the network of splicing components and their regulation by mirnas

... assess the implication of the Ras/Raf pathway, SMC were cotransfected with the )973 bp cyclin D1 gene promoter and either the dominant-positive or the dominant-negative Ras and Raf mutants, and the ... activity is a key event of the G1-S transition, the inhibition of Cdk2 phosphorylation and activity by EPA and DHA may explain the inhibition of DNA synthesis, as cyclins E and H are not modified ... the inhibition of MAPK by the incorporation of n-3 PUFAs could alter the phosphorylation of these transcription factors, affecting their binding to DNA and trans-activation As the egr-1 gene...

Ngày tải lên: 19/02/2014, 16:20

... (87.5%) of the adenomas and in 12/13 (92.3%) of the adenocarcinomas (Fig 3, G and H) Although the staining intensity of cyclin D1 and cyclin E was variable among the cases studied, the degree of immunoreactivity ... present study, we analyzed the expression pattern of cyclin D1 and cyclin E at the protein and mRNA levels and compared their expressions with the expression of PCNA In the present study, we observed ... that once the tumor has been established at the adenoma stage, there is no need for further expression of these proteins for malignant transformation Therefore, the overexpression of these genes...

Ngày tải lên: 07/08/2014, 14:23

... signaling and can re-enter the cell cycle [16-20] The study by Crescenzi et al [13] suggests that ATM is required for the maintenance of the premature senescent phenotype and hence the survival of cancer ... on their chemo- and radiosensitizing properties It remains unclear if the decline in cyclin D1 levels results from ATR inhibition, the inhibition of both ATM and ATR, or from the inhibition of ... contributions JPA and PS conceived and designed the study JPA performed the experiments JPA and PS analyzed and interpreted the data JPA and PS drafted and wrote the manuscript Acknowledgements...

Ngày tải lên: 09/08/2014, 10:20

... kinase inbibitor, inbibiting the binding of the CDK4 protein to cylclin D1 and thus preventing phosphorylation of the Rb protein and arresting the cell cycle in the G1phase [18,19] Cyclin D1 ... WL drafted the manuscript; BW and LG designed the project and drafted the manuscript All authors read and approved the final manuscript Competing interests The authors declare that they have no ... MDM2 and MDM4, mediated the ubiquitinylation and degradation of TP53 Also, the CDKN2A locus was frequently deleted or inactivated in glioblastomas and was involved in both the TP53 pathway and...

Ngày tải lên: 10/08/2014, 10:21

... development of novel oncological therapeutic strategies [6,7] Uncontrolled cell proliferation is the hallmark of malignant tumors that is why the evaluation of the prognostic significance of the expression ... families of cyclins (termed A, B, C, D, and E) have been isolated and characterized Cyclin D1 reaches it peak of synthesis and activity during the G1 phase, and is believed to regulate the G1-to-S ... drives the homologous recombination process [10] Cyclin D1 gene is located in the chromosome 11q13 [11] The expression of cyclin D1 and other cyclins has been often evaluated in many cancers and...

Ngày tải lên: 10/08/2014, 10:21

... phase of their cycle (thus committing them to cell division) This function is facilitated through binding and activation of cyclin-dependent kinases (CDK) and 6, with phosphorylation of the retinoblastoma ... from the same treatments and FACS data from Fig in LL97a lung fibroblasts The % number of cells present in G1, S and G2 phase of the cell cycle are presented ± SEM and is representative of independent ... (HIPF, LL29, and LL97a) and normal control equivalents CCD8LU Quantification of mRNA was performed by determining the threshold cycle; and standard curves were constructed using the values obtained...

Ngày tải lên: 12/08/2014, 16:20

Ngày tải lên: 04/06/2013, 01:26

... Xác định công thức X? A C3H5NH2 B C2H5NH2 C C6H5NH2 D C3H7NH2 Câu 11: (0,25đ) Hãy xếp chất sau theo trật tự tăng dần tính bazơ : (1) amoniac; (2) anilin; (3) etylamin ; (4) đietylamin; (5) kalihiđroxit ... NaOH C CH3OH/HCl D HCl II PHẦN TỰ LUẬN : (1,0 điểm) Câu 14: (1 điểm) Viết phương trình phản ứng theo sơ đồ biến hoá sau ( ghi rõ điều kiện phản ứng có) : Glucozơ → ancol etylic → cacbonic → tinh ... 2lit dung dịch Ca(OH)2 nồng độ 0,01 mol/l , thu đợc 1gam kết tủa Hãy xác định thành phần phần trăm theo thể tích khí hỗn hợp ban đầu (Cho: Na = 23; Fe = 56; Cu = 64; C = 12; H = 1; Cl = 35,5; S =...

Ngày tải lên: 11/06/2013, 01:26

... Mg, Zn B Mg, Fe, Cu, Zn C Ag, Mg, Au, Ba D Cu, Mg, Ca, Zn Câu 11: (0,25đ) Các kim loại sau xếp theo chiều hoạt động hoá học tăng dần? A Ag, Cu, Fe, Al, Mg B Ag, Fe, Cu, Al, Mg C Ag, Cu, Fe, Mg.Al...

