the mountain of the woman who is waiting for her husband

... comparison shows that there is a cluster of amino-acid differences in the C-terminal part of the enzyme (Fig 2A) where 13 of 44 amino acids are different Therefore, chimeric enzymes with the N-terminal ... but as Arg252 is so close to His264, where the structure is conserved, the model is still expected to be useful In this model, Arg252 is predicted to be on the surface of the enzyme where it could ... catalytic domain of TPP II We can now report that the region surrounding Arg252 is of importance for the formation of the oligomeric enzyme complex, which is a prerequisite for obtaining a fully...

Ngày tải lên: 21/02/2014, 15:20

... critical for interaction among the CP subunits monomeric form of the protein [10] This protein failed to assemble, form disks or interact with RNA in vitro [10] On the basis of this result, we hypothesized ... advantage of this mutant by fusing foreign peptides to the surface of the virus Alignment of the N-terminus of the PVX CP with the PapMV CP revealed that the PVX CP harbors an extension of 20 amino ... CP F13 Therefore, on the basis of our results, it is likely that a deletion of 32 amino acids will be tolerated by PVX without disturbing the assembly process Alignment of this F residue is also...

Ngày tải lên: 07/03/2014, 05:20

Ngày tải lên: 21/03/2014, 12:04

... specicity of the substrate) [26] Consequently, substitution of Val371 to isoleucine might prevent the full development of the active conformation This hypothesis is further conrmed by the results of ... proportional to the value of kcat Km of the activation, according to: k ẳ T kcat =Km 2ị where V120 is the velocity of S-2366 hydrolysis at 120 and FXIT is the total concentration of either wild-type ... interference with the binding of the activator to the FXI zymogen There are some examples of inherited coagulation disorders in which one of the peptide linkages required for the proteolytic zymogen...

Ngày tải lên: 23/03/2014, 07:20

... progressive deletion of the C-terminus of SUR1 affects the efficacy of drug response To further characterize this, dose–response curves were constructed for two of these and it was found that the Ki was ... and fire-polished using a MF-830 microforge (both Narishige) Pipettes had resistances of 1.5–3 MW for whole-cell recording and 6–9 MW for single-channel recordings The capacitance of pipettes ... analysis of each individual experiment The latter however, allows statistical analysis of the relevant data The response to bath applied diazoxide was determined in the whole-cell configuration The...

Ngày tải lên: 31/03/2014, 08:20

... brain is widespread and by no means confined to the area of the wound itself His memory for information, for example, is severely damaged Gone are the names of his mother and sisters and his address ... psychologist Donald Hebb) in action Simply put, the rule is this: neurons that fire together wire together The more often they fire together, the stronger their connection Mark Rosenzweig, whose ... Scanlan who rode the journey of this book, from the interviews of all the people who shared their stories, listening to and absorbing all of what they had to say for finding the poignant beauty in the...

Ngày tải lên: 11/07/2014, 22:33

... Vpu The inability of the triple cysteine mutant to inhibit virus release was therefore not due to gross mislocalization or misfolding of the protein Our results suggest that the formation of cysteine-linked ... high-mannose form of BST-2 Therefore, exogenously expressed BST-2 consists of two populations: a 30-40 kDa form containing complex sugar modifications (referred to as "postER form" for the remainder of the ... The fact that none of these mutations affected BST-2 function supports the notion that the loss of activity seen for the triple cysteine mutant is due to the lack of protein dimerization rather...

Ngày tải lên: 12/08/2014, 23:22

... affects the basic supports of life – air, water, food and fire The rate of change is now measured in decades versus the millennia of previous epochs Finally, there is wide distributional inequity of ... of Hawaii Human activities are responsible for this dramatic rise This increase in greenhouse gases is causing an increase in the surface temperature and affects weather and climate Weather is ... climate Weather is the continuously changing condition of the atmosphere; climate is any long-term change in the patterns of average weather of a specific region or the Earth as a whole Climate change...

Ngày tải lên: 05/03/2014, 10:20

... This study This study This study This study This study This study This study This study This study This study This study This study This study This study This study This study This study This ... shows that for Vps4p, regions outside of the AAA domain are also required for assembly Although this finding was unexpected, there is a precedent for the role of regions outside of the AAA domain ... interaction with these proteins may be responsible for loss of Vps4p function caused by the C-terminal mutations We therefore tested whether the conserved motifs in the C-terminal region of Vps4p are...

Ngày tải lên: 16/03/2014, 13:20

... Cultural history -Eating moldy grains? Cultural practices - Eating shellfish? - Do mother or father smoke tobacco? -Is the home water damaged or moldy? Parental work -What is the occupation of mother ... years of research, the exact mechanisms of their action remain unclear The present review starts with the history of glucans Next, attention is focused on sources and structure, comparing the effects ... consequential damages, arising out of the use of this publication The contents of this training module are based upon references available in the published literature as of its last update Users...

Ngày tải lên: 30/03/2014, 03:20

... really there is a necklace of three villages along the bottom of the valley – Shahpur, the biggest; Barkana, where my father grew up; and Karshat, which is where my mother lived At either end is ... mother’s father had died before I was born and we became close My parents say I have qualities of both grandfathers – humorous and wise like my mother’s father and vocal like my father’s father! ... in the hills, reciting it to the skies and birds as there was no privacy in their home There was not much to in the area where they lived so when the day arrived there was a huge gathering Other...

