... Nature 460, 909–913 89 Hong H, Takahashi K, Ichisaka T, Aoi T, Kanagawa O, Nakagawa M, Okita K & Yamanaka S (2009) Suppression of induced pluripotent stem cell generation by the p53–p21 pathway ... a CD34+ hESC-derived starting population has been considered as a potential AIDS therapy, and as a way to alleviate secondary effects produced by anti-retroviral drugs [16] Various studies have ... engraftment efficiency and functionality in various animal models of diseases before clinical medical application can become a reality Ontogeny of human hematopoiesis Hematopoietic ontogeny has...
Ngày tải lên: 22/03/2014, 17:20
... institutions The association acts principally as a forum for the exchange of ideas and the formation of opinions However, it also shares the responsibility with the National Bank of the savings banks ... (“Anstaltslast”) 10 nor a guaranty obligation (“Gewährträgerhaftung”)11 by the public authori- The National Association of the savings banks The National Association, as the second supreme body of the ... savings bank organisations As the National Association has limited decision- making powers, however, it plays only a subordinate role compared with the National Bank of the savings banks Against...
Ngày tải lên: 29/03/2014, 08:20
Báo cáo y học: "Sequencing the genome of the Burmese python (Python molurus bivittatus) as a model for studying extreme adaptations in snakes" ppsx
... the families Viperidae (for example, rattlesnakes, and adders) and Elapidae (for example, coral snakes, cobras, and mambas) In addition to these lineages that contain commonly used model research ... mate-pair library sequencing will mark the end of the data collection phase and the start of assembly and analysis The end of this phase will be marked clearly on the snake genomics website [21], as ... with other comparative data to estimate genomic characteristics of the ancestral amniote genome Page of (or the ancestral squamate genome) would be fascinating, including estimation of ancestral...
Ngày tải lên: 09/08/2014, 23:20
Báo cáo y học: "Vasculature deprivation – induced osteonecrosis of the rat femoral head as a model for therapeutic trials" ppsx
... of attempts at therapy The myriad sinusoidal vessels and their proximity to one another indicate that the intraosseous conduits support an exaggerated revascularization of the formerly avascular ... support the spread of the vasculature These factors, which are preferentially attracted to the heparin, increase the proliferation and migration of cells associated with neovascularization In as much ... metaphyseal and periosteal arteries, which enter the bone through the foramina of the cortex Having entered the marrow, they ramify and widely anastomose with each other On the other hand, there...
Ngày tải lên: 13/08/2014, 23:20
War Bonds in the Second World War: A Model for a New Iraq/Afghanistan War Bond? docx
... War Bonds in the Second World War: A Model for a New Iraq/Afghanistan War Bond? Summary The high costs of fighting the wars in Iraq and Afghanistan have rekindled congressional interest in the ... inadequate aggregate demand To date, no savings bond or any other Treasury security issue has ever had its funds earmarked for any specific purpose; rather, all funds raised have been placed in the ... States War Bonds to aid in funding of the operations in Iraq and Afghanistan.” All three bills are similar and state that the authorized war bonds “shall be in such form and denominations, and...
Ngày tải lên: 29/03/2014, 03:20
Báo cáo y học: "Direct Toll-like receptor 2 mediated co-stimulation of T cells in the mouse system as a basis for chronic inflammatory joint disease" ppsx
... obtained was used as a template for real-time quantitative polymerase chain reaction, which was performed with the LC FastStart DNA Master SYBR GreenI® (Roche Diagnostics, Mannheim, Germany) in a LightCycler® ... [27,60,61] TLR ligands have been implicated by other groups as a cause of CIJD or as enhancing factors in the disease, for example hypomethylated bacterial DNA [12], LPS [13] and heat shock protein ... 2:116-126 20 Matsuyama T, Yamada A, Kay J, Yamada KM, Akiyama SK, Schlossman SF, Morimoto C: Activation of CD4 cells by fibronectin and anti-CD3 antibody A synergistic effect mediated by the VLA-5 fibronectin...
Ngày tải lên: 09/08/2014, 01:23
Báo cáo y học: "The potential of human regulatory T cells generated ex vivo as a treatment for lupus and other chronic inflammatory diseases" pot
... Arthritis Research Vol No Horwitz et al can serve as a therapy for autoimmune diseases such as systemic lupus erythematosus (SLE) This T-cell-based therapy could also be used to prevent graft ... organ transplants Acknowledgements This research was supported in part by National Institutes of Health grant AI 41768, The Nora Eccles Treadwell Foundation, and the Arthritis Foundation-Southern ... self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease J Exp Med 1985, 161:72-87 Kuniyasu Y, Takahashi T, Itoh M, Shimizu J, Toda G, Sakaguchi S: Naturally anergic and...
