... protein and the mRNA were faint Effects of inhibitors of cGCS and GR on primary cultured testicular cells To investigate the contribution of de novo synthesis and the recycling of GSH to the intracellular ... protein metabolism in these cells Histone is rich inthe basic amino acids, lysine and arginine, but contains no cysteine Protamine, which is replaced for hitstone via transit proteins during ... level of GR inthe epithelia ofthe epididymis (Fig 1) As the epididymis is rich in sulfoxidase, the oxidation of sulfhydryls inthe sperm head and tail would be mediated by this enzyme in a specific...
... with the head or the front limbs); • drinking/eating/biting the cage (the animal stands upright and licks the bottle, chews the food, bites the bars); • grooming (rubbing, cleaning, licking the ... window Screening ofthe metronome and position ofthe apparatus Screening ofthe metronome and position ofthe apparatus and acquisition window • stretching; • scratching the fur with the front ... determined the level ofactivityof each animal in terms of number of signals counted by the software The mice showed a significant difference inthe length ofthe circadian period in LD and DD...
... concentration Therapeutic drug monitoring of infliximab could result in a lowering of dosage in patients having higher exposure than needed, in an increasing of dosage in others, or in a discontinuation of ... within the following three infusions The study design is summarized in Figure The patients gave their informed consent to participate inthe study, and the study protocol was in compliance with the ... to infliximab infusion and included clinical assessment, a blood sample for measurement of infliximab, and testdesign ing for antibody against infliximab The final therapeutic decision took into...
... change the fit indices (see Table for factor loadings and residuals) Together, these findings imply that there are no threats to longitudinal invariance for the revised version ofthe PACES, and the ... multiple age groups together, ranging in age from 25 to 75 Together, these findings call for a validation study ofthe PACES in a sample of older adults 5 To date, no version ofthe PACES has been ... was determined, group invariance and longitudinal invariance were examined Invariance testing involves the sequential comparison across nested models through the incremental addition of equality...
... deflate nominal box office dollars, instead of a film or entertainment-specific price index Since the individuals inthe sample are concentrated in certain areas ofthe country (southern California ... Data The dataset inthe paper involved a substantial collection exercise, merging four distinct sources The first source was the set of names of film stars to be included inthe sample In early ... distribution of box office returns is Pareto, with an infinite variance Participants inthe film industry are quite aware ofthe enormous riskiness their ventures entail Therefore, despite their high incomes,...
... phosphatases may possibly To examine whether MursiF retains kinase activityin spite ofthe loss of critical residues involved in ATP binding, as observed in our in silico analysis of MursiF WKD (Fig 3A), ... MursiF, the RsbW ⁄ kinase domain (WKD), shows 40% similarity to B subtilis RsbW, a serine kinase belonging to the GHKL family of kinases This family of kinases is defined by the presence of an ATP-binding ... UsfX, and interdomain interactions between its RsbW and RsbV domains also occur [13] The role and mechanism of regulation ofthe multidomain protein Rv1364c are intriguing, and underline the need...
... containing either the whole N-terminal domain of PrPC or the HD only, was sorted basolaterally, indicating that this domain acts as a dominant sorting signal Vice versa, Dpl or PrPC lacking the ... this domain, rather then the absence ofthe octarepeat region, is linked to the neurotoxic properties of PrPDF The internal HD was identified as an important domain for basolateral sorting of PrPC ... C-terminal globular domain of PrPC, but lacks the N-terminal octarepeats and the internal HD [33] (Fig 2) Interestingly, the expression of PrPDF, a mutant devoid ofthe octarepeats and the HD...
... protein bands of 52 kDa These results suggest that the Myc tag fusion inthe C-terminus of THTR1 protein may interfere with the cellular expression and/or stability ofthe protein In view of these ... counterpart inthe hRFC is embedded inthe end of TMD2 [13,23] An alignment ofthe deduced aminoacid sequence ofthe human THTR1 with that ofthe various members ofthe SLC19A family including rodent ... alignment ofthe aspartate 93 in human THTR1 with various members ofthe SLC19 family The conserved aspartate 93 is indicated in bold Light shading indicates the amino acids showing conservation in...
... for the inactivity zone learning Inthe case of intersection with activity zones, the assumed current sitting area B (candidate inactivity zone) is detected as false and ignored In case of no intersection, ... generated In order to verify the elderly presence inthe inactivity zone, centroid ofthe person silhouette inthe inactivity polygons is checked Similarly, a bending posture detected in an inactivity ... context The output ofthe TSVM classifier is further verified using zone-level context information Especially if the classifier output a lying posture, then the presence ofthe person in all inactivity...
