... contraction and instantaneous atrial volume). The pressure ofthe point at the bottom right corner ofthe loop is the pressure in the ventricle at the end ofthe cardiac cycle and is called the end-diastolic ... understanding ofthe heart as a muscular pump andofthe interaction between the heart andthe vasculature. The concepts of contractility, preload and afterload are paramount to this understanding ... understanding and will be the focus and repeating theme throughout the text. A sound understanding of cardiac physiology begins with basic understanding of cardiac anatomy andof the physiology of muscular...
... results inblocking ofthe binding ofthe SH2 domain to the substrate and thereby preventing interaction of the substrate with the kinase domain. For active n-Srcin which the C-tail tyrosine ... binding ofthe phosphorylatedC-terminus to the SH2 domain and ⁄ or binding ofthe SH2 kinase linker to the SH3 domain, lock the molecules in a closed conformation, disrupt the kinase active site, and ... reduced bydysfunctions ofthe SH2 and ⁄ or SH3 domains ofthe protein. Furthermore,we found that dysfunctions of SH2 and ⁄ or SH3 domains reduce auto-phosphorylation ofthe kinase activation...
... both the supply and demand sides of the market. If insurers and reinsurers are on both sides ofthe market, the market cannotbe said to have attracted very much new capital into the financing of ... programs. They alsorepresent an efficient use of funds in that they pay off in states ofthe world where both the insurer’s losses and industry-wide losses are high.Systematic data on the size ofthe ... half ofthe property insurance retrocessionmarket and are of growing importance in other parts ofthe market.Regulatory and accounting issues such as the regulatory accounting treatment of non-indemnity...
... extension ofthe current FTC guide-lines on advertising allowances and othermerchandising paymentsand services, which seek todefine the applicability of Sections 2(d) and 2(e) of Robinson-Patman ... industrytoday.n Support the development of FTC guidelines on the use of slotting and other promotional fees. Retail Consolidation and Produce Buying Practices7Economic Theories of Slotting and Other FeesMany ... that these fees are necessary to help share the risk ofthe potential failure of a product, to pay for the cost of re-shelving, or simply to share the cost of pro-motion, the imposition of such...
... the conformation of this loop. Changes in the conformation ofthe backbone at this point and changes in the orientation of other side chains, as aresult ofthe introduction ofthe large charged ... introduced alanineat these two positions, with the aim of determiningwhether any ofthe observed effects were a result of changes in the size and charge ofthe amino acid atthese positions.ResultsPreliminary ... 56 and 49, between the dimeric and monomeric forms of enolase. The loss of activityobserved in most studies [23–25] on dissociation of enolase may be the result of changes in other regionsof...
... regard to the objectives ofthe CAP, the measures were both theoretically and practically relevant for the objective of ensuring a fair standard of living for farmers. The measures were theoretically ... within the EU (section 2.2). It then charts the process ofthe loss of consumer confidence (section 2.3) andthe subsequent market developments (section 2.4). Finally, the industry, national and ... to the market developments is elaborated (section 2.5). This Chapter therefore sets the scene for the introduction ofthe Exceptional Measures. 2.1. The outbreak ofthe disease outside the...
... barren land his dwellings. He scorneth the multitude ofthe city, neither regardeth he the voice ofthe driver. The range ofthe mountains is his pasture. The magnificent description ofthe unicorn ... our words, if the nature ofthe language, framed for the purposes of business rather than those of philosophy, andthe nature of my subject, that leads me out ofthe common track of 29calamity; ... in the names they give them, and in their reasonings about them. Many are ofthe opinion, that pain arises necessarily from the removal of some pleasure; as they think pleasure does from the...
... foliation and dip to the east andthe degree of metamorphism increasefrom the eastto the west,thismetamorphismispost‐foliation and normal prograde. However,take into account ... acidplagioclase, biotite, apatite and zircon. The biotitesaretitaniferous and canexpulsetheirTiin the form of aiguillete of rutile. The agespectrum of this biotite (Fig. 5a) ... new synthesis, Journal of Geological Society of Thailand1(2002)1.[17] RuyuanZhang, Bolin Cong, Shiege Maruyama, and G. Liou, Metamorphism and tectonicevolution ofthe ...
