the modulating effect of ageing ethnicity and tp53 somatic abnormalities

... inactivated and a synergic effect occurs Also, the combination of SB and 5-aza-DC facilitates the transformation of chromatin into an activated state [8] In RKO cell lines, the effect of SB was ... For comparison of the treatment effect of radiation, the data were converted to a log scale Then, using SPSS ver 13.0, the results were compared with ANOVA(Analysis of Variance), and p values less ... radiation dose and culture time We irradiated the RKO cell line with the different dose of radiation(4G, 6G, 4G + 4G) and cultured the cells for 24 hours, 48 hours and 72 hours Then we analyzed the cell...

Ngày tải lên: 09/08/2014, 04:21

... using the description of light and darkness One of the most interesting examples for the using of the images of light and darkness to express the contrast of hopefulness and hopelessness is in the ... between light and darkness, while at the same time we find an association of the abstract ideas with the images of light and darkness, we can then speak of the imagery of light and darkness and we should ... that the light of the match is very strong and bright In the above poem by Coffin, the light of a match symbolizes the love of one father for his son He lights the match on a very dark night The...

Ngày tải lên: 22/12/2013, 12:59

... [30] The ionic strength P was calculated using the equation I = ½ ciZi2, where I is the ionic strength of the solution, and ci and Zi are the concentration and charge of species i, respectively The ... bonds with the P-loop main chain and Od1 and Od2 Although there are movements in the P-loop, there are no other major conformational changes in the protein Most notably, the loop containing the general ... separate and distinct conformation rearrangement regardless of the position of the general acid and active site arginine In summary, the conformation of the P-loop only changes: (a) when the general...

Ngày tải lên: 18/02/2014, 18:20

... C1 of the hexanucleotide is at the bottom left and the target adenine is at the top of each model The sidechains of RTA are shown in blue (A) Model has the tetraloop bound in the active site of ... levels and, as such, these mutants could not be purified To assess the effect of substitutions made at each of the arginyl residues on catalytic activity of RTA, the ability of each of the purified ... Electron density of RTA R213D in the vicinity of residue 213 The backbone and sidechains of the R213D substitution are shown as stereo images in thick ball and stick and the position of the Arg213...

Ngày tải lên: 19/02/2014, 12:20

... context the random effects model, which is applied in the third and fourth chapter and the logit model, which is applied in the fifth chapter are introduced In the third chapter the effect of social ... methods is the basic assumption about the relationship between the unobserved effect c and the explanatory variables The unobserved effect is called a random effect when there is no correlation and ... consequence that the sign of the partial effect is determined by the sign βj, This means that the direction of the effect of xj can be obtained before calculating the partial derivative To get the results,...

Ngày tải lên: 20/02/2014, 16:20

... comparison of the effects of rough and smooth LPSs of E coli, both in the presence and absence of EDTA (Fig 1) The rate of oxidation was increased in the presence of the LPSs of both the smooth and ... measure of the rate of oxidation of oxyHb RESULTS The effect of pH on the auto-oxidation of cross-linked Hb was studied The rate of decrease of the concentration of oxyHb increased as the pH was ... comparison of the effects of the LPSs of rough and smooth E coli on the oxidation of Hb A0, both in the presence and absence of EDTA, is provided in Fig The rate of oxidation was increased in the presence...

Ngày tải lên: 08/03/2014, 10:20

... rate can thus be the result of a shift of the rate constants of the branched part of mechanism, i.e increased cleavage at the expense of complex formation Therefore, the products of the reaction ... paid to the mitogenic effect of thrombin, and its control by PAI-1/VN in the pathogenesis of vascular disease [16,17] Together, the presence of PAI-1, VN and TM in the vessel wall, including the ... of the rate equations that describe the mechanism in Fig was performed to obtain theoretical insight into the effect of the second-order rate constants and concentrations of TM and PAI-1 on the...

Ngày tải lên: 23/03/2014, 17:21

... between now and 2050 in the case of the EU and Japan, while growing more modestly in the US to reach 21% at the end of the period While the share of the elderly also grew over the last number of decades, ... expenditures would have the effect of breaching the 60% rule and would have to be financed either on the revenue or the expenditure side of the budget Since the bulk of the increase in government ... Hayashi, Ando and Ferris (1988) Bosworth, Burtless and Sabelhaus (1991) -0.61 -0.86 These studies question the applicability of the life-cycle model on the basis of the observed saving behaviour of the...

Ngày tải lên: 23/03/2014, 21:20

... frequency and the generation of recombinant molecules, taking advantage 2984 of the capacity of the minisatellite MsH43 to form this kind of structure in the presence of K+ [12] We found that the presence ... colonies and the total number of colonies obtained in each assay The equal and unequal recombinant frequencies are given as the ratio between the total number of each type of recombinant and the total ... advantage of the unique sensitivity of quadruplex formation to K+ and other cations present in the cells [24,25] On the other hand, in vitro studies with G-rich telomeric DNA sequences and the minisatellite...

Ngày tải lên: 29/03/2014, 23:20

... combinations of these cytokines from 16 h before infection until the end of the experiment b Average number of plaques per well of Vero cells inoculated with 200 PFU of HSV-1 KOS and F and HSV-2 MS and ... the capacity of human IFNα and/ or IFN-γ to inhibit the replication of HSV-2 strains MS and G was initially performed in a plaque reduction assay The concentration of IFN-α and IFN-γ used in the ... herpesvirus; ii) the effect of CDM on interferons action Results Antiviral effect of IFN-α, IFN-γ and IFNs combination on HSV-2 plaque formation Since there is no published data on the effect of IFNs...