Ngày tải lên: 09/08/2014, 03:24
Báo cáo y học: "Chiropractic as spine care: a model for the profession" pptx
... described as the ideology of chiropractic or the hypothesis of chiropractic, rather than as a philosophy This model of chiropractic has continued to advance a hypothetical model of health and disease ... musculoskeletal pain complaints, the overwhelming majority of which are spine related A small subset, approximately 5%, of patients have headache as a primary complaint Any reasonable estimate would place ... fails to provide Among the reasons for this failure is that chiropractic has always been confused about the concept of a profession and has tended to view itself a champion of ideas rather than...
Ngày tải lên: 13/08/2014, 13:22
Flavor enhancement as a tool for increasing pleasantness and intakeof a snack product among the elderly
... first and half ate the heightened aroma samples first The subjects were asked to rate one sample a day at any time of the day they wanted Similarly to the tasting sessions, As the final task in the ... Preliminary data analysis revealed no significant main effects and only one significant interaction of day and aroma on the pleasantness ratings of the young, implicating an increase in pleasantness ... PEA) and liking of the vanilla beverage at any phase of the study The aim of the present study was to examine the effects of heightened aroma concentration on the pleasantness and intake of a...
Ngày tải lên: 03/04/2013, 21:06
Báo cáo khoa học: 2-Pyrimidinone as a probe for studying the EcoRII DNA methyltransferase–substrate interaction docx
... Piscataway, USA) and the amount of methylated DNA was determined as described [17] Data were analyzed by linear regression using the Microcal ORIGIN 6.0 software For quantication of the transfer ... methylation was calculated as the ratio of radioactivity of duplex VIm to the radioactivity of duplex Vm Methylation of duplex Vm (not shown) was accepted as 100% The research was supported by a ... concentrations at saturating AdoHcy concentrations A binding isotherm and corresponding autoradiograph of a typical experiment are shown in Fig The calculated apparent dissociation constants (K dapp...
Ngày tải lên: 07/03/2014, 15:20
Báo cáo khoa học: Effects of the G376E and G157D mutations on the stability of yeast enolase – a model for human muscle enolase deficiency pdf
... denaturation, any change at these positions was destabilizing G37 6A and G376E had identical Tm values At position 157, alanine had a smaller effect than aspartate, but even alanine decreased the ... the QuickChange method (Stratagene, La Jolla, CA, USA) The primer sequences were as follows: 5¢-GG GGT GTT ATG GTT TCC CAT CGA TCT GAA GAA ACT GAA GAC (G376E) and 5¢-CCA TTC TTG AAC GTT TTA AAC ... phosphoenolpyruvate, and glycines 157 and 376 are space-filled 98 Analytical ultracentrifugation (AUC) was used to examine the quaternary structure of the variants Wild-type enolase and the G157D variant had...
Ngày tải lên: 16/03/2014, 06:20
Relational Cloud: A Database-as-a-Service for the Cloud potx
... Minhas, A Aboulnaga, K Salem, P Kokosielis, and S Kamath Automatic virtual machine configuration for database workloads ACM Trans Database Syst., 35(1), 2010 [17] G Soundararajan, D Lupei, S Ghanbari, ... define as a billable entity (a distinct user with a set of applications, a business unit, or a company)—can load one or more databases A database has one or more tables, and an associated workload, ... Damiani, S D C di Vimercati, S Jajodia, S Paraboschi, and P Samarati Balancing Confidentiality and Efficiency in Untrusted Relational DBMS CCS, 2003 [7] S Das, D Agrawal, and A E Abbadi ElasTraS:...
Ngày tải lên: 16/03/2014, 16:20
Báo cáo Y học: The S100A8/A9 protein as a partner for the cytosolic factors of NADPH oxidase activation in neutrophils doc
... Rac2 and S10 0A9 Assay of NADPH oxidase activity after oxidase activation The dormant NADPH oxidase of neutrophil membranes was activated by mixing neutrophil plasma membranes and the recombinant ... GTPcS-loaded Rac2, MgSO4 and an optimal amount of arachidonic acid determined for each assay of oxidase activation [12] The rate of O2– production by the activated NADPH oxidase was calculated from the ... In all cases, the optimal amount of arachidonic acid was determined and used to analyze the effect of S10 0A8 /A9 on oxidase activation After an incubation of 10 at 20 °C, the oxidase activity was...
