the biology of adult acute lymphoblastic leukemia

... decrease, thus reducing the inhibitory effect of the peripheral signal informing of the accumulation of body stores of energy We cannot explain the presence of particular clusters of leptin receptor ... localized on the endothelial cells of the blood-brain barrier The dysfunction of these receptors might cause leptin resistance and obesity The ventromedial hypothalamus is the site of leptin, ghrelin, ... classified as overweight (BMI ≥ 85), the respective proportion at the time of the present study was 31% The prevalence of the overweight status at the time of ALL diagnosis/ after ALL treatment...

Ngày tải lên: 10/08/2014, 10:21

... Typical "flower cell" in the peripheral blood of an acute ATL patient Typical "flower cell" in the peripheral blood of an acute ATL patient In the peripheral blood of an acute ATL patient, leukemic ... http://www.retrovirology.com/content/2/1/27 Treatment of ATL – the remaining mission and challenges Regardless of intensive chemotherapies, the prognosis of ATL patients has not so improved The median survival time of acute or lymphoma-type ... cells Deletion of the p16 gene has also been reported in ATL cells [72] Moreover, DNA methylation of the promoter region of the p16 gene is also implicated in the suppression of p16 [73] In addition,...

Ngày tải lên: 13/08/2014, 09:21

... shown in the subset of patients with three or more of chromosome 21 copies in their leukemic clone suggesting that a gene-dosage effect of the RFC1 may compensate for the lower activity of the G ... through both the therapy-patient axis and the therapy-patient axis is likely to modify the therapy Patient and disease interact directly via immune responses, bone marrow stroma support of leukemia, ... high doses of expensive drugs can be avoided The opposite is the case in oncology, where most patients are treated to the limit of acceptable toxicity due to the low therapeutic indices of most...

Ngày tải lên: 13/08/2014, 13:20

... pothesis have attempted to include these theories [5-8] The theory of Greaves and that of Kinlen have been discussed in one of the chapters in this book One of the limitations of the theory of ... in the molecular biology of acute lymphoblastic leukemia (ALL) with application to the clinic There are four sections in the book The first section is about the hypothesis on the etiology of ... the peak age of onset of ALL reflects the degree of susceptibility with which a child is born and, on the other hand, the degree of proliferation of the cells involved in the development of the...

Ngày tải lên: 17/03/2014, 12:20

... (BCL2L1) for The relative amounts of the genes of interest and the b2M reference gene were measured in two independent assays The 2(-ΔΔCT) method was used to present the data of the genes of interest ... peak of the b2M reference gene begins at 81°C ##: Specific peak of the BCL2L1 gene begins at 84°C D: PCR products of the b2M gene by 2.5% agarose gel electrophoresis analysis The size of the PCR ... furthermore, in our previous study, the genes (SPP1 and CREBBP) of the TGF-b pathway (unpublished data) Little is known about the expression pattern of these genes in T-ALL Thus, analyzing the...

Ngày tải lên: 10/08/2014, 22:21

... patients is limited [18-21] The aims of this study were to assess the HRQOL in childhood acute lymphoblastic leukemia (ALL) patients in Indonesia and to assess the influence of demographic and medical ... to facilitate their coping with the disease and its treatment Abbreviations ALL: acute lymphoblastic leukemia; HRQOL: healthrelated quality of life; PedsQL™: the Pediatric Quality of Life Inventory™ ... quality of life in survivors of childhood cancer in Uruguay Pediatr Blood Cancer 2008, 50:838-43 Sutaryo , Sumadiono , Suhadi , et al.: The Protocol of Wijaya Kusuma acute lymphoblastic leukemia of...

Ngày tải lên: 18/06/2014, 19:20

... influence of dexamethasone: once at the end of a dexamethasone period (on-dex) and the second time at the end of a dexamethasone free period (off-dex) five weeks later Questionnaires were sent to the ... contributions to the interpretation of data and were involved in the drafting and critical revision of the manuscript RME and PHO helped with the acquisition of data and critically revised the manuscript ... Although the Infant and Toddler Quality of Life Questionnaire would have been more appropriate for the few younger children (n = 3) in our study sample [30], at the time of the design of our study,...

