the hedgehog signaling pathway in cancer pathogenesis and therapy
The NR4A orphan nuclear receptors are target genes of the novel drug c1 in cancer cells and potential mediators of drug induced apoptosis
... proteins, myosin, gelsolin, filamin, spectrins, microtubular proteins including tubulins, microtubule associated proteins, and intermediate filament proteins including vimentin keratin and nuclear ... varying degrees of success with photodynamic therapy for the derivation of molecules of interest in cancer therapy including photofrin, purpurins, xanthenes, phthalocyanines, oxazines, cyanines, ... drugs and the pathways they influence have been the subject of immense interest to biologists, and there has been some headway in understanding the signal transduction pathways these drugs initiate...
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báo cáo khoa học: "Regulation of cell cycle transition and induction of apoptosis in HL-60 leukemia cells by lipoic acid: role in cancer prevention and therapy" ppt
... permeability and contributing to its relocalization to the nucleus, and thereby promoting the induction of caspase-independent apoptosis A companion and equally important change in this regard may be the ... to nucleus and promoting the caspase-independent induction of apoptosis chrome c in the activation caspase-independent apoptosis, as involving the nucleus accumulation of cytochrome c instead of ... cyclins D, E and cdk2, as they play a pivotal role in controlling the phosphorylation status of Rb, which in turn activate transcription factor E2F to induce cell entry into the S-phase Results in...
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Báo cáo y học: " Potential applications of curcumin and its novel synthetic analogs and nanotechnology-based formulations in cancer prevention and therapy" pps
... sonic hedgehog (SHH/GLIs) and Wnt/b-catenin and their downstream signaling effectors (Figures and 2) The intracellular signaling Page of 19 transduction elements inhibited by curcumin include the ... emphasis on brain, prostate, pancreatic and colorectal cancers were included in the review Potential applications of curcumin in cancer prevention and therapy Curcumin exhibits in vitro and in vivo ... cells in vitro and in vivo [160-162] Together, these data support the therapeutic interest of using low doses of curcumin or its derivatives in combination therapy with other cytotoxic agents acting...
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Tài liệu Báo cáo khoa học: Implication of the glutamine synthetase ⁄glutamate synthase pathway in conditioning the amino acid metabolism in bundle sheath and mesophyll cells of maize leaves doc
... compounds in the phloem exudates, amounting to 51% of the total amino acids in the light and 56% in the dark (Fig 7A) The total amount of alanine, serine and glycine was reduced from 33% in the light ... light to 25% in the dark (Fig 7A) Glutamine and asparagine were the major amino acids in the xylem sap in both the light (63% of the total amino acids) and dark (60%) (Fig 7B) The amino acid percentage ... molecular signalling in the expression of the genes and encoded enzymes involved in nitrate assimilation and amino acid synthesis [7] The stalk and leaves below and above the ear act as the source...
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Báo cáo y học: "κ The TRAF6-NFκB signaling pathway in autoimmunity: not just inflammation" ppsx
... cell signaling pathways regulate survival and activation in the periphery and in the thymus, the immune system must balance antigen presentation and proinflammatory outcomes in the periphery in ... participate through the canonical pathway as ‘central mediators of the immune response’ [13] These include cytokines, adhesion and costimulatory molecules, and genes regulating the oxidative burst ... production The pathway is described in the text Deficient strains marked in red display defects in thymic organization and negative selection with increased numbers of peripheral autoreactive T cells The...
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Báo cáo khoa học:" A role for the JAK-STAT1 pathway in blocking replication of HSV-1 in dendritic cells and macrophages" docx
... of the STAT1 gene in mice revealed a role for STAT1 in the JAK-STAT signaling pathway [40] The JAK-STAT signaling pathway is involved in mediating biologic responses induced by many cytokines ... here for the first time that STAT1 (likely via the JAK-STAT1 pathway) is involved in suppressing HSV-1 replication in murine DCs and macrophages In addition, the lack of virus replication in wild-type ... infected with HSV-1 McKrae The kinetics of virus replication were quantitated by determining the amount of infectious virus at various times post infection using a plaque assay as described in...
