the challenges facing cell based therapy for treatment of lung disease

... Figure 2.4 The protective effect of NaHS on cell viability in the presence and absence of various PKC isoforms inhibitors…………………………………………51 Figure 2.5 Involvement of PI3K/Akt pathway in the neuroprotective ... With several groups of dopaminergic neurons in the central nervous system (CNS), it is the loss of the dopaminergic neurons in the SN that account for the motor manifestation of PD [42] Interestingly, ... drugs act to prolong the effects of L-Dopa by preventing the breakdown of dopamine, thus reducing the dose of L-Dopa in PD treatment The most common side effect is diarrhea The drugs may also cause...

Ngày tải lên: 13/10/2015, 15:57

... function of these channels in the heart Therefore, the effect of H2S on APD is probably attributed to the opening of KATP channels86 H2S is capable of opening KATP channels directly87, 88 Furthermore, ... into the hydrophobic core of the cell membrane and rapidly diffuses into or out of cells 26 Furthermore, H2S gas is very volatile It may rapidly diffuse out of blood into lungs 27, or out of organ ... Immunohistochemistry showing the effect of H2S treatment on renin release and mast cell infiltration in the LV tissues in ISO-induced HF model Figure 4.8 Effect of NaHS treatment on the numbers of mast cells in...

Ngày tải lên: 01/10/2015, 17:27

... overall survival of treated animals (Figure 6D) These results confirm the anti-tumor activity of anti-VLC therapy, as observed by others, and further support the use of anti-CD52 therapy in humans ... critical role for these cells in tumorigenesis and indicate that these cells may be novel therapeutic targets for solid tumor therapy Genetic manipulations to inhibit or eliminate these cells in both ... therapy twice-weekly for three weeks Therapy was then discontinued and tumor growth was monitored for several weeks Therapy significantly restricted solid tumor growth throughout the course of...

Ngày tải lên: 18/06/2014, 15:20

... footwear characteristics From a list of 16 styles of footwear, the examiner documented the style of shoe worn by the patient at the time of the assessment [13] The footwear assessment tool has been ... deformities for the forefoot (range 0-12) and calcaneus valgus/varus angle, ankle range of motion and pes planus/cavus deformities for the rearfoot (range 0- 7) Foot type was assessed using the ... or rigid (< 10°) The examiner grasped both the rearfoot and forefoot components of the shoe and attempts were made to bend the shoe at the midfoot in the sagittal plane [11] Forefoot sole flexion...

Ngày tải lên: 10/08/2014, 21:24

... figured out that these are the most profitable accounts.” “Our industry hasn’t addressed the blue-collar segment of the market One of the most profitable segments [due to fee income] is the blue-collar ... Furthermore, the assets of credit unions have grown much faster than the assets of community banks.16 Conclusion The slide in the number of community banks over the past 20 years is undeniable The ... surprisingly, the community bankers that we surveyed embrace the second of these two visions of the future of community banking NOTES There is no generally accepted definition of “community bank.” For...

Ngày tải lên: 16/02/2014, 11:20

Ngày tải lên: 21/02/2014, 08:20

... to decay: “Over the twenty years or so before the crisis of the 1970s, New York—at that time the leading industrial city in the World—saw the decline of one after another of the little firms, ... Throughout the course of our research, the vast majority of New Yorkers for the most part fierce defenders of the city—were alarmingly pessimistic about the current and future prospects of the local ... families out of the city.108 Indeed, the social successes of the past decade, particularly the reduction of crime, should be seen as a linchpin of a renewal for the city’s middle class Much of our...

Ngày tải lên: 10/03/2014, 08:20

... of the research tasks of the project Given the breadth of the issues involved in health care systems improvement, the first task of the initiative was to identify the areas of greatest need for ... educating them about the range of resources available in the community The community paraprofessionals are most successful when they reflect the demographics of the population served One of the programs ... as the keynote speaker The objectives identified at the retreat, along with the strategies for achieving them, formed the basis for the community action plan to overcome key systems barriers The...

Ngày tải lên: 22/03/2014, 09:20

... receptor of glutamate exercising an inhibitory effect that can mimicry schizophrenia This model constitutes the theory for the 'hypothesis of glutamatergic hypofunction' based on receptor hypofunction ... topiramate could fill the therapeutic vacuum in the treatment of bipolar depression as alternative or adjuvant to mood stabilisers The role of topiramate in the treatment of rapid cycling bipolar ... Evidence for the use of topiramate in binge eating disorders and bulimia nervosa is encouraging and suggest a complementary role of topiramate in the treatment of these conditions together with...

Ngày tải lên: 08/08/2014, 21:20

... information about the specificity of the T cells that mediate autoimmunity Although there are examples of discordance of the fine peptide epitope specificity of the autoreactive T -cell and B -cell ... nonspecific diseasemodifying therapies (already described), determination of the specificity of the autoantibody response may enable tailored antigen-specific therapy Such antigen-specific therapies ... Applications for proteomics profiling of autoantibody responses Autoantibody profiling for diagnosis Autoantibodies have diagnostic utility for several autoimmune diseases Such diseases include myasthenia...

Ngày tải lên: 09/08/2014, 06:22

... beam therapy Washington, DC: ICRU; 1993 27 Cox JF, Stetz J, Pajak TF: Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of ... Elective radiotherapy with intensity modulated radiation therapy (IMRT) technique in the treatment of pelvic lymph nodes and primary tumor region Analysis of acute toxicity Procedings of the 49th ... whenever the lymph nodes and primary tumor sites must be irradiated List of abbreviation ASTRO: Americal Society of Therapeutic Radiation Oncology; CRT: Conformal Radiation Therapy; CT: Chemotherapy;...

