the implications of the open access publishing model

... view, what are the major factors encouraging TB patients to undergo [HCT]?’ The face validity (i.e., whether the questions make sense as a measure of a construct in the judgment of others) and practicality ... about the confidential nature of the discussions and encouraged to express their opinions openly The individual interviews with the program managers were conducted by two researchers in either ... fact, all the program manager respondents mentioned patients’ fear of being the recipient of HIV-related stigma as a barrier to acceptance of HCT: They fear stigma in the community They fear...

Ngày tải lên: 10/08/2014, 10:23

... (66%) of them of both sexes having been informed of the results of the tests and thus being aware of their status Overall, nearly two-thirds of the respondents (64%) reported having changed their ... addressing the immediate concerns of companies in the wake of the pandemic As they stand, however, they are neither creative nor far-reaching in their orientation The progressive nature of the disease ... because of the 3-month strike in the private security sector that coincided with the start of the project It is possible that several of the smaller security firms closed as a result of the impact of...

Ngày tải lên: 22/03/2014, 18:20

... defined as the earliest date of the following events: (i) if the person was alive and on treatment at the end of the study, August 2005; (ii) if the person was lost to follow up, the date of the last ... follow-up if they did not attend the hospital within the previous 90 days and the community agent did not find the patient We followed the patients until they died, moved out of the area or were ... treatment, the mortality rate stabilized in the treated group, but in the untreated cohort there was steady increase in mortality The longer curve of the HAART group shows the longer follow-up in the...

Ngày tải lên: 10/08/2014, 05:20

... countries, the Ministry of Health officially funded the first pilot NEP in Guangxi and Yunnan province in 1999 [23,27,28] The program has expanded to other parts of China, with a total of 790 needle ... results of the available studies are encouraging, few studies reported the application of a theoretical framework for the intervention programs Studies from other countries have demonstrated that theorybased ... clients [31] The NEPs were first initiated by non-governmental organizations (NGOs) and other international donors rather than by the Chinese government because of the concern that these programs...

Ngày tải lên: 11/08/2014, 18:20

... make the least headway Another issue of concern is that the focus of many of these programmes is on treatment rather than prevention of HIV Initiatives geared to increasing the delivery of treatment ... end of 2005, is successful, it will have addressed only 50% of the demand for treatment at the current level of need The MDGs are unlikely to be met at the current rates of progress, with the ... aspects of society The ramifications of an epidemic of this nature and scale will be felt long after incidence of the disease has peaked, predicted in the case of HIV to be in 2040 [12] By way of...

Ngày tải lên: 11/08/2014, 18:20

... oncogene, the interleukin receptor gene (IL4R), the gene of the transporter protein TAP2, the gene of protease calpain small subunit (capn4) and other (in case of lymphoma h1) and SMG-1, the gene of ... of the cell populations examined Another open question is whether there are differences in the expression of genes in HIV/SIV-related and spontaneous lymphomas To address these questions, the ... part of the λIg gene, the mitochondrial genes of NADH dehydrogenase subunit (ND4), the interferon-inducible gene 6-16 (Inf-ind), the 16S rRNA gene (most probably the humanin gene [17]) These...

Ngày tải lên: 02/11/2012, 11:08

... Prevention of Mother to Child Transmission of HIV, Maternal, Neonatal, and Child Health and Pediatric HIV Services Objectives of the Guidance Supporting the integration of Prevention of Mother to ... committed to the goal of virtual elimination of mother-to-child transmission of HIV by 2015 These important goals have been adopted in the context of significant scientific advances that have the potential ... of ARV prophylaxis to the mother during labor, delivery, and the immediate postpartum period; and for the first time, (3) extension of prophylaxis, based on national guidelines, to either mother...

Ngày tải lên: 12/02/2014, 19:20

... violations of their human rights were prominent themes throughout the duration of both fora, and provided a backdrop to virtually all other topics discussed Another major theme was the lack of the most ... that they go to a clinic because they have an STI, which they want treated but when they get to the clinic they'll say, they have a discharge because they have changed their bath liquid They’ll ... inform the doctor of the error s/he is making, and to support the young women and seek the best for them.’ Injecting drug users often not seek treatment out of fear of stigmatisation Aside from the...

Ngày tải lên: 13/02/2014, 10:20

... conformation of Asp30 The water interaction with the amide of Ile50¢ was weakened (dis˚ tance of 3.5 A) The C-HÆÆÆO interaction between the carbonyl oxygen of APV and the Ca of Gly49 was lost in the minor ... previously [19,25] The increased catalytic efficiency of the PRL90M mutant is mainly due to an almost five-fold higher kcat On the other hand, the Km of the mutant is only about half that of the wild-type ... retaining the hydroxyl group, and not to Val or Asn, maintained enzymatic activity [36] These lines of evidence, taken together, strengthen the suggestion that loss of the C-HÆÆÆO interaction of residue...

Ngày tải lên: 18/02/2014, 04:20

... year in the developing world not have access to all (or, often, any) of these vital services Only about one-third of them receive even the least effective drug regimen: a single dose of the drug ... mothers are the source of the virus, rather than the latest link in a long chain of transmission In 2000 came good news: the pharmaceutical company Boehringer Ingelheim announced that for the ... them properly The problems, it seemed, were caused by the women In the meantime, researchers were concluding that for most of the world’s babies born to mothers with HIV, the best guarantee of...

