the interplay between the immune system brain control and metabolism
Paradoxical roles of the immune system during cancer development docx
Ngày tải lên :
15/03/2014, 01:20
... adaptive immune cells They are, therefore, key players in the interface between innate and adaptive immunity NK cells also participate in cellular crosstalk between innate and adaptive immune cells ... increased when there is a previous history of alcohol and tobacco use66,67 On the other hand, the RR for the most common non-viral-associated solid tumours of epithelial origin is decreased in immune- suppressed ... cancer, either because they are maintaining low-level chronic inflammation as a consequence of defects in their natural immune defence mechanisms, and/ or because they fail to normalize their immune...
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Báo cáo Y học: A new siglec family member, siglec-10, is expressed in cells of the immune system and has signaling properties similar to CD33 docx
Ngày tải lên :
24/03/2014, 04:21
... digesting the fragment with HindIII and Bgl II and the plasmid with HindIII and Bam HI The fragment was ligated into the plasmid and the integrity of the insertion was validated by digesting the plasmid ... purified (< 820 bp) The insert was then ligated into the pSPORT vector and the resulting full-length siglec-10 clone was designated 995-2 and the sequence was verified against the other siglec-10 clones ... peripheral blood cells The anti-(siglec-10) Ig recognized a single band approximately at the expected Mr of between 90 and 120 kDa There were no other visible bands, implying that the antibody is specific...
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scientific american - 1993 09 - special issue - life, death, and the immune system
Ngày tải lên :
12/05/2014, 14:50
... interlopers and guide the bodyÕs defenses This process is crucial to the function of the immune system and its failure 80 How the Immune System Recognizes the Body Philippa Marrack and John W Kappler The ... chemicals that boost the activity of other cells in the immune system the junctions between the V and D or D and J segments when they interlink, which further increases the number of possible ... American, Inc Life, Death and the Immune System By defining and defending the self, the immune system makes life possible; malfunction causes illness and death Study of the system provides a unifying...
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Báo cáo sinh học: "Parasite immunomodulation and polymorphisms of the immune system" ppsx
Ngày tải lên :
06/08/2014, 19:20
... varies markedly between pathogen species These graduated effects may, in turn, have driven quantitative polymorphisms in the contemporary immune system that control the strength of the immune response, ... exceptionally susceptible to either infection or pathology, and a deeper understanding of the intimate co-evolution of pathogens and the immune system 10 11 12 13 14 Acknowledgements The author’s research ... immunosuppressive controls both in humans [8] and animal models [9] The best-understood of these suppressive systems is the regulatory T cell (Treg), a cellular safety catch on the immune response...
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Báo cáo sinh học: "Beyond toxicity: aryl hydrocarbon receptor-mediated functions in the immune system" docx
Ngày tải lên :
06/08/2014, 19:21
... just the beginning We still know little about the physiological impact of AhR expression on other cells of the immune system and the consequences of exposure to AhR ligands for these Given the ... crosstalk between the immune system, the neuroendocrine system and the nervous system is more likely to come from models that use physiological ligands whose mode of action is under tight regulatory control ... remains to be seen how such endogenous AhR ligands influence various components of the immune system Unraveling the complex functions of AhR in the immune system, which may also give clues http://jbiol.com/content/8/7/61...
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Báo cáo khoa học: "The use of crossreactive monoclonal antibodies to characterize the immune system of the water buffalo (Bubalus bubalis)" pdf
Ngày tải lên :
07/08/2014, 15:20
... species With the mAbs identified here, it will now be possible to characterize the immune system of the water buffalo and begin to analyze the immune response to infectious agents and parasites ... T C and Gorham, J R The The use of crossreactive monoclonal antibodies to characterize the immune system of the water buffalo (Bubalus bubalis) development and analysis of species specific and ... anaplasmosis and babesiosis [25,25,26] To evaluate the immune responses of water buffalo to infectious agents and potential vaccines, it is necessary to characterize the immune system of the water...
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Báo cáo y học: "Regulating the immune system: the induction of regulatory T cells in the periphery Jane H Buckner1 and Steven F Ziegler2" pot
Ngày tải lên :
09/08/2014, 01:24
... impossible to prove whether the TR cells isolated from peripheral blood originate in the thymus, and are expanded in the periphery, or whether they have been generated in the periphery The possibility ... inducing the local induction of Th3 or Tr1 cells [74], extends this paradigm The fate of the TR cells induced at the site is not known — whether these cells exist only transiently then die, whether they ... treat autoimmune disease A better understanding of how these forces work together will allow us to understand immunologic settings where either the immune response is inadequate, such as the response...
