... superimpo- sition of five-residue segments of the crystal structure on the equivalent segments of each member of the family of the solution structure of the M domain of human eRF1. The resulting rmsd ... S4. A comparison of part of the protein backbone structure of the representative solution structure of the human eRF1 M domain and the Ca trace in the crystal structure of RF1 in the whole ribosome ... simi- larity to the crystal structure of the M domain of the same protein [3], but it is far from identical (Fig. 2A). The rmsd of the superposition of the heavy backbone atoms (Ca, N, O and C) of the family...
Ngày tải lên: 07/03/2014, 05:20
Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx
... between the Leu residues from v-KIND and MAP2 contributes to the interaction between the two proteins. In conclusion, the present study has clarified the structural and functional importance of the ... and 482) and one Thr residue (amino acid 487) were well conserved in the KIND2 of v-KIND in all species analyzed, although not in the other KINDs. To investigate the possible involvement of these ... under- stood, the data obtained in the present study indicate that the 43 residues (amino acids 702–744 in mice) that reside in the middle region of the CD act as the v-KIND binding core. The v-KIND-binding...
Ngày tải lên: 14/02/2014, 19:20
Tài liệu THE HISTORY OF THE RISE, PROGRESS, AND ACCOMPLISHMENT OF THE ABOLITION OF THE SLAVE-TRADE pdf
... foreign lands, were not confined within the shores of a little island. Most of the islands of a continent, and many of these of considerable population and extent, were filled with them. And the ... liberty, and make them slaves and sell them, are the worst of robbers, and ought to be considered as the common enemies of mankind; and that they who buy them, and use them as mere beasts for their ... nature of it; and of the extent of it; and of the difficulty of subduing it.—Usefulness also of the contemplation of this subject. I scarcely know of any subject, the contemplation of which...
Ngày tải lên: 15/02/2014, 09:20
Tài liệu Republican Legal Theory The History, Constitution and Purposes of Law in a Free State ppt
... correct, and just way of viewing the law. Law and government should serve the common good of the people. The common good of the people will be found best through the checks and balances of the ... Legal Theory The History, Constitution and Purposes of Law in a Free State M.N.S. Sellers Regents Professor of the University System of Maryland and Director of the Center for International and ... of the public good. 19 The rule of law The third traditional desideratum of republican government requires the rule of law ( the empire of laws and not of men”), which protects justice and the...
Ngày tải lên: 18/02/2014, 11:20
Tài liệu Báo cáo khoa học: Complete subunit sequences, structure and evolution of the 6 · 6-mer hemocyanin from the common house centipede, Scutigera coleoptrata pptx
... SDS/PAGE and in 2D PAGE (Figs 1 and 2; Table 1). The N-terminal amino acid sequences (see above) allow the assignment of the HcA clone to the major sequence of the upper hemocyanin band in the SDS/PAGE ... against the hemocyanin fraction show staining of the two 75 kDa bands in Western blot, but do not recognize any other proteins of the hemolymph. Although we expected that each of these bands contains two ... primers and the T3 vector primer. The sequences were obtained after the cloning of the PCR products into the pCR4-TOPO TA vector (Invitrogen). Protein structure modeling Homology models of the S....
Ngày tải lên: 20/02/2014, 11:20
Tài liệu Báo cáo Y học: The solution structure and activation of visual arrestin studied by small-angle X-ray scattering pot
... us. Neither of these parameters are within the range of our experimental observations, and therefore the predominant species in solution are the monomer and dimer. Additional evidence that the crystallographic ... arrestin and arrestin in the presence of phosphopeptide is given at the top of the (B) and (C), expressed as a percentage of the total signal from the detector. Ó FEBS 2002 Activation of visual ... provide the radius of gyration (R g ), defined as the root mean square distance of all atoms from their common centre of mass. The R g canbeusedtoevaluatethe overall shape of a scattering particle. The...
Ngày tải lên: 22/02/2014, 07:20
Báo cáo khoa học: NMR solution structure and function of the C-terminal domain of eukaryotic class 1 polypeptide chain release factor pdf
... region of the 1 H, 15 N-HSQC spectrum of the C-terminal domain of human eRF1 illustrating the presence of two conformational states of the protein. Fig. S2. Plot of the number and distribution of the NOEs ... However, these structures do not show the coordinates of the atoms in Fig. 6. Superposition of the representative NMR open conformer of the C-domain (red and blue) on the crystal structure [20] of the complex ... (C-domain). The high-reso- lution NMR structure of the human C-domain (residues 277–437) has been determined in solution. The overall fold and the structure of the b-strand core of the protein...