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Báo cáo khoa học: " A role for the JAK-STAT1 pathway in blocking replication of HSV-1 in dendritic cells and macrophages" pps
... of the STAT1 gene in mice revealed a role for STAT1 in the JAK-STAT signaling pathway [40] The JAK-STAT signaling pathway is involved in mediating biologic responses induced by many cytokines ... here for the first time that STAT1 (likely via the JAK-STAT1 pathway) is involved in suppressing HSV-1 replication in murine DCs and macrophages In addition, the lack of virus replication in wild-type ... infected with HSV-1 McKrae The kinetics of virus replication were quantitated by determining the amount of infectious virus at various times post infection using a plaque assay as described in...
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Evaluation of the role of autophagy in fungal development and pathogenesis 2
... protein involved in the Cvt pathway (Scott et al., 2001) Atg20 and Atg24 bind PtdIns(3)P and belong to the sorting nexin family that functions in protein trafficking from the Golgi to the endosome ... Neurotrophin signaling to sensory nerves in animals is mediated by receptor tyrosine kinases (RTKs) signaling pathway, in which neurotrophins stimulate endocytosis of TrkA in axon terminals and endosomes ... placed on induction medium plates containing 200 µM Acetosyringone, 60 µg/mL Streptomycin and 100 µg/mL Ampicillin Air-dry the liquid on the filter in the laminar flow hood Incubate the mixture...
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Evaluation of the role of autophagy in fungal development and pathogenesis 3
... OP-2 strains The indicated strains were initially grown in the dark for days and then subjected to constant illumination to induce conidiation At the specified time-points post induction, the fungal ... (MGG_04464) in the Magnaporthe genome was present in the atg8D mutant but absent in the wild-type or the complemented strains In yeast, Ams1 is delivered to the vacuoles via Cvt and autophagy pathway and ... during the complete conidiation process, indicating the increased breakdown of the cytosolic glycogen, which accumulates at a high level in the atg8∆.18 Interestingly, conidiation defects in the...
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Evaluation of the role of autophagy in fungal development and pathogenesis
... Yun long and Selvarai Poonguzhali, for making our lab a most pleasant and stimulating working environment The TLL community, especially the sequencing lab and the microscopy and imaging facility ... selective, depending on the specific biological circumstance and/ or the specific inducer involved Autophagy was first identified and characterized in yeast and in animal cells In recent years, ... 4.2.4 Investigation of pexophagy in the atg20∆ mutant 100 4.2.4.1 Pexophagy is defective in the atg20∆ mutant 100 4.2.4.2 Pexophagy is not induced during Magnaporthe conidiogenesis and pathogenesis...
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Genetic and molecular dissection of DELLA related GA signaling pathway in regulating arabidopsis seed germination
... might be involved in the induction of flowering by GA The expression of MYB33 is induced by GA in the shoot apex during the induction of flowering In addition, MYB33 binds to the promoter of the floral ... overexpressed the SHI protein (Friborg et al., 1999) SHI protein contains a RING fingerclass zinc finger motif, which indicates that it may play a potential role in protein-protein interaction involved in ... repressing plant growth, we compared the gene expression pattern in the ga1-3 mutant to that in the plants of no DELLA activity in the ga1-3 background and that in the wild type (WT) and obtained the...
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Functional study of zebrafish udu and its relationship to the notch signaling pathway
... to the PAH repeats found in yeast SIN3 (Wang et al., 1990) SIN3 protein has no intrinsic DNA binding abilities and it must be targeted to gene promoters by interacting with DNA binding proteins, ... regulatory checkpoints The first regulatory event is the G1/S checkpoint, which defines the entry into the cycle in late G1; the G2/M checkpoint, where entry into mitosis is controlled; and the metaphase-to-anaphase ... containing an extracellular domain (ECD) and an intracellular domain (NICD) Notch signaling occurs when the ligand DSL on one cell interacts with the receptor Notch on a neighboring cell (Mumm and...
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The role of language in adult education and poverty reduction in Botswan
... Botswana maintains the hegemony and the gap between the poor and the rich, the major and minority groups In order to redress poverty the adult education program needs to be aware of the social ... of the minority and poor people and use them to mobilize the poor and minorities who are struggling for the betterment of their conditions It could mobilize the so called minorities to oppose their ... is in Setswana and English contributes to an assimilation of these groups into Setswana, killing their identities and ignoring the knowledge and experience embodied in their native languages and...
