the blood cerebrospinal fluid barrier structure and functional significance
Báo cáo lâm nghiệp: "Links between tree structure and functional leaf traits in the tropical forest tree Dicorynia guianensis Amshoff (Caesalpiniaceae)" ppsx
Ngày tải lên :
08/08/2014, 00:22
... Total height (H) and basal diameter (D) of the trees were also measured Gasexchange was always recorded on the last leaf of the last GU of the main axis, and the structure of the leaves was analysed ... and cut branches Since similar rates were recorded, the fully expanded leaves from the other canopy trees were shot with a rifle, and the gas-exchange measurements were made, at the feet of the ... A3 which structure remains close to that of the A2 axis which carries them At the top of the crown, A2 form large reiterated complexes (Fig 1, circle) They are vertical and reproduce the architectural...
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Báo cáo khoa học: Quaternary structure and functional properties of Penaeus monodon hemocyanin docx
Ngày tải lên :
23/03/2014, 13:20
... The dashed line and the dotted line indicate the elution profile of a further chromatography of the material included in peak A and peak B, respectively The arrow identifies the broadening of the ... adopt the two conformations rR and tR When the · 6-mer is in the T-state, two other conformations (rT and tT) are available Thus, the conformation of the · 6-mer defines the conformation of the ... (A) and (B) show the results obtained with fractions and of Fig 2, respectively The solid and dashed lines represent the elution profiles as traced following the absorbance at 280 nm and the light...
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báo cáo hóa học:" Effective transvascular delivery of nanoparticles across the blood-brain tumor barrier into malignant glioma cells" docx
Ngày tải lên :
18/06/2014, 15:20
... [66-69] across the barrier may be from direct charge induced damage to endothelial cells of the barrier and disruption of the barrier Our proposed mechanism for the increased barrier permeation ... characterization of the functionalized dendrimers GLG supervised the synthesis and preliminary characterization of the functionalized dendrimers, and contributed to the design of the overall study ... traversing the pores of the blood- brain tumor barrier and accumulating within individual glioma cells Methods PAMAM dendrimer functionalization and characterization Bifunctional chelating agents and...
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báo cáo khoa học: " Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasets" potx
Ngày tải lên :
11/08/2014, 12:20
... signaling and HIF down-regulation, further supporting a role for these small molecules in the inhibition of angiogenesis Despite the fact that clinical trials establishing the activity of these agents ... contributions CS, JML, MG, AE, KAB, BN and ZS wrote the manuscript CS and ZS conceived the scientific approach, JL and SO designed the clinical trials All authors reviewed the manuscript Competing interests ... bevacizumab, the multi-targeted tyrosine kinase inhibitors sorafenib, sunitinib and pazopanib, which inhibit VEGFRs, and the mTOR inhibitors everolimus and temsirolimus Each of these drugs has...
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Báo cáo y học: "Survivors of war in the Northern Kosovo (II): baseline clinical and functional assessment and lasting effects on the health of a vulnerable population" ppsx
Ngày tải lên :
13/08/2014, 14:20
... strength in either hand; two had no strength in the right hand, and one had none in the left hand Only out of 62 male and 10 out of 63 female victims had handgrip strength for the dominant hand equal ... where the principles of the study instruments and procedures were explained They took the parts of the interviewer and respondent in a role-play practice and also practised doing interviews and ... took part in the examinations The objectives and procedure of the study, guarantees of anonymity and confidentiality and the use of the data were explained when victims first arrived at the mobile...
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Identification of novel cytosolic binding partners of the neural cell adhesion molecule NCAM and functional analysis of these interactions
Ngày tải lên :
25/11/2015, 13:27
... compensate for the absent NCAM In humans, the increase of soluble NCAM in affected brain regions and cerebrospinal fluid has been linked to schizophrenia and correlates with the progression of the illness ... of the functional role of kinesin-1 in the delivery of NCAM to the cell surface in primary cortical neurons 59 4.2.4 Localization of the KLC1-binding site within the NCAM-sequence and ... 11: Functional analysis of the influence of kinesin-1 on the delivery of NCAM to the cell surface in CHO cells 55 Fig 12: Functional analysis of the influence of kinesin-1 on the...
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Expression analysis and functional significance of chondroitin sulphate proteoglycans and heparan sulphate proteoglycans in prostrate cancer
Ngày tải lên :
12/09/2015, 11:08
... Introduction 1.1 Prostate gland and prostate cancer 1.1.1 The anatomy of the prostate gland 1.1.2 Functions of the prostate gland 1.1.3 The histology and histopathology of the prostate gland 1.1.3.1 Normal ... behind the urethra and below the ejaculatory ducts; glands are also present in the posterior lobe On the sides of the urethra lie the right and left lateral lobes of the prostate, in which there ... all of the prostatic glandular tissue at the apex and the tissue located posteriorly near the capsule; the central zone is a cone-shaped area of the adult gland, extending from the apex of the cone...