Ngày tải lên: 11/06/2013, 01:26

... – It is …… pen A a B an C the 17 This is …… desk And that is your desk A she B he C you 18 Is that ……………….pencil? – Yes, it is A you B your C she 19 What does your father do? – He is a ………………… ... doctor C engineers 20 What is this? – It is ………… eraser A a B the C an D He is ten D any D my D yours D engineer D some - The end./ Tiếng Anh - Đề 01 gồm có 02 trang ...

Ngày tải lên: 02/07/2013, 01:26

... chế tăng nồng độ ngợc dòng hoạt động thận b) Tại động vật sống cạn thải NH3 theo nớc tiểu, động vật sống nớc thải NH3 theo nớc tiểu? Câu (2 điểm) a) Một bệnh nhân bị hở van tim (van nhĩ thất đóng ... tâm trơng Sinh lý học thực vật (6 điểm) Câu 10 (1,5 điểm) Sự tạo thành ATP hô hấp thực vật diễn theo đờng nào? ATP đợc sử dụng vào trình sinh lý cây? Câu 11 (1,5 điểm) Rubisco gì? Trong điều kiện ... mềm sức chống chịu III Nó cần cho PS II, liên quan đến trình quang phân li nớc Các câu phát biểu (theo thứ tự I, II, III) tơng ứng với tổ hợp nguyên tố sau đây? A N, Ca, Mg B S, Mn, Mg C Mn, Cl,...

Ngày tải lên: 23/07/2013, 01:28

Ngày tải lên: 28/07/2013, 01:26

... (4 − x ) −1/2 d (4 − x ) = − − x = − 20 − x2 I = I1 − I = e − + 4 x+ y π x+ y ≤ ⇒ cos xy ≥ cos Theo BĐT Cô si Ta có ≤ xy ≤ x+ y x− y x+ y cos x + cos y = 2cos cos ≤ 2cos ≤ 2cos xy (1) 2 Với t...

Ngày tải lên: 21/08/2013, 20:10

... with two women They are very beautiful and tactful A The two women’s beauty and tact explain why he wants to work at their office B The offices where he and the two very beautiful and tactful women ... women They are very beautiful and tactful A The offices where he and the two very beautiful and tactful women work are the same B The two women’s beauty and tact explain why he wants to work at their ... beautiful and tactful C The offices where he and the two very beautiful and tactful women work are the same D The two women’s beauty and tact explain why he wants to work at their office Question...

Ngày tải lên: 29/08/2013, 14:20

... tượng xảy A Mạch luôn tổng hợp theo chiều từ 5’ đến 3’ B Mạch luôn tổng hợp theo chiều tháo xoắn ADN C Mạch luôn tổng hợp theo chiều từ 3’ đến 5’ D Mạch luôn tổng hợp theo hướng ngược chiều tháo ... thực C Theo bảng mã di truyền ba nuclêotit mạch gốc gen quy định cho axit amin D Có ba ba không mã hóa cho axit amin UAA, UAG, UGA Câu 21: Trong kỹ thuật tạo dòng ADN tái tổ hợp thao tác thực theo ... nhiên: A Tùy thuộc khả khai thác nguồn sống khu vực phân bố B Theo cấu trúc tuổi quần thể C Do hoạt động người trình tự nhiên D Theo mối quan hệ cá thể quần thể Câu 37: Nguyên tắc bổ sung thể...

Ngày tải lên: 30/08/2013, 23:10

... answer to each of the following questions Question 26: , the less polluted the environment will be A The more polluted landfills will be B The more landfills are there C The less landfills are ... polluted D The fewer landfills we have Question 27: Switch off all the lights A by the time you enter the room B until you enter the room C after you will leave the room D before you leave the room ... welcomed by the public Question 42: Which of the following is NOT true, according to the passage? A The only source of stress in our modern life is the media B Many TV channels supply the public...

Ngày tải lên: 31/08/2013, 07:53

... Such gases not only add to the pollution of the atmosphere, but also create a greenhouse effect, by which the heat of the sun is trapped This leads to the warming up of the planet Politicians are ... by the public Question 77: Which of the following is NOT true, according to the passage? A The only source of stress in our modern life is the media B Many people are under stress caused by the ... ones? A They occurred naturally over a long period of time B They were fully monitored by humans C They were partly intended D They were wholly the result of human activity Question 12: The word...

Ngày tải lên: 31/08/2013, 07:53

... indicate the correct answer to each of the following questions Question 56: , the less polluted the environment will be A The more polluted landfills will be B The fewer landfills we have C The ... of whom are nurses B one of them are nurses C most of whom are nurses D most of them are nurses Question 59: Switch off all the lights A before you leave the room B after you will leave the ... ones? A They occurred naturally over a long period of time B They were fully monitored by humans C They were partly intended D They were wholly the result of human activity Question 45: The word...

Ngày tải lên: 31/08/2013, 07:53

... Question 69: , the less polluted the environment will be A The less landfills are polluted B The fewer landfills we have C The more landfills are there D The more polluted landfills will be ... an extreme degree The further back we go in human history, the longer news took to travel from place to place, and the less news we had of distant people and lands altogether The printing press ... Question 54: Which of the following is NOT true, according to the passage? A Many people are under stress caused by the media B The only source of stress in our modern life is the media C The news that...

Ngày tải lên: 31/08/2013, 07:53