Ngày tải lên: 05/03/2014, 13:20

... policy implications Benefits of the use of assisted reproductive technology by women and men living with HIV are two-fold: avoidance of infection of an uninfected partner, and welfare and health of ... level of care), training curriculum, sensitisation workshops and training of local trainers and VCT providers Then, the results of a subsequent study conducted in 2004 and 2005 in 14 of the same ... evidence is limited, including in terms of the impact of integrated care on family planning.129 In HIV care centres, there is an increased awareness of the importance of links between sexual and reproductive...

Ngày tải lên: 05/03/2014, 17:20

... glycosaminoglycans [37] As the myc-his tag of the protein was present at the C-terminus of the receptor which is located on the inside of the cell, we then determined if signal transduction by the protein was ... respectively Purification of CCR5-myc-his For the purification of CCR5-myc-his we tested two different methods based on the presence of the six histidines at the C-terminus of the protein The first involved ... on the other [48] The success of this method thus probably depends on the relative affinities of interaction of the protein and lipid with the detergent As it is not always possible to predict these...

Ngày tải lên: 08/03/2014, 09:20

... 2004 to 54 in 2009 The site expansion was accompanied by an increased number of women testing There were marked increases in the rate of HIV testing following the introduction of routine opt-out ... (an NGO working on PMTCT) During the data collection, months reports were missing in one of the sub-city (Lideta) but we collected them from the service outlets Of the collected monthly reports, ... of standard testing algorithm, unreliable supply of test kits and other logistics, variable training among professionals who are doing the testing and lack of quality control system [12,21] The...

Ngày tải lên: 15/03/2014, 10:20

... However, there has been limited research to evaluate the effectiveness of these interventions (Guedes, 2004) The area of FP has witnessed the greatest number of systematic studies assessing the effect ... care, support and prevention of mother-to-child (PMTC) transmission of HIV There has been no systematic study to assess the effectiveness and impact of this model at the community level in achieving ... unable to attend counselling either because they could not obtain permission from their employer or due to the nature of their work Less than 30% of men in the intervention clinics attended couples...

Ngày tải lên: 22/03/2014, 12:20

... analysis of the peptide-binding sites on IN The structure of the PFV intasome in the presence and absence of several drugs served as the basis for the structural analysis [71] The sequences of PFV ... values of the enzymatic reaction, as inferred from the shift of the plots while the same slope was maintained (Fig 2AC and Table S2) These results further suggest that these peptides enhance the ... observed in several of the panels of Fig is the optimum point of the reaction, namely the ideal concentrations of DNA, peptide and amount of enzyme (IN) This may slightly vary with the different peptides...

Ngày tải lên: 22/03/2014, 16:21

... the surface of the protein Among the three complexes, the quality of the electron density maps decreased in the order: PR>PRL90M> PRV82A The distribution of the mean B factors for the main chain ... isolates [2] One of the conformations of the side chain of Lys45 in PR forms hydrogen bonds with the Od2 of Asp30, which is expected to stabilize the flap The other conformation of Lys45 forms hydrogen ... occupancy of ˚ 0.34, with the Ce atom at a short distance of 3.53 A from the carbonyl oxygen of Asp25 The other conformation of ˚ Met90, with 0.66 occupancy, had the Ce atom at 5.46 A from the carbonyl...

Ngày tải lên: 23/03/2014, 12:20

... analysis The thermodynamic parameters of unfolding of the monomer are expected to be different from those of the trimer Trimer dissociation is bound to alter the ratio of DHvH/ DHcal, indicative of the ... tryptophan residues to the solvent, giving rise to a shift in the maximum of the emission spectrum, as shown for the gp41 model [14] The maximum of the fluorescence emission spectrum of gp41 at pH 2.8 ... Differences in molecular ellipticity are in the range of the error associated with determination of the protein concentration pH dependence of the thermal unfolding of gp41(24–157) Monomer–trimer equilibrium...

Ngày tải lên: 30/03/2014, 13:20

... with these 53 health workers about their experience in implementation of services for PMTCT, their point of view about users of their services and their perception about the challenges they faced ... instance, when they know they have opportunity to have care and support, they often find ways to get as much as possible Or if they want to leave the hospital, they often lie to the nurse that the doctor ... lack of confidentiality of HIV test results [4,12] Our previous studies on the experiences and views of women about the provision of PMTCT in Hanoi included criticisms about the quality of services...

Ngày tải lên: 18/06/2014, 17:20

... participated in the design of experiments 14 MC, EEP, XL, and DYWL participated in the interpretation of the results MC and EEP prepared the manuscript 15 EEP, XL, KD, JJM, JCV, CT, and YL performed the ... Compared with the IC50 value of 860 µg to the whole extract previously reported by us, SP4-2 inhibited virus replication with an IC50 value of 3.7 µg, which represents a 230-fold enrichment of the antiretroviral ... inhibition of reverse transcriptase Conclusion Taken together, we have demonstrated an average of 53% inhibition of HIV-1 fusion, and approximately 47% of virions that enter cells are further inhibited...

Ngày tải lên: 20/06/2014, 01:20