the example of the vegf family
Tài liệu The Unix Family of Operating pdf
Ngày tải lên :
21/12/2013, 11:15
... Versions of Unix There are several versions of Unix Until a few years ago, there were two main versions: the line of Unix releases that started at AT&T (the latest is System V Release 4), and another ... systems Our examples show the bash shell and the GNOME and KDE window environments We’ve chosen them because they’re popular and make good examples, not because we think they’re always the best.” ... keyboard and then press the RETURN key The lefthand column tells you what will happen After you try the commands, you’ll have a better idea of the ones you want to learn more about You can then get...
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Tài liệu An Example of Using the Get* Methods phần 1 pdf
Ngày tải lên :
24/12/2013, 01:17
... knowing the type of the database column If you don't know the type of a column, you can get it using Visual Studio NET's Server Explorer For example, Figure 9.1 shows the details of the ProductID ... variables of the appropriate type are created in this while loop, each of which is used to store the result from the Get* method For example, the productID variable is used to store the ProductID ... ProductID is of the SQL Server int type, the appropriate C# type for the productID variable is int To get the ProductID column value as a C# int, you call the GetInt32() method Similarly, the productName...
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Tài liệu An Example of Using the Get* Methods phần 2 docx
Ngày tải lên :
24/12/2013, 01:17
... GetSqlGuid() Next you'll see how to use some of the methods shown in Table 9.7 An Example of Using the GetSql* Methods Let's take a look at an example that reads the ProductID, ProductName, UnitPrice, ... it may be used to read the columns from the Products table The following while loop uses the GetSql* methods and returned Sql* types shown earlier in Table 9.8 to obtain the column values from ... columns from the Products table using the GetSql* methods To figure out which GetSql* method to use to retrieve a particular column type, you use Table 9.7, shown earlier For example, the ProductID...
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Tài liệu 77 Introduction to the TMS320 Family of Digital Signal Processors docx
Ngày tải lên :
25/12/2013, 06:16
... “opcode” of the instruction The opcode is the unique identifier of the instruction The next four bits, 1000, are the shift of the operand Then there is one bit (zero in this case) to signal that the ... simplified form the key features of the TMS320C30 The major parts of the DSP processor are the memory, the CPU, the peripherals, and the direct memory access (DMA) unit Each of these parts will ... ALU of the TMS320C30 The heart of the TMS320C30 is the CPU consisting, primarily, of the multiplier and the ALU The CPU configuration is shown in Fig 77.16 which depicts the multiplier and the...
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Tài liệu Đề tài " Statistical properties of unimodal maps: the quadratic family " pptx
Ngày tải lên :
16/02/2014, 05:20
... Sketch of the proof of the phase-parameter relation The proof of the phase-parameter relation uses ideas from complex analysis We will provide a sketch of the proof assuming familiarity with the ... Ξi (Ci ) ∩ Fκ then Ξi (Ci ) = Ji+1 [g] We will concentrate on the analysis of the regularity of Ξi for the special class of simple maps f : one of the good properties of the class of simple maps ... to the validity of the Law of Large Numbers Are other theorems still valid, like the Central Limit or Large Deviation theorems? Those questions are usually related to the rates of mixing of the...
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Tài liệu Báo cáo khoa học: SREBPs: physiology and pathophysiology of the SREBP family ppt
Ngày tải lên :
18/02/2014, 13:20
... and pathophysiology of the SREBP family H Shimano at G1 [19] In particular, p21 is a direct target of SREBP [20] The role of SREBP-1a in the regulation of cell growth and the cell cycle might ... Physiology and pathophysiology of the SREBP family SREBP-1c and lipogenesis The SREBP family consists of three isoforms: SREBP1a, SREBP-1c, and SREBP-2 Each isoform has a different regulatory ... resistance [48] The exact roles of SREBP-1c ⁄ ADD1 are not yet fully defined SREBP and parasympathetic function in heart Parasympathetic stimulation of the heart involves activation of GIRK1 ⁄ 4,...
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Tài liệu Báo cáo khoa học: nsights into the reaction mechanism of glycosyl hydrolase family 49 Site-directed mutagenesis and substrate preference of isopullulanase doc
Ngày tải lên :
19/02/2014, 16:20
... composed of residues 25–540 The overall structure of the model of IPU and the mutated residues in this study are shown in Fig To elucidate the mechanism of the substrate recognition of IPU, two ... a-(1fi4)-linked glucose units of pullulan (Fig 4A) IPU is an anomer-inverting enzyme Comparison of the active sites of the model of IPU and Dex49A The active site structures of the model of IPU (Fig 4A) and ... compare the mechanism of hydrolysis of IPU and other GH family 49 dextranases, the anomer configuration of the hydrolysate of IPU was determined A polarimetric assay was carried out using panose as the...
