the multidimensional role of mitochondria in heart failure

... have heart failure worldwide Heart failure is primarily a disease of the elderly, and the prevalence of chronic heart failure increases with advancing age Currently, chronic heart failure is the ... by a chronic shortage of donor hearts Currently, the mainstay of heart failure treatment is pharmacologic and includes angiotensin converting enzyme inhibitors, angiotensin receptor blockers, ... diagnosis in patients over the age of 65 years Thus, as the population ages, the management of heart failure will become more frequent and of even greater importance The management of patients...

Ngày tải lên: 11/08/2014, 15:20

... better understanding of the anatomy and pathophysiology of heart failure The failing heart beats at more than 120,000 beats per day, pumping more than 6,000 L of blood against an increased systemic ... minority of patients who have heart failure, other surgical options may soon provide symptomatic relief for the majority The demand for treatment emerges from an increasingly elderly heart failure ... of percutaneous balloon angioplasty and stents In turn coronary intervention rates will fall because of public health initiatives on diet and smoking together with the widespread use of statins...

Ngày tải lên: 11/08/2014, 15:20

... returns to the intensive care unit with borderline cardiac index and a blood pressure of 110/70 mm Hg Over the next hours the blood pressure remains acceptable on inotropic support but the urine output ... unstable angina to a glycoprotein IIb/IIIa inhibitor or placebo, the 7-day mortality or myocardial infarction rate was 22.3% in almost 700 patients in the control arm [2] A collective review of 279 ... transvalvular gradient [4] Intraoperative myocardial injury remains prevalent in the increasingly elderly surgical population because tolerance to ischemia is reduced in aged myocardium [5] Patients...

Ngày tải lên: 11/08/2014, 15:20

Ngày tải lên: 11/08/2014, 15:20

... result of emerging knowledge, new procedures, and technical advances This article addresses the pathophysiology, the treatment options, and their rationale in the setting of life-threatening AMI ... Active systolic shortening progresses to passive lengthening Within 20 minutes of IRA occlusion, cardiac myocytes have depressed function and show the stigmata of myocardial stunning As occlusion persists, ... swelling), depending on available energy levels Apoptosis, the main 1551-7136/07/$ - see front matter Ó 2007 Elsevier Inc All rights reserved doi:10.1016/j.hfc.2007.04.006 heartfailure.theclinics.com...

Ngày tải lên: 11/08/2014, 15:20

Ngày tải lên: 11/08/2014, 15:20

... Heart Failure Clin (2007) 211–228 Revascularization in Heart Failure: Coronary Bypass or Percutaneous Coronary Intervention? Sorin V Pusca, MD, John D Puskas, MD* Emory University School of ... University School of Medicine, Atlanta, GA, USA Coronary artery disease (CAD) is currently the single most common cause of heart failure in adults [1] The prognosis of patients who have severe ... coronary interventions (PCI) in this setting Alternative modalities for the surgical treatment of ischemic heart failure, such as heart transplantation, surgical ventricular restoration, the Dor...

Ngày tải lên: 11/08/2014, 15:20

... architecture of the heart permits a shortening of 15% of the fibers to give an ejection fraction of 60% and the different distribution of the fibers within the wall from the epicardium to the endocardium ... connect the myocytes in a complex array of fibers forming the 3-D architecture of the wall and coordinating the delivery of forces generated by myocytes These forces are important determinants of diastolic ... for the twisting effect of the apex that optimizes the ejection of blood into the aortic vessel The elliptic shape enhances blood flow at the in ow and outflow tract When disease alters the shape of...

Ngày tải lên: 11/08/2014, 15:20

... clear from the outset that there is a role for both in the management of advanced heart failure Cardiac dyssynchrony * Corresponding author University of Hull, Castle Hill Hospital, Kingston-upon-Hull, ... been a prominent aspect of HCM and, in the early years of the disease’s recognition, its presence was inextricably linked to the diagnosis of this condition [5,6] Patients who have the obstructive ... Withdrawal of nonsteroidal anti -in ammatory drugs, including aspirin, also seems to reduce the need for hospitalization for worsening heart failure [6,7] However, when standard pharmacologic therapy...

Ngày tải lên: 11/08/2014, 17:20

... allows the heart a period of relative rest in which functional improvement may be achieved by interrupting the vicious circle of increasing wall tension and functional impairment The hearts of a ... disturbances are the consequence Finally, because of the inability of the heart to pump a sufficient volume of blood to the end organs, a globally impaired supply with oxygen is the result Medically, these ... imminent death [17] The development of cardiac assist devices has made much progress within the last 10 years In the 1980s, mainly paracorporeal devices were available; however, in the 1990s, the...

