the anti atherogenic effects of lycopene

... investigating the mechanisms underlying the effects of H1-antihistamines have indicated that, in addition to their being a potent antihistamine, levocetirizine exhibits anti- allergic/antiinflammatory effects, ... considerable interest in the effect of anti- inflammatory drugs on the pro-inflammatory processes responsible for the manifestations of allergic disease Antiinflammatory effects independent of H1-receptor ... conducted in vivo studies Anti- inflammatory effects - in vivo studies A number of reports suggest that additional antiinflammatory effects may be of relevance to the efficacy of levocetirizine Ciprandi...

Ngày tải lên: 08/08/2014, 21:20

... of the study, performed the experiments and carried out the majority of the assays, performed the statistical analysis, participated in the design and coordination of the study, and drafted the ... grant No 3-2994 from the Chief Scientist Office of the Ministry of Health, Israel This study was a part of the PhD thesis of Miri Brodsky Author details C.A.I.R Institute, The Safdiè AIDS and ... h, the lack of modulation of the NFkB pathway by AS101 at h, concomitantly with the inhibition of iNOS at that time point, prompted us to further explore the mechanism of iNOS inhibition at h The...

Ngày tải lên: 11/08/2014, 08:22

... focus of the projection bulb was directed to the middle of the plantar surface of the animal with the aid of a mirror attached to the stimulator The intensity of the light source was adjusted to the ... induced by subcutaneous injection of 50 μl of 2% CA lambda (Sigma-Aldrich, USA) in 0.9% saline at the center of the left paw on the planter surface At the end of the experiments, animals were sacrificed ... baseline taken before the induction of anesthesia and CA injection The assessor who took the above measurements was blinded to the group status of the animal Localization of auricular acupoints...

Ngày tải lên: 13/08/2014, 14:20

... conditions could reduce the inhibitory activity of these molecules These results confirm the potential of these molecules and the possibility that they contribute to the inhibition of neutrophil-mediated ... evaluating the anti- inflammatory properties of extracts, fractions and pure compounds, as well studying the presence of several anti- inflammatory mediators at the site of the inflammation In the present ... into account in the screening of anti- inflammatory compounds concerns the in vitro assays utilized and the prediction of the efficacy of test compounds in vivo in order to define their possible...

Ngày tải lên: 11/08/2014, 08:22

... before and after the clinical improvement This leaves us to the discussion of the anti- inflammatory effects of antipsychotic medication on CRP levels and a patient’s clinical symptoms The literature ... three months of treatment Between the commencement of the new psychotropic treatment regimen in October 2007 and the significant improvement of the depressive symptoms as described above, the arthritis ... Baune and Eyre: Anti- inflammatory effects of antidepressant and atypical antipsychotic medication for the treatment of major depression and comorbid arthritis: a case report Journal of Medical Case...

Ngày tải lên: 11/08/2014, 14:21

... flower The antioxidative effects of the ethanol extracts (0.1 mg/ml) were compared with those of water extraction .The ethanol extracts of the biennial flower showed lesser antioxidative effects ... 90% of ethanol extracts did not show any effects Discussion The present study, for the first time, demonstrated the anti- oxidative effects possessed by the water extract of the biennial flower of ... Results Anti- oxidative effects of Panax notoginseng’s biennial flower To reveal the anti- oxidative effects of Panax notoginseng, we carried out an in vitro assay of xanthine oxidase effects The abnormality...

Ngày tải lên: 13/08/2014, 14:20

... al., 2007) Epithelium serves as the main barrier for the airways; abnormal barrier function of the epithelium has been linked to high incidences of asthma, suggesting the role of epithelium dysfunction ... of NFκB in the airway epithelium is sufficient to provoke AHR and cause the thickening of ASM (Pantano et al., 2008) AHR, as a constant feature of the asthma, is the result of a combination of ... inhibition, but there might be other mechanisms for this drug The major limitation of theophylline is its narrow therapeutic index Therefore, theophylline is now considered as the second-line therapy...

Ngày tải lên: 11/09/2015, 16:03

... IgE levels, the number of IgE receptors expressed on the surface of basophils, the clinical severity of asthma, the 23 frequency of exacerbations, and the corticosteroids requirements of patients ... MBP and ECP on the airway wall These proteins are cytotoxic to the airway epithelium Damage of the airway epithelium may lead to AHR by removing enzymes important in the degradation of neuropeptides ... sensitizing them (Busse and Lemanske, 2001) Crosslinking of FcεRI with IgE and antigen is the triggering event of the activation of protein-tyrosine kinases (PTK), including those of the Src, Syk...

Ngày tải lên: 15/09/2015, 22:09

... activation There were no studies on the effects of the intervention of these signaling pathways in animal models of asthma The purpose of my thesis was to investigate the antiinflammatory effects of ... BAL fluid 125 6.4 Effects of LY294002 on the eotaxin level in BAL fluid 126 6.5 Effects of LY294002 on the IFNγ level in BAL fluid 127 6.6 Effects of LY294002 on the expression of VCAM-1 in lung ... I 97 Effects of U0126 on lung tissue eosinophilia 99 ix 5.5E-H, J Effects of U0126 on mucus production 100 5.6 Effects of U0126 on cytokine levels in BAL fluid 101 5.7 Effects of U0126 on the...

Ngày tải lên: 16/09/2015, 17:11

... of the cell cycle We next investigated the effect of combining CDO with the chemotherapeutic drugs 5-FU, SN38 and etoposide in the two CDO-sensitive cell lines There was neither enhancement of ... blockades in the G1, S or G2 phases of the cell cycle, suggesting that the reduction in cell number may have been the result of a general and simultaneous blockade of all three phases of the cell ... of p53 status [18,19], and accompanied by the hallmarks of apoptosis [20], which together suggests a more profound interaction The aims of the present study were threefold: first, to explore the...

