... posi- tioned in the connecting loops. Approximately one- third of all mutations in the BTK gene are missense and some of these reduce the stability of the protein. This is exemplified by mutations in the ... identify individuals with mild disease, thereby providing the missing data. The phenotype of XLA and the potential of BTK and ITK inhibitors The outcome of defective BTK signaling in humans has ... those of endogenous SYK in 293T cells. The kinase-deficient versions of the fusion proteins were not readily phosphorylated in either cell type. In particular, the phosphorylation, but also the...
Ngày tải lên: 14/02/2014, 18:20
... to the boisterous. Expert slavehunters, they mostly clothe themselves by the sale of their victims on the coast, though they do business by the sale of goats and grain as well. Nowhere in the ... speaking, they live upon the coast, and call themselves Diwans, headsmen, and subjects of the Sultan Majid; but they no sooner hear of the march of a caravan than they transpose their position, ... miles. On the north it is bounded by the Mukondokua, or upper course of the Wami river and on the south by the Ruaha, or northern great branch of the Lufiji river. It forms a link of the great...
Ngày tải lên: 15/02/2014, 09:20
Tài liệu Ghost Wave - The Discovery of Cortes Bank and the Biggest Wave on Earth pptx
... 1855) ghost wave The discovery of Cortes Bank and the biggest wave on Earth CHRIS DIXON A hundred miles off the California coastline, a fabled peak rises from the depths of the North Pacic, ... and down in the water column, far faster than you might equalize the pressure in your ears. There were abalone the size of Bibles, lobsters the size of men, and sharks the size of busses. Were ... motored out of Newport Harbor in Newport Beach, just south of Los Angeles. Clearing the lights at the end of the harbor’s long rock jetty, the skipper gave the boat’s twin Yanmars their first...
Ngày tải lên: 17/02/2014, 05:20
Tài liệu The Discovery of Guiana pot
... that we offered them no violence, neither entered their canoa with any of ours, nor took out of the canoa any of theirs, they then began to show themselves on the bank's side, and offered ... drinking thereof, and even the very horses poisoned therewith; insomuch as at the end of the six months that they abode there, of all their troops there were not left above 120 soldiers, and neither ... bury not their wives with them, but their jewels, hoping to enjoy them again. The Arwacas dry the bones of their lords, and their wives and friends drink them in powder. In the graves of the Peruvians...
Ngày tải lên: 21/02/2014, 21:20
Báo cáo khoa học: A novel 2D-based approach to the discovery of candidate substrates for the metalloendopeptidase meprin pot
... level 1 match-sets are the reference gels of the respective quadrants from the 2D gel sections of each condition and the four higher-level match-sets are the reference gels of the two different conditions ... triggered by the activation and not by the overexpression of meprina ⁄ b (Fig. 5C). Obviously, activation of meprina ⁄ b results in the release of proteins into the culture medium. Validation of direct ... [18]. For example, the major role of the MMP family is the control of cellular responses critical to homeostatic regulation of the extra- cellular environment and the immune response [19,20]. We...
Ngày tải lên: 07/03/2014, 06:20
The Discovery of the Source of the Nile docx
... half the tusks of which, as well as some portion of the flesh, they gave to Magomba for the privilege of residing there. There were many antelopes there, some of which both Grant and I shot for the Chapter ... time prior to the birth of our Saviour, when, associated with their name, Men of the Moon, sprang into existence the Mountains of the Moon. These Men of the Moon are hereditarily the greatest ... XIX Chapter XX The of the Source of the Nile, by Speke Project Gutenberg's Etext The of the Source of the Nile, by Speke Copyright laws are changing all over the world, be sure to check the laws...
Ngày tải lên: 08/03/2014, 18:20
THE PART BORNE BY THE DUTCH IN THE DISCOVERY OF AUSTRALIA 1606-1765 pdf
... acquaintance with the Dutch language of those who have made the history of the discovery of Australia the object of serious study, or even, in the case of some of them, their total ignorance of it, certainly ... have the colonial policy of the E.I.C. of the period to its full extent: commerce, increase of territory, colonies. And these ideas were at the bottom of most of the voyages of discovery to the ... Further discovery of the South-West coast of New Guinea. Discovery of the Gulf of Carpentaria (1623) XV. Voyage of the ship Leiden, commanded by skipper Klaas Hermansz(oon) from the Netherlands...
Ngày tải lên: 15/03/2014, 03:20
The Discovery of Yellowstone Park docx
... emerald, in another like that of the turquoise, another has the ultra-marine hue of the sapphire, another has the color of the topaz; and the suggestion has been made that the names of these jewels ... supposed at the time of my discovery of the five loaves that they belonged to the larder of the Washburn branch of the party not to the escort and I apologized to the soldiers when I learned the truth, ... out some of the most interesting portions of the story, thus destroying in some measure the continuity of the narrative. The office of the Western Monthly was destroyed by fire before the copies of the...
Ngày tải lên: 24/03/2014, 02:20
Gudrid the Fair A Tale of the Discovery of America doc
... ease. The first things foretold by Thorberg came about with the quickening of the year. With the first blowing of the warm wet wind of the west, the fogs began to roll away off the land and pile themselves ... were the neighbours, often in and out of the house, but always under the heedful eyes of the good wife. Then there were the ships. Last there were the priest, and his little church. All the people ... before they could get at their work, and it took them the best part of the summer. But they were away about the time of harvest, and still sailing north, and being east of the mainland, the country...
Ngày tải lên: 24/03/2014, 03:21
The Discovery of Type II Superconductors Part 1 pdf
... superconductors the width of the insulator film should be of the order of 10 4 angstroms. However, for high-T c oxide superconductors, where the coherence length is of the order of the distance ... (b) the order of magnitude of the coherence length (the mean distance between two electron pairs) is in accordance with the order of magnitude of the distance between the electron clouds of ... 2001), show that the order of magnitude of the pseudogap above T c is approximately equal to the order of magnitude of the energy gap below T c . If these experiments are confirmed, they should...
Ngày tải lên: 21/06/2014, 05:20
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