Ngày tải lên: 20/07/2014, 20:29

... mechanisms of cellular IRES-mediated ribosome recruitment remain unclear To further understand the mechanism of IRES activation, we wished to assess whether the mechanisms involved in regulation of ... instance, in the case of the PDGF2 5¢UTR, which contains three uORFs, the IRES has been mapped to the central part of the 5¢UTR at the vicinity of the first uORF [13] The need to scan through the second ... continuously as the gradient was collected The vertical bars on the abscissa indicate the boundaries of the polysomal (P) and subpolysomal (SP) fractions Peaks at the top of the gradient containing the 40...

Ngày tải lên: 22/02/2014, 07:20

... 20-fold [4,22] It is likely that either the modification of Rep, or the interaction of Rep with other viral or cellular proteins, may be involved in regulating the role of Rep as either a participant ... on the other hand, possess overlapping V1 and V2 ORFs, suggesting that an alternative mechanism of translational initiation may exist among these geminiviruses Furthermore, the V1 AUG codon of ... binds to the hairpin structure located within the LIR, nicks the virion sense-strand and initiates DNA synthesis from the 5¢-terminus As DNA synthesis progresses, the virion sense-strand is displaced...

Ngày tải lên: 16/03/2014, 13:20

... diagnosis, the extent of the disease and the presence of invasion mitigated against this diagnosis The immunohistochemical (ICH) findings are shown in Table Two years later, the patient presented herself ... patient is well Discussion Although the tumor was WDPM entering into differential diagnosis, the extent of the disease and the presence of invasion mitigated against this diagnosis Hence, the patient ... receptors may offer a new mode of therapy for this type of cancer Our studies have also shown that the expression of ERb in peritoneal mesothelioma offers a better prognosis (unpublished data)...

Ngày tải lên: 11/08/2014, 03:20

... diagnosis, the extent of the disease and the presence of invasion mitigated against this diagnosis The immunohistochemical (ICH) findings are shown in Table Two years later, the patient presented herself ... patient is well Discussion Although the tumor was WDPM entering into differential diagnosis, the extent of the disease and the presence of invasion mitigated against this diagnosis Hence, the patient ... receptors may offer a new mode of therapy for this type of cancer Our studies have also shown that the expression of ERb in peritoneal mesothelioma offers a better prognosis (unpublished data)...

Ngày tải lên: 11/08/2014, 03:20

... and the part of intestine The region IV, the hind gut, gives rise to the large intestine and colon 1.2.2 The liver morphogenesis Before the gut tube closes off by E9, the invagination of the foregut ... 1999) The visceral endoderm is an extraembryonic tissue to nourish the early embryo and does not give rise to embryonic tissue but to the yolk sac To distinguish with the visceral endoderm, the ... factors is a probable way to obtain the direct evidence of the indispensability of Gata factors in the hepatic competency establishment in the endoderm To investigate the mechanisms of the gain of...

Ngày tải lên: 11/09/2015, 16:06

... as it produces the aurora borealis It is in the fog of the one as in the light of the other; and in the flake of snow as in the streak of flame effluvium is visible Storms are the nervous attacks ... the West? Why is the contrary true of the Atlantic? Why, under the Equator, are they highest in the middle of the sea? Wherefore these deviations in the swell of the ocean? This is what magnetic ... in the grandeur of immensity; and the wave of effluvium sometimes aids, sometimes counteracts, the wave of the air and the wave of the waters He who is ignorant of electric law is ignorant of...

Ngày tải lên: 07/07/2014, 03:20

... What are the implications of these issues for education provision in the province of Balochistan? 1.9 Structure of the Thesis This research study is divided into chapters Chapter of the thesis has ... is also the mother tongue of the majority of the people based in the city of Karachi, in the province of Sind Finally, Balochi, which is a major language and the mother tongue of 4%, is spoken ... To the innocence of my mother and the deprivation of my people: Neither of them could attend school due to education being used as a battle- field by the opportunists of neoliberalism, Islamism...

Ngày tải lên: 22/12/2014, 16:41

... Xat District, in the northern mountainous province of Lao Cai, learn Vietnamese For the school year 2007-08, 40 rural provinces recorded low rates of learning the Vietnamese language after the ... other meetings to disseminate information to their staff, said Quach Tuan Ngoc, head of the Department of Information 11 and Technology under the Ministry of Education and Training The development ... effort to reduce the number of student dropouts The second will be to create a system of specialised kindergartens and a system of boarding schools for ethnic students The third is to organise...

Ngày tải lên: 19/07/2013, 16:34

... permeates the whole of the civil law of this country (I except the criminal law which is now irrelevant) and is, indeed the basis of the decisions in those countries where law is founded on the common ... is higher (Hemminki et al., 1985; Jolly et al., 1999) .The risk of CS in a subsequent pregnancy is increased, as is the risk of placenta praevia (where the afterbirth is in the lower part of the ... to protect the fetus, as in the cases of Re S (1992) and Ms S of 1996, despite the fact that the fetus is not a person in English law Is there a move to change the law, despite the forceful arguments...

Ngày tải lên: 01/11/2013, 08:20