the dynamic cytoskeleton of glioblastoma cells
báo cáo khoa học: "Different patterns of NF-B and Notch1 signaling contribute to tumor-induced lymphangiogenesis of esophageal squamous cell carcinoma" ppt
... [15] The finding that genes of the Notch signaling cascade are robustly expressed in the vasculature suggests that Notch signaling guides endothelial cells and associated mural cells through the ... proliferation [14], the association of NF-B with lymphangiogenesis in ESCC is less clear Members of the Notch family of cell surface receptors and their ligands also warrant attention based on their role ... a scale of 0-3 as follows: 0, negative; 1, light; 2, moderate; and 3, intense The percentage of positive tumor cells at each intensity level was presented as a ratio of the percentage of surface...
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báo cáo khoa học: "DOF-binding sites additively contribute to guard cell-specificity of AtMYB60 promoter" potx
... mW GUS mDOF1 GUS mDOF2 GUS mDOF3 GUS mDOF4 GUS mDOF(1+2) GUS mDOF(1+3) GUS mDOF(1+4) GUS mDOF(2+3) GUS mDOF(2+4) GUS mDOF(3+4) GUS 7Ó"WVT" 20 strong DOF on strand 7Ó-5Ó" intermediate DOF on strand ... to other DOF motifs of the same cluster (DOF2 at position -176, DOF3 at -159 and DOF4 at -147, Figure 3) These other DOF elements play partially additive roles, as clearly demonstrated by the ... of the AtMYB60 upstream region A, Schematic diagrams of different deletions of AtMYB60 upstream region fused to the GUS reporter gene The positions of the different DOF-binding sites and of the...
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Báo cáo y học: " Does a new polyomavirus contribute to Merkel cell carcinoma" pot
... Alignment of key functional domains of MCPyV, JC, and SV40 large T antigens At the top is a cartoon of the protein structure of the predicted MCPyV large T antigen, based on its homology to the well-characterized ... (MCV339) mutations of the two known MCPyV genomes [11] These predicted truncated proteins potentially preserve some of the cell-cycle progression activities of the amino terminus of large T but prevent ... skin Furthermore, there have been no reports of clusters of MCC or of several people in the same family developing MCC, as might be expected were it due to a viral infection The discovery of MCPyV...
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báo cáo hóa học:" Characterization of the tumor marker muc16 (ca125) expressed by murine ovarian tumor cell lines and identification of a panel of cross-reactive monoclonal antibodies" docx
... natural killer cells, the cell surface bound MUC16 is important for binding of the ovarian tumor cells to the mesothelial cells that line the peritoneal cavity Since the MOVCAR cells shed Muc16, ... deciphering the mechanisms that lead to the generation of the shed Muc16 Given the lack of cell surface Muc16 on MOVCAR cells, we can make important distinctions between the human and murine forms of the ... flow cytometry using the 618F antibody (Fig 6a) On the other hand, high levels of intracellular Muc16 were detected in the MOVCAR-10 cells using the 618F antibody (Fig 6b) These results are in...
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báo cáo khoa học: "A nanocomplex that is both tumor cell-selective and cancer gene-specific for anaplastic large cell lymphoma" ppt
... and light microscope The relative rate of cell growth was determined by calculating the ratio of the number of viable cells in treated samples to the number of cells in the control samples (no ... incorporation of PEI-citrate nanocores with synthetic ALK siRNA and CD30 aptamers The arrow indicates the addition of siRNA and aptamer components into the reaction mix The size of the nanocomplexes ... nanocores of the optimal size, different ‘R’ ratios (defined as the ratio of the number of carboxylate groups from citrate to the number of primary amine groups from PEI) were tested These ratios...
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Báo cáo khoa học: Do bacterial genotoxins contribute to chronic inflammation, genomic instability and tumor progression? pot
... to these genotoxins, we briefly review the state of the art of the DNA damage sensing and repair pathways in mammalian cells, as well as the consequences of an altered DDR in the promotion of ... and is based on the identification of the break and subsequent rejoining of the two ends Consequently, there is a loss or addition of nucleotides at the site of the lesion, and the repair mechanism ... of the MRN complex, and full activation of ATM at the site of the damage, which also requires a functional c-MYC Activation of ATM promotes phosphorylation of histone H2AX and activation of the...
