the genetic basis of diversity in malaria parasites

... T2DM in the Malays has not been examined In this thesis, we begin by examining the impact of a family history of diabetes; to further assess the genetic basis of type diabetes, we next examine the ... objective of this thesis is to examine the genetic basis of type diabetes in the Chinese, Malay and Asian-Indian population living in Singapore To this end, we have examined several different facets of ... modify the effect of FTO variants, the interaction variable (SNP*physical activity) was included into the regression models The test of linear hypothesis was used to estimate the p-values of the interaction,...

Ngày tải lên: 14/09/2015, 08:48

... selection on the reduction of the ovariole number with this strain, in order to study the genetic control (chromosomal and epigenetical) in the determinism of to the ovariole number in Sitophilus ... with the germ cells At the end of the 2nd day, the germ cells come in close contact with the adjacent coelomic sacs and their mass divides into right and left halves The investing sheath of the ... directly on the differentiation process The persistence of these anomalies in the next generations, as well as the appearance of abnormal females in the progeny of irradiated fathers suggested a genetic...

Ngày tải lên: 09/08/2014, 18:21

... within each linkage group A minimum LOD of and maximum recombination fraction of 0.3 were fixed for the linkage group determination using the "find groups" command The order of the markers within ... allowed the synteny analysis of the A and B genomes, the comparison with diploid and tetraploid maps and the analysis of the introgression segments from the wild synthetic into the background of a ... segment with the best possible return to the background of the cultivated variety provided a set of lines offering an optimal distribution of the wild introgressions Conclusion: The genetic map...

Ngày tải lên: 12/08/2014, 03:21

... member of the cytokine family of receptors with several splice variants The long leptin receptor isoform is considered the principal signaling isoform The intracellular signaling system for leptin ... leptin levels are reduced 12 in obese individuals who lose weight (Halaas et al., 1995) This led to the hypothesis of resistance to the action of leptin in these individuals, so that the increase ... and the hormonal link between adipocyte and the brain The melanocortin system downstream of leptin became the focus of research efforts in the past decade The phenotypic similarity between murine...

Ngày tải lên: 11/09/2015, 09:02

... by the markers rather than describing the genetic diversity of the organism Although the results correlate with genetic diversity, the indices often have no biological meaning in a population genetic ... earthquake in central Taiwan resulted in the extinction of populations of L konishii and a loss of the genetic diversity (Hung et al., 2005) A loss of diversity can result in an increase in the genetic ... is the portion of genotypes containing the band 18 The Molecular Basis of Plant Genetic Diversity 4.1.2 Shannons information index (I) A coefficient that is often called the Shannon index of...

Ngày tải lên: 28/06/2014, 11:20

... protein and the mRNA were faint Effects of inhibitors of cGCS and GR on primary cultured testicular cells To investigate the contribution of de novo synthesis and the recycling of GSH to the intracellular ... protein metabolism in these cells Histone is rich in the basic amino acids, lysine and arginine, but contains no cysteine Protamine, which is replaced for hitstone via transit proteins during ... level of GR in the epithelia of the epididymis (Fig 1) As the epididymis is rich in sulfoxidase, the oxidation of sulfhydryls in the sperm head and tail would be mediated by this enzyme in a specific...

Ngày tải lên: 17/03/2014, 17:20

... minimization of the resulting model The active site heme ligand in the model of the pea HO was derived from that found in the human enzyme Visual inspection of the model was performed using the ... cDNA sequences of PsHO1 indicating the location of intron-exon boundaries The position of the mutation in pcd1 causing premature chain termination is indicated Numbers refer to the first and last ... Overall fold of PsHO1 including position of the bound heme molecule (B) Close up of heme binding pocket An asterisk indicates the space above the plane of the heme molecule, that is present in plant,...

Ngày tải lên: 30/03/2014, 11:20

... role in the induction of seizure activity [63] and mediating spatial encoding [64] The finding indicating that the transcript levels of several neurotrophins were elevated in the brain of the transgenic ... associated with induced expression of insulin-like growth factor binding protein-2 in the uterus and ovary and decreased expression of insulinlike growth factor binding protein-3 in the uterus These changes ... elevation of tissue contents of L-ornithine through the inhibition of ornithine transaminase only further expanded putrescine pools but not those of spermidine or spermine [32], indicating that the...

Ngày tải lên: 30/03/2014, 13:20

... observation of swallow initiation In this manner, the time code on the analog video corresponded to the time index of the digital recording of the vibration signal Methods Representation of swallowing ... frequently in rehabilitation engineering, for example, in the control of neural prostheses [49] and in the design of an intelligent wheelchair guidance system [50] For our experiments, the number of inputs ... ni − mi )2 i =1 ˆ mi N=∑ (2) In the above, ni is the observed frequency in the ith bin, and ˆ mi is the expected frequency in the same bin under the null hypothesis of a normal amplitude distribution...

Ngày tải lên: 19/06/2014, 10:20

... fraction of the Drosophila genome may be related to aggressive behavior raises interest in determining whether specific genes are directly involved in the trait, in quantifying the magnitude of their ... pleiotropic action of behavioral genes One of the most interesting findings to emerge from the investigation of aggression in Drosophila concerns the size and localization of mutation-induced expression ... important form of corroboration of the role of a given gene in contributing to complex behavioral traits Demonstrations of the importance of pleiotropy in the genetic regulation of behavioral...

