the measurement of affinity and efficacy in functional assays

... in our understanding of the world,... confirmed by generations of scientists, and it explained everything from the orbits of the planets to the times of the tides, the ... Bohr and Heisenberg over the interpretation of the uncertainty principle In the early days of quantum theory Werner Heisenberg tried to explain the origins of uncertainty ... created the Tabulating Machine Company to speed up the processing of data using a system of punched cards In 1911 the company’s name changed to International Business Machines The

Ngày tải lên: 09/04/2014, 16:38

... The following theorem is then proven in exactly the same fashion as Theorem 1: Theorem 1  . Let (W, S) be a Coxeter system, and n 1 (w),n 2 (w), aseriesof 5 additive statistics. Then using the ... exp(x; q)  The theorem now follows upon replacing x by x(1 − t). Remarks. 1. The crucial encoding of functions K : {s 0 , ,s n }→ used in the middle of the preceding proof is a translation and generalization ... Weyl groups and affine Weyl groups. This section (and the remainder of the paper) is devoted to specializing Theorem 4 to compute generating functions for descents and length in all of the classical

Ngày tải lên: 07/08/2014, 06:20

... descendant of itself. The number of ascendants A n,j is the number of internal nodes in the path from the root of the tree to the j th node, both included. It is worth mentioning the following symmetry ... n,j in random LBSTs, then the proposition applies for the variant of quickselect that uses the median of a random sample of three elements as the pivot in each partitioning phase. The study of the ... moments, including the expected value and variance (Theorem 3.2). Then we analyze the number of descendants of a random node, obtaining the probability that D n = m, as well as the moments of D n (Theorems

Ngày tải lên: 07/08/2014, 06:22

... in species, a shortening of rotations and a mechani- sation of the thinning, harvesting and regeneration operations result in constraints to the physical, chemical and biological properties of ... )was installed in the stand to compare the soil moisture measurements with the theoretical values calculated by the model. Probes were left into the soil to quantify the effect of the clear-cutting ... the increase in the water flux, which is difficult to quantify because of the presence of ground vegetation. The monitoring of numerous fluxes before and after the clear-cutting could explain the

Ngày tải lên: 07/08/2014, 16:20

... of relaxin with or without β-estradiol on the modulation of MMPs in joint fibrocartilaginous explants, and assessed the contribution of these proteinases to the loss of collagen and glycosaminoglycan ... of these proteinases to the changes in collagen and glycosaminoglycan (GAG) content in fibrocartilaginous disc explants Our findings are consistent with the hypothesis that relaxin-mediated induction ... on the amount of collagen in fibrocartilaginous tissues from different sites, including the pubic symphysis and synovial joints These findings also suggest that in fibrocartilaginous tissues, including

Ngày tải lên: 09/08/2014, 06:22

... study and planning of the work that led to the manuscript, the acquisition, and interpretation of data, and has been involved in drafting and critically revising the manuscript for important intel- ... contributions to the conception and design of the study, the analysis and inter- pretation of data, and has been involved in drafting and critically revising the manuscript for important intellec- tual ... supports the oral counselling after the diagnosis 12 In my opinion working according the guideline requires that the content of the preoperative counselling is put in writing 13 In

Ngày tải lên: 11/08/2014, 05:21

... study and planning of the work that led to the manuscript, the acquisition, and interpretation of data, and has been involved in drafting and critically revising the manuscript for important intel- ... contributions to the conception and design of the study, the analysis and inter- pretation of data, and has been involved in drafting and critically revising the manuscript for important intellec- tual ... supports the oral counselling after the diagnosis 12 In my opinion working according the guideline requires that the content of the preoperative counselling is put in writing 13 In

Ngày tải lên: 11/08/2014, 16:21

... Stability after the combination of superior repositioning of the maxilla and advancement of the mandible: a, the percent of the patients with changes in the horizontal position of landmarks in the first ... of the mandible, but the majority of the patients experience >2 mm upward movement of gonion due to remodeling in that area. Clin- ically, > 90% of the patients treated with either of these ... repositioning of the maxilla: a, the percentage of patients with changes in the vertical position of skeletal and dental landmarks; b, the percentage with changes in the vertical position of soft tissue

Ngày tải lên: 11/08/2014, 23:22

... throughout the Everglades [2] However, during the past decades Typha has expanded rapidly and replaced thousands of hectares of Cladium marshes and aquatic slough areas in the northern part of the Everglades ... of P uptake was higher in Typha than in Cladium and higher in low-P acclimated plants than in high-P acclimated plants The affinity for P uptake was twofold higher in Typha than in Cladium, and ... [30] These inherently different traits are considered the main explanation for the rapid spread and competitive success of Typha in the P-enriched areas of the Florida Everglades Cladium and Typha

Ngày tải lên: 12/08/2014, 03:21

... action inactivates RPTP β/ζ, which results in an increase of the phosphorylation of β-catenin on its tyrosine residues (Tyr-Pi) and the release of β-catenin from cadherins. (B) In the absence of ... binds to the chondroitin sulfate portion of RPTPβ/ζ with high affinity [74]. In U373-MG glioblastoma cells, the binding of PTN with RPTPβ/ζ inactivates the receptor, and thus significantly increases ... Retinoid acid accelerates the development of the alveolar tree and promotes the expression of sur- factant proteins and enzymes for the synthesis of surfac- tant lipids [25]. On the other hand,

