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... multi-item index including subjective reporting of abdominal pain, general well-being, and diarrhea and physical findings, including linear growth and laboratory parameters (hematocrit, serum albumin, ... important role in the initiation and perpetuation of the disease(13,14) It has been hypothesized that the intestinal inflammatory response is the result of an exaggerated intestinal host immune ... preliminary investigation to address the question of underlying mechanisms of action of this probiotic in Crohn’s disease In conclusion, and fully acknowledging the limitations of an open-label study in...

Ngày tải lên: 05/03/2014, 12:20

... weeks for maintenance of remission After 54 weeks, the initial clinical response was maintained in only 17% of patients in the single dose group compared to 43% of patients maintained on 5 mg/kg ... to normal after months of discontinuing infliximab.56 In a study of 6290 adult patients on maintenance infliximab therapy, there was no increased risk of malignancy in the infliximab group compared ... risk of super-infection (32%) and the risk of tuberculosis.11 Adalimumab The immunogenicity of infliximab has led to the development of other less immunogenic TNF inhibitory agents, including...

Ngày tải lên: 22/03/2014, 10:20

... OPS had a linear structure Thus, the nonsubstituted Rha was estimated to be located at the nonreducing terminus of the OPS chain Taking these observations into account, the structure of the OPS ... active moiety of LPS in the induction of cytokines, including tumor necrosis factor, and the phosphate residue at the 4¢-position is a critical site for the activity [24] Therefore, the monophosphoryl ... Analysis of LPS As shown in Fig 1, a ladder-like pattern was observed in the SDS/PAGE profiles of LPS from B vulgatus IMCJ 1204, indicating that the LPS contains OPS The repeating unit of the OPS...

Ngày tải lên: 31/03/2014, 23:20

... conditions In the normal small intestine (left), laminins LM-322 and LM-511 are found in the BM of the villus epithelial cells while laminin LM-211, is found in the BM of crypt epithelial cells Tenascin-C ... result of protein cross-linking between mucin monomers Cross-linking occurs following disulfide bonding between cysteine-rich D domains in the NH2- and COOH-termini of the proteins Membrane mucins ... the epithelium are located in the lower ⅔ of the small intestinal crypts and the lower ½ of the colonic glands The functional cells of these renewing units are located on the villus and the surface...

Ngày tải lên: 27/06/2014, 16:20

... measuring the change in the daily GI (DGI) for the drug-containing vials compared with the GI for the control vials, where they report a lower MIC of 0.5–4 μg/ml, probably due to differences in the ... streptomycin the MIC range was of 0,5-2 μg/ml in both animal and human strains, for ciprofloxacin it was at 0.5–16 μg/ml, independently of the source of isolation, while rifampin produced a MIC of 0.5–1 ... considering that clarithromycin and ciprofloxacin are widely used antibiotics, strains resistant to these drugs can be very common Up to now, there is a urgent need of new information on the activity...

Ngày tải lên: 08/08/2014, 19:20

... long-term healing of draining fistulas was maintained over two years from the baseline of the CHARM study, while in the fistula cohort there were no differences in the rate of adverse effects in patients ... conceived of the study and participated in its design and coordination EIE participated in the design of the study, the acquisition and interpretation of the data and the drafting of the manuscript ... in the sequence alignment and the drafting of the manuscript NL participated in the design of the study and the coordination and helped to revise the manuscript VDS participated in the coordination...

Ngày tải lên: 11/08/2014, 00:23

... fistula, with surrounding inflammation and fibrosis Given the inability to repair the defect in the terminal ileum from the fistulous opening, resection of a segment of the terminal ileum and cecum ... fatigue, and painful urination, in addition to the presenting complaints He denied having a fever, but did complain of night sweats A physical examination revealed a tall, thin man in no acute distress ... achieve the diagnosis Nuclear imaging with a ‘Meckel’s scan’ was not pursued because of the complicated nature of the case Due to the lack of ectopic gastric mucosa in the resected specimen, the...

Ngày tải lên: 11/08/2014, 03:21

... fistula, with surrounding inflammation and fibrosis Given the inability to repair the defect in the terminal ileum from the fistulous opening, resection of a segment of the terminal ileum and cecum ... fatigue, and painful urination, in addition to the presenting complaints He denied having a fever, but did complain of night sweats A physical examination revealed a tall, thin man in no acute distress ... achieve the diagnosis Nuclear imaging with a ‘Meckel’s scan’ was not pursued because of the complicated nature of the case Due to the lack of ectopic gastric mucosa in the resected specimen, the...

Ngày tải lên: 11/08/2014, 07:20

... when combining rifabutin and clarithromycin leading to an increase in rifabutin levels, resulting in an increase frequency of uveitis, this could explain the acute onset of uveitis in our case[10] ... hypopyon often occurs several months after starting rifabutin In this case the presence of hypopyon, and rapid initial improvement following withdrawal of rifabutin, suggest rifabutin as the underlying ... days, the hypopyon had reduced to mm and the vision had improved to 6/9 in the right eye; a reducing course of dexamethasone was instituted One week after discontinuing rifabutin and clarithromycin,...

