the critical perioperative period in cancer patients

... on the firms, including the decrease in expected future earnings and the increase in cost of capital (Hribar and Jenkins, 2004) We are interested to examine the role of financial analysts in ... conclude that the earnings uncertainty reflected in the forecast dispersion originates largely from noise in the financial reporting system rather than the fundamental uncertainty in the firm’s ... that the optimistic bias in FAF for the bankrupt firms declines to insignificant levels by the year prior to the bankruptcy filing They attribute the decline to the increasing costs for financial...

Ngày tải lên: 08/11/2015, 17:09

... description of the determinants of the user's behaviors arising from the task context The first step in performing task analysis is to identify the objects involved in the task In our case, these objects ... Thus, the node N-1 immediately dominates N, the node N-2 dominates N-I, and so on The nodes subordinate to each of the nodes dominating N are indexed beginning with the left-most node and proceeding ... anaphors, and interruptions This paper will cover mainly the second structure and will attempt to find evidence linking the dialogue structure to the task structure The main point is that the structure...

Ngày tải lên: 21/02/2014, 20:20

... hypothesis further by examining the timing of chemotherapy doses with respect to the LCRP immune oscillatory cycle, in patients with advanced melanoma, while examining the clinical responses The ... each vaccination had occurred This allowed us to investigate the timing of vaccinations with respect to the CRP cycle, while examining the clinical responses Since the periodicity of the L-CRP ... Defining the Position on the CRP Cycle Serial L-CRP measurements were taken in the weeks around the time of each dose (vaccine or chemotherapy), and then used to identify the position on the...

Ngày tải lên: 18/06/2014, 15:20

... each other, in many instances when one includes both physical functioning and performance status in the regression models, the likelihood of finding inconsistent results can be expected In other ... that pain and appetite loss are independent determinants of overall survival One found that a 40-point increase in the pain subscale of the EORTC QLQ-C30 was associated with a 27% increase in the ... between patients receiving intermittent and continuous treatment strategies The findings indicated that changes in the quality of life index, measured by a series of Linear Analog Self Assessment...

Ngày tải lên: 18/06/2014, 19:20

... drug (750) during the longitudinal evaluation period Overall, considering the inception and the longitudinal evaluation, the entire duration of the study is estimated around months At the moment, ... the treatment (for example, the choice of morphine in eligible patients) , eventually the comparison of outcomes (for example, pian intensity) by matching or stratifing patients according to the ... Background Pain afflicts most cancer patients, mainly in the advanced and metastatic phase of the disease [1] Recent reviews of published literature suggest that the prevalence of pain in advanced cancer...

Ngày tải lên: 20/06/2014, 15:20

... is essential in patients with cancer, and the need for intravenous access devices for the administration of cancer therapy has increased proportionally with the increasing number of patients diagnosed ... disagreed with the recommendation that ultrasound imaging should be the preferred method for insertion of a central venous catheter in the internal jugular vein [19] In addition, a report in the United ... which determines an increase of the diameter of the veins Under ultrasoundguide in real time, a 16-gauge needle is introduced into the last portion of internal jugular vein This vein was reached...

Ngày tải lên: 09/08/2014, 03:22

... monitoring patients post-surgery Competing interests The authors declare that they have no competing interests Authors' contributions MI was involved in the design of the study and writing of the ... cytokine production Therefore, in gastrointestinal cancer patients, the initial tumor establishment may arise from, or be accompanied by, a reduced Th1/Th2 Hensler et al [16]reported that during the ... lymphocyte numbers The present findings showed that the Th1/Th2 balance in the LC group as well as malignancy group decreased on POD 2, but the decrease in the LC group was slight on POD The increase percentage...

Ngày tải lên: 09/08/2014, 04:21

... dimeric (inactive) state [16] The protein contains several important domains such as 1) the C-terminal protein kinase domain (PI3K-domain), 2) the substrate binding domain in the N-terminal of the ... domain, substrate binding domains and ATPbinding domains, is illustrated in Figure Single marker associations Risk for developing breast cancer The association between any variant in the ATM gene and ... and PI3K domain [17] together with exonic information (The size of the exons and the distance between them are not indicative of the sizes/distances in the gene/protein) cases combined (P-value...

Ngày tải lên: 09/08/2014, 10:21

... LMWH in cancer patients (Table 1) [39-45] The Enoxaparin and Cancer (ENOXACAN) study compared the LMWH enoxaparin and UFH in 1,115 patients undergoing abdominal or pelvic cancer surgery Enoxaparin ... excluded from clinical trials, the patients included in clinical trials are typically in better health than cancer patients seen in clinical practice Conclusion Cancer patients are at increased risk ... unfractionated heparin *For definitions of major bleeding see original studies † Included non -cancer patients for routine thromboprophylaxis in medical cancer patients [1,16-19] However, in the Fundamental...

Ngày tải lên: 10/08/2014, 22:20

... Aalborg, Denmark Competing interests The funding agencies (The Oak Foundation and The Danish Rheumatism Association) had no role in writing the report or in the decision to submit the manuscript for ... baseline the patients in the study groups were similar with respect to prognostic factors The reporting of double-blinding supports a low risk of performance bias as the authors state that the ... possibility that some patients were excluded from the analyses Although the authors performed their analyses according to the intention-totreat principle on what they claim is the correct sample...

