the expression of ideas
Báo cáo y học: "Effect of antibodies on the expression of Plasmodium falciparum circumsporozoite protein gene"
... observations the authors suggested that malaria sporozoites are able to control the protein synthesis machinery in cells of the vertebrate host, which could explain the differences in the levels of expression ... that there was no gDNA contamination PCR reaction triplicates showed no major differences among them and expression levels of the internal control were similar in the different experiments The expression ... which they were isolated had an inhibitory effect [7] The number of mature liver schizonts increased in the presence of mAbs anti-CSP of P yoelii and the authors suggested that enhancement of infection...
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Tài liệu Báo cáo khoa học: ¨ Induction of Kruppel-like factor 4 by high-density lipoproteins promotes the expression of scavenger receptor class B type I pptx
... inhibition of proliferation of VSMC, which is mechanistically linked to a KLF4-induced enhancement of the expression of the tumour suppressor gene p53 [5] Because of the important roles of KLF4 on the ... found that the promoter of SR-BI contained multiple putative KLF4 binding sites However, the direct effect of KLF4 on the expression of SR-BI remains unknown Here, the expression of KLF4 in response ... an important role in the activation of endothelial cells and macrophages, as well as the differentiation and proliferation of VSMCs Overexpression of KLF4 induced expression of multiple anti-inflammatory...
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Tài liệu Báo cáo khoa học: Hypoxia reduces the expression of heme oxygenase-2 in various types of human cell lines A possible strategy for the maintenance of intracellular heme level pdf
... Effects of hypoxia on HO-1 and HO-2 expression in human cell lines We initially analyzed the effects of hypoxia on the expression of HO-1 and HO-2 in human cell lines of Reduced expression of heme ... in the mouse liver after days of normobaric hypoxia (10% oxygen) and returned to the basal level after 14 days of hypoxia [26] It is therefore of significance to study the regulation of HO-2 expression ... together, these results indicate that hypoxia reduces the expression levels of HO-2 mRNA and protein in five out of six cell lines, with the exception of KG1 myeloid cells A Hypoxia decreases the...
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Tài liệu Báo cáo khoa học: Parvalbumin deficiency in fast-twitch muscles leads to increased ‘slow-twitch type’ mitochondria, but does not affect the expression of fiber specific proteins doc
... similar way [19] When comparing the MLC region of the 2D gels between TA from PV– ⁄ – and PV+ ⁄ + mice, the pattern is virtually identical with the exception of the lack of the PV spot in PV– ⁄ – mice ... promoter regions of the PV and MLC3F gene has been previously observed A segment of 32 bp was identical in both genes and, based on these findings, the authors proposed that the expression of PV and ... levels of MLC3 and PV are much higher in TA than in SOL, the ratio of the two proteins in each of the two muscles seemed to be constant (Fig 2C) A high degree of homology between short segments of...
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Tài liệu Báo cáo khoa học: Oxygen tension regulates the expression of a group of procollagen hydroxylases docx
... chromosomes the question arises concerning the mechanisms underlying the orchestrated expression of these enzymes by the oxygen tension The findings that the effect of hypoxia on the gene expression of the ... transcription factor (HIF) in the activation of P4h, and PLOD gene expression by hypoxia, we further examined the expression of these genes in a cell line with a defective HIF, namely the murine hepatoma ... thus on the one hand fully support these previous findings and on the other hand extend them by far and set them in a more general context, as both a-subunits of P4h, PDI as the b-subunit of P4h...
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Tài liệu Báo cáo khoa học: Adaptive changes in the expression of nuclear and mitochondrial encoded subunits of cytochrome c oxidase and the catalytic activity during hypoxia pptx
... study therefore, we investigated how O2 modulates the expression of mRNAs for CytOX subunits and also the catalytic activity of the enzyme complex Our results show that the levels of some of the ... and alters the expression of the two nuclear genome coded isoforms of CytOX V [10,32] The regulation of genes CytOX5a and CytOX5b, coding for the two isofoms Va and Vb, parallels that of genes ... hypoxia on the steady state levels of nuclear genome encoded CytOX IV and Vb mRNAs There was no change in the levels of these mRNAs in macrophages at h of hypoxia, the time point at which there was...
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Báo cáo khoa học: Neural retina leucine-zipper regulates the expression of Ppp2r5c, the regulatory subunit of protein phosphatase 2A, in photoreceptor development pdf
... [34–36], might regulate the expression of Ppp2r5c mRNA prior to the appearance of Nrl in the retina Like the increase in Nrl expression during development, Ppp2r5c mRNA expression was precisely ... the induction of Ppp2r5c transcripts that corresponded to the transcription factor association (Fig 4E) However, prior to the association of Nrl with the Ppp2r5c promoter in the early stage of ... To further examine whether the increased expression of Ppp2r5c transcripts was specifically modulated by Nrl, we used Nrl small interfering RNA (siRNA) transfectants in which the expression of Nrl...
