the dream of little tuk kitabının türkçesi
Tài liệu THE DREAM OF LITTLE TUK - truyện cổ Andersen pptx
... the horse, and thus they rode through the wood to the old town of Bordingborg, and that was a large and very lively town. High towers rose from the castle of the king, and the brightness of ... mother, as she looked out of the window. The poor woman can hardly drag herself along, and she must now drag the pail home from the fountain. Be a good boy, Tukey, and run across and help the ... yet as if he were not dreaming; however, somebody was close beside him. Little Tukey! Little Tukey!’ cried someone near. It was a seaman, quite a little personage, so little as if he were a...
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The Future of Justification: A Response to N. T. Wright pptx
... together the iden-tity of the whole of God’s people so that what is true of him is true of them and vice versa. Here we arrive at one of the great truths of the gospel, which is that the accomplishment ... celebration of the resur-rection of the Son of God, his vindication of the deity of Christ, his belief in the virgin birth of Jesus, his biblical disapproval of homosexual con-duct, and the consistent ... and of the knowledge of the Son of God” (Eph. 4:13, 16). “Grace and peace” 7He addresses the danger of boasting in leaders (1:10–3:23), the limits of sexual freedom (5:1–8), the extent of...
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The Great Ideas of Psychology Part I - Daniel N. Robinson
... identify the boundaries of the subject and its central issues. In wrestling with the problem of knowledge, the nature of good and evil, theories of governance, and the root question the sort of life ... Pavlovian theory. 5. Summarize the influence and some of the applications of the theory. Outline I. Perhaps the earliest reflex theory was offered by Rene Descartes. A. Statues in the Royal ... nine-part series, The Mind.” He is past president of two divisions of the American Psychological Association: the division of the history of psychology and the division of theoretical and philosophical...
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Tài liệu Báo cáo khoa học: Myristoylation of the dual-specificity phosphatase c-JUN N-terminal kinase (JNK) stimulatory phosphatase 1 is necessary for its activation of JNK signaling and apoptosis pdf
... preferentially the phosphorylation of the p46 isoform of JNK,whereas sorbitol treatment induced phosphorylation of both the p46 and p55 isoforms. To confirm functionalactivation of the JNK signaling ... phosphorylation of the transcription factorc-JUN was attenuated. Upon expression of wild-type JSP1, a subpopula-tion of cells, with the highest levels of the phosphatase, was induced tofloat off the dish ... cells as the expression system, as the presence of the SV40 largeT antigen in these cells enhances their resistance toapoptosis.Apoptosis is a tightly regulated mechanism for the disposal of damaged...
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Tài liệu Báo cáo khoa học: The antibacterial and antifungal properties of trappin-2 (pre-elafin) do not depend on its protease inhibitory function pptx
... properties of trappin-2involve the cationic nature of the molecule, as assessedfrom the salt and heparin dependence of the antimicro-bial and antifungal effects.ResultsAntimicrobial effects of recombinant ... source of nitrogen [15], thereby competing with the antibacterialeffect of trappin-2. However, none of the bacteriatested destroyed trappin-2 in the incubation mixtures,suggesting that another, ... concentration of trappin-2.Figure 4 shows the dose–response curve for the fun-gicidal effect of trappin-2 towards C. albicans yeastcells. The fungicidal activity of trappin-2 was dose-dependent but the...
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Tài liệu Báo cáo khoa học: High affinity copper binding by stefin B (cystatin B) and its role in the inhibition of amyloid fibrillation docx
... A binding isothermwas fitted to the data, expressed in terms of the heat changeper mole of ligand against the ligand to macromoleculeratio. From the binding isotherm values for the reactionstoichiometry, ... B at pH 5 [5,6]. In the present series of experiments we compared fibrillation of stefin B wildtype (E31 isoform), of stefin B variant2 (Y31 isoform) and the mutant P79S of the variant,all at ... The Authors Journal compilation ª 2006 FEBS 4251from the 3D structures [12,14]. Therefore, the differ-ences in the far UV CD must be due to the contribution of tyrosines to this region of the...
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Tài liệu Báo cáo khoa học: Final steps in the catabolism of nicotine Deamination versus demethylation of c-N-methylaminobutyrate doc
... may enter the citric acidcycle completing the catabolism of the pyrrolidine moiety of nicotine.Expression of the genes of these enzymes was dependent on the presence of nicotine in the growth ... expression of these genesdepends on the presence of nicotine in the growthmedium and we have determined the enzyme activities of the proteins. Our results demonstrate the presence of two pathways of ... RT-PCR analysis of transcripts. (A) Schematic representation of the pAO1 gene and ORFcluster flanked by Tn554 and DTn. The cluster consists of the pmfR gene, encoding the regulator of the purU-mabO-folD...