... excavation and disposal.52 The cost and extent ofthe cleanup atLarge Area Lead Sites depends on the level or concentration of lead in soil that isconsidered hazardous (i.e., the lower the level of ... healthconcern, the greater the extent and cost ofthe cleanup). Given the enormous volume of material involved, excavation and disposal could cost liable parties hundreds of millions of dollars for ... pp. 5-20.Gilman and EPA. 1994. Memorandum of Understanding between Gilman Paper Company andthe U.S.Environmental Protection Agency Regarding the Land Application of Pulp and Paper Mill Materials.Hanmer,...
... among the three industries covered by the pro-gram according to appropriate measures of impact, such as numbers and types of fatalities and nonfatal injuries and illnesses, andthe application of ... toward achieving the goals ofthe AFF Program. It is difficult to assess the adequacy of production inputs given the lack of detail regarding the distribution of Ag Center funding and how it is ... supposed causes ofthe lack of effectiveness, that is, will the sector-based approach give the director ofthe AFF Program adequate authority and resources to direct the intramural and extramural...
... within the RAND National Security Research Division (NSRD) ofthe RAND Corporation. NSRD conducts research and analysis for the Office ofthe Secretary of Defense, the Joint Staff, the Unified ... 3. THE EFFECT OF STRESS ON PERFORMANCE AND OTHER OUTCOME MEASURES Although the physiological manifestations of stress are largely identical regardless ofthe form ofthe external demand, the ... own appraisal ofthe event. Their work suggests that the physiological stress response is the result ofthe individual’s interaction with the environment and interpretation ofthe event, based...
... derived there from, taking into particular consideration the interests and needs ofthe devel-oping countries” and “exploitation ofthe resources ofthe Moon and other celestial bodies and their ... not prevent others from doing the same.2.2.4 e principle ofthe exploration and use of outer space for the bene t and in the interest of all countries, andthe ‘province of all mankind’ ... e principle ofthe exploration and use of outer space for the benefi t and in the interest of all countries, andthe ‘province of all mankind’ concept 232.2.5. Article II ofthe Outer Space...
... 4 6 9Synthesis and degradation of ketone bodies345Urea cycle and metabolismnof amino groups8920a The expression level ofthe gene is higher (fold change > 1) com-pared with the expression ... gastrectomy at the International Medical Center of Japan, Tokyo. The ethicscommittee ofthe hospital approved this study, and informedconsent was obtained from the patient. The CD105+fractionwas ... linked by the dendrogram above to show the similarity of their gene expression patterns. The expression profile of each gene is represented in the respective rows. Genes are linked by the dendrogram...
... bars)shows the results of analysis of 8-oxoG in the control and KD-1 cells. In the KD-1 cells, the concentration of endogenous 8-oxoG was significantly increased,indicating that PRDX5 contributed to the ... isinvolved in processing and formation of siRNA.We compared cDNAs synthesized using random pri-mer on total RNAs from the PRDX5 KD-1 clone and from the control clone. The sequences of primers used inreal-time ... in the regulation of these genes. It should be noted that,although the exact positions ofthe AREs are not con-served between different mammalian species, at least50% of all AREs in all of these...
... present on the pits epithelial cells and the chief cells ofthe glands. In the large intestine and the caecum, the A antigen was strongly expressed throughout the mucosa whereas presence ofthe B ... tissues than the A antigen. It could not be found in the tongue, the oesophagus, the parotid gland, the uterus, the seminalvesicle, the thyroid and parathyroid glands and the thymus where the A antigen ... thatone ofthe two other known members ofthe family,namely the iGb3 synthetase andthe Forssman synthetase,could have a dual specificity. Alternatively, there couldexist another gene in the rat...