Ngày tải lên: 09/08/2014, 09:20

... published Therefore, in the present double-blind and placebo-controlled clinical study, we sought to evaluate the efficacy and safety of 5-Loxin® in treatment of OA of the knee We assessed the effectiveness ... Department of the ASRAM Hospital were selected, based on the signs, symptoms and radiological changes consistent with OA in the first phase of the screening procedure A total of 75 patients suffering for ... was the average of the first five questions of WOMAC and measured using the NU scale from mm ('no pain') to 100 mm ('extreme pain') for each question The stiffness subscale was the average of...

Ngày tải lên: 09/08/2014, 10:23

... proposed to test the efficiency of apoptotic cell infusion to modulate the arthritic response The feasibility of cellular therapy based on the immunomodulatory properties of apoptotic cells has already ... 1d) At the time of arthritis induction by SCW injection, therefore, administration of apoptotic cells significantly decreases the course of arthritis occurrence and the severity of the disease, ... cNumber of rats with disease among the rats of each group; the lower number of animals in the chronic phase is due to sacrifice of animals at the end of the acute phase in some experiments Page of...

Ngày tải lên: 09/08/2014, 14:22

... areas of softening and necrosis The tumor had invaded the whole thickness of the bladder wall and penetrated into the perivesical fat tissue, as well as the anterior wall of the vagina The rest of ... identification of nested or clustered epitheloid tumor cells, of either conventional or other types of carcinoma, lying adjacent to sarcomatoid cells The presence of in-situ carcinoma is also another supporting ... dominant in adults There are only 30 published cases of primary osteosarcoma of the urinary bladder in the literature [3-5] and they show a male to female ratio of 4:1 The age of the patients ranges...

Ngày tải lên: 11/08/2014, 19:21

... Intraoperative endoscopic view of the foreign body in the supero medial aspect of the maxillary sinus Intraoperative endoscopic view of the foreign body in the supero medial aspect of the maxillary sinus ... MR performed surgery and wrote the main part of the paper All authors gave useful comment on the text of the manuscript Written consent was obtained from the patient or their relative for publication ... radiopacity of the left maxillary sinus Orthopantomography showing radiopacity of the left maxillary sinus Computed tomography scan (coronal plane) showing the foreignof the upper first the supero...

Ngày tải lên: 11/08/2014, 23:22

... different glioma cell lines, as demonstrated by the expression of the reporter gene, suggests the suitability of this vector for gene therapy The selectivity of the virus for glioma cells in the nervous ... vivo The evolution of infection and the distribution of EGFP-positive cells within the tumour area shows the selectivity of the virus for the tumour cells and its oncolytic properties Moreover the ... gene therapy for glioma supported the efficacy of the transduction of therapeutic genes to the targeted tumour cells in human patients [11] These data suggest a possible application in the long-term...

Ngày tải lên: 12/08/2014, 02:20

... Goodman for her comments on earlier drafts of the paper This paper is published with permission of the Director of KEMRI Funding for the data collection part of the study was granted by the Immunization, ... al [15] one of the most important determinants of bed day costs is the hospital bed occupancy rate; the higher the occupancy rate, the lower the costs per bed day Occupancy rates of the studied ... representing the central tendency and range of costs, but also the mean costs as these are the most useful for estimating total costs for any number of patients [21] At the seven facilities the mean...

Ngày tải lên: 13/08/2014, 11:22

... that the need for objectively controlled, randomized re-examination of the roles of these so widely used vasopressor and inotropic interventions will be ethically sanctioned Competing interests The ... Accordingly, the objective evidence contributed by Dubin and associates that points to a lack of benefit from vasopressor agents in the management of hypotension and raises the potential for adverse ... Critical Care Vol 13 No Weil and Tang from whom more than one half of his estimated blood volume was removed for treatment of what was more likely streptococcal pharyngo-epiglotitis [5] Current...

Ngày tải lên: 13/08/2014, 18:22

... domain The error bars represent the range between the maximum cost of each domain for CRRT and the minimum cost for IRRT and the maximum cost of each domain for IRRT and minimum cost for CRRT The ... multiplying the actual amount of fluid used for the first 24 hours by the cost of each type of fluid, which varied by each center and country Because of the on-line dialysate production for IRRT, ... Supportive Therapy for the Kidney; CRRT: continuous renal replacement therapy; ICU: intensive care unit; IQR: interquartile range; IRRT: intermittent renal replacement therapy; RRT: renal replacement therapy...

Ngày tải lên: 13/08/2014, 20:21

... contribution of the thesis Thesis is done at K Hospital – Biggest Cancer Center in Vietnam for studying lymphadenectomy and evaluating the results of LAPR for treatment of low rectal cancer The thesis ... dissection 1.4.1.2 Surgical types: depend on disease stage, patient condition, the ability of the surgeon According to the nature of the treatment, the type of surgery: * Radical surgery * Pelvic exenteration ... Adjuvant treatment for rectal cancer: * Chemotherapy: improving survival * Radiotherapy: reducing the incidence of local recurrence and improving disease free survival, so multidisciplinary treatment...

Ngày tải lên: 10/10/2014, 23:25