... for the inactivity zone learning Inthe case of intersection with activity zones, the assumed current sitting area B (candidate inactivity zone) is detected as false and ignored In case of no intersection, ... check for intersections The intersection procedure results in a clipped polygon consisting of all the points interior to theactivity zone polygon Ai (clip polygon) that lie inside the inactivity ... analysis and ellipse fitting [14,23] The defined key points ofthe silhouette are then used to learn theactivity and inactivity zones These zones are represented inthe form of polygons Polygon representation...
... explain this finding at this time Further investigations will be performed to explain why HNE does not affect the mRNA level of Col I by determining RNA-binding proteins Among them, alphaCP protein ... knockout mice[33] These findings underline the importance of OC in bone turnover, suggesting that OC retards bone formation/ mineralisation[34] Therefore, the increased OC levels in Page of 14 (page ... 8a) These results indicated that the inhibition ofthe IKKα pathway is the major regulator ofthe IL-6 response to HNE To further confirm that p38 MAPK plays a principal role in mediating HNE-induced...
... at 80% of 1-RM according to the guidelines ofthe ACSM [8] Six resistance training exercises, targeting the large muscle groups ofthe body, were performed inthe following order: seated leg ... reportedly minimizes depressive symptoms in women infected with HIV [7] There are few studies examining the effects of aerobic and resistance exercise training on lipodystrophy and quality of life in ... domains improved after exercise training, as reported by others [14] There were decreases in visceral and subcutaneous fat inthe central region of her body, which has been associated with insulin...
... number of cells showing nuclear staining inthe epithelium A number of cells showing nuclear staining inthe epithelium (control group) SB concieved and coordinated the study andparticipated inthe ... hematoxylin-eosin (H&E) All H&E-stained biopsies were evaluated for the presence of hyperplasia ofthe epithelium and the presence of inflammatory cells inthe stroma The degree of inflammatory cell infiltration ... nifedipine [7] and CsA is related to thickening ofthe spinous layer [9] Results of clinical studies indicate that gingival inflammation increases the incidence and severity of gingival overgrowth in...
... detecting endotoxin in whole blood based on the detection of enhanced respiratory burst activityin neutrophils following their priming by complexes of endotoxin and a specific antiendotoxin antibody ... or phenylephrine, epinephrine or norepinephrine at any dose to maintain systolic blood pressure > 90 mmHg) Assay of endotoxin by endotoxin activity assay The EAA assay is described in detail elsewhere ... calculated by subtracting the averaged 20-min light integral ofthe control from the assay tube and the maximally stimulated tube The response factor was the difference light integral ofthe test sample...
... patients inthe present study were carefully controlled during the conduct ofthe study, including two overnight stays inthe clinic and three visits inthe out The assays were performed in three ... theplasmaduring the patientsandthe study assessed for Change in plasma desmosines level and change in urine desmosines level during the 44 days ofthe study assessed for each ofthe 12 participating patients ... desmosines The calculated analytical interassay coefficient of variation (CVa) was 4.2 % Desmosines concentration in urine is normalized to urine creatinine (µg/g creatinine), whereas desmosines...
... inthe dorsal cluster, the ddaE neurons Whether the loss of function of gcm2 and pcaf leads to the absence of ddaD neurons, the other type I of DA neurons inthe dorsal cluster, or to their inability ... role inthe transcriptional repression of dendrite outgrowth and branching Ofthe 21 genes in group B, the normal function of 19 appeared to be to restrict the extension ofthe primary dendrite in ... dendrite outgrowth but also the coordination ofthe extension ofthe primary dendrite with the formation of lateral branches and with the direction of growth On thebasisof RNAi phenotypes, Parrish...
... al 1998), have all resulted in patterning defects inthe midbrain-hindbrain region, arguing for a role of these genes inthe establishment of midbrain and hindbrain identities 1.6.2 Extracellular ... these DA neurons in human pathology, survival and induction of dopaminergic neurons has always been the subject of intense study 1.4 Therapies used in treatment of Parkinson’s disease While there ... involved in dopaminergic neuron differentiation The elucidation ofthe genes and mechanisms that regulate the development ofthe dopaminergic neurons is an important goal In addition to being of immense...
... exception The objective of this report was to investigate the advantages and disadvantages of learning EEE as well as the main reason why they did not get good mark inthe final test Techniques of gathering ... Techniques of gathering data including different types of questionnaires administered to students in d06, k52 in FOFL, HUT The study found that most of them found difficulties in learning EEE Although ... Faculty of Foreign Language Ha Noi University of Technology The Situation of Learning English for Electrical Engineering of D06k52 Students in Faculty of Foreign Language, Ha Noi University of Technology...