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Tài liệu Báo cáo khoa học: Proteasome involvement in the degradation of the Gq family of Ga subunits pptx
Ngày tải lên :
20/02/2014, 03:20
... activation of Ga16 and Gaq subunits Therefore the lack of change in the rate of degradation cannot be due to lack of receptor-activation of the alpha subunits Given that the activation of G proteins ... Accordingly, the levels of Ga16 decay were the same in the presence or absence of carbachol (Fig 4C) in cells expressing the M2R Also the activated mutant of A B C D Fig Functional assay of the Ga ... forms of Gaq and Ga16 have the same behavior as the wild-type forms argues in favor of the need of other proteins to stabilize the proteins in the membrane The interaction of Ga subunits with Gbc...
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Tài liệu Báo cáo khoa học: Characterization of the promoter for the mouse a3 integrin gene Involvement of the Ets-family of transcription factors in the promoter activity doc
Ngày tải lên :
21/02/2014, 03:20
... factor of the Ets -family is involved in the regulation The members of the Ets -family of transcription factors bind to specific purine-rich sequences with a core motif of GGAA/T and control the expression ... CCAAT box at 324 bp upstream of the major transcription start site The presence of a CCAAT box and the absence of a TATA box seem to be one of the characteristics of the mouse integrin a3 gene ... and the sets of primers listed in Table After the PCR products were digested with KpnI and SacI, the fragments were inserted into the KpnI/SacI site of Fig Structures of the 5¢-flanking region of...
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Báo cáo khoa học: Expression and characterization of the protein Rv1399c from Mycobacterium tuberculosis A novel carboxyl esterase structurally related to the HSL family docx
Ngày tải lên :
07/03/2014, 16:20
... presence of Arg213 along with the proximity of the charge relay Asp260 within the active site could be responsible for the modification of the catalytic properties of the catalytic histidine The strength ... amides of Ala163, Gly89 and Gly90, the latter’s being found in the HGGG consensus sequence motif characteristic of members of the HSL family [35] Our model shows that the architecture of the active ... efficient nucleophilic attack of the substrate ester bond by the serine alcoholate The shape of the titration curve of the catalytic histidine shows an apparent pKa value of the essential histidine...
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Báo cáo khoa học: Secondary transporters of the 2HCT family contain two homologous domains with inverted membrane topology and trans re-entrant loops docx
Ngày tải lên :
07/03/2014, 17:20
... ‘filtering’ of the blast searches strongly improves the specificity of the search (the ratio of true over false hits) but at the expense of much of the sensitivity of the search (the number of observed ... FEBS Structure of 2HCT transporters Fig Model of the structure of the transporters of the 2HCT family in class ST3 See text for explanation The charge distribution gives the sum of the positive ... the loop regions of a multiple sequence alignment of 16 representative members of the 2HCT family a2 repeats) enter the membrane from opposite sides of the membrane However, the position of the...
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Báo cáo Y học: Properties of group I allergens from grass pollen and their relation to cathepsin B, a member of the C1 family of cysteine proteinases pdf
Ngày tải lên :
08/03/2014, 22:20
... parasites of the genus Giardia are one of the earliest lineages of eukaryotic cells, and the Giardia protease is the earliest known branch of the cathepsin B family [23] Its phylogeny confirms that the ... concentrating the allergen according to the isoelectric point (pI) of the molecule A pH gradient from to 11 was established for the characterization of Phl p After completion of the run, the individual ... further explore the biochemical function of group I allergens Expression of glycosylated and nonglycosylated rPhl p reveals differing stability of these allergens The expression of rPhl p in the...
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Báo cáo khoa học: Structures of type B ribose 5-phosphate isomerase from Trypanosoma cruzi shed light on the determinants of sugar specificity in the structural family ppt
Ngày tải lên :
15/03/2014, 00:20
... their equivalents in the other subunit of the second dimer (Fig 4A) In the case of P21212 (TcRpiB-R5P), the four molecules in the asymmetric unit represent the tetramer The two active sites of ... Some of these compounds inhibit MtRpiB [13] The difference in the behaviour of the two enzymes appears to arise from the slightly broader active site in MtRpiB as a result of the switch of the ... in the biological cycle of the parasite (i.e the epimastigote and the metacyclic trypomastigote in the insect vector, and the intracellular amastigote and the bloodstream trypomastigote in the...
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Báo cáo khoa học: The ROQUIN family of proteins localizes to stress granules via the ROQ domain and binds target mRNAs pdf
Ngày tải lên :
15/03/2014, 11:20
... above the relevant lanes, and the absence of any added protein is indicated by ()) The position of the free RNA and of the loading slots is indicated to the right of each gel A B abolished by the ... granules is shared by the MNAB protein encoded by the other member of the mammalian Rc3h gene family, Rc3h2 Stress granule localization is likely to be critical for the function of these proteins, ... series of GFP fusions with the various motifs of Roquin, and by selectively deleting domains from the full-length protein, we determined that the ROQ domain in the N-terminus of the protein is the...
