... responsible for lipid synthesis In particular, excess availability of FFAs, as is the case in the present experimental model, leads to increased formation of TAGs, which are either released from the ... ER stress When the available acyl-CoAs are in excess, they are channeled towards TAG synthesis The main findings of the present investigation were the observations that TAG synthesis in liver cells ... observed in this investigation (Fig 5B) The ER is the site of synthesis of all secretory proteins and resident proteins of the membrane system, and any perturbation that compromises the proteinfolding...
Ngày tải lên: 14/02/2014, 22:20
... for assistance with analysis of U.S Census data Finally, the author thanks the Missouri Foundation for Health for providing grant funding for health policy analysis, including the work on this ... whether Missouri moves forward with the expansion is up to the legislature There are many factors that policymakers must consider in deciding whether to implement the ACA’s Medicaid expansion The ... This paper analyzes key aspects of the State’s decision regarding this important state option The Supreme Court’s Decision and the New State Option: On June 28, 2012, the Supreme Court upheld the...
Ngày tải lên: 21/02/2014, 14:20
Báo cáo khoa học: The F13 residue is critical for interaction among the coat protein subunits of papaya mosaic virus doc
... critical for interaction among the CP subunits monomeric form of the protein [10] This protein failed to assemble, form disks or interact with RNA in vitro [10] On the basis of this result, we hypothesized ... in the PapMV CP Therefore, on the basis of the alignment, we propose that a hydrophobic residue at the position that corresponds to PapMV CP F13 is preferred in half of the potexvirus CP It is ... in spite of the lower affinity measured by EMSA The A280/260 nm ratio was also calculated for disks Results for PapMV disks and CP6–215 disks differed from those for F13L and F13Y disks, and suggest...
Ngày tải lên: 07/03/2014, 05:20
A Beginner’s Guide to Network Security: An Introduction to the Key Security Issues for the E-Business Economy doc
... and morale Legislation is another force that drives the need for network security Governments recognize both the importance of the Internet and the fact that substantial portions of the world’s ... 2001, Cisco Systems, Inc All rights reserved Printed in the USA Cisco, Cisco IOS, Cisco Systems, and the Cisco Systems logo are registered trademarks of Cisco Systems, Inc or its affi liates in the ... applications For example, software exists that is specifically designed to crack passwords Such software was created for network administrators to assist employees who have forgotten their passwords...
Ngày tải lên: 14/03/2014, 22:20
Báo cáo khoa học: The b domain is required for Vps4p oligomerization into a functionally active ATPase potx
... This study This study This study This study This study This study This study This study This study This study This study This study This study This study This study This study This study This ... role in the formation of a Vps4p ATPase complex that is functional in vivo The formation of the latter may be a prerequisite for interaction with Vta1p Furthermore, our data highlight the importance ... Although this finding was unexpected, there is a precedent for the role of regions outside of the AAA domain in oligomerization For example, the linker region between the two AAA domains of p97 is required...
Ngày tải lên: 16/03/2014, 13:20
Governance and organizational structure of the inter-agency secretariat to the United Nations International Strategy for Disaster Risk Reduction (ISDR) pot
... Inter-agency secretariat for Disaster Risk Reduction With the endorsement of the General Assembly, the inter-agency secretariat for ISDR was established to support the continued disaster risk reduction ... also the Special Representative of the Secretary-General (SRSG) for the implementation of the HFA The mandate of the secretariat is to act as the focal point in the United Nations system for the ... to the work of the United Nations in disaster risk reduction within the sustainable development programme of the United Nations 17 The Management of the ISDR secretariat accepted the revised formulation...
Ngày tải lên: 23/03/2014, 02:20
Báo cáo khoa học: A novel factor XI missense mutation (Val371Ile) in the activation loop is responsible for a case of mild type II factor XI deficiency doc
... results are consistent with the FXI:C and FXI:Ag measured in the patients plasma, further supporting the hypothesis that the Val371Ile mutation is a 6130 type II defect leading to the production ... in the activation loop at the N-terminus of the catalytic domain, are notable In the zymogen FXI, Ile371 is exposed to the solvent, while in the activated FXI it is inserted into the protein The ... does not form many contacts with other residues (Fig 6) Therefore, the additional methyl in the Val371Ile mutant probably does not disturb the structure and the domain rearrangement in the zymogen...