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Báo cáo y học: " Mimicking microbial ‘education’ of the immune system: a strategy to revert the epidemic trend of atopy and allergic asthma?" ppt
Ngày tải lên :
12/08/2014, 18:20
... through natural soil dust and contaminated food Rook and Stanford [11] proposed that mycobacteria might therefore have influenced the evolution of the immune system because they have been ubiquitous ... (dendritic cells) may be the target of a microbial bystander effect, that may dictate the pattern of accessory molecules and cytokines, and modulate the outcome (Th1- or Th2-like) of the allergen-specific ... allergen for allergen-specific immunotherapy, and from trials with Homeostasis of the immune system is so complex and microbial exposure is so diversified that, at the present state of our knowledge,...
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Báo cáo y học: " Network, degeneracy and bow tie. Integrating paradigms and architectures to grasp the complexity of the immune system" pps
Ngày tải lên :
13/08/2014, 16:20
... have been observed in the functional structure of some key components of the innate immune response, such as the human TLRs system, and of the adaptive immune system, such as the TCR Even if microbial ... DR and GCC conceived of the study, AZ and MM participated in its development, PT, AG and CF drafted the manuscript All authors contributed to write the manuscript, and then read and approved the ... upon the system s dynamics and functionality Indeed, the architectural characteristics of a system and the features of individual components together play indispensable roles in forming the symbiotic...
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Báo cáo y học: "Common angiotensin receptor blockers may directly modulate the immune system via VDR, PPAR and CCR2b" ppt
Ngày tải lên :
13/08/2014, 23:20
... 11 Candesartan docked into the VDR ligand binding pocket Candesartan docked into the VDR ligand binding pocket Note: The core structure of the hydrogen-bonded residues is expanded to a 'ball -and- stick' ... ARG274 and the hydroxyl of SER237, and another pair from the ligand's O3 oxygen to SER278 and TYR143 Figure shows that the VDR agonist TX522 [42] also forms a double hydrogen bond between the oxygen ... the text) LigPlot and HBPLUS McDonald's HBPLUS software [56,55] takes, as input, the computed 3D ligand-receptor complex and produces a table of hydrogen bonds formed between the ligand and the...
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Báo cáo y học: "Tumor microenvironments, the immune system and cancer survival" ppt
Ngày tải lên :
14/08/2014, 14:21
... different cell types of the immune system (indicated by round cells) may lead to elimination of the cancerous cells (b) If elimination is unsuccessful, the immune system and the cancer can reach ... cells their component cells, and their microenvironment Among the important advances that have derived from these technologies is the molecular classification of tumors on the basis of only their ... reinvigorated approach These studies highlight the importance of studying the genetics and phenotypes not only of cancer cells but also of the surrounding microenvironment The immune system has long...
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Báo cáo y học: "Gene regulation and signal transduction in the immune system" pptx
Ngày tải lên :
14/08/2014, 20:22
... transduction and gene regulation control diverse and fundamental biological processes This was underscored at the 2008 meeting We look forward to the next meeting in 2010, and anticipate follow-up to the ... in the immune system Tannishtha Reya (Duke University Medical Center, Durham, USA) used a reporter system that marks Notch expression to study stem-cell commitment, and showed that all of the ... Numb and the transcription factor T-bet, become localized to the immunological synapse (proximal) side of the cell, whereas protein kinase C-ζ becomes partitioned to the distal side of the cell...
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ROLE OF THE IMMUNE SYSTEM IN TUMOR PROGRESSION 1
Ngày tải lên :
10/09/2015, 15:50
... unique Therefore, the study of the cross-talk between cancer cells and the immune system must be analyzed in the context of the organ in which the tumor exists and the type of cells that the tumor ... syndrome and colorectal cancer [11] Despite these associations between the host immune responses and cancer development, the exact molecular mechanisms and complex interactions between cells of the ... stage, the immune system, comprising tumor-specific CD8+ and CD4+ T cells and natural killer (NK) cells, is able to control the growth of the tumor This is typically the longest of all the three...