Ngày tải lên: 07/03/2014, 15:20

... of a joint of a rat of similar age is also shown in Fig 3D There was no Induction of apoptosis of fibroblast-like synoviocytes by MK-4 Analogous to the effects of MK-4 on tumor cells, we hypothesized ... induction of caspase activation In the present study, we determined the effect of vitamin K2 (MK-4) on the proliferation of rheumatoid synovial cells and the development of arthritis in the experimental ... pathological feature of RA We therefore studied the biological effects of MK-4 on the proliferation of fibroblast-like synoviocytes (FLS) We observed that MK-4 inhibited the viability of FLS in a dose-dependent...

Ngày tải lên: 30/03/2014, 03:20

... glioblastoma therapy [15] The development of more selective antiangiogenic molecule would help to minimize the side -effects and increase the therapeutic effectiveness We have recently designed and synthesized ... Conclusions The present study indicates the importance of RGDechiHCit in the selective inhibition of endothelial aVb3 integrin Such inhibition opens new fields of investigation on the mechanisms of angiogenesis, ... in serum The RP-HPLC profile of the peptide before the incubation showed a single peak at tr = 16.64 min, ascribable to the complete sequence by the MS spectrum (Figure 1C) After 24h of incubation...

Ngày tải lên: 18/06/2014, 16:20

... death of the cells over the electrode The migration of healthy cells from the edge of the wounding to the wounding space was tracked Similar to the changes seen with adhesion, over-expression of ... utility for the gene-based therapy of diverse human cancers The location of the MDA-7 gene is closely linked to the Page of IL-10, IL-19, and IL-20 genes within a 195-kb region -the IL-10 family ... Quantitative analysis of TGase-4 The level of the TGase-4 transcripts in the above-prepared cDNA was also determined using a real-time quantitative Page of PCR, based on the Amplifluor™ technology...

Ngày tải lên: 18/06/2014, 19:20

... understanding of its mechanisms of action and therefore, for a better assessment of its antitumor efficacy The experimental hepatic colonization of B16 melanoma (B16M) is a unique model for determining therapeutic ... representative of the experiment after 60 of treatment NF-B nuclear translocation was detected by immunofluorescent staining with anti p-65 antibody (E) Western analysis was also performed with anti- p65 antibody ... μg/ml rabbit antip65 polyclonal antibody (Santa Cruz Biotechnology Inc., Santa Cruz, CA) for h at room temperature Further wash steps removed unbound antibody prior to the addition of the secondary...

Ngày tải lên: 18/06/2014, 19:20

... splenocytes [24,28] Both the vagus Page of 10 nerve and nicotine exert their inhibitory effects through the activation of Jak2 and STAT3 [15] and the antiinflammatory action of nicotine is mediated ... alterations in the ENS disrupt normal GI function Since the ENS controls the motility and secretion of the bowel these abnormalities indicate the impact of inflammation on neural signaling in the ENS ... in the knockout mice, suggesting that the absence of a5nAChR increases the susceptibility to disease initiation and the presence of a5nAChR in the wild-type animal appears to enhance the therapeutic...

Ngày tải lên: 18/06/2014, 22:20

... death of the cells over the electrode The migration of healthy cells from the edge of the wounding to the wounding space was tracked Similar to the changes seen with adhesion, over-expression of ... utility for the gene-based therapy of diverse human cancers The location of the MDA-7 gene is closely linked to the Page of IL-10, IL-19, and IL-20 genes within a 195-kb region -the IL-10 family ... Quantitative analysis of TGase-4 The level of the TGase-4 transcripts in the above-prepared cDNA was also determined using a real-time quantitative Page of PCR, based on the Amplifluor™ technology...

Ngày tải lên: 20/06/2014, 03:20

... splenocytes [24,28] Both the vagus Page of 10 nerve and nicotine exert their inhibitory effects through the activation of Jak2 and STAT3 [15] and the antiinflammatory action of nicotine is mediated ... alterations in the ENS disrupt normal GI function Since the ENS controls the motility and secretion of the bowel these abnormalities indicate the impact of inflammation on neural signaling in the ENS ... in the knockout mice, suggesting that the absence of a5nAChR increases the susceptibility to disease initiation and the presence of a5nAChR in the wild-type animal appears to enhance the therapeutic...

Ngày tải lên: 20/06/2014, 04:20

... corresponding to the loss of rest of the ligand’s components and formation of metal oxide [22] All attempts employing different sets of conditions to obtain single crystals of the synthesized complexes ... coordination linakge of imine with antimony center; all these facts proved the 1:1 ligand to metal stoichiometry in pseudotrigonal bipyramidal geometry (Figure 1) [19-21] Further, either of the carboxylic ... disappeared in the spectra of complexes indicating deprotonation of ligand In the spectra of compounds V-VIII, appearance of new band of medium intensity around 430 cm-1 indicated the coordination...

Ngày tải lên: 21/06/2014, 02:20

... The estimation of the economic benefit of clam cultured in the intertidal areas is showed in table The net profit is calculated based on the output cost and input cost and price of the clam The ... evaluate the effect of stocking biomass of the two sizes of M lyrata on growth performance and survival to enhance the production and profit of cultivation The other parameters within the culture system ... Microsoft Office EXCEL for Window Results and discussions 3.1 The environment conditions of the experiments The experiment site was situated in the intertidal areas near the estuary where the clams...

Ngày tải lên: 22/06/2014, 12:20