Ngày tải lên: 23/03/2014, 07:20
Official Report of the Exploration of the Queen Charlotte Islands for the Government of British Columbia doc
... RIVER Is the first stream crossed It is misnamed on the chart Chown Brooke Chown is the name of the point lying just to the westward, which is more prominent than shown on the chart This river is ... part the sun, another the moon, and the small fragments the stars ***** Carvings The Hydas are distinguished for their superior skill, above that possessed by any other aboriginal people on the ... and others have visited various parts of the islands, no systematic effort has hitherto been made for the exploration of the entire group Under the direction of the Dominion Government, the waters...
Ngày tải lên: 23/03/2014, 08:21
Official Report Of The Exploration Of The Queen Charlotte Islands For The Government Of British Columbia (dodo Press) By Newton H. Chittenden potx
... RIVER Is the first stream crossed It is misnamed on the chart Chown Brooke Chown is the name of the point lying just to the westward, which is more prominent than shown on the chart This river is ... part the sun, another the moon, and the small fragments the stars ***** Carvings The Hydas are distinguished for their superior skill, above that possessed by any other aboriginal people on the ... and others have visited various parts of the islands, no systematic effort has hitherto been made for the exploration of the entire group Under the direction of the Dominion Government, the waters...
Ngày tải lên: 23/03/2014, 10:21
Báo cáo khoa học: Homologous desensitization of guanylyl cyclase A, the receptor for atrial natriuretic peptide, is associated with a complex phosphorylation pattern pot
... role for the phosphorylation of this residue in the inhibitory regulation of GC-A activity To follow this hypothesis, we tested the influence of the substitution of Ser487 with glutamate on the ... In comparison, the cGMP responses of the mutant GC-A S487E to ANP were markedly blunted (Fig 6A) One possible explanation for this reduced responsiveness is the different steric conformation ... at Ser487 These computational analyses indicated that this site conforms to the consensus motifs for the DNA-dependent protein kinase catalytic subunit and for cyclin-dependent kinase The DNA-dependent...
Ngày tải lên: 29/03/2014, 09:20
Báo cáo Y học: The cytoplasmic C-terminus of the sulfonylurea receptor is important for KATP channel function but is not key for complex assembly or trafficking pdf
... Ig) was then applied the following day for h The antibody reactive to the Kir6.2 C-terminus was raised to the peptide sequence DALTLASSGPLRKRSC and has been characterized previously [17] The anti-myc ... analysis of each individual experiment The latter however, allows statistical analysis of the relevant data The response to bath applied diazoxide was determined in the whole-cell configuration The ... which the C-terminus of SUR1 was replaced by MRP1) when coexpressed with Kir6.2 could reach the plasma membrane One potential explanation for this is that the trafficking in these two systems is...
Ngày tải lên: 31/03/2014, 08:20
Báo cáo y học: "Rheumatoid arthritis seropositive for the rheumatoid factor is linked to the protein tyrosine phosphatase nonreceptor 22-620W allele" docx
... seronegative for rheumatoid factor Transmission, percentage of heterozygous 1858C/T parents transmitting the 1858T allele The plan was to test the hypothesis for RF+ RA; analysis for all RA and ... samples Linkage and association analysis were performed using the TDT [33] and the genotype relative risk (GRR) test [34] The TDT compares the transmission of the SNP alleles from heterozygous parents ... contribution to the acquisition of clinical data and the follow-up of the patients All authors read and approved the final manuscript Acknowledgements The authors thank the patients, their families, their...
Ngày tải lên: 09/08/2014, 07:20
Báo cáo khoa học: " Postoperative Chemoradiation for Resected Gastric Cancer - Is the MacDonald Regimen Tolerable? A Retrospective Multi-Institutional Study" pptx
... completed the chemotherapy, 87% completed the radiotherapy and 54% completed the entire chemoradiotherapy protocol The reason for discontinuation was toxicity in all cases Toxicity Overall, 46% of the ... It is unclear whether these are coincidental non-significant differences or whether they actually reflect the improvement in radiotherapy techniques and chemotherapy supportive measures since the ... of this regimen is clearly its chemotherapy component This is evident by the high rate of distant metastases among treated patients One possible way to improve the efficacy of INT-0116 chemotherapy...