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Tài liệu Báo cáo Y học: Molecular modeling of the dimeric structure of human lipoprotein lipase and functional studies of the carboxyl-terminal domain docx
Ngày tải lên :
21/02/2014, 15:20
... lipase and LPL and the tandem repeat approach of LPL [21,34] support the head-to-tail configuration According to the model structures, the distance between the catalytic site (Ser132) and the substrate ... illustrates the overall saddle shape of the dimeric structure and the key heparin-binding residues in the N-terminal domain held coordinately by the two subunits on the top of the hollow (Fig 1A) The ... workstation and was based on the structures of the human and porcine pancreatic lipases for the open form and on the horse pancreatic lipase for the closed form [16,18,19,30] For homology modeling, the...
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Báo cáo khoa học: Functional aspects of the solution structure and dynamics of PAF – a highly-stable antifungal protein from Penicillium chrysogenum pdf
Ngày tải lên :
29/03/2014, 23:20
... PAF Differences and similarities between the structures of PAF and AFP The common geometrical arrangement of the two proteins is the special Greek key fold, in which the Structure and dynamics of ... the present study, we report the 3D structure and backbone dynamics of PAF by 2D homonuclear and 3D 15 N resolved heteronuclear NMR spectroscopy and demonstrate the functional importance of the ... Asn12 and Lys17 (region 2) and between Lys34 and Asp39 (PAF) and Lys31 and Asp36 (AFP) (region 3) Two conserved GlyLys motifs are repeated in the structure, the glycines (i.e Gly5 from b1 and Gly20...
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báo cáo hóa học: " Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by luminal microvessel IL-6 and GM-CSF" potx
Ngày tải lên :
19/06/2014, 22:20
... 1C and D) Polarized response to IL-6 and GM-CSF in the permeability of BMEC monolayer To determine whether IL-6 and GM-CSF mediate HIV-1 transport across the BBB and decrease TEER with the functional ... GM-CSF to the abluminal chamber Neither antibody in the abluminal chamber inhibited the luminal LPS-induced changes in HIV-1 transport and TEER (Fig 1C and 1D) These results show that the IL-6 and ... blood- brain barrier to various sized molecules Am J Physiology 1985, 248:H712-H718 Chou S, Dix RD: Viral infections and the blood- brain barrier In Implications of the Blood- Brain Barrier and Its...
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báo cáo khoa học: " The effect of experimental warming on leaf functional traits, leaf structure and leaf biochemistry in Arabidopsis thaliana" pdf
Ngày tải lên :
11/08/2014, 11:21
... BJ and NJT designed the experiments LW, JW, KZJ, YW, XXJ, CYN, and YLW performed the experiments and analyzed the data BJ and NJT analyzed the data and wrote the manuscript All authors read and ... ± standard deviation) with the same letter are not significantly different at a = 0.05 by the Bonferroni t-test *The length of chloroplasts and mitochondria is the longest dimension, and the ... temperature (A and B), elevated temperature I (C and D), and elevated temperature II (E and F) Note that the leaf at elevated temperature II was the thinnest of the three temperatures In addition, there...
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Báo cáo y học: "Inhibition of complement C5a prevents breakdown of the blood-brain barrier and pituitary dysfunction in experimental sepsis" ppt
Ngày tải lên :
13/08/2014, 15:21
... TNF and IL-6 is upregulated during experimental sepsis • Authors' contributions MAF, PFS, MHL, PAW and KI designed the study and supervised the experiments MAF, DR, AND, LMH and BMT performed the ... physiological conditions, the BBB maintains the cerebral micro-environment by tightly regulating the passage of molecules into and out of the brain to protect the brain from microorganisms and neurotoxic ... vitro [54] Thus, these mediators interact with surrounding brain cells, relaying into the brain inflammatory response and jeopardising the functional integrity of the BBB [55-57] In the present study,...
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Báo cáo y học: "Analysis of proteomic profiles and functional properties of human peripheral blood myeloid dendritic cells, monocyte-derived dendritic cells and the dendritic cell-like KG-1 cells reveals distinct characteristic" doc
Ngày tải lên :
14/08/2014, 18:20
... are sentinels of the immune system and play a pivotal role in bridging innate immunity with the adaptive immune response Given the scarcity of peripheral blood DCs and the ethical and technical ... mDCs and moDCs [12] and moDCs and KG-1 cells [13], but no studies have compared the proteomes of all three cell types In this study we compare the proteomes of mDCs, moDCs and KG-1 cells, and then ... green, and spots that fall between the red and blue lines are within two-fold higher or lower in either of the gels A correlation coefficient was obtained from the regression line inflammatory and/ or...