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Báo cáo y học: "Interactions between IL-32 and tumor necrosis factor alpha contribute to the exacerbation of immune-inflammatory diseases" ppt
... approximately 15% of the cells were GFP-positive in the thymus and the spleen of the BM-hIL-32 mice (Figure 3b) The GFP expression of CD4+ cells, CD8+ cells, CD11c+ cells, CD19+ cells, and F4/80+ cells was ... the proliferation of the immune cells In the present study, we also demonstrated that the in vivo overexpression of hIL-32β resulted in the exacerbation of other mouse models of TNFα-related diseases ... with the supernatants of MIG-hIL-32β-transfected cells After 24 hours, the mRNA expression of TNFα was increased by the stimulation of hIL-32β (Figure 3a) In addition, the protein levels of TNFα...
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Evaluation of the Characteristics of Microorganisms that Contribute to Denitrification in the Paddy Drainage Treatment Apparatus by Quinone Composition Measurement
... representation of the PCA analysis of DNR The X-axis is the first principal component (PC1) and Y-axis is the second principal component (PC2) The diameters of the circles indicate DNRs The plots ... Outline of the experimental field and the water treatment apparatus - 422 - Journal of Water and Environment Technology, Vol 8, No.4, 2010 Paddy field The characteristics of the paddy field and the ... important indicator of the stabilization of denitrification activity in the water treatment apparatus and will help with the water treatment apparatus improvement Furthermore, the types of quinone related...
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Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer ppt
... discovery of the ‘tooth-lid factor’ led to the identification of the genetic causes of certain types of human cancers, and to the genetic classification of a variety of tumors of apparently the same ... the control of doxycyclin [22,23] Expression of either EGFR mutant led to the development of adenocarcinomas similar to human BACs, and the withdrawal of doxycycline to reduce expression of the ... (upper part of the figure) [12] and in the extracellular domain in glioblastoma (lower part of the figure) [8] common of the three types of deletion mutations is EGFR vIII This mutation often accompanies...
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Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR-targeted anticancer therapy doc
... genotype-directed therapy in this disease KRAS mutation as a mechanism of resistance to EGFR-targeted therapy The KRAS protein is localized to the inner surface of the cell membrane The binding of ligand ... repositioning of critical residues surrounding the ATP-binding cleft of the tyrosine kinase domain of the receptor and thereby stabilize the interaction with EGF-TKIs signaling cascade, independently of ... repositioning of critical residues surrounding the ATP-binding cleft of the tyrosine kinase domain of the receptor and thereby stabilize the interaction with EGF-TKIs, leading to an increase of 100-fold...
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Tài liệu Báo cáo khoa học: EGF receptor in relation to tumor development: molecular basis of responsiveness of cancer cells to EGFR-targeting tyrosine kinase inhibitors docx
... and the phosphorylation state of their proteins, thereby changing the amount and localization of Bcl-2 family members However, each type of cancer has its own way of disrupting the balance of the ... [56] These changes are temporally associated with recruitment of tumor cells in the G1 phase and a marked reduction in the proportion of cells in the S phase The G1 arrest and up-regulation of ... inhibition of Akt- and ERK1 ⁄ 2-dependent pathways eventually change the expression level of one or more of these Bcl-2 family members Bad Bad is one of the ‘death-promoting’ members of the Bcl-2...
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Tài liệu Báo cáo Y học: Bivalent cations and amino-acid composition contribute to the thermostability of Bacillus licheniformis xylose isomerase doc
... calculated for the apoenzyme in the presence and absence of metals (Table 3) The nature of the metal present clearly affected the Ea of BLXI inactivation It was remarkably high in the presence of Co2þ ... both the Ea of inactivation and the temperature at which the enzyme starts inactivating at a measurable rate increase from the apoenzyme to the Mn2þ-containing enzyme, loss of the metal cofactor ... precipitation temperatures The lower stability and lower Ea of inactivation of BLXI in the presence of Mg2þ reflect the fact that the enzyme binds Mg2þ with lower specificity (the Kact of Mg2þ is 10 times...