Ngày tải lên: 06/03/2014, 11:20
Báo cáo khoa học: Structure and mechanism of the ThDP-dependent benzaldehyde lyase from Pseudomonas fluorescens potx
... with the gene of the benzaldehyde lyase and for helpful discus- sions, the teams of the Swiss Light Source (Villigen ⁄ CH) and of the EMBL outstation Hamburg for their help with data collection and ... comparison of the relative B-factors along the ThDP molecules shows that the Fig. 4. Structure- based sequence alignment of BAL, BFD and PDC all of which are used in organic synthesis. The secondary structure ... consist of a cen- tral six-stranded parallel b-sheet flanked by a varying number of a-helices. Residues involved in binding of the cofactor ThDP are located at the C-terminal ends of the b-strands of...
Ngày tải lên: 07/03/2014, 12:20
THE STRUCTURE AND DEVELOPMENT OF THE CEREAL PLANT pptx
... parts of a leaf are the tip of the blade and the top of the sheath. Where the blade and sheath join, there are structures called the ligule and the auricles (Figure 2.3). Table 2.1 – Shoot structures ... EFFICIENCY Tim Setter and Peter Carlton The structure of the wheat plant described in this chapter is the starting point to understanding the growth and development of the crop, its nutrition and the reasons for ... determines the rate of uptake. Uptake of nutrient elements from the soil and into plants depends on: the availability of the nutrient in the soil; movement of the nutrient, in soil solution or along the surfaces...
Ngày tải lên: 08/03/2014, 23:20
Báo cáo khoa học: Structure and topology of the transmembrane domain 4 of the divalent metal transporter in membrane-mimetic environments docx
... in the presence and absence of the paramagnetic metal ions. The amplitudes of the spectra in the presence of the paramagnetic metal ions were normalized to the least affected cross-peaks. The paramagnetic ... biology aspects of DMT1 since the discovery of this gene, there has so far been no structural characterization of either this integral protein or a segment of it. Analysis of the structure of membrane ... in TFE and SDS. Ó FEBS 2004 Structure and topology of TM4 of DMT1 (Eur. J. Biochem. 271) 1951 peaks of Ile10, Ile12 and Val17. This suggested that the peptide was inserted in the interior of micelles....
Ngày tải lên: 16/03/2014, 16:20
Báo cáo khoa học: Solution structure and stability of the full-length excisionase from bacteriophage HK022 pot
... The structure images were prepared using the MOLMOL program [49]. Results Expression and purification of the Xis_wt and Xis_C28S proteins The isolation and purification of Xis was hampered by the fact ... to other proteins of this class, such as the DNA-binding domain of the Mu repressor [21]. Third, the backbone atoms of the region comprising the ÔwingÕ b-sheet (residues 2–4, 35–36 and 41–44 of ... the N-terminal, structured part of Xis is involved in the recognition of DNA [18,57]. On the other hand, the results also indicate that the C-terminal a-helix, predicted in the work of Wu and co-authors for...
Ngày tải lên: 23/03/2014, 15:21
Báo cáo khoa học: Functional aspects of the solution structure and dynamics of PAF – a highly-stable antifungal protein from Penicillium chrysogenum pdf
... highly twisted as a result of the conserved flexible Gly5 followed by the bulky side chain of lysine and the disulfide-paired Cys7, which pulls the strand towards Structure and dynamics of an antifungal ... 10. The electrostatic surface potential of AFP (left) and PAF (right) structures representing the orientation of the side chain lysine resi- dues. Lys9, Lys35 and Lys38 of PAF and Lys9, Lys32 and ... any redox activity of PAF. Differences and similarities between the structures of PAF and AFP The common geometrical arrangement of the two proteins is the special Greek key fold, in which the two orthogonally...
Ngày tải lên: 29/03/2014, 23:20
Báo cáo khoa học: Structure and activity of the atypical serine kinase Rio1 doc
Ngày tải lên: 30/03/2014, 20:20
Báo cáo hóa học: " Effect of thermal treatment on the growth, structure and luminescence of nitride-passivated silicon nanoclusters" pptx
Ngày tải lên: 21/06/2014, 05:20
Báo cáo khoa học: Protein transport in organelles: The composition, function and regulation of the Tic complex in chloroplast protein import pptx
... Additionally, because the demand of the chloroplast is ‘sensed’ inside the organelle, the IEM is closest to the origin of the signal, and thus regulation at the Tic complex could be one of the fastest ... transmembrane-helices at the extreme N-terminus, which anchor the protein in the membrane. The position and function of the long C-terminal tail on the other hand remains a matter of controversy [10,11,13–15]. ... description of recent advances in the understanding of the chan- nel-, motor- and regulatory components of the Tic complex. For reference, some of the available know- ledge, including the proposed...
Ngày tải lên: 07/03/2014, 03:20
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