Ngày tải lên: 20/06/2014, 01:20

... that the regions of contact between the stem and the cortical component of the composite bones were consistent between specimens The specimens were cut at 27 cm from the proximal end and the distal ... Axial and torsional loading of the actuator produced distal (Fd), medial (Fm) and anterior-posterior (Fap) loading of the femoral head due to the mounting geometry and the offset between the femoral ... commonly performed to assess the effect of implant design on the stability of hip endoprostheses pre-clinically There is no standard protocol for these tests, and the loading conditions used vary...

Ngày tải lên: 20/06/2014, 04:20

... collected the data, and drafted the manuscript FL designed this study, analyzed the data, performed statistical analyses and drafted the manuscript All of the authors read and approved the final ... by changing the types and thresholds of these variables in order to find the best regression model to predict the early femoral failures The final regression model determined whether these five ... take place as a result of the following thermal osteonecrosis of the underlying bone [2, 10] Both of these complications are unique to hip resurfacing procedures and neither occurred in stemmed...

Ngày tải lên: 20/06/2014, 07:20

... chloride, carbonate and phosphate and the combination of them by adding about 0.34 g of ZANDI into a 500 ml of the aqueous solution The accumulated amount of 2,4-D released into the solution was ... safe and environmentally friendly as the 2,4-D is not exposed directly to the user and the environment, and, therefore, could prevent the associated problems Materials and Methods Synthesis of ... affect the physiological process of rubber plant in order to improve the quality and to increase the latex yield, but the release of 2,4-D is in a controlled manner Further understanding of the...

Ngày tải lên: 22/06/2014, 00:20

... Reproduced with permission of the copyright owner Further reproduction prohibited without permission Reproduced with permission of the copyright owner Further reproduction prohibited without ... permission Reproduced with permission of the copyright owner Further reproduction prohibited without permission Reproduced with permission of the copyright owner Further reproduction prohibited without ... permission Reproduced with permission of the copyright owner Further reproduction prohibited without permission Reproduced with permission of the copyright owner Further reproduction prohibited without...

Ngày tải lên: 09/07/2014, 14:21

... weeks and then treated with 80 mg·l–1 of ethephon or 40 mg·l–1 of GA3, – seeds chilled for weeks and then treated with 100 mg·l–1 of ethephon or 300 mg·l–1 of GA3, – seeds chilled for weeks and then ... 80 mg·l–1 of ethephon or 40 mg·l –1 of G A3, – seeds chilled for weeks and then treated with 100 mg·l–1 of ethephon or 300 mg·l–1 of GA3, – seeds chilled for weeks and then treated with 120 mg·l–1 of ... to 10–3M The purpose of the present paper was to determine the effect of gibberellic acid and ethephon on overcoming beechnut dormancy and stimulation of beechnut germination Materials and methods...

Ngày tải lên: 07/08/2014, 10:21

Ngày tải lên: 07/08/2014, 17:22

... spruce and aspen trees in certain different proportions and with admixture of some other deciduous species are typical in the region of the southern European taiga The area of the southern European ... previous and at place which was 0.4 m higher), and the last hole was bored at the highest point of the plot 0.9 m above the well level The depth of the last hole was 140 cm; other holes reached the ... and t0 are the current day and the day of the first measurement in the growing season, S(t) is the stand basal area (in m2 ha–1), k and m are numbers of species and DBH classes, nij is the stocking...

Ngày tải lên: 08/08/2014, 00:22

... winters, the courses of the minimum temperatures were similar in the regions of the stands to be compared (figs 2, 3) For the examination of the nitrogen effect, two stands of adult sessile oaks ... stations of the German Meteorological Service (Deutscher Wetterdienst) which were at a distance of up to 50 km from the stands and reflected the weather situation of the region During both winters, the ... both the magnitudes and the of air temperatures measured at the meteorological stations used as a reference for the stands to be compared were very similar, the climatic conditions of those stands...

Ngày tải lên: 08/08/2014, 18:21

... Effect of site quality and thinning on the structural variables of the holm and stands The changes in site quality and management have different effects on the structural variables of the stands: ... representative of the best and the worst qualities were chosen The selection of plots was based on an assessment of the general aspect of the plot and the size and physiognomy of holm oaks Table ... differences in diameter, and only differed in the mean number of stems per stool between the stand of intense thinning and the stands of conservative thinning and old forest The stool equivalent...

Ngày tải lên: 08/08/2014, 18:21

... Experiment Effect of the herbicide imazapyr (Arsenal, CYANAMID) The following spring, selected plant material of the same origin and of about the same age and non-induced shoots (normal) after the Arsenal ... readily and others poorly, regardless of the cutting type and hormone level Several other workers have also noticed the effect of genotype on rooting of conifer cuttings According to our results and ... present study is the investigation of: a) the stimulation and development of fascicle shoots of the pine hybrid P brutia (Ten) x P halepensis (Mill); and b) the vegetative propagation of selected...

Ngày tải lên: 08/08/2014, 19:21