the basis of electrical activity in the neuron

... protein and the mRNA were faint Effects of inhibitors of cGCS and GR on primary cultured testicular cells To investigate the contribution of de novo synthesis and the recycling of GSH to the intracellular ... protein metabolism in these cells Histone is rich in the basic amino acids, lysine and arginine, but contains no cysteine Protamine, which is replaced for hitstone via transit proteins during ... level of GR in the epithelia of the epididymis (Fig 1) As the epididymis is rich in sulfoxidase, the oxidation of sulfhydryls in the sperm head and tail would be mediated by this enzyme in a specific...

Ngày tải lên: 17/03/2014, 17:20

... with the head or the front limbs); • drinking/eating/biting the cage (the animal stands upright and licks the bottle, chews the food, bites the bars); • grooming (rubbing, cleaning, licking the ... window Screening of the metronome and position of the apparatus Screening of the metronome and position of the apparatus and acquisition window • stretching; • scratching the fur with the front ... determined the level of activity of each animal in terms of number of signals counted by the software The mice showed a significant difference in the length of the circadian period in LD and DD...

Ngày tải lên: 10/08/2014, 09:20

... concentration Therapeutic drug monitoring of infliximab could result in a lowering of dosage in patients having higher exposure than needed, in an increasing of dosage in others, or in a discontinuation of ... within the following three infusions The study design is summarized in Figure The patients gave their informed consent to participate in the study, and the study protocol was in compliance with the ... to infliximab infusion and included clinical assessment, a blood sample for measurement of infliximab, and testdesign ing for antibody against infliximab The final therapeutic decision took into...

Ngày tải lên: 12/08/2014, 11:22

... change the fit indices (see Table for factor loadings and residuals) Together, these findings imply that there are no threats to longitudinal invariance for the revised version of the PACES, and the ... multiple age groups together, ranging in age from 25 to 75 Together, these findings call for a validation study of the PACES in a sample of older adults 5 To date, no version of the PACES has been ... was determined, group invariance and longitudinal invariance were examined Invariance testing involves the sequential comparison across nested models through the incremental addition of equality...

Ngày tải lên: 14/08/2014, 08:20

Ngày tải lên: 31/08/2012, 16:33

... deflate nominal box office dollars, instead of a film or entertainment-specific price index Since the individuals in the sample are concentrated in certain areas of the country (southern California ... Data The dataset in the paper involved a substantial collection exercise, merging four distinct sources The first source was the set of names of film stars to be included in the sample In early ... distribution of box office returns is Pareto, with an infinite variance Participants in the film industry are quite aware of the enormous riskiness their ventures entail Therefore, despite their high incomes,...

Ngày tải lên: 19/02/2014, 10:20

... phosphatases may possibly To examine whether MursiF retains kinase activity in spite of the loss of critical residues involved in ATP binding, as observed in our in silico analysis of MursiF WKD (Fig 3A), ... MursiF, the RsbW ⁄ kinase domain (WKD), shows 40% similarity to B subtilis RsbW, a serine kinase belonging to the GHKL family of kinases This family of kinases is defined by the presence of an ATP-binding ... UsfX, and interdomain interactions between its RsbW and RsbV domains also occur [13] The role and mechanism of regulation of the multidomain protein Rv1364c are intriguing, and underline the need...

Ngày tải lên: 30/03/2014, 02:20

... containing either the whole N-terminal domain of PrPC or the HD only, was sorted basolaterally, indicating that this domain acts as a dominant sorting signal Vice versa, Dpl or PrPC lacking the ... this domain, rather then the absence of the octarepeat region, is linked to the neurotoxic properties of PrPDF The internal HD was identified as an important domain for basolateral sorting of PrPC ... C-terminal globular domain of PrPC, but lacks the N-terminal octarepeats and the internal HD [33] (Fig 2) Interestingly, the expression of PrPDF, a mutant devoid of the octarepeats and the HD...

Ngày tải lên: 30/03/2014, 09:20

... protein bands of 52 kDa These results suggest that the Myc tag fusion in the C-terminus of THTR1 protein may interfere with the cellular expression and/or stability of the protein In view of these ... counterpart in the hRFC is embedded in the end of TMD2 [13,23] An alignment of the deduced aminoacid sequence of the human THTR1 with that of the various members of the SLC19A family including rodent ... alignment of the aspartate 93 in human THTR1 with various members of the SLC19 family The conserved aspartate 93 is indicated in bold Light shading indicates the amino acids showing conservation in...

Ngày tải lên: 30/03/2014, 20:20

... for the inactivity zone learning In the case of intersection with activity zones, the assumed current sitting area B (candidate inactivity zone) is detected as false and ignored In case of no intersection, ... generated In order to verify the elderly presence in the inactivity zone, centroid of the person silhouette in the inactivity polygons is checked Similarly, a bending posture detected in an inactivity ... context The output of the TSVM classifier is further verified using zone-level context information Especially if the classifier output a lying posture, then the presence of the person in all inactivity...