Ngày tải lên: 06/08/2014, 19:21

... stained in ES staining solution and the other proteins were stained Fig Serum protein loci separated on the horizontal polyacrylamide gel (HPAGE) Alb: albumin, GC: vitamin-D binding protein, ... glycoprotein, TF: tranferrin Genetic Polymorphism of the Serum Proteins of Horses in Jeju 257 1) Genetic polymorphism of Albumin(Alb) locus Albumin is the most fast migrating protein component ... from Hardy-Weinberg genetic equilibrium test were 0.0742(p>0.05) in CNH, 0.0061(p>0.05) in CRH and 0.1562(p>0.05) in TB 2) Genetic polymorphism of vitamin-D binding protein (GC) locus The GC variants...

Ngày tải lên: 07/08/2014, 15:20

Ngày tải lên: 07/08/2014, 16:20

... by the square root of the respective sampling variances, obtained from the inverse of the average information matrix Using the estimated components of variance, approximations of additive genetic, ... standard errors of σp i were obtained by the square root of the respective sampling variances, and these were calculated from the sampling (co)variances of the components in the denominator of equation ... because the influence of parental PBVs on net offspring PBVs could dampen any changes in them compared with within-family breeding values (which are based on the part of the net offspring PBVs...

Ngày tải lên: 08/08/2014, 00:21

... estimated as the ratio of the number of branches on the 1988stem increment to the length of that increment and expressed as the number of branches per 10 cm long shoot; A 4-point grading system ... years of age) Instead of a species effect, these results rather suggest maternal effects, such as the influence of seed weight on growth of seedling during the first years But later on, the male ... techniques enhancing additivity In addition, other practical and economical considerations (such as the simplicity of the strategy, the length of the breeding cycle, the relative cost of intra-species...

Ngày tải lên: 08/08/2014, 01:22

... rs2280714 (T > C) gains in narrowing the disease associated interval owing to different patterns of linkage disequilibrium In this study of a Korean SLE cohort, we present associations of IRF5 variants ... alternate exon of IRF5 and might thus have a functional role by altering the splicing of exon of the IRF5 [2] Conclusion Association analysis of IRF5 polymorphisms revealed that the results in the Korean ... Transcription factors of the IRF family have essential roles in the regulation of genes induced by viral infection and immunostimulation, in addition to regulation of cell growth IRF5 was originally identified...

Ngày tải lên: 09/08/2014, 10:20

... evaluate whether the same genes were expressed in males and females The results of this analysis were used to calculate genetic parameters of and of the ratio of the trait expressed in males to the trait ... Analysis The analysis model was: where yZ!k is the performance of the jth animal from the kth dam, reared in the ith hatch, a the direct genetic effect of the jth animal, m! the maternal j genetic ... from the kth dam, ez!! the residual of the jth animal from the kth dam, reared in the ith hatch and cov(a, m) the covariance matrix between the vector of direct genetic effects (a) and the vector...

Ngày tải lên: 09/08/2014, 18:21

... Assuming that the main cost of reproduction is the time consumed by the male in discerning the sex of potential mates, increasing the number of mountings per unit time, at the risk of making some ... between individuals resulting in mounting respectively Thus, the response to divergent selection can be analysed in terms of the corresponding changes in the ratio a of these probabilities A value of ... persistence in mounting and the differential resistance offered by males and females to being mounted In this situation, the behaviour of mounting males as well as the differential reactions of the individuals...

Ngày tải lên: 09/08/2014, 18:21

... crosses In some cases, the seeds are viable in such crosses in one direction of cross but not the other In other combinations of interploidy crosses of different ecotypes, the seed failure occurs in ... entirely, but in other cases they reside elsewhere in the genome These results indicate that diversity is caused by mechanisms other than point mutation One of us (J.B.) reported the development of a ... directions of reciprocal crosses An interesting set of recombinant inbred lines was generated from a cross of tetraploids of one ecotype and diploids of another The re-establishment of tetraploids...

Ngày tải lên: 09/08/2014, 20:20

... obtained in both cases The variability of the genetic variance within lines in different generations has been represented by the corresponding coefficient of variation, as the magnitude of the genetic ... show that when the within-line component of the genetic variance is directly estimated, its value diminishes with increasing inbreeding In parallel, the between-line component increases A good ... variance of the trait in the i th line is V and ; , the mean and the variance of the distribution of the variances of the lines are V and V(1; ), respectively In each line, the phenotypic variance...

Ngày tải lên: 09/08/2014, 22:22

... appraisal of the conformation according genetic determinism to In the experiment we report in this paper, the degree of muscling was evaluated by the total weight of the most important muscles So in ... or not The gene effect and the dominance deviation were estimated through the fitting to the data of a monogenic model Regarding their degree of muscling, the breeds used in this cross the Friesian ... outcome of the inspection of the distribution of this quantitative variable considered as an expression of the muscle hypertrophy Furthermore, estimations of the gene effect and of the dominance...

Ngày tải lên: 09/08/2014, 22:23