the molecular ca2 sensor for exocytosis
Báo cáo khoa học: Connection of transport and sensing by UhpC, the sensor for external glucose-6-phosphate in Escherichia coli ppt
... substrate changes the conformation of UhpC and that this change is required for UhpC to initiate the transcription of the uhpT gene Alternatively, the binding of Glc6P could change the conformation of ... to the E coli UhpC protein (for details see text) The multiple alignment was performed using CLUSTALW (default settings) The asterisks indicate the positions of the mutated amino acids of the ... respect to the sensor values in the wild-type, the K(induction) of R152C decreased fivefold, that of R149C increased almost 700-fold, and R318C became constitutive Unfortunately, the affinity for Glc6P...
- 8
- 411
- 0
Báo cáo khoa học: Molecular basis of the unusual catalytic preference for GDP/GTP in Entamoeba histolytica 3-phosphoglycerate kinase doc
... parameters in the forward reaction The Vm, Km and catalytic efficiency (Vm ⁄ Km) values for nucleotides were determined in the forward and reverse reactions for the wild-type and the five EhPGK ... affinity for ATP compared with the wild-type, the other four mutants displayed a tendency to increase their affinity for ATP, producing a 1.8–10.8 times increment in their catalytic efficiencies Therefore, ... bring the two substrates together for the phosphoryl transfer reaction [20,29,32] In contrast to the single-mutant enzymes, the double mutant Y239F ⁄ E309M showed both an increased affinity for the...
- 11
- 449
- 0
ag doped wo3-based powder sensor for the detection of no gas in air
... and was then diffracted onto the detector The detector collected data for all angles in the range 4±648, 2y, simultaneously Fig gives the diffraction spectra of the WO3 before and after the NO ... after the interaction with gases [11] However, there is limited work reported in the literature on addressing the precise sensing mechanism for the NOx gases detection over WO3-based sensors and there ... WO3 On the other hand, the poor sensitivity at low temperature is related to the high activation barrier for NO to form adsorbate on the oxide surface As typical of compressed powder, there are...
- 8
- 502
- 0
Báo cáo khoa học: The molecular identity of the mitochondrial Ca2+ sequestration system potx
... earlier, the molecular identity of the protein(s) that actually form the PTP channel remains the most intriguing question On the basis of structural and other information, we hypothesize that the ... essential for Ca2+ transport in both the glycoprotein and the peptide On the basis of these studies, the authors proposed a model in which the peptide is an active Ca2+ -transporting portion of the ... a Ca2+ ⁄ 2H+ exchanger that is also located in the IM The process of Ca2+ uptake is driven by the membrane potential; the process of Ca2+ release is driven by the pH gradient, in the case of the...
- 12
- 533
- 0
Báo cáo khoa học: H NMR study of the molecular structure and magnetic properties of the active site for the cyanomet complex of O2-avid hemoglobin from the trematode Paramphistomum epiclitum pdf
... is the angle between the projection of the tilt of the z axis on the xÂ, y plane (dened direction of tilt of z and the x axis), and j % a + c denes the location of the rhombic (x, y) axes The ... to the iron and positioned to provide the H-bond to the bound cyanide, and by implication, to the bound O2 in the reduced form in each of the three globins The extensive sequence homology for ... [32] that will conrm whether the active site structure is closer to one or the other crystal forms, or distinct from both The hyperne shifts of the heme are sensitive to the presence of an H-bond...
- 14
- 504
- 0
A gene expression database for the molecular pharmacology of cancer pptx
... heterogeneous The breast cell lines positive for the oestrogen receptor, T-47D and MCF7, appeared together and grouped with the colon lines, whereas the breast cell lines negative for the oestrogen ... action on Top2, they may therefore act on DNA in other ways Because most of the DNA-binding Top2 inhibitors clustered together and were in the same cluster as etoposide and teniposide, the Top2 activity ... as they have been removed from their in vivo environment and selected for growth characteristics in culture They should therefore be considered as surrogates that may contain information on the...