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Tài liệu Báo cáo khoa học: Role of K22 and R120 in the covalent binding of the antibiotic fosfomycin and the substrate-induced conformational change in UDP-N-acetylglucosamine enol pyruvyl transferase docx
... wild-type enzyme, whereas the K22E mutant proteinfailed to form the covalent adduct. On the other hand, the K22V mutant protein requires the presence of UDPNAGfor the formation of the adduct indicating ... wall biosynthesis areattractive targets for the development of new drugs [1]. The biosynthesis of the cell wall component peptidoglycan (ormurein) commences with the transfer of the intact ... (MurA),catalyzes the first step in the biosynthesis of peptidoglycan,involving the transfer of the intact enolpyruvyl moiety fromphosphoenolpyruvate to the 3¢-hydroxyl group of UDP-N-acetylglucosamine...
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Tài liệu Báo cáo khoa học: Co-operative effect of the isoforms of type III antifreeze protein expressed in Notched-fin eelpout, Zoarces elongatus Kner ppt
... on, the addition of a smallamount of a QAE1 isoform, nfeAFP8 (Fig. 7). This issimilar to the case of the QAE2 isoform, nfeAFP13; the activity of its monomer was enhanced by the pres-ence of ... and lowers the energy barrier toallow adsorption of the ‘less active’ isoform; (b) the less active isoform (SP or QAE2) can then adsorb to the ‘open space’ between the prebound AFPs of the icecrystal ... sequence alignment of nfeAFPs The complete amino acid sequences of the 13 isoforms of nfeAFP were determined based on the cDNAABFig. 2. (A) HPLC purification of the isoforms of type III AFP from...
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Tài liệu Báo cáo khoa học: The role of N-glycosylation in the stability, trafficking and GABA-uptake of GABA-transporter 1 Terminal N-glycans facilitate efficient GABA-uptake activity of the GABA transporter pptx
... Cl–[1]. The main physiological function of the transporter isbelieved to be the control of the concentration anddwell time of GABA in the synaptic cleft. Because the transport of one molecule of ... important for the GABA transport activity.1-Deoxymannojirimycin inhibits the GABA-uptake of GAT1In order to gain further insight into the role of the terminal structures of the N-glycans of GAT1, ... resultsindicate that the impaired plasma membrane traffick-ing and reduced stability of the N-glycosylationmutants of GAT1 must be a result of misfolding of these proteins. The deficiency of N-glycosylation...
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The Project Gutenberg EBook of The Car of Destiny by C. N. Williamson and A. M. Williamson pot
... yet discovered the cause of the car's sudden loss of power. But even as he spoke, the mystery was solved. There wasa leak in the petrol-tank, near the bottom; the last drop of essencehad ... fired the diamonds in a tiara which crowned a head of waved grey hair.There were billows of violet satin and lace to keep off the ground; and as the groom helped the wearer to adjust them underher ... and passedon through the gate.I could have sung the song of the stars. She had not forgottenme since the afternoon. The look in my eyes then, had arrestedsome thought of hers, and set me apart...
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Báo cáo khoa học: Kinetics of the inhibition of neutrophil proteinases by recombinant elafin and pre-elafin (trappin-2) expressed in Pichia pastoris ppt
... Figure 4B shows the theoretical curve calculated by non linear regressionanalysis of the data using Eqn (7) and using the bestestimate of kdissgoverning the dissociation of the HNE–rec-elafin ... evaluate the inhibitory properties of bound trappin-2, as this covalentlinking may increase significantly the bioavailability of such an inhibitor at the site of inflammation, e.g. in the case of therapeutic ... yeast protein and wasnot further characterized. To limit the appearance of the 13 kDa clipped form of trappin-2 for the large-scaleproduction of trappin-2, the duration of fermentation wasreduced...
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Báo cáo khoa học: Identification of two cysteine residues involved in the binding of UDP-GalNAc to UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1) ppt
... to40% of the parent enzyme activity.In a more in-depth evaluation of the function of the threeserine mutants, the kinetic properties of the mutant enzymeswere compared to those of the parent ... ends of the putative b-strands, lining the face of the predicted activesite cleft [15]. These proposed structural features of the GT1motif in GalNAc-T1 are similar to the UBD, raising the possibility ... scanning of the bands on the blotting membrane. The enzymatic activities were correlated with the concen-tration of recombinant proteins in the media. This was doneto evaluate the effects of the...
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Báo cáo khoa học: The properties of phosphodiesterase 11A4 GAF domains are regulated by modifications in its N-terminal domain pptx
... with 72.5 lmin the non-mutated chimera. Therefore, as in PDE5,phosphorylation at the N-terminus of the PDE11A4GAF tandem may constitute a mechanism regulating the cGMP affinity of the PDE11A4 tandem ... allosterically affect PDE11 activity. The role of the N-terminus of the PDE11A4 GAFtandem domain The N-termini that precede the GAF domains inmammalian PDEs are of significant length, 221 aminoacids ... with the expression of PDE5 and PDE11in the transitional zone of the prostate, these PDE iso-forms might also have a role in regulating the prolifer-ation of glandular epithelial tissue; PDE5...
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