... decrease, thus reducing the inhibitory effect ofthe peripheral signal informing ofthe accumulation of body stores of energy We cannot explain the presence of particular clusters of leptin receptor ... localized on the endothelial cells ofthe blood-brain barrier The dysfunction of these receptors might cause leptin resistance and obesity The ventromedial hypothalamus is the site of leptin, ghrelin, ... classified as overweight (BMI ≥ 85), the respective proportion at the time ofthe present study was 31% The prevalence ofthe overweight status at the time of ALL diagnosis/ after ALL treatment...
... Typical "flower cell" in the peripheral blood of an acute ATL patient Typical "flower cell" in the peripheral blood of an acute ATL patient In the peripheral blood of an acute ATL patient, leukemic ... http://www.retrovirology.com/content/2/1/27 Treatment of ATL – the remaining mission and challenges Regardless of intensive chemotherapies, the prognosis of ATL patients has not so improved The median survival time ofacute or lymphoma-type ... cells Deletion ofthe p16 gene has also been reported in ATL cells [72] Moreover, DNA methylation ofthe promoter region ofthe p16 gene is also implicated in the suppression of p16 [73] In addition,...
... shown in the subset of patients with three or more of chromosome 21 copies in their leukemic clone suggesting that a gene-dosage effect ofthe RFC1 may compensate for the lower activity ofthe G ... through both the therapy-patient axis and the therapy-patient axis is likely to modify the therapy Patient and disease interact directly via immune responses, bone marrow stroma support of leukemia, ... high doses of expensive drugs can be avoided The opposite is the case in oncology, where most patients are treated to the limit of acceptable toxicity due to the low therapeutic indices of most...
... pothesis have attempted to include these theories [5-8] The theory of Greaves and that of Kinlen have been discussed in one ofthe chapters in this book One ofthe limitations ofthe theory of ... in the molecular biologyofacutelymphoblasticleukemia (ALL) with application to the clinic There are four sections in the book The first section is about the hypothesis on the etiology of ... the peak age of onset of ALL reflects the degree of susceptibility with which a child is born and, on the other hand, the degree of proliferation ofthe cells involved in the development of the...
... (BCL2L1) for The relative amounts ofthe genes of interest and the b2M reference gene were measured in two independent assays The 2(-ΔΔCT) method was used to present the data ofthe genes of interest ... peak ofthe b2M reference gene begins at 81°C ##: Specific peak ofthe BCL2L1 gene begins at 84°C D: PCR products ofthe b2M gene by 2.5% agarose gel electrophoresis analysis The size ofthe PCR ... furthermore, in our previous study, the genes (SPP1 and CREBBP) ofthe TGF-b pathway (unpublished data) Little is known about the expression pattern of these genes in T-ALL Thus, analyzing the...
... patients is limited [18-21] The aims of this study were to assess the HRQOL in childhood acutelymphoblasticleukemia (ALL) patients in Indonesia and to assess the influence of demographic and medical ... to facilitate their coping with the disease and its treatment Abbreviations ALL: acutelymphoblastic leukemia; HRQOL: healthrelated quality of life; PedsQL™: the Pediatric Quality of Life Inventory™ ... quality of life in survivors of childhood cancer in Uruguay Pediatr Blood Cancer 2008, 50:838-43 Sutaryo , Sumadiono , Suhadi , et al.: The Protocol of Wijaya Kusuma acutelymphoblasticleukemia of...
... influence of dexamethasone: once at the end of a dexamethasone period (on-dex) and the second time at the end of a dexamethasone free period (off-dex) five weeks later Questionnaires were sent to the ... contributions to the interpretation of data and were involved in the drafting and critical revision ofthe manuscript RME and PHO helped with the acquisition of data and critically revised the manuscript ... Although the Infant and Toddler Quality of Life Questionnaire would have been more appropriate for the few younger children (n = 3) in our study sample [30], at the time ofthe design of our study,...
... patients is limited [18-21] The aims of this study were to assess the HRQOL in childhood acutelymphoblasticleukemia (ALL) patients in Indonesia and to assess the influence of demographic and medical ... to facilitate their coping with the disease and its treatment Abbreviations ALL: acutelymphoblastic leukemia; HRQOL: healthrelated quality of life; PedsQL™: the Pediatric Quality of Life Inventory™ ... quality of life in survivors of childhood cancer in Uruguay Pediatr Blood Cancer 2008, 50:838-43 Sutaryo , Sumadiono , Suhadi , et al.: The Protocol of Wijaya Kusuma acutelymphoblasticleukemia of...
... amplification plot for the lymphocyte samples The level ofthe common mitochondrial deletion in the lymphocyte samples is within the linear range ofthe standard curve Figure Relative change of mtDNA content ... mtDNA content The lines connect the medians, the boxes cover the 25th to 75th percentiles, and the minimal and maximal values are shown by the ends ofthe bars Patients with lower amount of CD ratio ... ratio of mtDNA molecules relative to total genomic DNA molecules per cell A third TaqMan assay targeted the CD breakpoint and measured the abundance ofthe CD in the samples The level of CD was...
... Journal of Hematology & Oncology 2008, 1:17 Background Acutelymphoblasticleukemia (ALL) is the most common malignancy of childhood Cure of many of these children is difficult ... Study Group for AdultAcuteLymphoblastic Leukemia: Clinical significance of minimal residual disease quantification in adult patients with standard-risk acutelymphoblasticleukemia Blood 2006, ... system and software (Leica, Germany) Statistical Methods The study cutoff time limit was September 2006 Overall survival (OS) was calculated from the first day of chemotherapy to the date of last...