- 9
- 484
- 0
Báo cáo y học: "The clinical utility of molecular diagnostic testing for primary immune deficiency disorders: a case based review" doc
... analysis of the proband's sister (V:2) and two maternal aunts (IV:4, IV:5) showed they had not inherited the mutation Therefore, their children are not at risk of inheriting the disorder In other disorders, ... from our own experience, there are many others in the published literature We strongly encourage clinicians to refer their patients for genetic counseling before testing for these disorders It is ... other female carriers including the mother (IV:1) were at risk of symptomatic XLP in this kindred Analysis of the methylation patterns of the human androgen receptor locus (HUMARA) of the mother...
- 9
- 480
- 0
Báo cáo y học: "A novel informatics concept for high-throughput shotgun lipidomics based on the molecular fragmentation query language" ppt
... representative mass for this bin and the procedure is repeated for the next mass bin We assume that the variation of peak masses is normally distributed within the bin and therefore the procedure should ... I(mi) is the intensity of the peak having mass m i , I max is the intensity of the most abundant peak within the bin B and mavg is the intensity weighted average mass The average mass is then stored ... interpreted the datasets with LipidXplorer Within the series of successive MS experiments, mass accuracy of the Orbitrap analyzer was dependent only on the target resolution R; therefore, for matching the...
- 25
- 514
- 0
Báo cáo khoa học: "A The Molecular Adsorbent Recirculating System (MARS®) in the intensive care unit: a rescue therapy for patients with hepatic failure" pdf
... stages the degree of encephalopathy after five days of therapy [12] The study showed a significant improvement in the degree of encephalopathy in 64% of the patients treated with MARS® and 38% of the ... patients and the dialysate solution is supplemented with approved human albumin that has no ability to cross the hemofilter membrane and to enter the patients blood, the risks of the treatment ... standard medical therapy (SMT) in two groups, SMT versus SMT plus MARS® The determining factors for acute decompensation were infection, drug intoxication, hemorrhage and alcohol abuse The results...
- 3
- 188
- 0
Báo cáo y học: "The Proteomic Code: a molecular recognition code for proteins" docx
... sequences immediately before and after the exon There are, of course, no known codons in the intronic sequences, therefore we continued the same phase that we applied for the exon, assuming that ... nucleotide sequence For example, the usual step-by-step (base by base) protocol can be followed except at the positions for the synthesis of the 2nd codon residue At those points in the synthesis process, ... target sequences the progression of the residues Synthesis pattern for construction of depending on the and Synthesis pattern for construction of target sequences and the progression of the permutations...
- 44
- 418
- 0
Báo cáo y học: "Insight into the molecular requirements for pathogenicity of Fusarium oxysporum" pdf
... sizes The negative results for the pPZP probe for the transformants depicted in (b-f) are omitted for clarity ing to MIPS [40] (Additional data files 1-3) Examples of identified genes and their ... in the parental strain (data not shown) Finally, for four of the pathogenicity mutants more T-DNA borders were identified in the TAIL-PCR than was expected based on the Southern analysis These ... borders were integrated in close proximity of each other (
- 18
- 375
- 0
NVESTIGATING THE MOLECULAR MECHANISM OF PHOSPHOLAMBAN REGULATION OF THE Ca2+-PUMP OF CARDIAC SARCOPLASMIC RETICULUM
... the Ca2+ pump, SERCA2a, making Ca2+ available for the next contraction (1) Therefore, the rate of Ca2+ transport by SERCA2a determines both the rate of myofilament relaxation, and the size of the ... contraction Ca2+ is subsequently removed from the cytosol by the sarcolemmal Ca2+ -ATPase, the Na+ /Ca2+ exchanger, and by SERCA2a, the Ca2+ ATPase in the SR membrane Most of the cytosolic Ca2+ is re-sequestered ... N30C-PLB Therefore, to gain further insights on the specific conformation of the Ca2+ pump that binds PLB, and to estimate the relative binding affinities of the PLB mutants for SERCA2a, the effects...
- 86
- 153
- 0
Developing miniemulsion polymerization for use in the molecular imprinting of protein with nanoparticles
... serves to strengthen and fix the positions of the functional moieties for the creation of the complementary binding sites Upon the completion of the polymerization reaction, the imprinted polymer ... extremely advantageous for the subsequent application of the particles Nonetheless, due to the presence of surfactant and other additives, the polymer may be contaminated Other than the normal o/w emulsion ... will enter the micelles and initiate the polymerization reaction The micelles provide the locus for the start of the reaction 21 _Chapter Figure 2.4 Molecular imprinting...
