the critical appraisal of structures

... clinicians There has, however, been increased scrutiny of the quality of guidelines in recent years This emphasis is in part related to the relatively recent work of the Appraisal of Guidelines ... related to the weaker evidence regarding the effectiveness of these interventions The role of these interventions should be specified in future guidelines AGREE evaluation of guidelines The AGREE ... and design of the study, in the acquisition and interpretation of data, and in the revision of the manuscript All authors read and approved the final manuscript SP additionally drafted the manuscript...

Ngày tải lên: 09/08/2014, 10:22

... important to assess the relative efficacy of the two treatments Our first analysis reviewed the studies of frontline treatment of patients with FL using either R-CVP or R-CHOP There are no published ... of those met all inclusion criteria as studies of frontline or re-treatment Two of those four met the criteria for the first analysis (frontline treatment alone) Outcome The primary goal of the ... Combining the studies, there were 439 patients, and over 98% of these were late-stage Treatment efficacy The main characteristics of the four studies are shown in table 3, where it is seen that the...

Ngày tải lên: 10/08/2014, 22:20

... those in the Randomized IABP Trial Critical appraisal of randomized clinical trials of IABP therapy in AMI patients Thorough critical appraisal involves determining the validity of the study ... determining the validity of a therapeutic article, we ask whether the results represent an unbiased estimate of the treatment effect [13] First, we ask if the assignment of patients was randomized? In the ... single measure of its desirability from an efficiency perspective Critical appraisal of the economic analysis of IABP therapy in AMI patients The factors which we consider when critically appraising...

Ngày tải lên: 12/08/2014, 18:20

... finding and the investigators should be congratulated for their efforts Nevertheless, because of the landmark nature of the trial, a critical analysis is certainly in order The purpose of the present ... comparison with the results of prior studies, and provide potential explanations for the different results Finally, we discuss the implications of the ATN results for clinical practice Design of the Acute ... supporting the overall high level of illness severity in the study is the high percentage (78%) of patients who were oliguric In accordance with the baseline cSOFA score, CRRT or SLED was the initial...

Ngày tải lên: 13/08/2014, 11:22

... the highlands separating the Atlantic watershed from that of the St Lawrence, should follow these highlands to the head of the Connecticut River, and then descend the middle of the river to the ... the forty-fifth parallel, thence running westward and through the centre of the water communications of the Great Lakes to the Lake of the Woods, thence to the source of the Mississippi, which was ... intercourse;] The Americans retained the right of catching fish on the banks of Newfoundland and in the Gulf of St Lawrence, but lost the right of drying their fish on the Newfoundland coast On the other...

Ngày tải lên: 08/03/2014, 18:20

... will then remain the specifying of Arabia as the home of the Magi, the phrase [Greek: kathezomenos] used of John on the banks of the Jordan, the two unparallelled sentences, and the cave of the ... be the adoration of the Magi, the slaughter of the innocents, the flight into Egypt, the conjunction of the foal with the ass in the entry into Jerusalem All these are strong evidence for the ... notices of the miracles in general, the healing of the lame and the paralytic, of the maimed and the dumb, and the raising of the dead not only did they include several discourses, such as the reply...

Ngày tải lên: 17/03/2014, 15:20

Ngày tải lên: 17/03/2014, 20:21

Ngày tải lên: 28/06/2014, 22:20

... both in the phloem and the sapwood in response to bark inoculation They may therefore, together with the development of the fungus, have a negative impact on the water conducting ability of the sapwood, ... Impact of the density of inoculations with Ophiostoma brunneo-ciliatum into bark of young Scots pine trees on: (a) the length of the induced reaction zones in the bark tissues; (b) the fraction of ... potential The most striking result was the significant but nonlinear relationship between the amount of damage and the loss of conductivity; the latter increasing much faster then the former Loss of...

Ngày tải lên: 08/08/2014, 14:22

... consequence of the matrix-tree theorem that the number of elements of the sandpile group with sink w∗ is equal to κ(G, w∗ ) For a basic exposition of the properties of the sandpile group, the reader ... Further, in the case in which the out-degree of each vertex of G is a fixed integer k, we show the kernel of this surjection is the k-torsion subgroup of K(LG, e∗ ) These results appear as Theorem ... = (w∗ , v∗ ), then κ(G, w∗ ) divides κ(LG, e∗ ) under the hypotheses of our Theorem This leads him to ask the natural question as to whether K(G, w∗ ) is a subgroup or quotient of K(LG, e∗ )...

Ngày tải lên: 08/08/2014, 14:23

... one of approximately 1.5 kb and the other of approximately kb The 1.5 kb fragment contained CDR2 and CDR3 of the IgG VL region and also part of the downstream expression vector containing the ... cDNA, while the kb fragment contained CDR1 and the rest of the vector The kb fragment derived from one VL expression vector was ligated with the 1.5 kb fragment derived from the other The resulting ... pairs from the beginning of VL, but does not cut the expression vector outside the insert Pvu I cuts the vectors at a single site approximately kb downstream of the insert Each vector was therefore...