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Báo cáo khoa học: Amino acid limitation regulates the expression of genes involved in several specific biological processes through GCN2-dependent and GCN2-independent pathways ppt
... effects on the expression of 12 genes and opposite effects on the regulation of eight genes These results suggest that rapamycin inhibition of TORC1 modifies the expression of a set of genes that ... (indicated in bold) The enrichment for a given GO category was computed as the ratio of the distribution of the amino acid-regulated genes* versus the distribution of the genes spotted onto the microarray** ... threefold higher than the background in the control medium We then measured the effect of amino acid depletion on gene expression The results are given as the induction ratio between the expression levels...
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Báo cáo khoa học: Silencing the expression of mitochondrial acyl-CoA thioesterase I and acyl-CoA synthetase 4 inhibits hormone-induced steroidogenesis potx
... production (the major steroid produced by the MA-10 cell line) and correlated the steroid-producing capability with the level of protein expression as assessed by western blot The expression of MTE-I ... 8Br-cAMP and arachidonic acid synthesis [12] On the basis of these results, silencing the expression of ACS4 should also result in inhibition of hormone-induced steroid synthesis siRNA duplexes directed ... acids were unable to reproduce its effect The role of MTE-I in the regulation of steroid synthesis was further confirmed by the observation that overexpression of this acyl-CoA thioesterase leads to...
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Báo cáo khoa học: The expression of retinoblastoma and Sp1 is increased by low concentrations of cyclin-dependent kinase inhibitors ppt
... annealing of primers to nontarget DNA The lower solution contained the cDNA, the MgCl2, the dNTPs, the [32P]dATP[aP] and one half of the buffer, and the upper solution contained the four primers, the ... autoradiographs of the amplified products and the quantification of the bands is shown in the bottom panels Rb and Sp1 mRNA levels were determined from the ratio of the intensities between the Rb or Sp1 and the ... However, there are also some differences, namely (a) in the case of Rb, there is an increase in both the levels of mRNA and the stability of the protein, while the degradation rate of Sp1 does...
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Báo cáo Y học: The expression of glutathione reductase in the male reproductive system of rats supports the enzymatic basis of glutathione function in spermatogenesis doc
... during their migration through the epididymis, the oxidation of sulfhydryls is related to the acquisition of motility [4,5] During epididymial migration, sulfhydryls in the nucleus and the tail of ... Kelce, W.R & York, J.L (1996) Differential expression of glutathione S-transferase isoforms in compartments of the testis and segments of the epididymis of the rat Drug Metab Dispos 24, 725–733 Ó ... immunohistochemistry (data not shown) As the activity difference was small, the difference in intensity of the bands for the protein and the mRNA were faint Effects of inhibitors of cGCS and GR on primary cultured...
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Báo cáo khoa học: Thyroid hormone induces the expression of 4-1BB and activation of caspases in a thyroid hormone receptor-dependent manner pptx
... (Affymetrix) and the levels of the expression of each cDNA and of the reliability (Present/Absent call) were calculated with software (AFFYMETRIX MICROARRAY SUITE ver.4.0) For comparisons of the expression ... contains the sequence of TRE, but DR0 does not Therefore, the transcription of the luciferase from the DR4-pGL2 enhancer/promoter should be dependent on the activation of TR and that from the DR0-pGL2 ... responses We also examined the expression of TRAF1 and TRAF2 because they interact and regulate the function of the 4-1BB proteins to induce NF-jB [18] In the absence of T3, neither HeLa nor HeLaTR...
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Báo cáo khoa học: Glutamine stimulates the gene expression and processing of sterol regulatory element binding proteins, thereby increasing the expression of their target genes docx
... imply the involvement of the O-glycosylation of Sp1 in the induction of SREBP-1a transcription by glutamine The gene expression of SREBP-1c, which represented less than 20% of the SREBP-1a gene expression ... after the addition of glutamine, the gene expression of the SREBP targets, such as HMG CoA synthase and the LDL receptor, was slightly increased, but then the mRNA levels of both SREBPs and their ... for the constituent of membrane, we examined whether glutamine regulates the expression of genes involved in cholesterol homeostasis To investigate the effect of glutamine on the transcription of...
