the influence of particle size and structure on drug delivery

... interrupt the connections between the PFC and the rest of the brain [28] The post-surgical care and drug administration were identical to the PFC intact animals The disruption between PFC and VTA ... a common mechanism of addiction through neural adaptation [6, 7] The disconnection of the functional pathway between PFC and VTA could significantly reduce the effects of drugs of addiction, including ... that, the functional input loss from PFC and/ or NAc may reduce the effects of these drugs on the addiction process [14, 16-18] In VTA, the AMPA/NMDA receptors’ ratio response of dopamine neurons...

Ngày tải lên: 19/06/2014, 08:20

... have examined the influence of serum-derived factors on the growth and survival of IVD cells, even though these factors generally are considered to be essential for the survival of most normal ... the diffusion rate of molecules through the cartilage endplate, the major route of glucose and oxygen to the central nucleus pulposus (NP) [9,10], was dependent on their size, charge, and shape, ... by scoring a minimum of 200 cells for each condition and each sample Collagen immunolocalisation The production of type I and II collagens was examined by immunolocalisation of cytospins, as described...

Ngày tải lên: 09/08/2014, 10:23

Ngày tải lên: 21/06/2014, 01:20

... analysis and interpretation of the data MB participated in the design of the study and the statistical analysis RJ and MP participated in the design of the study and coordinated the data acquisition ... perspectives: the treating therapist (THER), the team of therapists concerned with the patient (TEAM), and the patient him- or herself (PAT) The team of therapists concerned with the patient performed ... member of the team of therapists and might have influenced the consensus rating in his favoured direction Nevertheless, at least under the conditions described, our results suggest that in contrast...

Ngày tải lên: 11/08/2014, 15:22

... Purpose of the study The purpose of the study is to establish the influence of the electronic tax filing system on tax collection and tax compliance The wave and era of technology/information systems ... administration of the organization and pro- people and pro- business policies advanced by the MOFEPD 4.8 Findings on the Ease of Use of the Electronic Tax System 4.8.1 URA staff Opinion about the use of ... Areas of Further Research The researcher suggests the following as areas of further research; • The influence of e-tax on tax administration • The impact of e-tax on tax evasion and avoidance • The...

Ngày tải lên: 12/01/2016, 13:43

... 2005 Effect of nitrogen levels and initial propionate concentrations Continuous illumination The effect of nitrogen levels and initial propionate concentrations on hydrogen production from pineapple ... capable of both hydrogen production and consumption (Koku et al., 2002) It is not inhibited by the presence of nitrogen sources but by carbon monoxide, oxygen and high concentrations of organic ... illumination The effect of nitrogen levels and acetate concentrations on hydrogen production under periodic illumination was conducted At each level of total nitrogen, the hydrogen production potential...

Ngày tải lên: 05/09/2013, 09:08

... Surveys Unit of the National Centre for Social Research and the Department of Epidemiology and Public Health, Royal Free and University College London Scotland, Northern Ireland and Wales have ... is a function of parental education, S, measured as the ages at which the mother and father left full-time education,26 and the (log of) household income Yh27 (and, in some specifications, we have ... variable, for mothers and fathers, has a very strong and negative effect on schooling, and the smoking status of grandparents also have strong, negative effects on the schooling of both parents...

Ngày tải lên: 28/03/2014, 09:20

... relative to the market’s expectation of the cash rate The cost of long-term wholesale debt continues to place upward pressure on banks’ funding costs, as still nearly one-fifth of bonds outstanding ... also fallen since the onset of the financial crisis, as the amortisation of the outstanding stock of residential mortgage-backed securities (RMBS) has exceeded new issuance Furthermore, Australian ... about one-fifth of banks’ funding, and is priced mainly off 1-month and 3-month bank bill rates Prior to mid 2007, bank bill rates closely tracked the market’s expectation for the cash rate with the...

Ngày tải lên: 29/03/2014, 01:20

... beginning of a combat mission (“start -of- mission capability”) and the reliability of that equipment over the course of the mission (“during-mission reliability”) While the usefulness of these measures ... responding to the commands of his battalion commander At a certain level of losses at each echelon of command, the leader may elect to change the course of action or request a changed course of ... against the other, regardless of how the two force sizes compare, and vice versa In the limit, any weapon system on one side can engage any target on the other side Other observers describe the differences...

Ngày tải lên: 29/03/2014, 16:20

... construction, the transfixion of soft tissue by the tensioned wires or the transfixion of the hindfoot within the frame Efforts have been made to simplify both the application and configuration ... to the anatomical conditions, and the tibiae were mounted eccentrically in the sagittal plane to mimic the soft tissues of the calf At the site of the osteotomy, the distance between the bone and ... wire on the top side and one on the bottom side of the ring They were attached to the ring with slotted bolts and tensioned to 1080 Nm with the standard tensioning device that is part of the Ilizarov...

