the emphasis is placed on

Ngày tải lên: 13/08/2014, 16:21

... region of Rac1b (dotted green line on the right), where the 19 amino acid insertion of Rac1b is found, is disordered in the crystal. The mostly disordered structures of the switch II region are ... expression relative to the control in the untreated condition, considered as 100%. The data are representative of two independent experiments. O. Visvikis et al. Ubiquitination of Rac1 is regulated ... orange on top. There is only a minor change in orientation of the lysine side chain. O. Visvikis et al. Ubiquitination of Rac1 is regulated by JNK FEBS Journal 275 (2008) 386396 ê 2007 The Authors...

Ngày tải lên: 18/02/2014, 16:20

... when in the inner nuclear membrane compared with when it is still in the ER [5]. This is con- sistent with the theory that it is stably anchored at the nuclear membrane through its interaction with ... a PKA-dependent manner, one of which we identified as S49. This is consistent with earlier results describing the isolation of a large protein complex consisting of PKA, the A-kinase anchoring protein ... YT521-B, since their binding sites all encompasses this residue [37]. If this proves to be the case, then the X-EDMD patient with the mutation S54F (which is in the Btf binding region), where emer- in...

Ngày tải lên: 17/03/2014, 17:20

... về từ đó) The girl is having a birthday party on next Sunday. The girl is having a birthday party on next Sunday 3. Tại sao câu trên lại dịch như vậy? - The girl” – ... nhật, trong cụm danh từ này nó sẽ dùng để bổ nghĩa cho danh từ “party” - bữa tiệc/ buổi liên hoan. - on next Sunday”- vào ngày chủ nhật tuần sau. Trong đó on là giới từ (preposition) có ... *The girl is having a birthday party on next Sunday. 1. Chúng ta hãy quan sát câu sau. Các bạn hãy di chuột vào từng từ một để biết thể loại từ của từ đó trong câu: (Các bạn...

Ngày tải lên: 20/03/2014, 00:20

... rather taken into account the steps taken to minimise bias. In this review, this study therefore retains its status as a high quality evaluation. This decision is discussed further in section ... assumptions is not sufficient. There is a need for rigorous impact evaluation and systematic review of the evidence to inform such decisions. The work of the Poverty Action Lab, 3ie and others is ... institutions. In the context of the commercialisation (both the turn towards profitability by MFIs and the entrance of private financial institutions into the microfinance field), concerns about mission...

Ngày tải lên: 22/03/2014, 21:20

... between the two monomers is the prehelix loop comprising resi- dues Phe66 to Met72 of BMP-6 (Fig. 1C). In con- former 1, the loop strongly deviates from the canonical backbone conformation observed ... that the noncanonical conformation of the prehelix loop of BMP-6 would prevent binding of BMPR-IA, due to steric hindrance, whereas the canonical loop conforma- tion (BMP-2-like conformation) ... undergoes a disorder-to-order transition upon complex formation. This induced-fit mechanism might explain the high degree of promiscu- ity in the BMP ligand–receptor interaction, as it allows the ligand...

Ngày tải lên: 23/03/2014, 07:20

... (at least the one generated chemically) does not proceed via the quinone methide tautomer of the phosphonic acid. This pathway has also been discounted for the decomposition of the o-quinone generated ... from the interaction of this compound with the enzyme but arises primarily from the reduction of dopaquinone by the shorter phosphonic diphenol. Correspondence to H. Wojtasek, Institute of Chemistry, University ... this system is the decomposition of the phosphonic o-quinone. This decomposition prevents the redox reaction from reaching equilibrium and provides a long-lasting sink for dopaquinone. Our current...

Ngày tải lên: 31/03/2014, 09:20

... this height the adsorbate-tip interaction is too weak to allow ma- nipulation. At the threshold this interaction is just strong enough to allow the tip to pull the adatom along the surhcc. The ... registered effect in atomic forcc micmscopy. The contact mode where the tip rides on the sample in close contact with the surface is the common mode used in AFM. The force on the tip is ... duldl is thc acceleration. In many problems the collision term is treated by the introduction of a relaxation time r : (a f /at),,l~ = , where f~ is the distribution function in thermal...

