the dream of little tuk kitabının türkçesi
Tài liệu THE DREAM OF LITTLE TUK - truyện cổ Andersen pptx
Ngày tải lên :
14/12/2013, 09:15
...
the horse, and thus they rode through the wood to the old town of
Bordingborg, and that was a large and very lively town. High towers rose
from the castle of the king, and the brightness of ... mother, as she
looked out of the window. The poor woman can hardly drag herself along,
and she must now drag the pail home from the fountain. Be a good boy,
Tukey, and run across and help the ... yet as
if he were not dreaming; however, somebody was close beside him.
Little Tukey! Little Tukey!’ cried someone near. It was a seaman, quite a
little personage, so little as if he were a...
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The Future of Justification: A Response to N. T. Wright pptx
Ngày tải lên :
06/03/2014, 11:20
... together the iden-
tity of the whole of God’s people so that what is true of him is true of
them and vice versa. Here we arrive at one of the great truths of the
gospel, which is that the accomplishment ... celebration of the resur-
rection of the Son of God, his vindication of the deity of Christ, his belief
in the virgin birth of Jesus, his biblical disapproval of homosexual con-
duct, and the consistent ... and of
the knowledge of the Son of God” (Eph. 4:13, 16). “Grace and peace”
7
He addresses the danger of boasting in leaders (1:10–3:23), the limits of sexual freedom (5:1–8), the
extent of...
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The Great Ideas of Psychology Part I - Daniel N. Robinson
Ngày tải lên :
07/11/2012, 14:21
... identify the boundaries of the subject and its central issues. In wrestling with the problem of
knowledge, the nature of good and evil, theories of governance, and the root question the sort of life ... Pavlovian theory.
5. Summarize the influence and some of the applications of the theory.
Outline
I. Perhaps the earliest reflex theory was offered by Rene Descartes.
A. Statues in the Royal ... nine-
part series, The Mind.” He is past president of two divisions of the American Psychological Association: the
division of the history of psychology and the division of theoretical and philosophical...
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Tài liệu Báo cáo khoa học: Myristoylation of the dual-specificity phosphatase c-JUN N-terminal kinase (JNK) stimulatory phosphatase 1 is necessary for its activation of JNK signaling and apoptosis pdf
Ngày tải lên :
16/02/2014, 14:20
... preferentially
the phosphorylation of the p46 isoform of JNK,
whereas sorbitol treatment induced phosphorylation of
both the p46 and p55 isoforms. To confirm functional
activation of the JNK signaling ... phosphorylation of the transcription factor
c-JUN was attenuated. Upon expression of wild-type JSP1, a subpopula-
tion of cells, with the highest levels of the phosphatase, was induced to
float off the dish ... cells as the
expression system, as the presence of the SV40 large
T antigen in these cells enhances their resistance to
apoptosis.
Apoptosis is a tightly regulated mechanism for the
disposal of damaged...
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Tài liệu Báo cáo khoa học: The antibacterial and antifungal properties of trappin-2 (pre-elafin) do not depend on its protease inhibitory function pptx
Ngày tải lên :
18/02/2014, 17:20
... properties of trappin-2
involve the cationic nature of the molecule, as assessed
from the salt and heparin dependence of the antimicro-
bial and antifungal effects.
Results
Antimicrobial effects of recombinant ... source of
nitrogen [15], thereby competing with the antibacterial
effect of trappin-2. However, none of the bacteria
tested destroyed trappin-2 in the incubation mixtures,
suggesting that another, ... concentration of trappin-2.
Figure 4 shows the dose–response curve for the fun-
gicidal effect of trappin-2 towards C. albicans yeast
cells. The fungicidal activity of trappin-2 was dose-
dependent but the...
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Tài liệu Báo cáo khoa học: High affinity copper binding by stefin B (cystatin B) and its role in the inhibition of amyloid fibrillation docx
Ngày tải lên :
19/02/2014, 06:20
... A binding isotherm
was fitted to the data, expressed in terms of the heat change
per mole of ligand against the ligand to macromolecule
ratio. From the binding isotherm values for the reaction
stoichiometry, ... B at pH 5 [5,6]. In the
present series of experiments we compared fibrillation
of stefin B wildtype (E31 isoform), of stefin B variant
2 (Y31 isoform) and the mutant P79S of the variant,
all at ... The Authors Journal compilation ª 2006 FEBS 4251
from the 3D structures [12,14]. Therefore, the differ-
ences in the far UV CD must be due to the contribution
of tyrosines to this region of the...
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Tài liệu Báo cáo khoa học: Final steps in the catabolism of nicotine Deamination versus demethylation of c-N-methylaminobutyrate doc
Ngày tải lên :
19/02/2014, 07:20
... may enter the citric acid
cycle completing the catabolism of the pyrrolidine moiety of nicotine.
Expression of the genes of these enzymes was dependent on the presence of
nicotine in the growth ... expression of these genes
depends on the presence of nicotine in the growth
medium and we have determined the enzyme activities
of the proteins. Our results demonstrate the presence
of two pathways of ... RT-PCR analysis of transcripts. (A) Schematic representation of the pAO1 gene and ORF
cluster flanked by Tn554 and DTn. The cluster consists of the pmfR gene, encoding the regulator of the purU-mabO-folD...