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ROLE OF THE IMMUNE SYSTEM IN TUMOR PROGRESSION 2
Ngày tải lên :
10/09/2015, 15:50
... is the number of melanoma cells at the end of the experiment, N is the number of melanoma cells at the onset of the experiment, k is the fraction of proliferating cells, t is the duration of the ... to the cubic root of the cell number Therefore the ratio between the diameters of tumors from control and depleted mice is given by: (3) 𝐷𝐷𝑐𝑐 � 𝐷𝐷 = {𝑒𝑒 ( 𝑑𝑑 } [𝑘𝑘 𝑐𝑐 −𝑘𝑘 𝑑𝑑 ]𝑡𝑡 ) 𝜏𝜏 k c and ... experiment, N is the number of melanoma cells at the onset of the experiment, k is the fraction of proliferating cells, t is the duration of the experiment (6 weeks), τ is the duration of the cell cycle...
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Interaction of burkholderia pseudomallei with cells of the immune system
Ngày tải lên :
08/11/2015, 16:31
... studying the interaction between the bacterium and host T cells and dendritic cells We first examine the ability of the virulent B pseudomallei to invade and replicate within cultured T lymphocyte and ... cells are central players that control the adaptive immune responses Therefore, the entry and persistence of the pathogen within these cells could potentially affect their functions by inhibiting ... Yong Mei, Justin and Ying Ying The project could not have been completed without the support and encouragement and from them all Being placed under the supervision of Dr Gan and her laboratory...
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Basic immunology functions and disorders of the immune system
Ngày tải lên :
04/08/2016, 15:18
... infections is called the immune system, and the coordinated reaction of these cells and molecules to infectious microbes is the immune response Immunology is the study of the immune system and its responses ... MICROBES The principal barriers between the host and the environment are the epithelia of the skin and the gastrointestinal and respiratory tracts Infectious microbes usually enter through these ... for their ligands on the endothelium Concurrently, TNF and IL-1 act on the endothelium to stimulate expression of ligands for integrins The firm binding of integrins to their ligands arrests the...
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A REPORT COMMISSIONED BY THE CENTERS FOR DISEASE CONTROL AND PREVENTION pot
Ngày tải lên :
23/03/2014, 23:20
... (DNA) the hope that an understanding of the complex interplay belonging to a particular organism of genes and the environment will lead to new avenues Genomics: The study of the structure and for ... humans These disease results from the interaction between genetic advances allow an expanded approach to susceptibility factors and the environment, broadly understanding how multiple genes and ... bridging the gap between genomics research and the application of research findings in public health and clinical care METHODS DEFINING THE QUESTION In initial literature review and discussions, the...
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THE CARDIOVASCULAR SYSTEM – PHYSIOLOGY, DIAGNOSTICS AND CLINICAL IMPLICATIONS pot
Ngày tải lên :
28/03/2014, 09:20
... analysis’ describes the development and use of the electrocardiogram (ECG) and the rheogram Furthermore the use of both the ECG and rheogram to assess cardiovascular function in normal and diseased ... RHEO and the respective functions of the cardiovascular system Although it seems that the hemodynamic mechanism as a whole and the performance of the cardiovascular system are very complicated, the ... Rather, Prx-1 enhanced both the rate of association and the rate of dissociation between SRF and CArG element, thereby increasing the rate of exchange of SRF on the CArG element Although further...
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the mit press the handbook of brain theory and neural networks second edition nov 2002
Ngày tải lên :
11/06/2014, 16:35
... cross-references to other articles in the Handbook These may occur either in the body of the article in the form THE TITLE OF THE ARTICLE IN SMALL CAPS, or at the end of the article, designated ... SYSTEMS and MODULAR AND HIERARCHICAL LEARNING SYSTEMS) Minds Here, I want to distinguish the brain from the mind (the realm of the “mental”) In great part, brain theory seeks to analyze how the ... different parts of the human brain during different tasks (see IMAGING THE GRAMMATICAL BRAIN, IMAGING THE MOTOR I.2 Levels and Styles of Analysis BRAIN, and IMAGING THE VISUAL BRAIN) The grand aim of...
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THE CARDIOVASCULAR SYSTEM – PHYSIOLOGY, DIAGNOSTICS AND CLINICAL IMPLICATIONS pot
Ngày tải lên :
27/06/2014, 09:20
... RHEO and the respective functions of the cardiovascular system Although it seems that the hemodynamic mechanism as a whole and the performance of the cardiovascular system are very complicated, the ... Rather, Prx-1 enhanced both the rate of association and the rate of dissociation between SRF and CArG element, thereby increasing the rate of exchange of SRF on the CArG element Although further ... mode that is the most efficient and therefore fully in compliance with the said principle of optimization The theory of the third mode is a foundation for the development of new mathematical models...
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