Ngày tải lên: 18/06/2014, 22:20

... for the inactivity zone learning In the case of intersection with activity zones, the assumed current sitting area B (candidate inactivity zone) is detected as false and ignored In case of no intersection, ... check for intersections The intersection procedure results in a clipped polygon consisting of all the points interior to the activity zone polygon Ai (clip polygon) that lie inside the inactivity ... analysis and ellipse fitting [14,23] The defined key points of the silhouette are then used to learn the activity and inactivity zones These zones are represented in the form of polygons Polygon representation...

Ngày tải lên: 20/06/2014, 21:20

... explain this finding at this time Further investigations will be performed to explain why HNE does not affect the mRNA level of Col I by determining RNA-binding proteins Among them, alphaCP protein ... knockout mice[33] These findings underline the importance of OC in bone turnover, suggesting that OC retards bone formation/ mineralisation[34] Therefore, the increased OC levels in Page of 14 (page ... 8a) These results indicated that the inhibition of the IKKα pathway is the major regulator of the IL-6 response to HNE To further confirm that p38 MAPK plays a principal role in mediating HNE-induced...

Ngày tải lên: 09/08/2014, 08:22

... at 80% of 1-RM according to the guidelines of the ACSM [8] Six resistance training exercises, targeting the large muscle groups of the body, were performed in the following order: seated leg ... reportedly minimizes depressive symptoms in women infected with HIV [7] There are few studies examining the effects of aerobic and resistance exercise training on lipodystrophy and quality of life in ... domains improved after exercise training, as reported by others [14] There were decreases in visceral and subcutaneous fat in the central region of her body, which has been associated with insulin...

Ngày tải lên: 10/08/2014, 23:20

... number of cells showing nuclear staining in the epithelium A number of cells showing nuclear staining in the epithelium (control group) SB concieved and coordinated the study andparticipated in the ... hematoxylin-eosin (H&E) All H&E-stained biopsies were evaluated for the presence of hyperplasia of the epithelium and the presence of inflammatory cells in the stroma The degree of inflammatory cell infiltration ... nifedipine [7] and CsA is related to thickening of the spinous layer [9] Results of clinical studies indicate that gingival inflammation increases the incidence and severity of gingival overgrowth in...

Ngày tải lên: 11/08/2014, 23:22

... detecting endotoxin in whole blood based on the detection of enhanced respiratory burst activity in neutrophils following their priming by complexes of endotoxin and a specific antiendotoxin antibody ... or phenylephrine, epinephrine or norepinephrine at any dose to maintain systolic blood pressure > 90 mmHg) Assay of endotoxin by endotoxin activity assay The EAA assay is described in detail elsewhere ... calculated by subtracting the averaged 20-min light integral of the control from the assay tube and the maximally stimulated tube The response factor was the difference light integral of the test sample...

Ngày tải lên: 12/08/2014, 18:21

... patients in the present study were carefully controlled during the conduct of the study, including two overnight stays in the clinic and three visits in the out The assays were performed in three ... theplasmaduring the patientsandthe study assessed for Change in plasma desmosines level and change in urine desmosines level during the 44 days of the study assessed for each of the 12 participating patients ... desmosines The calculated analytical interassay coefficient of variation (CVa) was 4.2 % Desmosines concentration in urine is normalized to urine creatinine (µg/g creatinine), whereas desmosines...

Ngày tải lên: 12/08/2014, 18:21

... in the dorsal cluster, the ddaE neurons Whether the loss of function of gcm2 and pcaf leads to the absence of ddaD neurons, the other type I of DA neurons in the dorsal cluster, or to their inability ... role in the transcriptional repression of dendrite outgrowth and branching Of the 21 genes in group B, the normal function of 19 appeared to be to restrict the extension of the primary dendrite in ... dendrite outgrowth but also the coordination of the extension of the primary dendrite with the formation of lateral branches and with the direction of growth On the basis of RNAi phenotypes, Parrish...

Ngày tải lên: 14/08/2014, 16:21

... al 1998), have all resulted in patterning defects in the midbrain-hindbrain region, arguing for a role of these genes in the establishment of midbrain and hindbrain identities 1.6.2 Extracellular ... these DA neurons in human pathology, survival and induction of dopaminergic neurons has always been the subject of intense study 1.4 Therapies used in treatment of Parkinson’s disease While there ... involved in dopaminergic neuron differentiation The elucidation of the genes and mechanisms that regulate the development of the dopaminergic neurons is an important goal In addition to being of immense...

Ngày tải lên: 08/11/2015, 17:09

... exception The objective of this report was to investigate the advantages and disadvantages of learning EEE as well as the main reason why they did not get good mark in the final test Techniques of gathering ... Techniques of gathering data including different types of questionnaires administered to students in d06, k52 in FOFL, HUT The study found that most of them found difficulties in learning EEE Although ... Faculty of Foreign Language Ha Noi University of Technology The Situation of Learning English for Electrical Engineering of D06k52 Students in Faculty of Foreign Language, Ha Noi University of Technology...

Ngày tải lên: 13/12/2013, 12:15