Ngày tải lên: 20/06/2014, 15:20

... patients is limited [18-21] The aims of this study were to assess the HRQOL in childhood acute lymphoblastic leukemia (ALL) patients in Indonesia and to assess the influence of demographic and medical ... to facilitate their coping with the disease and its treatment Abbreviations ALL: acute lymphoblastic leukemia; HRQOL: healthrelated quality of life; PedsQL™: the Pediatric Quality of Life Inventory™ ... quality of life in survivors of childhood cancer in Uruguay Pediatr Blood Cancer 2008, 50:838-43 Sutaryo , Sumadiono , Suhadi , et al.: The Protocol of Wijaya Kusuma acute lymphoblastic leukemia of...

Ngày tải lên: 20/06/2014, 16:20

... amplification plot for the lymphocyte samples The level of the common mitochondrial deletion in the lymphocyte samples is within the linear range of the standard curve Figure Relative change of mtDNA content ... mtDNA content The lines connect the medians, the boxes cover the 25th to 75th percentiles, and the minimal and maximal values are shown by the ends of the bars Patients with lower amount of CD ratio ... ratio of mtDNA molecules relative to total genomic DNA molecules per cell A third TaqMan assay targeted the CD breakpoint and measured the abundance of the CD in the samples The level of CD was...

Ngày tải lên: 09/08/2014, 09:21

... Journal of Hematology & Oncology 2008, 1:17 Background Acute lymphoblastic leukemia (ALL) is the most common malignancy of childhood Cure of many of these children is difficult ... Study Group for Adult Acute Lymphoblastic Leukemia: Clinical significance of minimal residual disease quantification in adult patients with standard-risk acute lymphoblastic leukemia Blood 2006, ... system and software (Leica, Germany) Statistical Methods The study cutoff time limit was September 2006 Overall survival (OS) was calculated from the first day of chemotherapy to the date of last...

Ngày tải lên: 10/08/2014, 22:20

... (specifically the change in the ratio between the partial pressure of oxygen and the fraction of inspired oxygen (PaO2:FiO2 ratio)), the number of ventilation-free days, and the mean duration of ventilation ... Spragg and colleagues [19] the surfactant group chosen for analysis was the group who were given the same dose of surfactant as the two other trials [20] using the same type of surfactant (recombinant ... ratio), the number of ventilation-free days, and the mean duration of ventilation Unfortu- Page of Characteristics of the trials eligible for meta-analysis Article (Jadad score) Design Number of patients...

Ngày tải lên: 12/08/2014, 23:22

... and Björn Malmqvist The Biology of Mangroves Peter F Hogarth The Biology of Soft Shores and Estuaries Colin Little The Biology of the Deep Ocean Peter Herring The Biology of Lakes and Ponds, ... habitat The Biology of Rocky Shores Colin Little and F A Kitching The Biology of Polar Habitats G E Fogg The Biology of Lakes and Ponds Christer Brönmark and Lars-Anders Hansson The Biology of Streams ... Glacier Bay, on the coast of southeast Alaska, is one of the 12 THE BIOLOGY OF SOIL best known places for research on soil and ecosystem development because of the continuous retreat of the glaciers...

Ngày tải lên: 29/03/2014, 17:20

... race against the media and surely also against other people The future of the adapted mind is the creation of artificial people 401 XIII THE FUTURE OF THE ADAPTED MIND A feature of the adapted ... problem of these studies is that women included in the samples not represent the average of the actual female population at the age of optimal reproduction German measurements of 10 000 young adult ... other societies, and the mere success of the industry is a reflection of the immense strength of the relevant psychological adaptations and mate preferences The strong beliefs among women in the...