- 197
- 332
- 0
Báo cáo y học: " Derivation and preliminary validation of an administrative claims-based algorithm for the effectiveness of medications for rheumatoid arthritis"
... used only to capture the DAS28, the CDAI and other clinical characteristics measured at the baseline and outcome VARA visits; all other data used for the analysis were from the administrative claims ... months) after the index date If there was no VARA visit at year, then these treatment episodes were excluded as there was no clinical gold standard with which to compare the algorithm’s performance ... that account for the within-person variance by widening the confidence intervals of the PPV, NPV, Se and Sp, but leave the point estimates unchanged For all treatment episodes where there was discordance...
- 29
- 581
- 0
Báo cáo y học: "Godoy & Godoy technique in the treatment of lymphedema for under-privileged populations."
... compression on the vessels; the authors suggest the use of the term ‘myolymphokinetic therapy’ when these activities or exercises result in a volumetric reduction of the limb These exercises ... types of movement The same activity can increase or decrease the volume of the limb depending on several factors such as, for example, the weight and the fitness of the patient and the duration of ... these patients to return to a productive life Guidance, adaptations and supervision when performing these activities are necessary for this form of treatment until the patients are aware of the...
- 4
- 646
- 0
10 minute toughness the mental training program for winning before the game begins
... one day before the end of the season, and the upstart Milwaukee Brewers were ahead, 2-0 The Cards were fighting for the National League Central Division crown Over the past two weeks, they had ... ball off a pitch that up in the strike zone The left fielder caught the ball at the warning track for the first out Again, the camera closed in on the pitcher; this time, there was a look of relief ... lasts fifteen seconds The formula is 62-7: breathe in for six seconds, hold for two, and breathe out for seven seconds Individuals under the age of twelve should try to have the centering breath...
- 86
- 500
- 0
CHECK YOUR VOCABULARY FOR ENGLISH FOR THE EXAMINATION a WORKBOOK FOR STUDENTS
... to change the form of some of the words The queues for the embassy were so long they the street all the way down "What you think you're doing?" he angrily The government decided that the best ... /shortly before the conflict began, the army pulled down the border posts • The minister spoke about the need for political reform channel /canal The television received a formal complaint about the ... (1-901659-06-2) Despite the poor harvest, there was for the whole population called the Thames separates the city of London from the suburbs to the south 10 gathered to see their favourite football...
- 125
- 1,061
- 3
The 4000 words essential for an educated vocabulary
... food foray raid forbear abstain, restrain oneself force majeure superior force foreboding ominous foreclose exclude forensic pertaining to debate foresight ability to predict the future forthright ... a word formed by rearranging the letters of another word amalgamation mixture analgesic pain-soother The Words 13 Quiz (Antonyms) Directions: Choose the word most opposite in meaning to the capitalized ... appear in the list of words, but with their less common meanings For example, the common meaning of champion is “winner.” A less common meaning for champion is to support or fight for someone...
- 159
- 512
- 3
The effect of inactivation for C.parvum by Pulse lamp
... inactivate C parvum, the pulse lamps performed to a higher level in the high-luminance region than the other lamps 2) The sensitivity to ultraviolet rays was found to be in the following order ... Comparison of the lamps in turbid water samples The inactivation effects of the lamps on turbid water with the excystation and the cell culture methods were compared Fig shows that, concerning the inactivation ... Inactivation effect of the lamps using the excystation method Fig Inactivation effect of the lamps using the cell culture method 3) Comparison of the evaluation methods used The experiment results...
- 4
- 508
- 0
Sanitation in Urban Poor Settlement and the Importance of Education for the Reduction of the Diffused Pollution - A Case Study of Bauniabad, Bangladesh
... document how the local people came to use the biogas plant for sanitation purpose, and to clarify the performance of the biogas plant for the reduction of the pollution load to the surrounding ... 2688) was included in the survey The housewife or main female member of the first household from the selected plot was requested for the interview The questionnaire used for the interview was on ... that these improper design and improper management were because of the lack of appropriate technical knowledge Therefore, there is a possibility to improve the performance of the plant with the...
- 9
- 971
- 0
Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25