Ngày tải lên: 18/03/2014, 01:20
microsimulation as a tool for the evaluation of public policies potx
Ngày tải lên: 19/03/2014, 00:20
The welfare state as a determinant of women’s health: support for women’s quality of life in Canada and four comparison nations pptx
... figures for 2000 from Statistics Canada (Statistics Canada, 2002) The data and analysis related to the availability and quality of childcare for Canadian women and those from the four comparisons nations ... and administration, labour market training, youth measures, subsidised employment and measures for the disabled Canada is very low in comparison to the social welfare nations The value for Canada, ... provincial fiscal circumstances than it was in the 1980’s In several provinces, federal withdrawal has been associated with downsizing and reduced regulation In some cases, as in Alberta and Ontario,...
Ngày tải lên: 22/03/2014, 11:20
Báo cáo khoa học: Distribution of the extrinsic proteins as a potential marker for the evolution of photosynthetic oxygen-evolving photosystem II ppt
... red algal protein than with the cyanobacterial one The C paradoxa thylakoid membranes also contained a band cross-reacted with anti-(R-PsbQ¢), the apparent molecular mass of which was remarkably ... the nuclear genome in this organism, as in the case of red algae On the other hand, the failure of cross-reaction with anti-(C-PsbU) suggests that C paradoxa PsbU has a higher homology with the ... Cyanobacteria Synechocystis sp PCC6803 Rhodophyceae (red algae) Cyanidioschyzon merolae Nuclear DNA Chloroplast DNA Cyanidium caldarium Chloroplast DNA Bacillariophyceae (diatoms) Thalassiosira pseudonana...
Ngày tải lên: 23/03/2014, 15:21
Báo cáo Y học: A model for recognition of polychlorinated dibenzo-p-dioxins by the aryl hydrocarbon receptor docx
... low, as in our case, the correctness of the alignment plays a crucial role both in the selection of the correct template and in the expected ®nal quality of the model Other information, such as ... neither photoaf®nity labeled by a dioxin analog, nor activated by b-naphto¯avone in a yeast system [20]; the rainbow trout AhRa that binds TCDD [21] and the Microgadus Tomcod AhR also activated ... domain and PYP are activated by ligands; in FixL, oxygen binding at the heme binding PAS domain controls the activity of a histidine kinase domain [12]; and in PYP, a local conformational change...
Ngày tải lên: 24/03/2014, 00:21
Báo cáo Y học: High pressure-induced changes of biological membrane Study on the membrane-bound Na+/K+-ATPase as a model system pdf
... of pyruvate kinase, and 2.5 lgámL)1 LDH in a total volume of mL The reaction was initiated by an addition of 50 ng of Na+/K+-ATPase Na+-dependent ATPase activity was also measured using the coupled ... Na+/K+-ATPase, K+-activated phosphatase, and Na+-dependent ATPase at 0.1 MPa were 1240, 110, and 29 lmoláh)1ámg)1, respectively Na+/K+-ATPase activity was determined h later after the pressurization at ... changes in membrane-bound Na+/K+-ATPase can be summarized as follows Pressure eects at 100 MPa or lower The decreased reaction rate of the Na+/K+-ATPase with an increase in pressure can be rationalized...
Ngày tải lên: 24/03/2014, 00:21
báo cáo sinh học:" A model for integrating strategic planning and competence-based curriculum design in establishing a public health programme: the UNC Charlotte experience" doc
... are one area where practica and capstones (theses or projects) can serve a critical catch-all role, in much the same way as qualifying exams for doctoral students External assessments, such as ... programmes has nearly tripled over the past decade The number of accredited schools has also increased substantially, with some, such as those at the University of Arizona [16] and George Washington ... 5, the Department has had a string of rapid successes and ambitious plans for attaining status as a school of public health in the next decade Notable achievements include the graduation of the...
Ngày tải lên: 18/06/2014, 17:20
Báo cáo sinh học: "An NIH intramural percubator as a model of academic-industry partnerships: from the beginning of life through the valley of death" pptx
... will aid in assessing the translational potential of ideas that are still in the percolation phase The NIH intramural program is an ideal test site for such new translational research approaches, ... scenario may be an important feature of the percubator, particularly in light of today’s usual translational approach: a) academia hands off an application to the private sector only if and when ... And as a practical matter, designating percubator investigators and their companies as ‘contractors and contract companies’ would be a simple route to initiating a pilot program in Bethesda as...
Ngày tải lên: 18/06/2014, 19:20