Ngày tải lên: 30/03/2014, 16:20

... The larval development of the prawns Macrobrachium equidens and Macrobrachium sp (Decapoda : Palaemonidae), reared in the laboratory Journal of Zoology Proceedings of the Zoological Society of ... der Wissenschaften Mathematisch-Naturwissenschaftliche Classe Wien 45: 389426 Holthuis, L B (1950) The Decapoda of the Siboga Expedition Part 10 The Palaemonidae collected by the Siboga and Snellius ... Decapoda) from the Xishuangbanna region of Yunnan province, southern China Hydrobiologia, 400: – 41 Cai, Y & P K L Ng (2001) The freshwater decapod crustaceans of Halmahera, Indonesia Journal of Crustacean...

Ngày tải lên: 02/04/2014, 09:20

... eight to eighty five and yet the favorite of each age group, N7, had a waist to hip ratio of or 70% So here is the definition of beauty as portrayed by the article The ideal man should be above ... psychologist at the University of Texas studying the attractive traits of the female figure His survey on attractive female figures gives an outlook on what men find most attractive According to the results ... waist-hip ratio of or 90% The ideal woman, on the other hand, should have large eyes, a small jaw, chin, and nose, full lips, firm, symmetrical breasts, unblemished skin, and a waist-hip ratio of or 70%...

Ngày tải lên: 02/04/2014, 17:59

... in the development of his own ideas In the preface to the French edition of his book The Wisdom of the Body, Cannon acknowledged that its main tenet, that the stability of the inner medium of the ... mammals, the great cetaceans, so spectacularly adapted for life in the sea, are confined to the surface layers of the ocean The crushing pressure of the seawater, the cold, and the darkness make the ... but if both occur the probability of death is (set at) 1.0 (certainty) Therefore, the overall risk of death is the sum of the three products, or 2.1 in 100,000 The bottom part of the diagram shows...

Ngày tải lên: 11/06/2014, 10:45

... to the presence of excessive adipose tissue inside the thighs, as previously suggested [5] and to the presence of flat foot due to the overload Recent studies of the load distribution on the ... phase, that is likely due to the excessive load that the knee must support during the stance phase In normal gait the load of the body is supported by the muscle activity of the leg, but in an overweight ... rotation of the foot (external/internal rotation) in respect to the walking direction and is defined as the angle formed with the line of progression and the segment connecting the marker on the V...

Ngày tải lên: 19/06/2014, 10:20

... The effect of consequent exposure of stress and dermal application of low doses of chlorpyrifos on the expression of glial fibrillary acidic protein in the hippocampus of adult mice Journal of ... proportional to the amount of corticosteronetracer bound to the well The amount of free corticosterone present in the well was inversely proportional to the amount of emission The purification of serum ... [17,18] The effect of dermal application of CPF on GFAP expression in the hippocampus has not been reported The aim of this study was to determine the expression of GFAP in the hippocampal region of...

Ngày tải lên: 20/06/2014, 00:20

... http://www.psywb.com/content/1/1/4 The main aim of the present study was to examine the relations of adult playfulness with strengths of character This was tested by means of a global assessment of playfulness as ... in the study by Proyer (2011), the German version of the scale has been used The Short Measure of Adult Playfulness (SMAP; Proyer RT: Development and initial assessment of a short measure for adult ... playfulness When examining the content of the items of the VIA-IS humor-scale, it can be noted that only three out of the ten items refer to playfulness while the others refer to humor directly...

Ngày tải lên: 21/06/2014, 06:20

... materials along the inside of their axons, or the blood supply that nourishes them from the outside The loss of vision results from the death of these nerve cells The hardness of the eye to touch ... interface of the cornea (the clear front surface of the eye), than at the fluid– tissue–fluid interface of the lens Thus, two‐third of the focusing of light is done by the cornea and only one‐third by the ... glaucoma, the pressure increase in the aqueous humor in the front of the eye is transmitted to the back of the eye Although the pressure increase is caused by events in the front of the eye, the damage...

Ngày tải lên: 27/06/2014, 10:20