... degrada-tion in the population of hemoglobin-positive cells.To the best of our knowledge, there has been noreport on the promoter function ofthe human HO-2Fig. 7. Characterization ofthe human ... degradation ofthe HO-2mRNA.Functional analysis ofthe HO-1 and HO-2 genepromoters under hypoxiaTo address the question of whether hypoxia influences the promoter activity ofthe human HO-1 ... Takentogether, these results indicate that hypoxia reduces the expression levels of HO-2 mRNA and protein infive out of six cell lines, with the exception of KG1myeloid cells.Hypoxia decreases the...
... for the majority of cells to contain sub2N DNA. Furthermore, the Ymin (minimum response ofthe dose response curve)and the T = 0 values (the number of cells at Time zero)were determined from the ... beFigure 3 The response profile of GSK1070916 for cell lines with a primary diploid chromosome number (<50).Thepercentageofpolyploidy within subpopulations of these cells is provided on the y ... to the sensitivity observedin these cell lines. Comparison ofthe two response phenotypes formodal chromosome number, using a chromosomecount of (3n) as the cutoff, showed a difference in the response...
... for the majority of cells to contain sub2N DNA. Furthermore, the Ymin (minimum response ofthe dose response curve)and the T = 0 values (the number of cells at Time zero)were determined from the ... to the sensitivity observedin these cell lines. Comparison ofthe two response phenotypes formodal chromosome number, using a chromosomecount of (3n) as the cutoff, showed a difference in the response ... GSK1070916. Ymin values represent the bottom of theresponsecurveanddefinethelargesteffectofthecompound. These Ymin values are evaluated relative to the number of cells at time zero using a Ymin/T0...