the basics of new product development

... industry.26 Many of the compounds in the top decile of the returns distribution involve the first mover, or other early entrants, in a new therapeutic class The family of medicines in a given therapeutic ... percent of the returns, measured at the time of the final distributions to investors, are realized by the top decile of venture capital projects At the same time roughly half of the projects in these ... different stages of the R&D process, and the length of time that it takes to move through all the stages of the R&D process and gain FDA approval Recent studies of the probability of success and...

Ngày tải lên: 13/03/2014, 21:59

... audited the balance sheets of the New York City Industrial Development Agency (the Agency), a component unit of The City of New York, as of June 30, 2010 and 2009 and the related statements of revenues, ... IDA is considered a component unit of The City of New York (the City) for financial reporting purposes, and a public benefit agency of the State of New York (the State) IDA was established in ... recognition in the Agency’s financial statements Since the Tax Exempt PILOT Bonds were issued to finance the construction of the stadiums and the Agency is the legal owner of the stadiums, the Tax Exempt...

Ngày tải lên: 19/06/2014, 21:20

... (IDA or the Agency) is considered a component unit of The City of New York (the City) for financial reporting purposes of the City, and a public benefit corporation of the State of New York (the ... obligations of the United States of America and obligations of the State of New York As of June 30, 2010, the Agency’s investments in corporate bonds carry the explicit guarantee of the United States of ... is the risk that in the event of the failure of the counterparty, the Agency will not be able to recover the value of its investments or collateral securities that are in the possession of the...

Ngày tải lên: 19/06/2014, 21:20

... in the amount of $942,555,000, which consist of the PILOT Revenue Bonds and the CPI Bonds in the amount of $744,435,000 and $198,120,000, respectively, for the purpose of paying a portion of the ... outstanding under the Yankee Stadium project, IDA has entered into a SWAP Agreement to hedge the changes in the cash flows of the CPI bonds Based on the consistency of the terms of the swap and the CPI ... either of Moody’s or S&P and (ii) the market value of the swap transactions covered by the credit support annex is in favor of the Agency in an amount that exceeds the threshold amount and the...

Ngày tải lên: 19/06/2014, 21:20

... Standards The Board of Directors New York City Industrial Development Agency We have audited the balance sheet of New York City Industrial Development Agency (the Agency), a component unit of the City ... for the information and use of the management, Board of Directors, others within the entity and the City of New York and is not intended to be and should not be used by anyone other than these ... Economic Development Corporation on the accompanying balance sheets This is trial version www.adultpdf.com 30 New York City Industrial Development Agency (a component unit of The City of New York)...

Ngày tải lên: 19/06/2014, 21:20

... result from the design stage, particularly during the drug development process Consider the drug development sequence from the perspective of the sponsor A promising agent is found Then, there are ... and not upon the value of any single arm The principle of ‘equal uncertainty between the arms of the RCT’ must be replaced with the principle of a reasonable ‘expected value’ for the participant ... violate the principle of equipoise Publication bias Results The results from every RCT (45 out of 45) favored the drug of the sponsor (P < 0.0001) Discussion Clearly, the results of these trials could...

Ngày tải lên: 09/08/2014, 01:23

... more than the sum of all students in the class This then raises the question of the validity and authority of knowledge gained over the Internet How can the learner be sure of the sources of information? ... some of the developments at my own institution and my understanding of how these developments relate to the question of the forms and nature of knowledge Using technology for teaching at the University ... wide variety of ways to stimulate various forms of learning The most significant feature of the multiple forms of media is that they allow for the presentation of knowledge in a variety of ways Thus...

Ngày tải lên: 04/11/2013, 20:15

... shortly by the first iteration of the product The product, the architecture, the plans, and the specifications evolved as the team adapted to the ever-unfolding reality of the market and the technology ... but they don’t test them in the cauldron of reality Documents don’t work Products Agile development and project management stress delivery of versions of the actual product, or in the case of ... statement the customer is the individual or group who uses the created product to generate business value or, in the case of retail products, the person who uses the product Customers define value Other...

Ngày tải lên: 23/11/2013, 14:19

... above the swell of the roots; when reinforced at the ground and also at the branching point, as often in the American elm, the measurements are made at the smallest place between the swell of the ... prepared the index To these and to all others who have given assistance in the preparation of this work, the grateful thanks of the authors are due.[Pg vii] [Pg viii] KEY TO THE TREES OF NEW ENGLAND ... Terry), probably about the southern limit of the species; Rhode Island and Connecticut, not reported West through the northern sections of the northern tier of states to the Rocky mountains Habit....

Ngày tải lên: 13/02/2014, 12:20

... improving the quality of life The differences are between perspectives: the individual and the societal; the negative and the positive; the curative and the preventive; the reductivist and the holistic ... Pediatric Asthma I Context: The context addresses issues such as the what, the whys, the who, and the when It provides the ‘meaning or reason’ for the development of the educational material It ... variety of EMs, some culturally specific, but the majority reported biomedical concepts of etiology, pathophysiology, and triggers Although 76% of mothers knew the names of more than one of their...