Ngày tải lên: 09/08/2014, 09:21
Báo cáo y học: "LV reverse remodeling imparted by aortic valve replacement for severe aortic stenosis; is it durable? A cardiovascular MRI study sponsored by the American Heart Association" pot
... data analysis DV statistical analysis VR helped interpret CMR exams served as the second cardiologist on the study GR assisted in primary data analysis and was the software engineer for the study ... primary data, assisted in recruitment, IRB issues as well as wrote the manuscript JM discussed the design of the study and performed the majority of the aortic valve replacements SG was the nurse coordinator, ... ANOVA was performed for comparisons over time Statistical analyses were performed using SPSS for Windows, version 11.0 (SPSS, Inc., Chicago) All statistical comparisons were performed using two-tailed...
Ngày tải lên: 10/08/2014, 09:21
Báo cáo y học: " A double shunt technique for the prevention of ischaemia of a congenital, solitary, pelvic kidn" pps
... interposed, and the procedure was carried out without further difficulty The selection of the graft size was based upon the wide width of the aortic bifurcation The total time of renal ischaemia did ... solitary pelvic kidney, and the composition of the renal vasculature One renal artery originated from the aortic bifurcation and the other from the proximal portion of the right common iliac artery ... arteries and the left renal artery were dissected and controlled with vessel loops The right axillary and common femoral arteries were then exposed via separate incisions, and the cannulae of the axillofemoral...
Ngày tải lên: 11/08/2014, 00:22
gherghina et al - 2014 - a study on the relationship between cgr and company value - empirical evidence for s&p [cgs-iss]
... The t-statistic for each coefficient is reported in parentheses The description of the variables is provided in Table Source: Authors’ computations Therefore, the hypothesis regarding the existence ... which the companies included in the research database operate The difference between the Tobin’s Q ratio for each company and the median ratio for the respective sector represents the ∆Q, and the ... respective activity sector The median was preferred to the mean because the data did not follow a normal distribution The source for the financial information is represented by the annual financial...
Ngày tải lên: 02/01/2015, 17:33
Besides increasing the number of universities,rasing the education quality is also urgent problem
... Xat District, in the northern mountainous province of Lao Cai, learn Vietnamese For the school year 2007-08, 40 rural provinces recorded low rates of learning the Vietnamese language after the ... vitality for education reform around the country One expert noted the concept of e-learning is by now familiar with Vietnamese educators Using ICT in education now is fortuitous as the country’s ... on the television set or computer for their children in stead of talking to them or playing with them." Kim Anh said this had led to many children being detached from the real world, opting for...
Ngày tải lên: 19/07/2013, 16:34
Characterization of the Carbon Stable Isotope Ratio and Fatty Acid Structure of Zostera japonica in Coastal Areas
... japonica The δ13C in the roots and rhizomes seems to be larger than the δ13C in the leaves and stems For the same species of seagrass, when the δ13C of the parts were compared, the difference is lesser ... Fig shows the dominant fatty acids in the leaves and stems of Z japonica in each sampling site The term “other” in the x-axis designates the sum of all the fatty acids with < 5% content The three ... at the center of the meadows, and then the samples were frozen immediately upon reaching the laboratory In September 2008, Z marina were collected from the sublittoral zone in the same area The...
Ngày tải lên: 05/09/2013, 10:17
Networks- The Connection
... address is selected and the datagram is forwarded to the specified interface If the gateway field is filled, then the datagram is forwarded to that host via the specified interface, otherwise the ... that the device files for an aliased ethernet device uses the format ethX:Y where X is the number for the ethernet card and Y is the number of the aliased device Since aliased devices use the ... simply uses the characteristics of ethernet The information is placed on the ethernet network and gets broadcasted to every ethernet card on the network The ethernet card which has the appropriate...
Ngày tải lên: 19/10/2013, 02:20