Ngày tải lên: 12/08/2014, 11:22

... life-sustaining therapy in ICU patients independently predict hospital death Intensive Care Med 2003, 29:1895-1901 Moreno R, Matos R: Outcome prediction in intensive care Solving the paradox Intensive ... discrimination with poor calibration This pattern has been observed in different settings and with different instruments [27] Information regarding the usefulness of these general scores in cancer patients ... patients requiring MV, 76% died in the hospital [33] In the present cohort about 37% of patients received MV Whether studying the entire population or the subgroup of nonscheduled surgical patients, ...

Ngày tải lên: 12/08/2014, 20:20

... with many anti -cancer agents, including gemcitabine, bleomycin, cisplatin, CCNU, cytosine arabinoside, daunorubicin, deoxycoformycin, 5-FU, azathioprine and interferon α [25] Lastly, the association ... cytoreductive therapy and develops in 20% to 40% of BMT recipients [47] Amphotericin during conditioning Acyclovir during conditioning Vancomycin during conditioning The main site of liver damage in this ... Intern Med 1990, 150:1693-1695 Available online http://ccforum.com/content/10/2/211 20 Ying WZ, Sanders PW: Mapping the binding domain of immunoglobulin light chains for Tamm-Horsfall protein...

Ngày tải lên: 12/08/2014, 23:23

... RVD A striking finding from this study is that the cutoff value of NTproBNP to detect high-risk patients in the first 24 hours was two times lower in patients with cancer than in the general ... consent of the patients or next of kin, we performed the study in 51 consecutive adult cancer patients with medical septic shock Septic shock was defined according to the criteria of the American ... for detecting high-risk cancer patients within the first 24 hours after septic shock diagnosis Key messages • The ICU mortality in patients with cancer is even more important than in the general...

Ngày tải lên: 13/08/2014, 03:20

... 154 critically ill septic cancer patients were included in the present study, 86 with neutropenia, that represents all neutropenic septic cancer patients admitted in the ICU during the study period, ... concentrations Finally, our findings demonstrate that the course of CRP during the first week of antibiotic therapy was similar in neutropenic and non-neutropenic septic critically ill cancer patients Since ... score evaluated in patients with febrile neutropenia to assess their performance in the diagnosis of infection [18-24], in the identification of the underlying agents [18-20,22,24], in the characterization...

Ngày tải lên: 14/08/2014, 08:21

... perspective, the hazard ratios for PFS obtained in the current analysis compare well with those obtained in other studies that have investigated the addition of another drug in the taxane-based chemotherapy ... gastrointestinal perforation, with a significant interaction according to the chemotherapeutics combined (against the use of platinum or taxanes) With specific regard to breast cancer, a further ... phase III trial evaluating the addition of capecitabine to docetaxel in the same setting of patients, the HR for time to disease progression is 0.65 [29] Taking into account the different approaches...

Ngày tải lên: 10/08/2014, 10:21

... than 97% homology in their DNA binding domains They also display 37 – 53% homology in the N terminal transactivation domains and 53 - 77% in the C terminal ligand binding domains (Fu et al., 2007) ... associated proteins, myosin, gelsolin, filamin, spectrins, microtubular proteins including tubulins, microtubule associated proteins, and intermediate filament proteins including vimentin keratin and ... 116 kDa intact form into 85 kDa and 25 kDa fragments This process separates the aminoterminal DNA-binding domain of the enzyme from the carboxy-terminal catalytic domain resulting in the loss...

Ngày tải lên: 14/09/2015, 14:04

... cellular proteins Although the binding site for LXCXE motif containing proteins is present in the B subdomain, the crystal structure of the pRb A/B pocket bound to the LXCXEcontaining part of HPV-16 ... subdomains A and B and the spacer region) the highest homology between the pRb protein family is found in the A and B subdomains The pocket-domain is responsible for binding to proteins containing ... motifs while the pocket-domain and the C-domain are involved in binding E2F proteins Mdm2 (as well as c-Abl) binds to the C-domain All pocket proteins are subject to phosphorylation (indicated with...

Ngày tải lên: 25/10/2013, 21:20

... Visbal AL, Horgan AM, Guindi M, Hornby J, Xu W, Ringash J, Keshavjee S, Chen E, Haider M, Darling G: Phase trial of preoperative irinotecan plus cisplatin and conformal radiotherapy, followed by ... chemoradiotherapy in esophageal cancer: is it still the question? J Clin Oncol 2008, 26(31):5133-4, author reply 5134 doi:10.1186/1477-7819-9-41 Cite this article as: Cafarotti et al.: Chemoradiotherapy ... Radiation Oncology Group; Australasian Gastro-Intestinal Trials Group: Surgery alone versus chemoradiotherapy followed by surgery for resectable cancer of the oesophagus: a randomised controlled phase...

Ngày tải lên: 09/08/2014, 01:24

... clavicular fossa and above the seventh rib Any relapse involving the axillary lymph nodes, and/or other nodes in the infra or supraclavicular fossa or in the internal mammary chain was considered as ... showed in Table None of the patients in the entire group developed brachial plexopathy, any symptomatic pneumonitis and/ or severe lymph edema, neither any had secondary cancer in the follow-up period ... (eight patients, four of them having their primary tumor location medially and centrally) Most remarkable event of all is that in all patients developing DM but one (in no-RT group) had lymphatic invasion...

Ngày tải lên: 09/08/2014, 09:20