the genetic basis of development

... background of the cultivated variety provided a set of lines offering an optimal distribution of the wild introgressions Conclusion: The genetic map developed, allowed the synteny analysis of the A ... introgression of a small fraction of the wild genome species while keeping the genetic background of the cultivated is a good mean to explore the largely untapped reservoir of useful alleles of interest ... development and the analysis of the genome-wide segment introgressions of the most probable wild progenitors of the cultivated peanut species (A duranensis and A ipaënsis) into the background of the cultivated...

Ngày tải lên: 12/08/2014, 03:21

... progression of appropriately timed pubertal development These reports of human leptin deficiency and the effects of leptin replacement provided the first evidence of the importance of leptin in ... on the AGRP/NPY neurons in the arcuate nucleus The Elusive Satiety Factor The regulation of energy balance has been the focus of discussion dating back to 1783, and the quest to understand the ... 1995) This led to the hypothesis of resistance to the action of leptin in these individuals, so that the increase in adipose tissue mass is maintained As the vast majority of obese individuals...

Ngày tải lên: 11/09/2015, 09:02

... contribute to the development of T2DM, genetic factors are also important in the pathogenesis of T2DM Over the course of my studies, the ease of genotyping has increased while the cost has continued ... examined In this thesis, we begin by examining the impact of a family history of diabetes; to further assess the genetic basis of type diabetes, we next examine the contribution of recently identified ... likely the cause of familial aggregation of diseases 7.3 THE COMPLEXITY OF THE GENETICS OF TYPE DIABETES Genetic studies of diseases have traditionally relied on two methods to discover the responsible...

Ngày tải lên: 14/09/2015, 08:48

... and evaluation of genetic diversity in plant populations These techniques can be chosen on the basis of how they display genetic differences, the type of data which they produce, the taxonomic ... dynamic process of genetic variation by presenting the thoughts of some of the scientists who are engaged in the development of new tools and ideas used to reveal genetic variation, often from very ... by the markers rather than describing the genetic diversity of the organism Although the results correlate with genetic diversity, the indices often have no biological meaning in a population genetic...

Ngày tải lên: 28/06/2014, 11:20

... the effects of large numbers of genetic variants of relatively small effect and, therefore, that genetic dissection of such traits will require investigation of samples of considerable size The ... determining whether specific genes are directly involved in the trait, in quantifying the magnitude of their effect, and in evaluating whether these genes also contribute to other traits The effect of a ... important form of corroboration of the role of a given gene in contributing to complex behavioral traits Demonstrations of the importance of pleiotropy in the genetic regulation of behavioral...

Ngày tải lên: 06/08/2014, 19:21

... or required further explanation of the need for their samples I often thought of the irony of the situation At these reunion parties, Dr Garcia would oversee the administration of the electrical ... with the arrowheads representing the short, direct repeats formed at the point of insertion The left half of Alu contains the A and B boxes of the RNA polymerase III promoter The two halves of the ... (3) elucidation of the chemical basis of heredity, the molecular basis of disease has been addressed in the context of how mutations affect the structure, function, or regulation of a gene or its...

Ngày tải lên: 05/03/2014, 23:20

... during their migration through the epididymis, the oxidation of sulfhydryls is related to the acquisition of motility [4,5] During epididymial migration, sulfhydryls in the nucleus and the tail of ... immunohistochemistry (data not shown) As the activity difference was small, the difference in intensity of the bands for the protein and the mRNA were faint Effects of inhibitors of cGCS and GR on primary cultured ... investigate the contribution of de novo synthesis and the recycling of GSH to the intracellular glutathione pool, the Ó FEBS 2002 1574 T Kaneko et al (Eur J Biochem 269) Fig GR activity and the protein...

Ngày tải lên: 17/03/2014, 17:20

Ngày tải lên: 18/03/2014, 02:20

... thought of as being in the domain of the doctor These nurses need to be taught skills during the first weeks of training which are themselves based on sound knowledge One of the skills they need ... existence of the individual The blood has the task of transporting: water and nutrients from the digestive system to the cells; oxygen from the lungs to the cells; carbon dioxide from the cells to the ... valve on the left and pulmonary valve on the right The aorta is the main artery taking blood from the left side of the heart for distribution around the body 31 THE BIOLOGICAL BASIS OF NURSING:...

Ngày tải lên: 22/03/2014, 22:20

... The structural basis of calpain behavior Y Benyamin two parts, DIIa and DIIb, come closer together, with concomitant release of constraints between the domains (large arrows) ... questions are raised by these molecular studies What is the correlation between the in vitro and in vivo Ca2+ requirements for calpain activity? How the two isoforms target their specific substrates ... and oscillations of [Ca2+], in particular those involving specific phosphorylations of calpastatin, calpains and targets The following Minireviews develop three themes on the role of calpain and...