Ngày tải lên: 20/06/2014, 07:20

... in a non-fasting condition or a fasting condition differ after injection of insulin and furthermore assess the effect on FDG kinetics in the muscle and brain Knowledge of the extent of these ... investigated the effect of the metabolic condition on the biodistribution and uptake rates of FDG in mice We found that FDG plasma clearance rates depend on the dietary state and on insulin stimulation ... http://www.ejnmmires.com/content/1/1/8 Page of Figure Distribution of FDG in the LV blood pool and the myocardium in the early phase of the study Initial phase of the radiotracer input function in a “control animals”...

Ngày tải lên: 21/06/2014, 02:20

... 1.2 F and the Lipschitz constant of T tends to if ε ↓ For more information on the structure of fixed point sets see 4, and references therein In 1973, Goebel and Kirk introduced the class of uniformly ... − T ny 1.3 and proved the following theorem Theorem 1.2 Let E be a uniformly convex Banach space with modulus of convexity δE and let C be a nonempty bounded closed convex subset of E Suppose ... only connected but even a retract of C, and next the author proved the following theorem 7, Corollary Theorem 1.3 Let H be a Hilbert space, C a nonempty bounded closed convex subset of H, and...

Ngày tải lên: 21/06/2014, 20:20

... Each cross represents one value of the three repetitions Figure Illustration of the model of evolution of one criterion respect to temperature seems that the softening phenomenon is not completed ... and one criterion Compression test and ER are selected 3.3 Detailed study of one mechanical criterion: ER from compression test To go further in the investigations, we studied the influence of ... we can work on the average value on the ten species Figure presents the evolution of average values of ey, gR and df in function of temperature Deformation criterion from compression test (ey),...

Ngày tải lên: 08/08/2014, 01:21

... in the statistical analysis and interpretation RC made substantial contributions to the design and collection SH made substantial contributions to the design and collection All authors read and ... for the retinal venous dilation (p = 0.03) but not for the retinal artery dilation (p = 0.08) With the subject's consent, the experiment was repeated on three additional occasions, each one month ... 2B and Retinal vein dilation and reaction time, but not artery dilation and reaction time, were statistically significantly lower in fasting versus non-fasting conditions (dilation: p = 0.02 and...

Ngày tải lên: 11/08/2014, 23:21

... examine the relative impact of recent and remote hospitalization on further hospitalization for asthma over longitudinal followup, we removed hospitalization from the established severity score and ... hospitalization (during the 12 months prior to baseline interview), or remote hospitalization (past hospitalization not meeting the previous definition of recent) As a result, the hospitalization and ... evaluated the association between baseline characteristics and the risk of hospitalization for asthma during the ensuing 18-month follow-up period, reported at the 18-month interview We use the data...

Ngày tải lên: 12/08/2014, 18:20

... procedures, the Institutional Board on the Ethics of Clinical Studies waived the need for informed consent Further details on the setting of the study are described elsewhere [9,10] Analysis of risk ... intubation at ICU admission, infection present already at the time point of ICU admission (pneumonia, urinary tract infection and other infections), hospitalization prior to ICU admission, elective ... endpoint, the cumulative incidence function of the patient group with pneumonia on admission is below the function of the group without until about 40 days in the ICU, but above afterwards Analysis of...

Ngày tải lên: 13/08/2014, 08:21

... capital model; the theory of discrimination; the gender gap and gender occupational segregation; the skill-bias technological change hypothesis and models on gender and identity The models on human ... determinants of the evolution of the female wage and the widening of the gender gap over time Notice that, although their findings not contradict this thesis’ initial hypothesis, they find that occupational ... determinant in the evolution of the wage differential Nonetheless, other studies, which would be mentioned later, point out to the contribution of the field of study in explaining the gender gap,...

Ngày tải lên: 10/10/2014, 23:14

... Taking the volume of an order sequence and the submission time as predetermined, the impact of these variables on the duration of the 867 sequence may be estimated from the regression specification: ... part of the offer side of the limit order book and was trying to decide whether or not to hit a special bid could condition on the size of the special bid, subject to the time limits imposed by the ... can condition on the total size of the order While this is a distinct possibility, there are some practical limitations Since the progression of the warning or special quotes may be rapid and the...

Ngày tải lên: 31/10/2014, 12:51

... supported on iron oxide support Deposition-precipitation is a modification of the precipitation methods in solution It consists of the conversion of a highly soluble metal precursor in another substance ... fraction of the particles emitted from the sample There are two different modes of analytical SIMS application: static and dynamic SIMS In static SIMS, 21,22 the information on the composition of the ... magnified image of the sample on the viewing screen One can obtain the high-resolution image that contains information on the atomic structural of the materials if the transmitted beam and one or more...

Ngày tải lên: 14/09/2015, 08:27

... temperature The Conversion and Selectivity are calculated in terms of concentration: CO conversion (%) = Inlet CO concentration – Outlet CO concentration Inlet CO concentration x 100% CO2 conversion (%) ... for the average concentration of each component ċi, at the in- and outlet of the reactor; mAu, mass of Au in the reactor bed; V, total molar flow rate; XCO, conversion of CO on the basis of CO2 ... conclusions.33 The CO conversion of both CO oxidation reaction and PROX reaction over AuCP and AuDP samples decreased after reaching 100% conversion, while the CO selectivity of RROX reaction...

Ngày tải lên: 14/09/2015, 08:27