the domain of cooking tasks
Tài liệu Báo cáo khoa học: "Defining the Semantics of Verbal Modifiers in the Domain of Cooking Tasks" pptx
... TotalTime. The number of inter- vals present during the total time period is calculated by dividing the total time period by the sum of the length of one incident of the action and the length of a ... duration of each of these actions. 65 Defining the Semantics of Verbal Modifiers in the Domain of Cooking Tasks Robin F. Karlin Department of Computer and Information Science University of Pennsylvania ... is part of the representation of the primitive actions. The number of stirring events which fit in the total time period is calculated. The output consists of repetitions of pairs of the following...
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The art of cooking
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Báo cáo y học: "Anticancer Activity of the PR Domain of Tumor Suppressor RIZ1"
... not yet been addressed. The first question is whether the expression level for RIZ1 varies over the progression of cancer; and the second question is whether the PR domain alone possesses ... described below; and the cell death rate was exam-ined by the trypan blue method after 24 and 48 hr of transfections, respectively. Western blot of PR domain The expression of the PR domain was examined ... suggested that the PR domain alone pos-sesses anticancer activity. However, it is still unclear whether the anticancer activity of the PR domain is due to its methyltransferase activity or the interaction...
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Tài liệu Báo cáo khoa học: An autoinhibitory effect of the homothorax domain of Meis2 ppt
... independently of Pbx, and does notpossess the autoinhibitory function of the Hth domain. In summary, our data suggest that one function of the conserved Hth domain is to inhibit the activity of the transcriptional ... significantlyderepressed by deletion of the Hth domain, suggestingthat the inhibitory effect of this domain is notspecific to the Meis2d AD. Comparison of the relativeexpression levels of these GBD fusion proteins ... region 2 (hr2) of the Hth domain, derepressed it to a similar degree as the fullHth deletion (Fig. 4A). To test whether the inhibitoryactivity of the Hth domain was specific to the Meis2AD,...
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Tài liệu Báo cáo khoa học: NMR structural characterization of HIV-1 virus protein U cytoplasmic domain in the presence of dodecylphosphatidylcholine micelles doc
... tertiary fold in the cytoplasmicregion of VpU, as indicated by a small number of observed long-range NOEs [24].Another important aspect is the topology of the cytoplasmic domain of VpU on a membrane. ... most studied activities of VpU is the induc-tion of CD4 degradation in the endoplasmatic reticu-lum of infected CD4+cells. Only the cytoplasmic domain of VpU, together with any membrane anchor,is ... undetectable in the presence of Mn2+. The sol-vent-exposed C-terminus of VpUcyt probably pointedaway from the surface of the micelle. The three amidecross-peaks originating from the hydrophobic...
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Tài liệu Báo cáo khoa học: Crystal structure of the catalytic domain of DESC1, a new member of the type II transmembrane serine proteinase family pptx
... fix the SEA domain in a loca-tion on the opposite side of the proteinase domain from the active site cleft. It seems very unlikely, there-fore, that the SEA domain would directly influence the binding ... cystein-rich(SRCR) domain, which was rigidly bound to the back of the proteinase domain in the crevice between the C-terminal helix, the 204-loop and the 126-loop [7]. The C-terminus of hepsin is elongated ... Lys224–Tyr228 (the back of the pocket) and the disulfide bridgeCys191–Cys220 (the front of the pocket) (Fig. 4A). The backbones of these segments form a deep hydrophobicpocket with the negatively...
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Tài liệu Báo cáo khoa học: Evidence for noncooperative metal binding to the a domain of human metallothionein ppt
... domainsdiffer with respect to the lability of the zinc ions andthat, despite the increased thermodynamic stability of the a domain with Zn2+over the b domain, the Zn2+sites in the a domain were shown ... siteswithin the two domains. This was followed by coordi-nation of the fourth and fifth metal ions to the a domain for completion of the metallation of this domain prior to filling of the b domain. ... example of the complexity introduced by the presence of the b domain in efforts to elucidate the potentially cooper-ative nature of the metal-binding reaction within each of the domains. Thus, the...
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Tài liệu Báo cáo khoa học: Influence of modulated structural dynamics on the kinetics of a-chymotrypsin catalysis Insights through chemical glycosylation, molecular dynamics and domain motion analysis pptx
... within a cutoff distance (rc¼ 6.0 A˚). The dynamics of the resulting network are then defined by the Ni · Nj Kir-chhoff connectivity matrix of interresidue contacts (G)where the off diagonal ... (nucleophilicity) for the in silico creation of the various glycoconjugates wasdetermined by calculating the electrostatic potentials (EP)for the Ne of the lysine residues of a-CT at pH 9 were the chemical ... some of these phenomena maybe interconnected within the catalytic mechanism of the enzyme.Structural insights into the mechanochemicalnature of a-CT catalysisA more detailed analysis of the...