Ngày tải lên: 23/03/2014, 10:21

... it arises in the same way with the lexis The first stage is likewise one of translation equivalence, the second stage is the use of the determining features of the target language The question ... equivalences The autonomy thus acquired by the lexis of the target language allows the thesaurus stage of the dictionary to be the same for one target language whatever the source language, and at the ... language, and the particular determining features of the latter The less use made of comparative systematization, the more use must be made of the particular systematization of the target language...

Ngày tải lên: 23/03/2014, 13:20

... characterized the contribution of these assay components by omitting them individually In the absence of ferredoxin the reaction rate decreased to 46.5% of the complete reaction while the absence of ascorbate ... account for the failure of the PsHO1 probe to detect any HO2-like sequences in Southern blot experiments Whatever the basis of the recovery of phytochrome responses in older pcd1 plants, they still ... Arrows indicate the direction of the major changes in absorption over the course of the measurements (C) Michaelis– Menten plot of the PsHO1 reaction for heme concentrations of 1, 2, 5, 10 and...

Ngày tải lên: 30/03/2014, 11:20

... the amount of DNA belonging to a haploid nucleus, expressed in picograms (10–12 g) This is an indicator of the size of the nuclear genome It has become clear that the size of the genome has often ... barley (Hordeum vulgare), adapt their biosynthetic pathways by reducing the synthesis of glycine and serine, but increasing the synthesis of many other kinds of amino acid, including those with ... CONCERN Watson’s book The Double Helix9 The Watson–Crick model laid the foundation for breaking the genetic code For a sequence of bases in one strand of DNA to specify the sequence of amino acids in...

Ngày tải lên: 20/04/2014, 14:26

... the amount of DNA belonging to a haploid nucleus, expressed in picograms (10–12 g) This is an indicator of the size of the nuclear genome It has become clear that the size of the genome has often ... barley (Hordeum vulgare), adapt their biosynthetic pathways by reducing the synthesis of glycine and serine, but increasing the synthesis of many other kinds of amino acid, including those with ... CONCERN Watson’s book The Double Helix9 The Watson–Crick model laid the foundation for breaking the genetic code For a sequence of bases in one strand of DNA to specify the sequence of amino acids in...

Ngày tải lên: 24/04/2014, 14:00

... in the common sense of the word Chance and confusion play no role in the weather, in the irregular pattern of the earth’s orbit, in the growth pattern of a tree, or in the population limits of ... to further the systems basis of architecture: function as the foundation of design and industrial standardization as the basis of construction The Bauhaus sought to close the gap between the progress ... coincidence that placed these presentations back to back: the last of the structural eras and the first of the environmental ones The changing of the guard officially occurred in the early 1970s and...

Ngày tải lên: 29/04/2014, 15:42

... of the ownership, regardless of the level of the target group Finally, since the development agency is the source of the aid, it usually retains a great deal of control over the distribution of ... there was a strong sense of Swedish ownership of the Programme, both influencing the pattern of support and the phase out problems The lack of Tanzanian ownership was reflected in the role of ... individual has of the likely behavior of others Strategies are designed based on the individual’s perceptions of the likely benefits or costs that they will receive in light of their own and others’ actions...

Ngày tải lên: 10/06/2014, 23:39

... surrounding development assistance and the environment The compilation and analysis of the PLAID database that forms the backbone of this book has put us in the debt of many people, most of all our ... generating hypotheses, and establishing the scope conditions of more general theories However, no matter how compelling the case studies, they cannot alone bear the weight of the broad theoretical ... the effect of reducing dirty aid and increasing environmental aid on the social development of the poorest states There are many ‘lost’ countries that receive little aid of either type, and often...

Ngày tải lên: 11/06/2014, 00:10

... length of human life, according to the Greeks, was in the hands of the Fates, or Moerae These three sisters, daughters of the Goddess of the Night, measured out the beginning, the middle, and the ... isolation of many elderly people T h e overall loss of the ability to control the image of ourselves seen by others may be one of the most devastating changes of growing old, ranking with the fear of ... percent of what it was at the end of the nineteenth century These factors still compromise the survival of women in some parts of the world T h e reason for the longer average lifespan of women...

Ngày tải lên: 11/06/2014, 05:26

... readers to put the development industry into the context of the global political economy of development, or at least that is the book’s aim In other words, despite all the recent talk of poverty ... this level, but there is another, higher level, the zone of the anti-market, where the great predators roam and the law of the jungle operates This … is the real home of capitalism’ (Braudel 1982: ... internationalisation of capital and which in turn help shape the character of uneven and combined capitalist development in the South The series questions neoliberal theories of development and modernisation...

Ngày tải lên: 20/06/2014, 20:20

... the Northern states, borrowing money from them rarely helps the poor, it just deepens the debt cycle and turns the private sector of the developing country into a playground for the rich of the ... moved into the position of primary lenders In this sense, a process of socialisation of cost in development finance took place, in lieu of a return to the privatisation of profit The weight of credit ... introduces the reader to the contours of the political economy of development and the institutional regime within which ‘creditor states’13 compete and co-operate in the extension of markets The term...

Ngày tải lên: 20/06/2014, 20:20