medical charts ICK and MK obtained outcome data ... questionnaires and telephone interviews MK, PDS, and SS co-interpreted the data and critically reviewed the manuscript All authors approved the final version of the manuscript 19 20 21 22 Competing interests...
... cause increased metabolic activity inthe area of the brain responsible for that task With these images, the relationship between brain activation andthe tasks can be detected and thus the location ... children and adults, linked to internal mental brain activities (36, 37, 38, 39) Resting state fMRI has now becoming an important tool for understanding the brain functional development in infants and ... degrees to the B0 field) The T E is the time between the initial 90 degree RF pulse andthe echo The most common pulse sequences are the T -weighted and T -weighted spin-echo sequences Inthe case...
... mobile phase interact withthe immobilized ligand in preference over the bound proteins This "shields" the stationary phase from the protein, (and vice versa) and allows the protein to be eluted ... 1982) and irridovirus (Tidona and Darai, 1997) replicate inthe cell nucleus (Kasamatsu and Nakanishi, 1998) Inthe first step of infection, viruses import their genomic DNA into the nuclei of infected ... data indicated that VP9 binds with both Zn2+ and Cd2+ VP9 adopts a similar fold as the DNA binding domain of the E2 protein from human papillomavirus Based on our present investigations, we hypothesize...
... diarrhea and hemolytic-uremic syndrome after colonizing inthe large intestine, watery diarrhea after colonizing inthe small intestine and urinary tract infection after survival and colonizing inthe ... which is present at the N-terminus guides the protein to the sec machinery at the inner membrane Once the protein reaches the periplasm withthe help of the sec system, the N-terminal signal sequence ... right The four functional domains of the proteins are shown: the signal sequence, the passenger domain, the linker region, andthe β-domain The autotransporter polyproteins are synthesized and...
... 79 Urinary incontinence: Post stroke urinary incontinence is more commonly seen inthe aged stroke patients than the younger ones.87,88 Stroke patients with urinary incontinence have more institutionalization ... inthe general population 97 andinthe elderly Chinese population in Singapore with a sensitivity of 84% and a specificity of 85.7% 98 It was divided into no depression and depression withthe ... of stroke andwith cognitive impairment They had diagnosed depression inthe patients using Hamilton depression scale and clinical examination of the patients Jong-ling et al 55 in their cross...
... effect on the latency and amplitude of the evoked MMN, the elicited N2b was found to continuously increasein latency and decrease in amplitude with increasing age These findings suggest the constancy ... associated with concentration ability, and passive latency with verbal proficiency and recall [72] The decreases in P3 and novelty P3 with increasing age, and indeed a similar attenuation inthe MMN, ... applications of ERP analysis as a psychological diagnostic and feedback tool are growing more and more promising, and as we gain more insight into the nature of the ERP, the search for clinical integration...
... These included: semi tandem stand, full tandem stand, rising from chair without using arms and shoulder external rotation (full) A younger member of the household present at the time of the interview ... of the total group, others not being able to so, due to injury or an illness Best performance was in "standing from chair without using arms" (84%), semi tandem stand was completed by 78% and ... present in 1167 (97%) of the interviews Comparison of the physical health rating made by the informant with 'selfiassessment' indicate that the elders rate their level of health to be marginally...
... exerted by the PIN domain, as shown by experiments with mutated MCPIP (either lacking the PIN domain, or with two conservative amino acid mutations within PIN domain) Interaction of MCPIP withthe IL-1b ... removed from the entire coding sequence of the MCPIP gene The coding sequence lacking the PIN domain was obtained in two steps First, the fragment of 423 bp situated in front of the PIN domain was ... either with an empty vector or with vector overexpressing wild-type MCPIP or its mutant forms: mutMCPIP without the PIN domain or D ⁄ A-MCPIP with two mutated amino acids located within the PIN...