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The ubiquitin-proteasome pathway in cell cycle control
... contain an F-box motif near their amino termini and one of several protein-protein interaction motifs carboxy ter- The ubiquitin-proteasome pathway in cell cycle control 157 minal to the F-box In ... ubiquitin addition, the predominant linkage for protein turnover is through lysine 48 (Chen and Pickart 1990) Once chains of significant length have been produced, the Fig The ubiquitin proteasome pathway ... at either end (Pickart and Cohen 2004) The regulatory particle is responsible for recognizing ubiquitylated targets, removing the polyubiquitin chains for recycling of ubiquitin, unfolding the...
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Tài liệu Area Socioeconomic Variations in Cancer Incidence and Stage at Diagnosis in New Jersey, 1996-2002 pdf
... INTENTIONALLY BLANK ACKNOWLEDGMENTS The following staff of the New Jersey State Cancer Registry and the Cancer Surveillance Program in the Cancer Epidemiology Services were involved in the ... inactivity, and a diet high in saturated fat and/ or red meat and low in fruits and vegetables • The lower incidence for whites and blacks in the areas with low poverty may be due in part to increased ... colorectal cancer, melanoma of the skin, oral cancer, and prostate cancer) , as well as lung cancer, the number one cancer killer in New Jersey The time period is the seven years from 1996 to 2002 for incidence...
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Tài liệu Nanotechnology in Cancer Treatment and Detection doc
... target the Cancer cells -Nanoparticles can be used to detect/monitor (by utilizing or adding optic, magnetic, and fluorescent properties) and to treat Cancer (by Heat ablation, chemotherapy, gene therapy) ... smaller than most human cells Cancer Nanotechnology research is interdisciplinary and incorporates Biology, Chemistry, Engineering, Medicine, and Physics Properties of Cancer Cells • Epidermal Growth ... chemotherapy drugs not reach the Cancer cells • Nanotubes, nanorods, dendrimers, nanospheres, nanoantennas, … using carbon, iron, gadolinium, gold, silicon, etc • Antigen binding peptide ligands...
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NOTES ON THE ROLE OF EDUCATION IN PRODUCTION FUNCTIONS AND GROWTH ACCOUNTING pot
... attainment; on the quality of his education (quality of the school facilities); and other knowledge he gained from his educational training or otherwise, in and outside of the school These are interrelated ... white and nonwhite), while the observed increase in ability with education in the South is only average or even lower.27 Given the quality of these data, the inherent arbitrariness in the scaling ... it in the future We know, however, the following things: Intelligence is not a fixed datum independent of schooling and other environmental influences It can be affected by schooling.17 It in...
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Báo cáo khoa học: Increased NADPH concentration obtained by metabolic engineering of the pentose phosphate pathway in Aspergillus niger docx
... Enzymes in boxes were subjected to metabolic engineering in this study Metabolites and enzymes in italics were measured in wild-type and engineered strains Enzymes involved in polyol formation and ... resulted in an increase of synthesis of pyridine nucleotide cofactors, as the total pool of these increased Whether the synthesis is regulated by the NADPH concentration remains speculation The G6PDH ... of the PLS regression than the data from the Gnd20 strain, in which the G6PDH activity and NADPH concentration were generally increased Therefore the correlations shown in Fig 4B should be interpreted...
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Minimum Wages and Employment: A Case Study of the Fast-Food Industry in New Jersey and Pennsylvania pot
... to the increase in the minimum wage by reducing on -the- job training and flattening the tenure-wage profile (see Jacob Mincer and Linda Leighton, 1981) Indeed, one manager told our interviewer in ... findings for the fast-food industry by comparing changes in teenage employment rates in New Jersey, Pennsylvania, and New York in the year following the increase in the minimum wage Again, these ... fell between the existing federal minimum wage in 1986 ($3.35 per hour) and the effective minimum wage in the state in April 1990 (the maximum of the federal minimum wage and the state minimum wages...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản xác định thời lượng học về mặt lí thuyết và thực tế điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha thông tin liên lạc và các dịch vụ từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25