Ngày tải lên: 14/02/2014, 13:20

... guarantee a portion of the investment; • MDRC oversees the day-to-day implementation of the project and manages the Osborne Association and Friends of Island Academy, the two non-profit service providers ... deliver the intervention; • The Vera Institute of Justice, an independent evaluator, determines whether the project achieves the targeted reductions in reincarceration; • The Department of Correction ... is relatively new and New York City will be the first in the nation to implement this innovative financing model What are the Benefits? • Investing in outcomes to improve the lives of those in...

Ngày tải lên: 15/02/2014, 13:20

... intervention, however, there was no Christmas peak as there had been the previous year The number of cases in the year of the project (11) was lower than during the same weeks of the previous year ... and how it affects the desired change? ® Taken together, will the overall mix of interventions reach enough of the target audience often enough to have the desired impact? ® Is the overall mix feasible ... barriers of lack of time and convenience for exercising, or raising cigarette taxes to increase the financial costs of smoking Product One of the “Four P’s of Marketing,” product refers to the desired...

Ngày tải lên: 18/02/2014, 02:20

... of Chapter II then look at different aspects of new media interfaces: their reliance on 38 the conventions of other media and the relationship between the body of the user and the interface The ... from the level of binary code to the level of a computer program, and then moves further to consider the logic of new media objects driven by these programs: I II III IV V “What is New Media”: the ... understand the logic driving the development 34 of the language of new media (I am not claiming that there is a single language of new media; rather, I use it as an umbrella term to refer to a number of...

Ngày tải lên: 19/02/2014, 14:20

... remarkable The grandchildren of the men who had witnessed the spectacle of a king of France and a king of England humbled at the feet of Innocent III., the children of the men who had found the gigantic ... nevertheless of infinite value, and the possession of it was the subject of an everlasting struggle between the powers of heaven and the powers of hell In presence of the awful responsibility of ... admitted to the freedom of this body politic, but such as are members of some of the churches within the limits of the same." Into the merits of this measure as illustrating the theocratic ideal of society...

Ngày tải lên: 21/02/2014, 08:20

... address the perception of the brand that the firm brings to the marketplace If the product does not match the value proposition expected from the given brand, then customers will reject the product Product ... changing needs of consumers (buyers), the power of other partners in the supply chain, the emergence of new players, the development of technologies that might render a company’s existing products ... competition and the brand position of the new offering Customers will view a new and potentially innovative offering in the context of the available products, and determine if the given consumer has undersatisfied...

Ngày tải lên: 21/02/2014, 18:20

... important for New Yorkers to understand the burden of air pollution on New Yorkers’ health, the health benefits of addressing it and the costs of inaction 37 I Air Pollution and the Health of New Yorkers: ... emissions of other harmful pollutants Studies on concentrations of individual 35 I Air Pollution and the Health of New Yorkers: The Impact of Fine Particles and Ozone air pollutants and the risk of ... quantify the relationship between the concentrations of pollutants measured in the air and the risk of adverse health effects in the population The report uses the results from both types of studies...

Ngày tải lên: 06/03/2014, 16:20

... per day? Could they make one per day by writing their name on it? They could There are loads of other ways of both saving the company money and respecting the planet Brainstorm them 91 Be fast ... At The Basics of Business 100: 85 Don’t rush recruitment; you’ll live with the consequences for years Spend the right amount of time and money making the process as brilliant as you can Rather ... Sending great ideas to the board? Challenging-constructively-ideas coming out of product marketing? What are they afraid of? That fear is not good for the firm 69 Where is the waste in your business?...

Ngày tải lên: 06/03/2014, 19:20

... indications Therefore, our quantity measures are not literally the number of patient-days of therapy being consumed, but rather the number of patient-days of therapy which would be consumed if all of the ... these quantities are therapeutically equivalent The quantity of patient-days of therapy of a drug sold in a given month is equal to the total number of milligrams sold divided by the number of ... Introduction The introduction of Tagamet into the U.S market in 1977 marked the beginning of a revolutionary treatment for ulcers and the emergence of a new industry What distinguished the products of...

Ngày tải lên: 07/03/2014, 08:20

... their children; they disapproved of the lax Dutch observance of Sunday and saw in the temptations of the place a menace to the habits and morals of the younger members of the flock, and, in the ... island where the law and the lawgivers were in favor of the maintenance of feudal rights The expectations of all were aroused by visions of wealth from the El Dorados of the West, or of profit from ... " 205 THE FATHERS OF NEW ENGLAND CHAPTER I CHAPTER I THE COMING OF THE PILGRIMS The Pilgrims and Puritans, whose migration to the New World marks the beginning of permanent settlement in New England,...

Ngày tải lên: 08/03/2014, 13:20

... fleeing toward the city, who told them of the arrival of the British at Villere's, and of the capture of the outpost there It was then but half-past one o'clock The two scouts put spurs to their horses, ... delay of the arrival of the troops, and with this, the failure of the arrival of the arms and munitions necessary to equip the men for service, had their beginning in the culpable negligence of the ... In the course of the night all the enemy's troops recrossed the river, to join their main body The result of this attack of the enemy on the right bank was, the loss of one hundred and twenty of...

Ngày tải lên: 08/03/2014, 15:20