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Tài liệu Báo cáo khoa học: Role of K22 and R120 in the covalent binding of the antibiotic fosfomycin and the substrate-induced conformational change in UDP-N-acetylglucosamine enol pyruvyl transferase docx
Ngày tải lên :
19/02/2014, 13:20
... wild-type enzyme, whereas the K22E mutant protein
failed to form the covalent adduct. On the other hand, the
K22V mutant protein requires the presence of UDPNAG
for the formation of the adduct indicating ... wall biosynthesis are
attractive targets for the development of new drugs [1]. The
biosynthesis of the cell wall component peptidoglycan (or
murein) commences with the transfer of the intact ... (MurA),
catalyzes the first step in the biosynthesis of peptidoglycan,
involving the transfer of the intact enolpyruvyl moiety from
phosphoenolpyruvate to the 3¢-hydroxyl group of UDP-N-
acetylglucosamine...
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Tài liệu Báo cáo khoa học: Co-operative effect of the isoforms of type III antifreeze protein expressed in Notched-fin eelpout, Zoarces elongatus Kner ppt
Ngày tải lên :
19/02/2014, 16:20
... on, the addition of a small
amount of a QAE1 isoform, nfeAFP8 (Fig. 7). This is
similar to the case of the QAE2 isoform, nfeAFP13;
the activity of its monomer was enhanced by the pres-
ence of ... and lowers the energy barrier to
allow adsorption of the ‘less active’ isoform; (b) the
less active isoform (SP or QAE2) can then adsorb to
the ‘open space’ between the prebound AFPs of the ice
crystal ... sequence alignment
of nfeAFPs
The complete amino acid sequences of the 13 isoforms
of nfeAFP were determined based on the cDNA
A
B
Fig. 2. (A) HPLC purification of the isoforms
of type III AFP from...
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Tài liệu Báo cáo khoa học: The role of N-glycosylation in the stability, trafficking and GABA-uptake of GABA-transporter 1 Terminal N-glycans facilitate efficient GABA-uptake activity of the GABA transporter pptx
Ngày tải lên :
19/02/2014, 17:20
... Cl
–
[1]. The
main physiological function of the transporter is
believed to be the control of the concentration and
dwell time of GABA in the synaptic cleft. Because the
transport of one molecule of ... important for the GABA transport activity.
1-Deoxymannojirimycin inhibits the GABA-uptake
of GAT1
In order to gain further insight into the role of the
terminal structures of the N-glycans of GAT1, ... results
indicate that the impaired plasma membrane traffick-
ing and reduced stability of the N-glycosylation
mutants of GAT1 must be a result of misfolding of
these proteins.
The deficiency of N-glycosylation...
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The Project Gutenberg EBook of The Car of Destiny by C. N. Williamson and A. M. Williamson pot
Ngày tải lên :
07/03/2014, 11:20
... yet discovered the cause of the car's sudden loss of
power. But even as he spoke, the mystery was solved. There was
a leak in the petrol-tank, near the bottom; the last drop of essence
had ... fired the
diamonds in a tiara which crowned a head of waved grey hair.
There were billows of violet satin and lace to keep off the
ground; and as the groom helped the wearer to adjust them under
her ... and passed
on through the gate.
I could have sung the song of the stars. She had not forgotten
me since the afternoon. The look in my eyes then, had arrested
some thought of hers, and set me apart...
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Báo cáo khoa học: Kinetics of the inhibition of neutrophil proteinases by recombinant elafin and pre-elafin (trappin-2) expressed in Pichia pastoris ppt
Ngày tải lên :
07/03/2014, 15:20
... Figure 4B shows
the theoretical curve calculated by non linear regression
analysis of the data using Eqn (7) and using the best
estimate of k
diss
governing the dissociation of the HNE–rec-
elafin ... evaluate the
inhibitory properties of bound trappin-2, as this covalent
linking may increase significantly the bioavailability of
such an inhibitor at the site of inflammation, e.g. in the
case of therapeutic ... yeast protein and was
not further characterized. To limit the appearance of the
13 kDa clipped form of trappin-2 for the large-scale
production of trappin-2, the duration of fermentation was
reduced...
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Báo cáo khoa học: Identification of two cysteine residues involved in the binding of UDP-GalNAc to UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1) ppt
Ngày tải lên :
08/03/2014, 10:20
... to
40% of the parent enzyme activity.
In a more in-depth evaluation of the function of the three
serine mutants, the kinetic properties of the mutant enzymes
were compared to those of the parent ... ends of
the putative b-strands, lining the face of the predicted active
site cleft [15]. These proposed structural features of the GT1
motif in GalNAc-T1 are similar to the UBD, raising the
possibility ... scanning of the bands on the blotting membrane.
The enzymatic activities were correlated with the concen-
tration of recombinant proteins in the media. This was done
to evaluate the effects of the...
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Báo cáo khoa học: The properties of phosphodiesterase 11A4 GAF domains are regulated by modifications in its N-terminal domain pptx
Ngày tải lên :
16/03/2014, 06:20
... with 72.5 lm
in the non-mutated chimera. Therefore, as in PDE5,
phosphorylation at the N-terminus of the PDE11A4
GAF tandem may constitute a mechanism regulating
the cGMP affinity of the PDE11A4 tandem ... allosterically affect PDE11 activity.
The role of the N-terminus of the PDE11A4 GAF
tandem domain
The N-termini that precede the GAF domains in
mammalian PDEs are of significant length, 221 amino
acids ... with the expression of PDE5 and PDE11
in the transitional zone of the prostate, these PDE iso-
forms might also have a role in regulating the prolifer-
ation of glandular epithelial tissue; PDE5...
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