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Báo cáo khoa học: "Entailment-based Text Exploration with Application to the Health-care Domain" pot
... as the roots of the DAG As a starting point, only the roots of the DAG are displayed to the user Figure shows the five roots for the ‘asthma’ query Exploration process The user selects one of the ... Fragment of the entailment graph for ‘asthma’ (top), and its conversion to a DAG (bottom) Figure 4: The roots of the entailment graph for the ‘asthma’ query 3.2 Exploration Scheme The objective of the ... common type of entailment rules, in which the left-hand-side of the rule (LHS) and the right-hand-side of the rule (RHS) are propositional templates - a proposition, where one or both of the arguments...
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Báo cáo khoa học: Structural features in the C-terminal region of the Sinorhizobium meliloti RmInt1 group II intron-encoded protein contribute to its maturase and intron ppt
... Effect of mutations in the C-terminal region of the RmInt1 IEP on RNA splicing in vivo We constructed a series of mutants to identify the functional features of the C-terminal region of the RmInt1 ... DIVa of the intron, whereas other regions of the RT and domain X interact with conserved catalytic core regions [12] Domain X is located in the position corresponding to the ‘thumb’ and part of the ... residue at the N-terminus of a-helix a4, the domain X contains the conserved amino acid residues HKXRA (RmInt1 residues 388–392) carrying a stretch of basic amino acids Some of the residues of the HKXRA...
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Báo cáo khoa học: Assessment of telomere length and factors that contribute to its stability potx
... ratio of the telomere to the centromere, referred to as the TC ratio These values can be determined accurately from as few as 800 whole cells or ng of DNA, thereby enhancing the sensitivity of the ... are calculated as the ratio of the telomere fluorescence signal (TFS) of the sample to that of the internal control, normalized to the DNA values at the G0/G1 phase The use of an internal control ... increase the rate of the telomere length attrition process [55] Analysis of the molecular structure of the G-rich overhangs is useful as they are suitable targets in cancer therapy Stabilization of the...
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Báo cáo khoa học: Detergent-resistant membrane fractions contribute to the total 1 H NMR-visible lipid signal in cell potx
... component of DRMs The authenticity of our DRM fractions was confirmed not only by the presence of typical DRM protein markers, but also by the presence of other DRM lipid components described in the ... are expressed as percentages of the sum of the areas of all peaks identified Results Examination of stimulated Jurkat cells by NMR spectroscopy Stimulation of Jurkat T cells with PMA/ionomycin was ... than the equivalent signal observed in stimulated Jurkat cells In contrast, the intensity of the choline resonance was very low, compared with the unstimulated Jurkat or CEM-T4 cells The THP-1 cells...
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Báo cáo khoa học: Sendai virus N-terminal fusion peptide consists of two similar repeats, both of which contribute to membrane fusion ppt
... related to their different potency in facilitating the rupture of the dimple in the center of the TMC The peptide that better promotes the rupture of the TMC will favor formation of fusion pore-like ... measure of the relative stability of the La and HII lipid phases A reduction in TH with the addition of a peptide can be interpreted as a tendency of the peptide to promote negative curvature of the ... increase in the size of the vesicles, confirming that the ability of the peptides to induce lipid mixing is the result of membrane fusion In order to shed light into their mechanism of action,...
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Greener Pastures How grass-fed beef and milk contribute to healthy eating ppt
... explain some of the complexities in the literature, then present the study results • Chapter discusses the implications of the comparison studies, including the nutrition significance of the differences ... either side of the carbon atoms When the hydrogen atoms are on the same side as the carbon atoms, the structure has a cis configuration; when they are on opposite sides of the carbon atoms, the ... Some of the strongest evidence supports the effect of these compounds on coronary heart disease Interestingly, the first evidence of the importance of EPA and DHA was epidemiological studies of...
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Báo cáo khoa học: Structure and function of human a-lactalbumin made lethal to tumor cells (HAMLET)-type complexes pptx
... on the method of production [27] The stoichiometry of oleic acid in the complexes probably significantly modifies the mechanism of cytotoxicity and the tumor selectivity of the complexes In the ... radii of HAMLET (Rh = 26.9 A), which is intermediate of the hydrodynamic radii of the acidic molten globule state of a-lactalbumin ˚ (Rh = 20.9 A) and the theoretically extreme expansion state of ... by tumor cells from 30 to h HAMLET is initially bound to the membrane of the cells and subsequently transported into the cells The cells maintain cellular integrity for a long period of time (180...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25