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Báo cáo khoa học: Sp1 binds to the external promoter of the p73 gene and induces the expression of TAp73c in lung cancer doc
... development [7] The gene produces numerous isoforms as a result of: (a) alternative splicing in the 3¢-end (leading to the formation of a, b, c, d, e, f and g isoforms) [8–12]; (b) the use of an extrinsic ... progression is attributed to the TA ⁄ DM ratio, rather than the overexpression of a specific p73 isoform or a specific class of p73 isoforms per se [20,21] In line with this concept, the selective promoter ... affect the use of the p73 P1 promoter, we identified a region )233 to )204 bp upstream of the TSS of the human p73 P1 promoter containing conserved, functional Sp1-binding sites Reduction of the...
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Báo cáo khoa học: PKA independent and cell type specific activation of the expression of caudal homeobox gene Cdx-2 by cyclic AM pptx
... observations, we further investigated the involvement of PKA in Cdx-2 expression First, we compared the effects of PKAc cotransfection on the expression of the Cdx-2 promoter vs the proglucagon gene ... cotransfection of PKAc restores its PKA activity Finally we tested the effect of H-89, a known inhibitor of PKA, on the expression of both the proglucagon gene promoter and the Cdx-2 gene promoter in the ... shown in Fig 5, the effects of H-89 on these two promoters are apparently different At the concentrations of either 0.1 or lm, H-89 significantly repressed the basal expression of the proglucagon...
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Báo cáo khoa học: Myocyte enhancer factor 2 (MEF2) is a key modulator of the expression of the prothoracicotropic hormone gene in the silkworm, Bombyx mori ppt
... the lateral region of the brain in each hemisphere [14] Regulation of PTTH gene expression by controlling BmMEF2 expression To investigate whether the expression of BmMEF2 affects PTTH gene expression, ... that the MEF2 binding sequences in the PTTH promoter enhance expression of the EGFP reporter gene in PTPCs and are important for binding of the BmMEF2 protein Furthermore, overexpression of the ... nih-image/), the relative fluorescence intensity of the PTPCs was determined as the intensity of the individual cells relative to the mean pixel fluorescence for the entire somata (S) of the brain...
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Báo cáo khoa học: "THE EXPRESSION OF LOCAL RHETORICAL RELATIONS IN INSTRUCTIONAL TEXT*" pdf
... the action determines, in part, the form of the expression In (4a), the action is being performed by the reader which leads to the use of a present tense, relational clause In (4b), on the other ... this the terminating condition form In this case, the use of this form marks the fact that the readers don't have to redo the action PURPOSES One important factor in the choice of form is the ... regularities in their expression We will now look at some representative examples of these alternations which illustrate the various contextual factors that affect the form of expression of rhetorical...
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Báo cáo hóa học: "Inhibiting adenoid cystic carcinoma cells growth and metastasis by blocking the expression of ADAM 10 using RNA interference" pdf
... to the standards of animal care as outlined in the Guide for the Care and Use of Experimental Animals of the Medical College of Shanghai Jiaotong University The study protocol was approved by the ... efficiency of the target gene after RNAi The cell line with stable transfection and effective inhibition of the ADAM 10 gene was named SACC-ADAM 10-RNAi, and the cell line with stable transfection of the ... counting the cells that migrated to the lower side of the filter with optical microscopy at 400× A total of five visual fields at the center and in the surrounding areas were counted, and the average...
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báo cáo hóa học: " 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) attenuates the expression of LPS- and Aβ peptide-induced inflammatory mediators in astroglia" pptx
... 172 of the α1/α2 subunits and on Ser 108 of the β subunit of AMPK AICAR treatment of glial cells activated AMPK as evident from the enhanced intensities of the phosphospecific protein bands of ... (in the form of 'neurofibrillary tangles') are pathological hallmarks of the disease and are believed to contribute to many of these alterations of neuronal structures [42] More so, areas of the ... upregulated by the addition of Aβ (25–35) peptide The induction of these pro-inflammatory mediators was also significantly attenuated by AICAR (Fig 5) Further, the increased expression of anti-oxidant...
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báo cáo hóa học: " Participation of MCP-induced protein 1 in lipopolysaccharide preconditioning-induced ischemic stroke tolerance by regulating the expression of proinflammatory cytokines" pdf
... regulation of expression of proinflammatory cytokines Furthermore we investigated the effects of MCPIP1 on JNK signal pathway under brain ischemia conditions and the effects of JNK inhibitor on the ... generated the figures, and wrote the manuscript JW did parts of the animal surgery JW, YS, LW, EB performed the experiments PEK provided advice in the design of the study and in interpreting of data ... 8D) and the expression of proinflammatory cytokines measured at 12 h and 24 h after MCAO compared with vehicle group (Figure 8E) These results support the hypothesis that activation of JNK signaling...
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