Ngày tải lên: 12/08/2014, 11:22

... were involved in the planning of the study. ISH performed the faecal exams, performed the sta- tistical analyses, drafting and revising of the manuscript. BKG and LJR have been involved in drafting ... prevalences of both parasites were found to be higher in winter than in spring and summer, but this finding must be interpreted with caution due to the (clustered) nature of the data in the present ... Cryptosporidium and Giardia positive during the course of the study, which is to be expected due to the similar epidemiology of these par- asitic infections and the repeated sampling regimen used in the

Ngày tải lên: 12/08/2014, 18:22

... type of housing unit, the number of earners in the household, and the level of education of the household head The results of the estimation are used to predict the presence of the household in the ... households in the sample 17 The bottom and top edges of the box indicate the intra-quartile range (IQR), i.e., the range of values between the 25th and 75th percentiles The marker inside the box indicates ... time deficit to their poverty line increases their income deficit (the difference between the poverty line and income) This has the effect of increasing the average income deficit of all poor households...

Ngày tải lên: 23/09/2015, 08:53

... Finally, the kernel informs the hardware physical map module of the new virtual to physical mapping With the exception of the hardware validation, all of these steps are implemented in a machine-independent ... surviving the introduction of new hardware architectures and was never able to efficiently support the large body of UNIX software used within the academic community [16] In addition, from the point ... Mach runs on the majority of workstations and mainframes within the Department of Computer Science, and supports projects in distributed computing and parallel processing such as the Camelot distributed...

Ngày tải lên: 12/09/2012, 15:05

... reduce the extent of burning of last portions of fuel injected into the prechamber The unburned fuel in the prechamber may therefore increase with load, but its burning rate in the main chamber ... because of the increase of injection pressure and the increase of the injected fuel mass due to the increased effective flow area with increased nozzle needle lift Therefore, as shown in Figure ... (BSFC) of the IDI engine to increase and the total engine efficiency to decrease compared to that of a DI diesel engine Because of these disadvantages of the IDI diesel engines, most engine research...

Ngày tải lên: 05/09/2013, 16:11

... that we inhabit Poetry is anarchic in the original sense of the word In the Republic Plato formalized this link between poetry and anarchy (and, in the bargain, instituted the discipline of philosophy) ... 112).) Levinas figures this experience of exteriority in terms of insomnia and the interminability of the night, as well as in terms of certain kinds of mystical or magical events in which subjectivity ... by saying that the temporality of the work of art ‘does not have the quality of the living instant which is open to the salvation of becoming The value of this instant is thus made of its...

Ngày tải lên: 01/11/2013, 10:20

... advertisements of food and drink in English and Vietnamese at discourse level? linguistic features of the advertisements of food and drink in What are the similarities and differences of the speech ... in the ads of foods and drinks in English and Vietnamese samples were taken from the online electronic texts and the 4.1.1.1 Introducing the existence of a particular food product magazines in ... corpus of study I have found instances of the use of words that rhyme in poetry or songs/jingles We can see the rhyme between the word at the end of one line with that in the next line: Rhyming...

Ngày tải lên: 26/11/2013, 13:27

... that of the Interrogatives is the Interrogative word and that of the Imperatives is the Imperative form of the verb And Rheme is the remainder of the message, and also the part in which the Theme ... Interpersonal Themes, on the other hand, reveal something of the attitude of the speaker or the writer And Textual Theme is the link between the clause contains that Theme and the rest of the discourse ... principles of the analysis, and finally describing the procedure of studying 2.2 Research Hypothesis In the investigation, we would like to present a sufficient overview of Theme and Rheme in theory...

Ngày tải lên: 22/12/2013, 12:59

... When there is more rain, the bark becomes soft and the concentration of latex decreases, the At the end of the rainy season, the soil starts to dry and the rubber leaves start to shed, causing ... is the most convenient for them in terms of time consumed majority prefer Option because other options involve them in many other activities including harvesting, cutting roots and drying and ... primarily because of limited capacity and facilities of the responsible supporting institutions : There are serious gaps and overlaps in the mandates of institutions supporting agriculture and rural...

Ngày tải lên: 21/02/2014, 04:20

... fisheries of northern Norway for cod, capelin and other fish appeared to go into decline after the opening of the country’s first whaling station in the 1860s.19 In the early years of the twentieth ... on -the- spot “snapshots” of the abundance of different kinds of marine life there by visitors in the 1500s and 1600s Among them were turtles in “inestimable numbers,” “an in nite number of them ... capelin in the Barents Sea collapsed in the mid-1980s, resulting in the closing of the capelin fishery for five years Iceland’s cod catch fell by about half in 1994 The cod fishery there has since...

Ngày tải lên: 06/03/2014, 18:21

... So, in 2000, in collaboration with the Population Health Division of the Commonwealth Department of Health and Ageing, the NHMRC initiated the development of the guidelines In working on the ... Behavioural therapy can increase the effectiveness of other weight-loss treatments, and the duration of the therapy influences the ability to maintain the weight loss No single behavioural therapy ... particular intervention They diminish the effectiveness of weight-reduction programs and suggest caution in the interpretation of data based on the weight losses of people who remain in the programs...

Ngày tải lên: 08/03/2014, 14:20