Ngày tải lên: 11/08/2014, 17:20

... ‘‘destination treatment’’ or ‘‘lifetime therapy’’ are used to describe the intention at the moment of insertion of the device: that it should remain in place for the life of the patient and that there ... changes on the understanding and refinement of the therapeutic orchestra available for patients in the advanced phase of heart failure have occurred, specifically with the introduction of highly ... availability on the market of many devices to assist the pumping function of the heart has resulted in a new vocabulary This has led to a surplus of confusion, even misunderstanding, extending from the characteristics...

Ngày tải lên: 11/08/2014, 17:20

Ngày tải lên: 11/08/2014, 17:20

... are in the terminal phase of heart failure (Stage D, New York Heart Association [NYHA] IV) and refractory to maximum medical therapy [2] With around 10% of the population older than 65 years of ... With the exception of the United States, Germany, and France, bridge to transplantation is an expensive and infrequent intervention In the study by Sharples and colleagues [11] evaluating the ... older than 65 years of age suffering systolic left ventricular dysfunction, the number of patients who have heart failure will double within the next 25 years In this global context cardiac transplantation...

Ngày tải lên: 11/08/2014, 17:20

... surgery, in advanced heart failure, 328 Coronary interventions, percutaneous, in advanced heart failure, 327–328 D Defibrillator, cardiac, automatic implantable, in advanced heart failure, 326–327 in atable, ... regurgitation, 293 in advanced heart failure, 329–330 B Biomedical devices, for heart failure, 295–296 Cardiac defibrillator, automatic implantable, in advanced heart failure, 326–327 in atable, 269 ... Heart Failure Clin (2007) 377–380 Index Note: Page numbers of article titles are in boldface type A C Aldosterone antagonists, in advanced heart failure, 323 Cardiac assist...

Ngày tải lên: 11/08/2014, 17:20

... in the process of DNA laddering (as is the case with EndoG) rather than in the production of large-sized DNA fragments, considering the timing of uptake of the mitochondria in the autophagosome, ... detecting the loss of membrane potential in mitochondria [19] The DePsipher dye accumulates in the multimeric form in the intermembrane spaces of mitochondria, and fluoresces bright red when the mitochondria ... which appear to be involved in the final resorption of the parental macronucleus during PND in T thermophila, and suggested the involvement of mitochondria in this process [19] In mammalian apoptosis,...

Ngày tải lên: 20/02/2014, 03:20

... results in trimming something off something else; in the case of example (9) above trimming the bush results in trimming the dry branches off the bush And this is what the semantic type in (16) ... Impingement Predicates In order to capture the semantic properties of the arguments of the most representative verb of the impingement predicates class in German, the verb schlagen (hit) in examples ... argument of the embedded stateof-affairs Finally, as far as direct arguments are concerned, in Koenig and Davis (2000) these are predicted to link off the value of the KEY attribute 3.1 The verbs...

Ngày tải lên: 17/03/2014, 22:20

... happens: from the rise of the internet and the spread of McDonalds to the establishment of the International Criminal Court and the emergence of global terrorism Focusing on the implications of globalization ... as the municipality of Amsterdam, understand the importance of preventing this, and stress the necessity of a local international policy being in line with the international policies of other involved ... gain as well from maintaining a certain image and attracting foreign capital An interesting aspect of this diplomatic game is the theory and practice of city branding – the notion of applying...

Ngày tải lên: 24/03/2014, 21:20

... mutants of the MetAP-I from E coli S Mitra et al affect the DG value for the binding of the rst metal ion; however, the entropic factor (TDS) for the binding of the rst metal ion decreases in the ... Co(II)-binding site, and indeed bidentate binding of Glu97 may prevent binding of the solvent ligand that appears to be present in other mono-cobalt(II) species of EcMetAP-I Combination of these ... metal-binding site, but also probably assists in binding and positioning the substrate through interactions with the N-terminal amine The 6256 data reported herein highlight the complexity of the...

Ngày tải lên: 30/03/2014, 02:20

... of nerves and networks in the brain, involving several areas near the edge of the cortex concerned with instinct and mood This area of the brain is intricately involved in motivation and basic ... to combine the findings of the neurological perspective regarding the complex process of aesthetic experience with the interactive model of representation In this combination, we focus on the process ... about through the interrelationship of the outcomes of basic emotional systems (in the appraisal process), that elicit aesthetic emotions, and the process of learning in the course of interaction...

Ngày tải lên: 30/03/2014, 16:20

... being inherited together, whereas the farther away they are from each other, the more chance of their INTRODUCTION being separated by the process of crossing over The Morgan is now the unit of ... Einstein’s theories of relativity This already indicates the sensitivity of society to new concepts in biology involving humans and our position in the living world The original criticisms of ... consistent theories of how we age First formulated in the 1950s, the somatic mutation theory explains aging as a gradual accumulation of random alterations in the DNA of the genome in the cells of our...

Ngày tải lên: 11/06/2014, 10:21