Ngày tải lên: 11/08/2014, 10:22

... occurred in the terminal web of the epithelial cell and in the lateral junctions of the cells The localization of CSF1R in actin-rich areas of the cell is not surprising in view of data from in vitro ... epithelium of the terminal ileum with cytoplasmic staining of the terminal web and lateral junctions of the epithelial cells (green arrow) B Staining of the superficial epithelium of the colon C Staining ... deletions in the CSF1R gene [25-27] There is a paucity of literature regarding the expression of the CSF1R protein in the intestine despite documentation of its presence in the epithelium of a variety...

Ngày tải lên: 11/08/2014, 10:23

... symptoms but also in diminishment of the size of the lip swelling Another point of interest was the fact that granulomatous cheilitis was the only extraintestinal manifestation in our patient, ... course of the patient was the fact that during the exacerbations of CD, the enlargement of the lip was more evident, returning to almost normal during the periods of remission and that the administration ... manifesting as a significant swelling of the lower lip could be the first clinical sign of CD This lesion could well be correlated with the activity of the intestinal disease, being quite prominent in...

Ngày tải lên: 11/08/2014, 11:20

... those of the underlying disease, the recognition of cancer arising in an inflamed bowel becomes difficult Thompson et al [12] recognized the occult nature of intestinal cancer in Crohn's disease They ... suggested by the clinicopathological data obtained from over 150 case reports [6] The extent of this association has been assessed by incidence studies comparing the risk of colon cancer in patients ... that they have no competing interests Authors' contributions KM, KI and AA operated on our patient All authors participated in the followup examinations of our patient and in formulating the diagnostic...

Ngày tải lên: 11/08/2014, 12:20

... defects in innate immunity and both systems confront a host of commensal bacteria The risk of CD or UC is the result of the interaction between the genetic hand that is drawn and the bacteria residing ... assembly, the so-called inflammasome, interleukin 23 receptors, epithelial barriers, Paneth cells of the gut, the NFkB/IRF system, and other pathways interact with genetic imbalances of Th1/Th17 ... residing in the gut In this model, CD is seen as a disorder arising from both the environment (including micro-organisms, smoking and ‘stress’) and one’s individual reactive genotype, including variations...

Ngày tải lên: 11/08/2014, 12:20

... from these lesions Histology on the specimens revealed severe papillary edema The dermis contained an infiltrate of neutrophils and nuclear dust was also present These findings supported the clinical ... from the patient for publication of this case report and accompanying images A copy of the written consent is available for review by the Editor -in- Chief of this journal Competing interests The ... bacilli) and meningococcal polymerase chain reaction negative Since these results initially suggested bacterial meningitis, g of intravenous ceftriaxone twice daily was started In addition, the patient...

Ngày tải lên: 11/08/2014, 14:20

... and therapy Competing interests The authors declare that they have no competing interests Authors' contributions NM was involved in the management of the patient while in hospital, wrote the ... evidence of vasculitis Punch dermis ,of a skin lesion showing neutrophilic infiltration Punch biopsy of a skin lesion showing neutrophilic infiltration in the dermis, with no evidence of vasculitis ... dose of intravenous Infliximab The rash showed no improvement after three days of antibiotics A punch biopsy of one of the skin lesions revealed dense dermal infiltrate composed predominantly of...

Ngày tải lên: 11/08/2014, 21:22

... showed no lesion in the oesophagus, stomach, or small intestine including the terminal ileum and cecum Abdominal CT scan showed thickening of the abdominal aorta (4 mm) and narrowing of renal arteries ... be clinically silent [2] Due to the involvement of the aorta and its vasculature, TA may present with gastrointestinal bleeding [6] Since most of these features may also be present in CD, there ... Therefore, it may present with gastrointestinal bleeding and exacerbate the clinical course of patients with inflammatory bowel disease Clinical suspicion, proper imaging, and consideration of...

Ngày tải lên: 11/08/2014, 23:21

... manifestations of IBD are uncommon [2,3] Any part of the lung and its vasculature may be involved in association with IBD Large airways disease is the commonest site of lung involvement in IBD In a recent ... showed evidence of inflammation which is the most prevalent involvement in IBD [5] The location of stenosis in the medium size bronchi lead to the unique radiological picture of dilated, fluid ... stopping prednisolone resulted in a relapse of his symptoms necessitating a small maintenance dose along with inhaled budesonide He remains well on the above treatment Competing interests The...

Ngày tải lên: 13/08/2014, 10:20

... potential new therapies for ulcerative colitis are currently being developed in preclinical testing and clinical trials, including molecules targeting interleukin 12, interleukin 17, and endothelial integrins ... determined each symptom domain's rating for each of the three endpoints by independently measuring the distance in millimeters from the left end of the Visual Analogue Scale (0 mm) to the point ... determined by asking the patient if they knew the extent of their disease Disease extent was then verified in the medical record from either a recent clinic note or colonoscopy report by the patient's...

Ngày tải lên: 18/06/2014, 19:20

... Improvement of ileitis, healing of ulcers (after wk of the initial dose of infliximab) Improvement of ileitis, healing of ulcers (after wk of the initial dose of infliximab) However, a review of the ... Improvement of edema and healing of linear ulcers in sigmoid colon (8 weeks after the initial dose of infliximab) Improvement of edema and healing of linear ulcers in sigmoid colon (8 weeks after the initial ... hallmark findings of HPS presented to the University Hospital of Alexandropoulos in 2005 complaining of an 10-month history of recurrent episodes of abdominal pain worse with defecation and intermittent...

Ngày tải lên: 11/08/2014, 10:22