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Báo cáo khoa học: A structural overview of the PDI family of proteins docx
Ngày tải lên :
15/03/2014, 23:20
... Specifically, the side chains of Leu343 and Trp347, which are part of the linker between the b¢ and a¢ domains, are inserted into the PDI family of proteins hydrophobic cavity of the b¢ domain The binding ... Representation of the full-length ERp57 structure with the region recognized as the x-linker colored in red (B) The N-terminal part of the x-linker folds against the b¢ domain in the structures of the ERp57 ... conformations in the structures of the isolated b¢ domain and full-length proteins In the crystal structure of the b¢x fragment of human PDI, the C-terminal part of the x-linker turns back to contact the...
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Báo cáo khoa học: Structural recognition of an optimized substrate for the ephrin family of receptor tyrosine kinases pot
Ngày tải lên :
16/03/2014, 02:20
... they in the EPHOPT complex (Fig 3) In addition, the backbone atoms of the Trp– Table Kinetic data The upper panel shows the effect of varying amino acids at the +2 position of the substrate The ... flexibility of these two regions, several other kinase resi˚ dues within A of the EPHOPT substrate are also shown These residues are clearly fixed in their orientation regardless of whether substrate ... movement) and the N-terminal part of the substrate has moved out of the kinase subsite delineated by residues Arg712 and the region including residues Arg823–Asn830 The side chain of Lys785 in the EphA3:OPTYF...
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Báo cáo khoa học: The noncatalytic C-terminus of AtPOLK Y-family DNA polymerase affects synthesis fidelity, mismatch extension and translesion replication ppt
Ngày tải lên :
16/03/2014, 10:20
... incorporation of a G opposite the next C in the template or by misalignment of the primer-terminal G with the next C followed by the incorporation of a C We incubated either AtPOLK or AtPOLKDC in the presence ... On the other hand, truncation of the C-terminal domain increases the bypass efficiency and decreases the efficiency of A insertion, thus reducing mutagenic translesion synthesis Taken together these ... reduction in the apparent Km for the nucleotide It is possible that deletion of the C-terminal 193 amino acids of AtPOLK modifies the conformation of the active site, causing higher affinity of the enzyme...
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Báo cáo khoa học: Characterization of ubiquitin-like polypeptide acceptor protein, a novel pro-apoptotic member of the Bcl2 family pptx
Ngày tải lên :
17/03/2014, 10:20
... performed immunoblotting of the 33.5 kDa Ubi-L adduct using an antibody against synthetic peptide based on the sequence of Bcl-G The results of the Fig Primary structure of Bcl-G (A) The predicted amino ... the gene products of Bcl-G and Ubi-L The fourth column indicates the number of the first and last amino acid of the identified Bcl-G and Ubi-L peptides, whereas the fifth shows the corresponding ... bonds between the C terminal of the glycine residue of Ubi-L and the lysine of Bcl-G The 33.5 kDa Ubi-L adduct was digested by V8 protease and subjected to MALDI-MS analysis The data in the first column...
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Báo cáo khoa học: New members of the brachyurins family in lobster include a trypsin-like enzyme with amino acid substitutions in the substrate-binding pocket potx
Ngày tải lên :
23/03/2014, 03:20
... modelling The aim of the present work was to study the diversity of trypsins in the digestive gland of P argus, with focus on: (a) the position of lobster trypsins within the brachyurins family ... from the 3¢ UTR region of PaTry2 However, the 3¢ UTR sequence of PaTry4 differed to those of the other trypsins in more than 36% of its nucleotides All ORFs started at the first ATG codon of the ... the wall of the binding pocket and allow the access of bulky residues, like Arg and Lys, whereas the basic side chain of these residues is stabilized by Asp189 (chymotrypsin numbering) near the...
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Báo cáo khóa học: The structure–function relationship in the clostripain family of peptidases potx
Ngày tải lên :
23/03/2014, 12:20
... mechanisms [42,44] The study of the effect of pH on enzyme inactivation allows the calculation of the pKa of the His176 side chain involved in the inactivation reaction The rate of inactivation ... nitrogen atoms of the backbone of the residue preceding the catalytic Cys The conservation of this interaction is suggestive of its Fig The nal model of the clostripain catalytic domain The ribbon ... nonapeptide The nal residue of the resultant a-chain, Arg181, and the rst residue of the b-chain, Ala191, are also labelled (italics) The magenta colouring towards the bottom of the gure marks the position...
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