Ngày tải lên: 04/06/2014, 14:50

... where k is the correlation distance and N is the length of the series. The argument of the autocorrelation function is the correlation distance k, and the function value at k expresses the average ... emission – an emission of electrons from the surface of a conduc- tor by application of an external electric field in the temperature range where conventional thermo-stimulated electron emission ... Deflection of the cantilever, to a good approximation, is directly proportional to the acting force. It is optically or electronically monitored with high precision. The deflection signal is used...

Ngày tải lên: 04/06/2014, 15:18

... 3C, ∆C2). These data indicate that the coiled coil region of NP influences the interaction with VP35. To address the question of whether the interaction domain for VP35 is present in the coiled ... 3D). Further elongation of the protein, however, diminished binding of the respective NP mutant to GST-VP35. These results suggested that the interaction between NP and VP35 is dependent on the coiled ... of NP is necessary for the formation of the helical nucleocap- sids [20]. It might be that the coiled coil-mediated bind- ing of NP molecules to each other is only one step in the formation of the...

Ngày tải lên: 18/06/2014, 18:20

... harvested the samples. KA established the immunohistochemistry, analyzed the tissue samples, interpreted the data, and performed the histopatholgic analysis of BRONJ- related and control tissue samples. ... acti- vation in BRONJ-affected oral mucosa connective tissue could explain the prolonged wound healing and the lack of mucosal regeneration in BRONJ lesions. Indeed, this study confirmed the in-vitro ... compared to the peri- osteal fibrous tissue of the normal jaw. Discussion This was the first study to address the influence of BP on key regulators of oral mucosa tissue regeneration in BRONJ. We...

Ngày tải lên: 18/06/2014, 19:20

... Poliovirus, once thought to be on the brink of elimination, has surged with a widespread distri- bution in nearly a dozen African nations that now poses a serious risk to the polio eradication initiative. ... universally accessible online as soon as they are published, so an author's work can be read by anyone at no cost. Second, the authors hold copyright for their work and grant anyone the right to reproduce ... further exacerbate their impact on public health. There is an urgent need for a rapid forum for communications among virologists. Virology Journal will present high-quality original research concerning...

Ngày tải lên: 18/06/2014, 22:20

... of NP is necessary for the formation of the helical nucleocap- sids [20]. It might be that the coiled coil-mediated bind- ing of NP molecules to each other is only one step in the formation of the ... 3C, ∆C2). These data indicate that the coiled coil region of NP influences the interaction with VP35. To address the question of whether the interaction domain for VP35 is present in the coiled ... 3D). Further elongation of the protein, however, diminished binding of the respective NP mutant to GST-VP35. These results suggested that the interaction between NP and VP35 is dependent on the coiled...

Ngày tải lên: 20/06/2014, 01:20

... bioterrorism. However, lack of information or misinformation regarding viruses can further exacerbate their impact on public health. There is an urgent need for a rapid forum for communications among ... in the field. Once the reviewers have provided their feedback, the monitoring editor makes the final recommendation. Managing Edi- tor, David Sander will be available to assist authors with content ... However, BioMed Central insists that decisions about a manuscript must be based on the quality of the work, not on whether the article-processing charge can be paid. This policy will certainly...

Ngày tải lên: 20/06/2014, 04:20

... on actions taken on these recommendations. You should send the statement to the Senate Committee on Governmental Affairs and the House Committee on Government Operations within 60 days of the ... Estimating Collectibility Is consideration of both historical collection experience and current Not Reliable economic conditions since collectibility may change as economic conditions change. Also, ... forecast economic conditions. Recommendations GAO recommends that the Commissioner of the Internal Revenue Service provide the IRS Chief Financial Officer authority to ensure that the IRS...

Ngày tải lên: 20/06/2014, 06:20

... because its emphasis has traditionally been on supporting enforcement actions and monitoring the status of assessments in the collection process. As a result, the information on its receivables ... of the same size from this population, 95 out of 100 times, the estimate would fall within the confidence interval. In other words, the true value is between the lower and upper limits of the ... of our ongoing financial statement audit. Unreliable Information on Receivables Hampers IRS Operations and May Mislead the Congress and Taxpayers Reliable information on receivables is important...

Ngày tải lên: 20/06/2014, 06:20

Ngày tải lên: 20/06/2014, 06:20

Ngày tải lên: 20/06/2014, 06:20

Ngày tải lên: 07/07/2014, 03:20

Ngày tải lên: 11/08/2014, 14:21