Ngày tải lên: 09/08/2014, 06:22

... Bank The Economic Appraisal of Investment Projects at the EIB rate of return (FRR), i.e the discount rate that yields a zero net present value of the cash flow over the lifetime of the project The ... adequate indicator for the This introduction builds partly on the note to the Board of Directors of 2008 The Economic Appraisal of Projects: An Overview of the Approach within the Bank” 08/580 prepared ... associated to the intrinsic quality of the asset, the operation and maintenance policies, the use of the asset and the environmental conditions The PJ team will also assess the probability that the economic...

Ngày tải lên: 04/10/2015, 20:31

... Critical Care February 2002 Vol No Whitley and Ball that cover the ideas presented in this series, and more, in considerably greater detail [1–4] However, even these might frequently ... these might frequently not be sufficient and it is vital that researchers recognise their own limitations and seek professional advice whenever it is needed, if only for reassurance Medical statistics ... role only after years of training and practical experience Most academic departments, and also many clinical departments, include properly qualified medical statisticians and they should be consulted...

Ngày tải lên: 25/10/2012, 10:45

... receives BPDUs from the Root If multiple BPDUs are received, then there must be a loop in the network The BPDU with the lowest cost is the best path to the Root • The goal of every non-root bridge/switch ... protocol is the protocol being mapped across the frame relay cloud, such as IP or IPX • destination-IP is the IP address of the frame relay interface at the other end of the PVC • local-DLCI is the local ... called the “last mile” • Normally not more than a few miles Demarcation Point (Demarc) • The line between the customer site and the provider network • Inside of the demarc is the CPE • Outside of the...

Ngày tải lên: 17/01/2014, 06:20

... rows in the race ought to live till the age of 60; and if all the members of the Oxford 1829 crew had lived till the 10th of June, 1869, the 40th anniversary of the race, and then died, their lives ... Matches came off, in which 32 crews competed In the case of each of these crews I have calculated the probable duration of life of the different Oarsmen of whom they were composed: the following ... expectation of life of each one of them, according to Dr Farr's Tables, would then be 14 years, the value of the five lives together being 70 years On adding these 70 years of estimated life to the years...

Ngày tải lên: 14/02/2014, 21:20

... of the structure are not seen on the map, probably owing to disorder of these regions The overall geometry of the model according to the procheck program [21] is of good quality, with 95.4% of ... to elucidate the mechanism of the elevated thermostability of TtAKb In this article, we describe the crystal structures of TtAKb in two forms, Thr-bound and Thr-free, and discuss the regulatory ... regulatory mechanism of Thr and the structural features responsible for the high thermostability of TtAKb Results and Discussion Model quality The crystal structure of the Thr-bound form of TtAKb ˚ (TtAKb-Thr)...

Ngày tải lên: 18/02/2014, 08:20

... targeting of Toc75 remains unknown In this report, we extended the analysis of the polyglycine stretch of the Toc75 transit peptide in order to better understand the targeting mechanism of the chloroplast ... frequently in these regions Together they account for 17% of residues within this stretch We replaced the critical tri-glycine within the pea Toc75 transit peptide with repeats of these three FEBS ... considered the possibility that the difference between AAG and the other two mutants might be due to kinetics of the import; i.e., AAG precursor might be imported into the stroma more slowly than other...

Ngày tải lên: 19/02/2014, 07:20

... differences in the spectral maxima in the visible region of the Fe(III) species, spectra of the Asp40 mutants were essentially similar to that of the wild-type protein Additionally, spin states of the Fe(III), ... significantly affect the binding of exogenous ligands, such as the cyanide anion, to the Fe(III) complex [17], and O2 and CO to the Fe(II) complex [18] However, the PDE activities of these mutants are ... binding provide valuable information on the haem distal structure of Ec DOS PAS [17] As the structure of the cyanide-bound complex of FixL is similar to that of its oxygen-bound complex [10], a cyanide...

Ngày tải lên: 19/02/2014, 16:20

... intermediate [11] The sum of these ndings points at the involvement of more than one active oxidant in the diverse types of P450-catalyzed substrate processing [1215] The goal of the present perspective ... which small alterations in the environment can cause drastic changes in the reactivity of the active species [76] Further support in favour of the idea of the involvement of a high-valent iron-oxene ... alignment of the CYP19 sequence with the known crystal structures of bacterial P450s, E302 was postulated to be essential to activation of the 19-oxo group of the substrate for attack by the peroxo-iron...

Ngày tải lên: 19/02/2014, 16:20

... important It is the blending of the roles of the board and the executive director that moves the organization towards its missions and vision When the differences in the roles of the two are clearly ... of the reporting The committee coordinates the information from the external feedback sources Working with the executive director, the committee sets the schedule for the appraisal meeting, the ... on the working relationships between the executive director and the staff Step 4: Gather Documentation The information that the committee needs to gather for the performance appraisal of the...

Ngày tải lên: 21/02/2014, 17:20