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the structure and meaning of president nguyen minh triet’s speech addressed on the occasion of the 1000th anniversary of the foundation of thang long – hanoi a systemic functional analysis
Ngày tải lên :
28/02/2015, 11:54
... to the nature of the participants, their statuses and roles: what kind of role relationships of one kind or another, both the types of speech role that they are taking on in the dialogue and the ... ‘relevance’ or the enabling function As a message structure, a clause consists of a Theme accompanied by a Rheme The Theme is the element which serves as the point of departure of the message, and the Rheme ... are used The former is concerned with the description of the main areas of functional grammar and the latter deals with the analysis of the text for discussion 3 1.5 Data collection The text...
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Nanoparticles of biodegradable polymers for delivery of therapeutic agents and diagnostic sensitizers to cross the blood brain barrier (BBB) for chemotherapy and MRI of the brain
Ngày tải lên :
26/11/2015, 22:48
... INTRODUCTION 1.1 BLOOD BRAIN BARRIER 1.1.1 History and Anatomy of the Blood Brain Barrier 1.1.2 Functions of the Blood Brain Barrier 1.1.3 Clinical Significance of the Blood Brain Barrier 1.2 METHODS ... drugs across the blood brain barrier and the surface coating plays key roles in determining the extent of the particles to cross the BBB To further investigate the potential for the nanoparticles ... constituents and isolate the central nervous systems from toxic chemicals in the blood 1.1.1 History and Anatomy of Blood Brain Barrier It was in the late 19th century that the concept of blood- brain barrier...
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Ensuring Financial Stability: Financial Structure and the Impact of Monetary Policy on Asset Prices
Ngày tải lên :
24/10/2012, 09:40
... zero even at the 95% level in Canada, Finland, the Netherlands, Norway, Sweden, Switzerland, the UK and the US Moreover, while in some countries, (including Finland, the UK and the US) residential ... Canada, Denmark, Finland, France, Germany, Ireland, Italy, Japan, the Netherlands, Norway, Spain, Sweden, Switzerland, the UK and the US The sample starts in 1986 in order to avoid the more turbulent, ... the whole sample period are available for Australia, Canada, Switzerland, Denmark, Finland, France, the Netherlands, Sweden, the UK and the US For, Belgium we link an older series for small and...
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The relationship between an organization’s structure and culture and the effects on business performance
Ngày tải lên :
12/04/2013, 21:50
... group-decision On the other hand, Ballmer has reduced a level of management to manage more easily and efficiently Microsoft structure is less flat therefore, the span of control is narrower and the gap ... where the product managers and the development teams are the champions, and that is a process that has allowed us to have many more products than any one else in the industry” In general, with the ... of the definition is described as follow: “Culture (in the sense of organizational ‘climate’) is the collective self-image and style of the organization; its shared values and beliefs, norms and...
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THE SIMPLE SENTENCE IN TRADITIONAL GRAMMAR AND THE CLAUSE SIMPLEX IN SYSTEMIC FUNCTIONAL GRAMMAR a COMPARATIVE STUDY
Ngày tải lên :
07/09/2013, 13:48
... the structure of the clause has to be described three times over the structure of the clause as representation of experience, the structure of the clause as an exchange and the structure of the ... given or demanded is information; language is the end as well as the means, and what is expected from the listener is the verbal answer On the other hand, giving and demanding goods -and- services ... combination of Theme and Rheme, which gives the clause its character as a message, is known as Thematic structure The Theme-Rheme structure is the basic form of the organization of the clause as...
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Tài liệu Báo cáo " The effect of cobalt substitution on structure and magnetic properties of nickel ferrite " pptx
Ngày tải lên :
13/02/2014, 04:20
... (3) where B2θ is the full width half maximum (rad), λ the wavelength of the X-ray, θ the angle between the incident and diffracted beams (degree) and d the particle size of the sample (nm) (in ... weights of all the atoms in the unit cell, V is volume of the unit cell and N is the Avogadro’s number Since each primitive unit cell of the spinel structure contains molecules, the X-ray density, ... according to the following relation and is shown in Table1 Dx = 8M (2) N A a Where, M is molecular weight of the particular ferrite, NA is the Avogadro’s number and a3 is the volume of the cubic...
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