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Tài liệu Báo cáo khóa học: The C-terminal domain of Escherichia coli Hfq increases the stability of the hexamer ppt
... binding of the polyadenylated rpsO RNA.We have shown that the presence of the remainder of the acidic tail results in the thermodynamic stabilization of Hfqby 1.8 kcalÆmol)1. A comparison of the ... destabilize the network of hydrogen bonds. The crystal structure of the first 71 amino acids of E. coliHfq indicates that the C-terminal domain is probablylocated at the top of the ring, because the ... another. The differencebetween the Hfqs results from the insertion of a fragment of variable length between the first 67 amino acids and the end of the acidic C-terminal domain. Determining the...
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Tài liệu Báo cáo khoa học: Single phosphorylation of Tyr304 in the cytoplasmic tail of ephrin B2 confers high-affinity and bifunctional binding to both the SH2 domain of Grb4 and the PDZ domain of the PDZ-RGS3 protein ppt
... to the Grb4 SH2 domain. The 1H-15N HSQC spectrum of the Grb4 SH2 domain (Fig. 2A)Fig. 2. Characterization of the Grb4 SH2 by heteronuclear NMR. (A) The 1H-15N HSQC spectrum of the SH2 domain ... step of the expressed SH2 domain of Grb4. Lane 1: the soluble part of the cell lysate; Lane 2: the insoluble part of the cell lysate; Lane 3: the Ni-nitiloacetic acid agarose beads bound with the ... conditions. The quality of the expressed SH2 domain is improved at each step of the purification procedure (Fig. 1B). A synthetic DNAfragment encoding the PDZ domain of PDZ-RGS3 wasprepared in the same...
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Tài liệu Báo cáo khoa học: Long-distance interactions between enhancers and promoters The case of the Abd-B domain of the Drosophila bithorax complex pdf
... later than in the case of the histone gene cluster [10]. This difference in the tim-ing of somatic pairing perhaps reflects the differencebetween the complexities of the regulation of the twosystems: ... approach theirproper target promoter in the viscous environment of the nucleus.Somatic pairing of chromosomes and the regulation of Abd-BA peculiarity of Drosophila is the fact that the homo-logous ... required for the formation of the complex looping structure in the case of BX-C,while a shorter time is sufficient for the establishment of the much simpler regulatory interactions of the his-tone...
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Tài liệu Báo cáo khoa học: Solution structure of the matrix attachment region-binding domain of chicken MeCP2 ppt
... cluster in these two regions. Know-ledge of the structure of a larger portion of MeCP2including the transcriptional repression domain wouldresolve these speculations and clarify the role of the helical ... [18]. The structure of the helicalcoil a2/a3allows us to interpret the consequences of the six mutations. As P153(152) and G162(161) are buried in the protein core, replacement of each of these ... one-turn helix on the other face. It is thoughtthat the two inner strands of the b-sheet lie within the majorgroove of the DNA and that a hydrophobic pocket formedby the side chains of Y123 and...
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Tài liệu Báo cáo khoa học: Mapping the functional domain of the prion protein docx
... PrP.Production of deletion mutants of PrPOn the basis of the results with antibodies, a series of PrPmutants were made to assess whether deletions of certaindomains of the protein decrease the SOD-like ... for the SOD activity.We determined that the active site consists of two domains. The first includes the Cu-binding domain and the secondincludes the conserved hydrophobic domain in the middle of ... activity of the protein. The domains deleted were based on the epitopes of the antibodies that had a clear effect on SOD-like activity of PrP. The mutants used in the study include the completeN-...
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Tài liệu Báo cáo khoa học: The single tryptophan of the PsbQ protein of photosystem II is at the end of a 4-a-helical bundle domain docx
... possesses the samecharacteristics of the interior of the protein matrix. The script a is the peak–peak distance between the maximumat %287 nm and the minimum at %283 nm, and the script b is the peak–peak ... alignment of the N-terminal domain of PsbQ from spinach and Chlamydomonas reinhardtii, where the charged residues are indicated. (C) View of the 3D model for PsbQ, where the non-modelled N-terminal domain ... Cl–[32] and (c) to tune up the magnetic properties of the Mn cluster [33].It will be very useful to address the analysis of the complex with information about the structure of the individual complexes....
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