... (specifically the change in the ratio between the partial pressure of oxygen and the fraction of inspired oxygen (PaO2:FiO2 ratio)), the number of ventilation-free days, and the mean duration of ventilation ... Spragg and colleagues [19] the surfactant group chosen for analysis was the group who were given the same dose of surfactant as the two other trials [20] using the same type of surfactant (recombinant ... ratio), the number of ventilation-free days, and the mean duration of ventilation Unfortu- Page of Characteristics ofthe trials eligible for meta-analysis Article (Jadad score) Design Number of patients...
... and Björn Malmqvist TheBiologyof Mangroves Peter F Hogarth TheBiologyof Soft Shores and Estuaries Colin Little TheBiologyofthe Deep Ocean Peter Herring TheBiologyof Lakes and Ponds, ... habitat TheBiologyof Rocky Shores Colin Little and F A Kitching TheBiologyof Polar Habitats G E Fogg TheBiologyof Lakes and Ponds Christer Brönmark and Lars-Anders Hansson TheBiologyof Streams ... Glacier Bay, on the coast of southeast Alaska, is one ofthe 12 THEBIOLOGYOF SOIL best known places for research on soil and ecosystem development because ofthe continuous retreat ofthe glaciers...
... race against the media and surely also against other people The future ofthe adapted mind is the creation of artificial people 401 XIII THE FUTURE OFTHE ADAPTED MIND A feature ofthe adapted ... problem of these studies is that women included in the samples not represent the average ofthe actual female population at the age of optimal reproduction German measurements of 10 000 young adult ... other societies, and the mere success ofthe industry is a reflection ofthe immense strength ofthe relevant psychological adaptations and mate preferences The strong beliefs among women in the...
... The larval development ofthe prawns Macrobrachium equidens and Macrobrachium sp (Decapoda : Palaemonidae), reared in the laboratory Journal of Zoology Proceedings ofthe Zoological Society of ... der Wissenschaften Mathematisch-Naturwissenschaftliche Classe Wien 45: 389426 Holthuis, L B (1950) The Decapoda ofthe Siboga Expedition Part 10 The Palaemonidae collected by the Siboga and Snellius ... Decapoda) from the Xishuangbanna region of Yunnan province, southern China Hydrobiologia, 400: – 41 Cai, Y & P K L Ng (2001) The freshwater decapod crustaceans of Halmahera, Indonesia Journal of Crustacean...
... eight to eighty five and yet the favorite of each age group, N7, had a waist to hip ratio of or 70% So here is the definition of beauty as portrayed by the article The ideal man should be above ... psychologist at the University of Texas studying the attractive traits ofthe female figure His survey on attractive female figures gives an outlook on what men find most attractive According to the results ... waist-hip ratio of or 90% The ideal woman, on the other hand, should have large eyes, a small jaw, chin, and nose, full lips, firm, symmetrical breasts, unblemished skin, and a waist-hip ratio of or 70%...
... in the development of his own ideas In the preface to the French edition of his book The Wisdom ofthe Body, Cannon acknowledged that its main tenet, that the stability ofthe inner medium ofthe ... mammals, the great cetaceans, so spectacularly adapted for life in the sea, are confined to the surface layers ofthe ocean The crushing pressure ofthe seawater, the cold, and the darkness make the ... but if both occur the probability of death is (set at) 1.0 (certainty) Therefore, the overall risk of death is the sum ofthe three products, or 2.1 in 100,000 The bottom part ofthe diagram shows...
... to the presence of excessive adipose tissue inside the thighs, as previously suggested [5] and to the presence of flat foot due to the overload Recent studies ofthe load distribution on the ... phase, that is likely due to the excessive load that the knee must support during the stance phase In normal gait the load ofthe body is supported by the muscle activity ofthe leg, but in an overweight ... rotation ofthe foot (external/internal rotation) in respect to the walking direction and is defined as the angle formed with the line of progression and the segment connecting the marker on the V...
... The effect of consequent exposure of stress and dermal application of low doses of chlorpyrifos on the expression of glial fibrillary acidic protein in the hippocampus ofadult mice Journal of ... proportional to the amount of corticosteronetracer bound to the well The amount of free corticosterone present in the well was inversely proportional to the amount of emission The purification of serum ... [17,18] The effect of dermal application of CPF on GFAP expression in the hippocampus has not been reported The aim of this study was to determine the expression of GFAP in the hippocampal region of...
... http://www.psywb.com/content/1/1/4 The main aim ofthe present study was to examine the relations ofadult playfulness with strengths of character This was tested by means of a global assessment of playfulness as ... in the study by Proyer (2011), the German version ofthe scale has been used The Short Measure ofAdult Playfulness (SMAP; Proyer RT: Development and initial assessment of a short measure for adult ... playfulness When examining the content ofthe items ofthe VIA-IS humor-scale, it can be noted that only three out ofthe ten items refer to playfulness while the others refer to humor directly...
... materials along the inside of their axons, or the blood supply that nourishes them from the outside The loss of vision results from the death of these nerve cells The hardness ofthe eye to touch ... interface ofthe cornea (the clear front surface ofthe eye), than at the fluid– tissue–fluid interface ofthe lens Thus, two‐third ofthe focusing of light is done by the cornea and only one‐third by the ... glaucoma, the pressure increase in the aqueous humor in the front ofthe eye is transmitted to the back ofthe eye Although the pressure increase is caused by events in the front ofthe eye, the damage...